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2,478
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2,478 results for “nasal”
Gene expression analysis of nasal mucosa in birch pollen allergic and non-allergic individuals upon nasal provocation with birch pollen
GEO Series GSE261239. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling of brain-infiltrating and peripheral CD4+Foxp3+ Tregs following traumatic brain injury and nasal anti-CD3 treatment
GEO Series GSE276646. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps reveals distinct lncRNA expression profiles
GEO Series GSE72713. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14
GEO Series GSE107898. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The effect of crosslinking density on nasal chondrocytes' redifferentiation
GEO Series GSE217738. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Interferon signaling in the nasal epithelium distinguishes among lethal and common cold respiratory viruses and is critical for viral clearance
GEO Series GSE253542. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA sequencing and single cell TCR sequencing of Type 2 lymphocytes in human nasal polyps
GEO Series GSE255544. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Respiratory syncytial virus nonstructural protein 1 inhibits secretion of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface
GEO Series GSE309353. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide methylation studies in nasal epithelial cells using a custom Asthma&Allergy DNAm array.
GEO Series GSE220874. Homo sapiens. 280 samples. Type: Methylation profiling by array.
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
GEO Series GSE163151. Homo sapiens. 404 samples. Type: Expression profiling by high throughput sequencing.
Strong correlation between air-liquid interface cultures and in vivo transcriptomics of nasal brush biopsy
GEO Series GSE145096. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
A single-cell analysis of nasal epithelial cells development in domestic pig
GEO Series GSE274334. Sus scrofa. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiles of the nasal epithelium from the Genes-environments & Admixture in Latino Americans (GALA) II study
GEO Series GSE152004. Homo sapiens. 695 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of microglia following traumatic brain injury and nasal anti-CD3 treatment at acute and chronic timepoints
GEO Series GSE276647. Mus musculus. 54 samples. Type: Expression profiling by high throughput sequencing.
High flow nasal oxygen during procedural sedation: A randomized controlled trial
<p>Data and code for publication</p>
Nasal ventilation and Rapid Maxillary Expansion (RME): a randomized trial
<p>Dataset for all analyses of the paper</p>
Data from: Airflow in the human nasal passage and sinuses of chronic rhinosinusitis subjects
Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease of the paranasal sinuses that is characterized by clinical symptoms that include a blocked nasal airway, mucus discharge, facial pain, headaches and anosmia [1, 2]. Functional endoscopic sinus surgery (FESS) is performed on patients who fail to improve following medical therapies such as antibiotics and corticosteroids (both systemic and topical nasal sprays). In sinus surgery, the goals are to open the obstructed sinus openings (ostia), to improve sinus ventilation and to restore mucociliary clearance. After initial surgery, a number of patients may continue to have ongoing symptoms and recalcitrant disease for which a more extensive operation such as the Modified Endoscopic Lothrop procedure (MELP) is performed [3–5]. The MELP procedure differs from standard frontal sinus dissection because both the frontal beak that narrows the frontal ostia, and the adjacent upper part of the nasal septum and frontal intersinus septum are removed, creating a single large common drainage pathway for both frontal sinuses. Current understanding of the relationship between nasal geometry (pre- and post-operative) and sinus ventilation is poor; and despite surgical intervention, efficient topical distribution of therapeutic drugs remains a significant challenge. Simulating nasal airflow in this complex patient group will improve our understanding of how surgical strategies affect post-surgical sinus ventilation, as well as providing new understanding for how drug delivery treatments and devices [6–10] can be designed to target delivery to the sinuses. Nasal passage is connected to sinus air pockets through an opening called ostia. Airflow in the human nasal cavity has been extensively studied using fluid dynamic simulations. We refer the reader to [11] and references there on. A number of studies have simulated airflow in both nasal passage and the sinuses [10, 12–24]. Xiong et al [12] simulated nasal airflow at 21 L/min in a normal healthy subject and found very little flow between the nasal passage and the sinuses. At the frontal sinus ostium they observed a limited flow rate of 0.014mL/s during inspiration and 0.018 mL/s during expiration. Zhu et al. [20] evaluated post-surgical airways after uncinectomy and bilateral inferior turbinate reduction and noticed that the surgery that aimed to affect flow partitioning also increased sinus ventilation in only one respiratory phase. The effects of surgery on altering nasal airflow is a complex realm and are not completely understood. Also, these studies do not sufficiently describe airflow in the sinus. This study describes airflow in the nasal passage and sinuses using fluid dynamic simulations. Specifically, airflow in pre-operative and post-operative CRS subject is investigated. FESS in CRS patients is known to increase nasal airway patency, however although this leads to reduced nasal resistance, the role of surgery in altering exchange of air between the sinus and nasal passages is not clear. Transient airflow is simulated in a healthy normal subject, a pre-operative subject with CRS, the same subject post-operatively after a standard FESS procedure, and a post-operative subject after a Lothrop procedure. Particular focus is given to describing airflow at the openings to the frontal and maxillary sinuses.
Data from: Lambda interferon restructures the nasal microbiome and increases susceptibility to Staphylococcus aureus superinfection
Much of the morbidity and mortality associated with influenza virus respiratory infection is due to bacterial coinfection with pathogens that colonize the upper respiratory tract such as methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. A major component of the immune response to influenza virus is the production of type I and III interferons. Here we show that the immune response to infection with influenza virus causes an increase and restructuring of the upper respiratory microbiota in wild-type (WT) mice but not in Il28r−/− mutant mice lacking the receptor for type III interferon. Mice lacking the IL-28 receptor fail to induce STAT1 phosphorylation and expression of its regulator, SOCS1. Il28r−/− mutant mice have increased expression of interleukin-22 (IL-22), as well as Ngal and RegIIIγ, in the nasal cavity, the source of organisms that would be aspirated to cause pneumonia. Proteomic analysis reveals changes in several cytoskeletal proteins that contribute to barrier function in the nasal epithelium that may contribute to the effects of IL-28 signaling on the microbiota. The importance of the effects of IL-28 signaling in the pathogenesis of MRSA pneumonia after influenza virus infection was confirmed by showing that WT mice nasally colonized before or after influenza virus infection had significantly higher levels of infection in the upper airways, as well as significantly greater susceptibility to MRSA pneumonia than Il28r−/− mutant mice did. Our results suggest that activation of the type III interferon in response to influenza virus infection has a major effect in expanding the upper airway microbiome and increasing susceptibility to lower respiratory tract infection.
Figure 9 from: Knee W (2018) New species of parasitic nasal mites infesting birds in Manitoba, Canada (Mesostigmata, Rhinonyssidae). ZooKeys 786: 1-17. https://doi.org/10.3897/zookeys.786.28767
Figure 9 Female Vitznyssuserici sp. n. legs I–IV, coxae omitted.
Figure 7 from: Knee W (2018) New species of parasitic nasal mites infesting birds in Manitoba, Canada (Mesostigmata, Rhinonyssidae). ZooKeys 786: 1-17. https://doi.org/10.3897/zookeys.786.28767
Figure 7 Female Vitznyssuserici sp. n. ventral idiosoma including coxae.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.