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Annex A to the technical report on the raw primary commodity (RPC) model - Input data
<p><strong>The raw primary commodity model</strong>:</p> <p>Dietary exposure is typically calculated by combining food consumption data with occurrence data. EFSA’s food consumption data are stored in the Comprehensive European Food Consumption Database (Comprehensive Database). Some of these data, however, cannot be used in exposure assessments when the occurrence data are reported for the raw primary commodities (RPCs). The RPC model aims to bridge this gap by transforming the Comprehensive Database into RPC consumption data. Using the RPC model, EFSA successfully developed a new RPC Consumption Database, which contains 51 dietary surveys from 23 different countries. These surveys cover a total of 94,532 subjects and 26,573,088 RPC consumption records. The consumption data generated by the RPC model were manually checked and validated by means of case studies. These case studies demonstrated that the RPC consumption data are suitable for assessing dietary exposure to chemicals where the occurrence data are predominantly available for RPCs.</p> <p><strong>Annex A to the technical report on the raw primary commodity model:</strong></p> <p>Annex A is an excel file which presents input data tables used by the RPC model. The annex contains the following tables:</p> <p>Table A.1 (Survey table) - An overview of the food consumption surveys incorporated in the RPC model</p> <p>Table A.2 (FoodEx table) - An outline of the food classification system used in the RPC model (EFSA's FoodEx classification system with additional codes)</p> <p>Table A.3 (Probability table) - Manages foods coded at food group level (example, breakfast cereals)</p> <p>Table A.4 (Disaggregation table) - Disassembles composite foods into their single components (RPC derivatives and/or RPCs)</p> <p>Table A.5 (Conversion table) - Converts amounts of RPC derivatives into corresponding amounts of RPC</p> <p>Table A.6 (Component table) - Overview of the search strings used for the probability analysis of components</p>
Tsunamis due to ice masses: Different calving mechanisms and linkage to landslide-tsunamis - Data storage report
<p>Land ice melt and retreat is one of the most visible effects of climate change and contributes ≈1.5 mm/year to global sea-level rise (SLR) of a total of ≈2.7 mm/year. Global warming results in the shrinking of ice masses in most ice covered regions in the World, particularly in the Alps and in Greenland and the Greenlandic mass loss is estimated at –269 ±51 Gt/year. A significant part of this mass loss is through the detachment of icebergs at glacier fronts in a mechanism called iceberg calving. Such iceberg impacting into a water body generate tsunamis, such called "iceberg-tsunamis". Such an iceberg-tsunami reached a height of 50 m at the Eqip Sermia outlet glacier in 2014. These tsunamis pose a considerable hazard for the local community, the fishing industry and the increasing number of tourists in ice covered areas. Several iceberg calving mechanisms have been proposed including fall, over-turning and capsizing. Reliable guidance on the upper limit of iceberg-tsunami heights are currently unavailable. A main reason for this limited understanding is that reliable field data are rare, such that laboratory tests complemented with numerical simulations are important to advance this research field. This was the aim of this HYDRALAB+ funded study. The wave features (height, length, velocity) caused by icebergs in function of the iceberg calving mechanisms (fall, over-turning, capsizing), as well as the mass volume and kinematics, were modelled in unique large-scale experiments. This minimised both scale effects and wave reflection. The attached file is an HYDRALAB+ standard Data Storage Report about these experiments.</p>
Case report: Large-cell calcifying Sertoli cell tumor
<p><strong>Case history</strong></p> <p>21-year-old male with a painless mass in the right testicle and a prior history of cutaneous lesions.</p> <p> </p> <p><strong>Histologic findings</strong></p> <p>Figures show a proliferation composed of large, polygonal cells with ample, eosinophilic cytoplasm, round nuclei, evident nucleoli, with a trabecular, cord-like pattern of growth, associated with foci of dystrophic calcification and psammomatous bodies, within a myxoid loose stroma.</p> <p> </p> <p><strong>Discussion</strong></p> <p>Large-cell calcifying Sertoli cell tumor is an unusual morphological variant of Sertoli cell tumors composed of large polygonal Sertoli cells associated with calcification. Around one third of all cases appear in patients with the Carney or, less frequently, with the Peutz-Jeghers syndrome.</p> <p>Clinically, it presents as a small (<2 cm), painless testicular mass, which can be bilateral and multifocal in about 40% of the cases, especially in syndromic settings. In non-sporadic cases extratesticular manifestations are related to the associated syndrome, such as myxomas of the skin, soft-tissue, and heart and myxoid lesions of the breast, facial lentigines, cutaneous blue nevi, secondary Cushing syndrome due to pigmented adrenocortical nodular hyperplasia, pituitary somatotroph adenomas, and psammomatous melanotic schwannomas.</p> <p>Microscopically, solid, tubular, and cord-like growth patterns can be observed. Tumor cells are large polygonal with abundant eosinophilic, finely granular cytoplasm, vesicular nuclei with prominent nucleoli, within a myxohyaline stroma. Distinct calcifications characterized by large, laminated calcified nodule, psammoma bodies and focal ossification, and neutrophilic infiltration, can be also found.</p> <p>The presence of large tumor size (>4 cm), overt nuclear atypias, increased mitotic activity (>3 mitosis/10 HPF), necrosis, extratesticular extension, and vascular invasion are associated with clinical aggressive behavior. Malignant tumors appear in patients older than 25 years old and are usually not associated with syndromes.</p> <p>Tumor cells are positive for vimentin, S-100, EMA, melan-A, desmin, and inhibin, and focally positive for cytokeratins. The main differential diagnoses of large-cell calcifying Sertoli cell tumor include Sertoli cell and Leydig cell tumors.</p> <p>Most of the cases behave indolently, and surgical excision is the treatment of choice.</p>
Experimental CCN properties of 6 pollenkitts and two mixtures with ammonium sulfate reported in the study "Cloud condensation nuclei activity of six pollenkitts and the influence of their surface activity" by Prisle et al. (2019)
<p>Critical dry particle size Dp<sub>50</sub> measured for supersaturations 0.1–1.4% with a DMT CCN Counter (CCN-100). Size and composition resolved, and size-averaged hygroscopicity values calculated using the method presented by Rose et al. (2010), Cloud condensation nuclei in polluted air and biomass burning smoke near the mega-city Guangzhou, China - Part 1: Size-resolved measurements and implications for the modeling of aerosol particle hygroscopicity and CCN activity, <em>Atmospheric Chemistry and Physics</em>, <em>10</em>, 3365–3383.</p>
Experimental surface tensions of aqueous poplar and ragweed pollenkitts reported in the study "Cloud condensation nuclei activity of six pollenkitts and the influence of their surface activity" by Prisle et al. (2019)
<p>Surface tensions measured with a ramé-hart goniometer (Model 250) for aqueous solutions of varying concentrations comprising poplar and ragweed pollenkitts and their mixtures with ammonium sulfate</p>
Case report: Adenosquamous carcinoma of the penis
<p><strong>Case history</strong></p> <p>55-year-old patient with a penile tumor located in the perimeatal area of the glans</p> <p> </p> <p><strong>Histologic findings</strong></p> <p>Microphotographs show a biphasic proliferation of tumors cells showing squamous and glandular differentiation, deeply infiltrating penile erectile tissues. Squamous and glandular structures are found either segregated or in the same tumor nests.</p> <p> </p> <p><strong>Discussion</strong></p> <p>Adenosquamous carcinoma is a rare penile SCC variant characterized by the presence of solid squamous tumor nests intermingled with areas of glandular differentiation. Less than 20 cases have been reported. The tumor originates in the glans central/perimeatal region and has a tendency for deep infiltration. Most tumors are of high-grade, with frequent vascular and perineural invasion. Metastatic rate is high but cancer-specific mortality remains low.</p> <p>Histologically, areas with squamous differentiation predominate. The glandular component is positive for mucin stains and CEA.</p> <p>The main differential diagnosis is with penile tumors with glandular features, including mucoepidermoid, pseudoglandular, urothelial carcinomas of distal urethra with glandular differentiation and true adenocarcinomas of Littré glands. Mucoepidermoid carcinoma of penis is an exceedingly rare tumor which is histologically similar to its cervical counterpart. Neoplastic population is composed of cell with squamous differentiation and cells showing evidence of glandular differentiation (pale, granular and ample cytoplasm with positivity for mucin stains and CEA) without well-defined glandular or ductal structures. Although more data are needed, it seems that mucoepidermoid carcinoma is more aggressive than conventional adenosquamous carcinoma.</p> <p>In pseudoglandular carcinoma the extensive acantholysis can simulate glands lumina but there is no true epithelial lining. Urothelial carcinomas originating in the penile distal urethra or extending from prostate, bladder or even ureter/renal pelvis, can depict glandular features. However, a previous history of urothelial carcinoma elsewhere and the frequent finding of in situ urothelial carcinoma (which is absent in adenosquamous carcinoma) aid in the differential diagnosis.</p> <p>In adenocarcinomas originating in Littré glands there is no true squamous differentiation and tumors tend to be ventrally located with only secondary extension to the perimeatal glans area. Finally, entrapment of Littré’s glans by an otherwise usual SCC can simulate the aspect of an adenosquamous carcinoma. However, the morphology of the glandular component remains bland and admixtures are limited to the periurethral area.</p> <p> </p> <p><strong>Selected references</strong></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/22641956">Chaux & Cubilla. Semin Diagn Pathol. 2012 29(2): 72-82</a></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/8554104">Cubilla et al. Am J Surg Pathol. 1996 20(2): 156-60</a></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16924331">Romero et al. Clinics (Sao Paulo). 2006 61(4): 363-4</a></p>
Tables and Figures complementing the European Union Summary Report on Antimicrobial Resistance in Zoonotic and Indicator Bacteria from Humans, Animals and Food in 2017
<p>All tables, figures and maps produced for the European Union Summary Report on Antimicrobial Resistance in Zoonotic and Indicator Bacteria from Humans, Animals and Food in 2017 are provided.</p>
Report of the Focus Group with Stakeholders in the Middle-East
<p>As part of the MENARA project, the Issam Fares Institute for Public Policy and International Affairs at the American University of Beirut (IFI – AUB) organized a focus group in Beirut (Lebanon) on 2 November 2018 with twelve scholars, experts, civil society leaders and activists from Lebanon and the Arab Middle East. </p> <p>The discussions were linked to the general aims of the MENARA project – characterizing the regional order, defining scenarios and discussing policy options for the EU – and was initially (informally) structured in four parts (though participants themselves were allowed to take the discussion in directions that made sense to them):</p> <p>1. Regional rivalries and new regional order<br> 2. State–society dynamics<br> 3. The role of the EU and other external actors<br> 4. Future scenarios</p> <p>This report contains the summary of the discussion during the focus group.</p>
The Middle East in 2025: Stakeholder's Engagement Meeting Report
<p>On 10 and 11 January 2019, the Istituto Affari Internazionali (IAI), in collaboration with the Near East and South Asia (NESA) Center for Strategic Studies of the United States Department of Defense and the Qatar Armed Forces Strategic Studies Center (QAFSSC), organized the second MENARA Stakeholders’ Engagement Meeting with 32 participants, including representatives of Qatar’s government, academics and experts from Europe, the United States and the Persian Gulf region.</p> <p>The goal of the meeting was among others to discuss and test some of the Project's preliminary findings with regard to the regional order in the Middle East and North Africa (MENA) and the role of the European Union (EU) and other external players in the region with a group of authoritative stakeholders. This report summarizes the discussion during that meeting.</p> <p>This activity is part of the EU research project Middle East North Africa Regional Architecture (MENARA).</p>
Summary for policymakers of the assessment report on land degradation and restoration of the Intergovernmental SciencePolicy Platform on Biodiversity and Ecosystem Services: Figure SPM.1
<p>The purpose of Figure SPM.1 is to support the statement that land degradation occurs just about everywhere in the world (i.e. it is ‘pervasive’), takes many forms, and that examples of successful restoration are also widespread. The figure consists of a backdrop map of the world from a multiple land degradation perspective, showing the level of uncertainty between studies, overlaid with dots representing all the places specifically mentioned in the eight chapters of the main Assessment Report on Land Degradation and Restoration, including case studies of both degradation and restoration. Around the map are brief notes regarding the main forms of degradation encountered.</p>
Data for dissemination and communication reporting
<p>This data was collected through the periodic monitoring of the project's miscellaneous dissemination activities, such as publications in relevant journals, posts, etc. The data consist of a list that depicts the number of publications, posts, events organized or attended by the consortium partners, etc. as well as the number of different type of stakeholders reached by the project's dissemination activities. The purpose of collecting this data is to assess the outreach and efficiency of the dissemination activities during the implementation of the project.</p>
(1729) Venice Biennale Danish pavilion, Venice, I - Structural analysis report
<p>This report contains structural analysis results of the textile membrane installation at the Danish Pavilion of the Venice Biennale 2018. Load assumptions, support reactions, deflections, reaction forces and stress state of the main load bearing members are presented.<br> Basis for the design are the EN 1990 (Basis of structural design) [1], EN 1991 (Actions on structures) [2], EN 1993 (Design of steel structures) [3] and DIN EN 13782 (Temporary structures) [4].<br> The installation is placed at the “Giardini della Biennale” in Venice as part of the Biennale exhibition which will run from May until November. The loads acting upon the structure are partially reduced due to the temporary nature of the installation.</p>
SparBOFWEC Spar Buoy for Offshore Floating Wind Energy Conversion - Data Storage Report
<p>The present work describes the experiences gained from the design methodology and operation of a 3D physical model experiment aimed to investigate the dynamic behaviour of a spar buoy (SB) off-shore floating wind turbine (WT) under different wind and wave conditions. The physical model tests have been performed at Danish Hydraulic Institute (DHI) off-shore wave basin within the European Union-Hydralab+ Initiative, in April 2019. The floating WT model has been subjected to a combination of regular and irregular wave attacks and wind loads.</p>
ENERGISE Living Lab Country Report - Switzerland
<p>In Switzerland, the two ENERGISE Living Labs (ELLs) took place in the City and Canton of Geneva, in the French-speaking region of the country. The first Living Lab (ELL1) included 20 households with diverse profiles, from one- and two-person households to families with two or three children, and with participants of all age groups. A large majority of them lived in multi-family houses or larger apartment buildings, reflecting the housing situation in Switzerland. The second Living Lab (ELL2) was organised in a community of place, a housing cooperative located in the Geneva city center. The participants' profile was also varied in terms of age group and type of households.</p>
ENERGISE Living Lab Country Report - Hungary
<p>The ENERGISE Living Labs in Hungary were located in the town of Gödöllő in Central Hungary in order to provide a better opportunity to make comparisons between the individual (ELL1) and the community or group approach (ELL2). Thus, while an attempt was made to recruit a socio-economically diverse group of participants, the two ELLs had a similar make-up in terms of household types. The final number of households participating in the ENERGISE Living Labs in Hungary was 41. Out of this number 21 participated in ELL1 and 20 in ELL2. It is notable that all 41 households remained engaged in the ELLs up until the end. This report provides a summary of the qualitative and quantitative data as well as a country-level analysis of outcomes.</p>
ENERGISE Living Lab country report - United Kingdom
<p>This national country report describes the two living labs run in the United Kingdom for the pan-European ENERGISE (European Network for Research, Good Practice and Innovation for Sustainable Energy) project funded by the European Commission Horizon 2020 framework programme for 36 months (December 2016 - November 2019). The report discusses the main findings arising from the living labs. It also considers some of the implications for policy-making and future research of the project.</p>
ENERGISE Living Lab country report - Finland
<p>ENERGISE Living Labs (ELLs) employ practice-based approaches to reduce energy use in households while co-creating knowledge on why energy-intensive practices are performed and how they depend on the context in which they are performed. Altogether 16 living labs were implemented in eight European countries in 2018.</p> <p>The Finnish ELLs were implemented in two different sites. ELL1 for individual households took place in a Porvoo region, about 50 kilometres from Helsinki and engaged 19 households living mainly in single-family homes. ELL2 (with collective elements) was implemented in Merihaka, urban district close to Helsinki city centre, and 18 households living in apartment buildings in Merihaka joined the ELL challenges and community activities.</p>
Data Storage Report. RODBreak - Wave run-up, overtopping and damage in rubble-mound breakwaters under oblique extreme wave conditions due to climate change scenarios
<p>Wave breaking / run-up / overtopping and their impact on the stability of rubble-mound breakwaters (both at trunk and roundhead) are not adequately characterized yet for climate change scenarios. The same happens with the influence of high-incidence angles on such phenomena.</p> <p>To study these phenomena a stretch of a rubble-mound breakwater (head and part of the adjoining trunk, with a slope of 1(V):2(H)) was built in the wave basin of the LUH, The trunk of the breakwater was 7.5 m long and the head had the same cross section as the exposed part of breakwater. The model was 9.0 m long, 0.82 m high and 3.0 m wide. The angle between the longitudinal axis of the breakwater and the tank wall was 70º. Two types of armour elements (rock and Antifer cubes) were tested.</p> <p>60 tests were carried out in this experiment to assess, under extreme wave conditions (wave steepness of 0.055) with different incidence wave angles (from 40º to 90º), the structure behaviour in what concerns wave run-up, wave overtopping and damage progression of the armour layer.</p> <p>The report describes the data collected in those tests as well as how such data is stored.</p>
Underlying data of the project "A survey exploring biomedical editors' perceptions of editorial interventions to improve adherence to reporting guidelines"
<p><em><strong>Survey dataset.xlsx</strong></em> contains the anonymised responses to the survey.</p>
Annexes to the external scientific report on the cumulative dietary exposure assessment of pesticides that have acute effects on the nervous system using MCRA software - Input and output data sets
<p>Retrospective dietary exposure assessments were conducted for two groups of pesticides that have acute effects on the nervous system: </p> <ol> <li>brain and/or erythrocyte acetylcholinesterase inhibition (CAG-NAN);</li> <li>functional alterations of the motor division (CAG-NAM).</li> </ol> <p>The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system (<a href="https://doi.org/10.2903/j.efsa.2019.5800">here</a>).</p> <p>The exposure calculations used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual food consumption data from ten populations of consumers from different countries and from different age groups. Regarding the selection of relevant food commodities, the assessment included water, foods for infants and young children and 30 raw primary commodities of plant origin that are widely consumed within Europe.</p> <p>Exposure estimates were obtained with Monte Carlo Risk Assessment (MCRA) software using a 2-dimensional Monte Carlo simulation, which is composed of an inner-loop execution and an outer-loop execution. Variability within the population is modelled through the inner-loop execution and is expressed as a percentile of the exposure distribution. The outer-loop execution is used to derive 95% confidence intervals around those percentiles (reflecting the sampling uncertainty of the input data).</p> <p>Furthermore, calculations were carried out according to a tiered approach. While the first-tier calculations (Tier I) use very conservative assumptions for an efficient screening of the exposure with low risk for underestimation, the second-tier assessment (Tier II) includes assumptions that are more refined but still conservative. For each scenario, exposure estimates were obtained for different percentiles of the exposure distribution and the total margin of exposure (MOET, i.e. the ratio of the toxicological reference dose to the estimated exposure) was calculated at each percentile.</p> <p>The input and output data for the exposure assessment are reported in the following annexes:</p> <ul> <li>Annex A.1 – Input data for the exposure assessment of CAG-NAN</li> <li>Annex A.2 – Input data for the exposure assessment of CAG-NAM</li> <li>Annex B.1 – Output data from the Tier II exposure assessment of CAG-NAN</li> <li>Annex B.2 – Output data from the Tier II exposure assessment of CAG-NAM</li> </ul> <p>Further information on the data, methodologies and interpretation of the results are provided in the external scientific report on the cumulative dietary exposure assessment of pesticides that have acute effects on the nervous system using MCRA software (<a href="https://doi.org/10.2903/sp.efsa.2019.en-1708">here</a>).</p> <p>The results reported in this assessment only refer to the exposure and are not an estimation of the actual risks. These exposure estimates should therefore be considered as documentation for the final scientific report on the cumulative risk assessment of dietary exposure to pesticides for their effects on the nervous system (<a href="https://www.efsa.europa.eu/en/consultations/call/public-consultation-scientific-report-cumulative">here</a>). The latter combines the hazard assessment and exposure assessment into a consolidated risk characterisation, including all related uncertainties.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.