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12,346 results for “derivatives”
A targeted metabolomics-based assay using human induced pluripotent stem cell-derived cardiomyocytes identifies structural and functional cardiotoxicity potential
<p>Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and the cost and time required to bring new drugs to market. In this study, a metabolic biomarker-based assay was developed that predicts the cardiotoxicity potential of a drug based on changes in the metabolism and viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). Assay development and testing was conducted in two phases: (1) biomarker identification and (2) targeted assay development. In the first phase, metabolomic data from hiPSC-CM spent media following exposure to 66 drugs was used to identify biomarkers that identified both functional and structural cardiotoxicants. Four metabolites that represent different metabolic pathways (arachidonic acid, lactic acid, 2'-deoxycytidine, and thymidine) were identified as indicators of cardiotoxicity. In phase two, a targeted, exposure-based biomarker assay was developed that measured these metabolites and hiPSC-CM viability across an eight-point concentration curve. Metabolite-specific predictive thresholds for identifying the cardiotoxicity potential of a drug were established and optimized for balanced accuracy or sensitivity. When predictive thresholds were optimized for balanced accuracy, the assay predicted the cardiotoxicity potential of 81 drugs with 86% balanced accuracy, 83% sensitivity, and 90% specificity. Alternatively, optimizing the thresholds for sensitivity yields a balanced accuracy of 85%, 90% sensitivity, and 79% specificity. This new hiPSC-CM-based assay provides a paradigm that can identify structural and functional cardiotoxic drugs that could be used in conjunction with other endpoints to provide a more comprehensive evaluation of a drug's cardiotoxicity potential.</p>
Data file for the paper "General Models for the Electrochemical Hydrogen Oxidation and Hydrogen Evolution Reactions – Theoretical Derivation and Experimental Results Under Near Mass-Transport Free Conditions", J. Phys Chem. C., 2016, DOI:10.1021/acs.jpcc.6b00011
<p>The data in this folder is supplementary information for the paper:<br /> Anthony Kucernak and Christopher Zalitis, "General Models for the Electrochemical Hydrogen Oxidation and Hydrogen Evolution Reactions – Theoretical Derivation and Experimental Results Under Near Mass-Transport Free Conditions", J. Phys Chem. C., 2016, DOI:10.1021/acs.jpcc.6b00011</p> <p>The information is © Anthony Kucernak</p> <p>A description of the models used in these files is provided in that paper. Below is a description of the files</p> <p>Experimental Data.xlsx - This file contains the experimental data used to produce figures 6 and 7 in the aforementioned paper<br /> Model.xlsx - This file contains verified versions of the Heyrovsky-Volmer, Tafel-Volmer and Heyrovsky-Tafel-Volmer mechanisms developed in the paper mentioned above. These excel spreadsheets may be used to fit experimental data user the Solver function in Excel.</p> <p>Heyrovsky-Tafel.cdf, Heyrovsky-Tafel-Volmer.cdf, Tafel-Volmer.cdf, Heyrovsky-Volmer.cdf - These are "computable document format" files produced using Wolfram Mathematica. They allow easy and quick modification of model parameters to allow real-time exploration of the effect of the parameters on current density (as linear and Tafel plots), hydrogen coverage, Effective Tafel slope, and derived parameters. The CDF viewer is availble to download from the Wolfram site - www.wolfram.com</p>
Patch-based image reconstruction for PET using prior-image derived dictionaries
<p>This collection contains figures and reconstructed images in .mat format associated with the manuscript tiled "<strong>Patch-based image reconstruction for PET using prior-image derived dictionaries</strong>" . The file, Data_Fig9-10.zip contains the reconstructed images associated with Fig 9 and 10 as a function of iteration for different methods. Data_Fig10-12.zip contains reconstructed images of the real data for different methods.</p>
FIGURE 1. Maximum likelihood phylogram derived from a Bayesian backbone constraint consensus tree constructed using only taxa for which 12S, 16S, cytochrome b and cytochrome oxidase I in A new species of Dendrobates (Anura: Dendrobatidae) from the Amazonian lowlands in Perú
FIGURE 1. Maximum likelihood phylogram derived from a Bayesian backbone constraint consensus tree constructed using only taxa for which 12S, 16S, cytochrome b and cytochrome oxidase I sequence data were available. Numbers indicate posterior probabilities from the Bayesian analysis. Species of the Ventrimaculatus group are denoted with s.s. (sensu stricto), s.l. (sensu lato) and sp. aff (species affinis).
FIGURE 33 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 33. Nanotanaupodus gracehallae sp. n. (adult male). A, prodorsal shield; B, genital opening; C, eugenital structure; D, eugenital seta.
FIGURE 28 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 28. Nanotanaupodus andrei sp. n. (deutonymph). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus; E, genital opening; F, anal opening.
FIGURE 19 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 19. Allotanaupodus winksi sp. n. (deutonymph). A, prodorsal shield; B, genital opening; C, anal opening; D, dorsal idiosomal seta; E, ventral idiosomal seta.
FIGURE 15 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 15. Allotanaupodus orete sp. n. (adult male). A, leg I; B, leg II; C, leg III; D, leg IV; E, detail view of tarsus I.
FIGURE 18 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 18. Allotanaupodus winksi sp. n. (deutonymph). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus.
FIGURE 9 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 9. Allotanaupodus williamsi sp. n. (adult male). A, prodorsal shield; B, genital opening; C, eugenital structure; D, dorsal idiosomal seta; E, ventral idiosomal seta.
FIGURE 32 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 32. Nanotanaupodus gracehallae sp. n. (adult male). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus; E, anal opening; F, dorsal idiosomal seta; G, ventral idiosomal seta.
FIGURE 23 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 23. Nanotanaupodus andrei sp. n. (adult female). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus.
FIGURE 20 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 20. Allotanaupodus winksi sp. n. (deutonymph). A, leg I; B, leg II; C, leg III; D, leg IV; E, detail view of tarsus I.
FIGURE 8 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 8. Allotanaupodus williamsi sp. n. (adult male). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus; E, anal opening.
FIGURE 4 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 4. Allotanaupodus williamsi sp. n. (adult female). A, prodorsal shield; B, genital opening; C, anal opening; D, dorsal idiosomal seta; E, ventral idiosomal seta.
FIGURE 24 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 24. Nanotanaupodus andrei sp. n. (adult female). A, prodorsal shield; B, genital opening; C, anal opening; D, E, dorsal
FIGURE 14 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 14. Allotanaupodus orete sp. n. (adult male). A, prodorsal shield; B, genital opening; C, anal opening.
FIGURE 3 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 3. Allotanaupodus williamsi sp. n. (adult female). A, chelicerae; B, subcapitulum; C, palp; D, palpal tarsus.
FIGURE 13 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 13. Allotanaupodus orete sp. n. (adult male). A, chelicerae; B, subcapitulum; C, palp; D, palpal tibia claw and tarsus.
FIGURE 25 in Allotanaupodidae, a new family of early derivative Parasitengona (Acari: Prostigmata)
FIGURE 25. Nanotanaupodus andrei sp. n. (adult female). A, leg I; B, leg II; C, leg III; D, leg IV; E, detail view of tarsus I.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.