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1,544
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1,544 results for “microenvironment”
Gene-expression profiles of ovarian cancer regarding its microenvironment
GEO Series GSE55512. Homo sapiens. 12 samples. Type: Expression profiling by array.
CCL3-Mediated Inflammatory Reprogramming of the Hepatocellular Carcinoma Microenvironment Enhances Macrophage Antigen Presentation and Adaptive Immune Response (RNA-Seq)
GEO Series GSE277065. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Human Subperitoneal Fibroblasts and Cancer Cell Interaction Creates Microenvironment Enhancing Tumor Progression and Metastasis
GEO Series GSE53059. Homo sapiens. 12 samples. Type: Expression profiling by array.
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naive hosts. Host irradiation induces a metaprofile consisting of gene modules representing stem cells, cell motility, macrophages and autophagy. Human orthologs of the host irradiation metaprofile discriminated between radiation-preceded and sporadic human thyroid cancers. An irradiated host centroid was strongly associated with estrogen receptor negative breast cancer. When applied to sporadic human breast cancers, the irradiated host metaprofile strongly associated with basal-like and claudin-low breast cancer intrinsic subtypes. Comparing host irradiation in the context of TGFB levels showed that inflammation was robustly associated with claudin-low tumors. The association of the irradiated host metaprofiles with estrogen receptor negative status and claudin-low subtype suggests that host processes similar to those induced by radiation underlie sporadic cancers. Total RNA was extracted from mammary tumors derived from transplantations of non-irradiated p53null mammary fragments into irradiated hosts. We analyized a total of 32 p53null tumors from irradiated wild type mice: 9 from sham-irradiated hosts, and 23 from irradiated hosts. We also analyzed 24 tumors from irradiated TGFb1 heterozygote hosts: 6 from sham-irradiated hosts, and 18 from irradiated hosts.
Densely Ionizing Radiation Effects on the Microenvironment Promote Aggressive Trp53 Null Mammary Carcinomas
Densely ionizing radiation is a major component of the space radiation environment and has potentially greater carcinogenic effect compared to sparsely ionizing radiation that is prevalent in the terrestrial environment. It is unknown to what extent the irradiated microenvironment contributes to the differential carcinogenic potential of densely ionizing radiation. To address this gap, 10-week old BALB/c mice were irradiated with 100 cGy sparsely ionizing g-radiation or 10, 30, or 80 cGy of densely ionizing, 350 MeV/amu Si particles and transplanted 3 days later with syngeneic Trp53 null mammary fragments. Tumor appearance was monitored for 600 days. Tumors arising in Si-particle irradiated mice had a shorter median time to appearance, grew faster and were more likely to metastasize. Most tumors arising in sham-irradiated mice were ER-positive, pseudo-glandular and contained both basal keratin 14 and luminal keratin 8/18 cells (designated K14/18), while most tumors arising in irradiated hosts were K8/18 positive (designated K18) and ER negative. Comparison of K18 vs K14/18 tumor expression profiles showed that genes increased in K18 tumors were associated with ERBB2 and KRAS while decreased genes overlapped with those down regulated in metastasis and by loss of E-cadherin. Consistent with this, K18 tumors grew faster than K14/18 tumors and more mice with K18 tumors developed lung metastases compared to mice with K14/18 tumors. However, K18 tumors arising in Si-particle irradiated mice grew even faster and were more metastatic compared to control mice. A K18 Si-irradiated host profile was enriched in genes involved in mammary stem cells, stroma, and Notch signaling. Thus systemic responses to densely ionizing radiation enriches for a ER-negative, K18-positive tumor, whose biology is more aggressive compared to similar tumors arising in non-irradiated hosts. Key Words: ionizing radiation; breast cancer; heavy ion radiation;initiation; promotion 3 different dose of Si were used. Total RNA was extracted from mammary tumors derived from transplantations of non-irradiated p53null mammary fragments into irradiated hosts. We analyzed a total of 45 Trp53-null tumors: 18 from sham-irradiated hosts, 9 from 10 cGy Si-irradiated hosts, 10 from 30 cGy Si-irradiated hosts, and 8 from irradiated hosts.
Metabolism regulates muscle stem cell self renewal by connecting the microenvironment and histone acetylation
GEO Series GSE117229. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis
GEO Series GSE225190. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Glutamine is critical for the maintenance of Type 1 Conventional Dendritic cells in normal tissue and the tumor microenvironment.
GEO Series GSE279324. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Epithelial cholangiocarcinoma cells can contribute to desmoplasia by extracellular matrix deposition and mesenchymal transition depending on the microenvironment
GEO Series GSE188527. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Sphingosine kinase 2 in stromal fibroblasts creates a hospitable tumor microenvironment in breast cancer
GEO Series GSE136655. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Combining SHP2 inhibition with CX3CR1 inhibition shrinks tumors and normalizes the tumor microenvironment
GEO Series GSE261435. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in Type 2 Diabetic Mice
GEO Series GSE212726. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment
GEO Series GSE288406. Homo sapiens. 136 samples. Type: Other.
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and metastasis of carcinogen-induced colorectal tumors
GEO Series GSE28129. Mus musculus. 4 samples. Type: Genome variation profiling by genome tiling array.
CXCL14 suppresses the progression of colon cancer by regulating tumor epithelial-mesenchymal transition and tumor microenvironment [MC38-CXCL14]
GEO Series GSE256328. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Fibrosis Like Phenotype in TP53KO Hepatic Organoids within a Pro Carcinogenic Tumor Microenvironment (pc-TME)
GEO Series GSE252464. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Evading immune evasion via reprograming of the tumor microenvironment by radiotherapy and simultaneous targeting of TGF-β/PD-L1
GEO Series GSE182004. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Dasatinib Remodels the Tumor Microenvironment and Sensitizes Small Cell Lung Cancer to Immunotherapy [PD1CTLA4]
GEO Series GSE297818. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
GEO Series GSE209683. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Immunocompetent murine models recapitulate the heterogeneous tumor immune microenvironment of human liposarcoma [human]
GEO Series GSE300935. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.