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1,353
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1,353 results for “single-cell transcriptomics”
Single-cell transcriptome-based analysis reveals hub genes and key pathways in acute B-lymphoblastic leukemia
<p><span>急性</span><span>B </span><span>淋巴细胞白血病(</span><span>Acute B Lymphoblastic Leukemia B-ALL</span><span>)发病机制复杂,与基因突变和信号通路的异常密切相关。本研究旨在对</span><span>B-ALL</span><span>患者的基因表达和信号通路进行系统分析,我们期望揭示疾病发生和发展的分子机理,为临床治疗提供新的靶点。</span><span>在</span><span>GSE130116</span><span>数据集中,通过使用特定标记基因鉴定</span><span>B</span><span>细胞亚型。应用高维加权基因共表达网络分析(</span><span>high-definition Weighted Gene Co-expression Network Analysis hdWGCNA</span><span>)对单细胞</span><span><span>RNA</span></span><span><span>测序(</span><span>single-cell RNA sequencing</span><span> <span> </span>scRNA-seq</span></span><span><span>)</span></span><span>数据进行细胞亚群聚类和基因模块关联,结合伪时间轨迹分析,以确定与</span><span>B-ALL</span><span>相关的关键细胞状态和基因模块。基因组富集分析识别与基因模块相关的生物过程。使用用于活性推断的通路响应基因(</span><span>Pathway RespOnsive GENes for activity inference PROGENy</span><span>)软件包用于基于单细胞转录组数据推断通路活性。分析伪时序变化中的关键基因,并用</span><span>FindMarkers</span><span>函数进行差异表达分析,识别不同伪时间状态中显著变化的基因。</span></p>
Single-cell transcriptomics of mammalian prion diseases identifies dynamic gene signatures shared between species [human_scRNAseq]
GEO Series GSE214374. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study
GEO Series GSE185988. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics and translatomics dual-omics analysis reveals the potential mechanism of HFD-induced maternal RNA degradation abnormalities
GEO Series GSE294093. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing; Other.
scHiCAR: a tri-modal single-cell genomics technology for integrated transcriptome, epigenome, and 3D genome analysis in complex tissues [mouse_skeletal_muscle_scHiCAR]
GEO Series GSE304674. Mus musculus. 50 samples. Type: Other.
Single-cell transcriptome combined with spatial transcriptome to investigate the molecular mechanism associated with autophagy of clear renal cell carcinoma
GEO Series GSE304466. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic datasets of the amphibious plant Water wisteria
GEO Series GSE309844. Hygrophila difformis. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell Transcriptome Atlas of Testis Aging
GEO Series GSE215754. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Single-cell and spatial transcriptomic analysis of homeostatic adult human skin
GEO Series GSE173651. Homo sapiens. 6 samples. Type: Other.
Characterization of cuprizone mouse model at single-cell and spatial transcriptomics level[snRNA-seq]
GEO Series GSE255369. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome unravels spermatogonial stem cells and dynamic heterogeneity of spermatogenesis in seasonal breeding teleost
GEO Series GSE269124. Larimichthys crocea. 3 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome atlas in C57BL/6 mice encodes morphological phenotypes in the aging kidneys
GEO Series GSE262959. Mus. 2 samples. Type: Expression profiling by high throughput sequencing.
A single-cell resolution spatial transcriptomics atlas of human multiple sclerosis lesion (MERSCOPE)
GEO Series GSE284005. synthetic construct; Homo sapiens. 17 samples. Type: Other.
Single-cell transcriptome analysis reveals phenotypically diverse islet-infiltrating T cell subsets in type 1 diabetes
GEO Series GSE125456. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome reveals drug-resistance signature and immunosuppressive microenvironment in lung adenocarcinoma harboring EGFR mutation
GEO Series GSE253718. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions - Microglia cell culture
GEO Series GSE301696. Mus musculus; synthetic construct. 4 samples. Type: Other.
Temporal single-cell transcriptomic profiling of cardiac differentiation in pulmonary atresia with intact ventricular septum (PA-IVS) derived induced pluripotent stem cells
GEO Series GSE223414. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Simultaneous Single-cell Genome and Transcriptome Sequencing with Digital Microfluidics Identifying Essential Driving Genes
GEO Series GSE199010. Homo sapiens. 91 samples. Type: Expression profiling by high throughput sequencing; Other.
LOESS-Corrected UMI Counts Enable Absolute RNA Quantification in Single-Cell Transcriptomics
GEO Series GSE291906. Rattus norvegicus. 1 samples. Type: Expression profiling by high throughput sequencing.
spatiotemporal single-cell transcriptomics in mouse and human to investigate TAM evolution during GBM progression
GEO Series GSE241037. Homo sapiens; Mus musculus. 51 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.