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18,654 results for “Pain”
Do dog breeds differ in pain sensitivity? Veterinarians and the public believe they do
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Acute pain after total knee arthroplasty: 2-arachidonoylglycerol tone and endocannabinoid/eicosanoid crosstalk
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Examining patterns in opioid prescribing for non-cancer-related pain in Wales: preliminary data from a retrospective cross-sectional study using large datasets
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Adolescent alcohol exposure, pain, and synaptic function at BLA inputs onto prelimbic neurons
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Tables S2-S3. SMR-HEIDI results for 8q24.21 locus between back pain and other phenotypes.
<p><strong>Supplementary Table S2. SMR-HEIDI results for 8q24.21 locus between back pain and other complex traits. </strong></p> <p><strong>Column headers of Tables S2:</strong></p> <p>Secondary Trait Name: Name of complex trait<br> Dataset: Name of dataset (UKB Neale's lab or UKB Gene Atlas)<br> Index_SNP: RsID of SNP used as target in SMR-HEID analysis<br> Proxy_SNP: RsID of top SNP in the selected locus - SNP presented in both GWAS data with minimum P-values in back pain GWAS<br> r(proxy_SNP,index_SNP): linkage disequilibrium coefficient between index and proxy SNP<br> beta_SMR: Beta SMR for proxy SNP<br> p_SMR: P-value of beta SMR<br> qFDR-BH SMR: P-value of beta SMR after Bonferroni correction<br> p_HEIDI: P-value of HEIDI test<br> n_HEIDI: Number of SNPs used in HEIDI test<br> SNPs_HEIDI: List of rsID of SNPs used in HEIDI test</p> <p> </p> <p><strong>Supplementary Table S3.</strong> <strong>SMR-HEIDI results for 8q24.21 locus between back pain and expression of genes.</strong></p> <p><strong>Column headers of Tables S3:</strong></p> <p>Secondary Trait Name: Name of complex trait<br> Tissue: Name of the tissue from which the samples were taken to study gene expression<br> Gene_name: Gene name corresponding to the transcript name<br> Transcript Name: Transcript name (ID)<br> Dataset: Name of dataset (CEDAR, GTEx_v6)<br> beta_SMR: Beta SMR for proxy SNP<br> p_SMR: P-value of beta SMR<br> qFDR-BH SMR: P-value of beta SMR after Bonferroni correction<br> p_HEIDI: P-value of HEIDI test<br> n_HEIDI: Number of SNPs used in HEIDI test<br> SNPs_HEIDI: List of rsID of SNPs used in HEIDI test</p> <p> </p> <p>Part of the article: Williams FMK et al. "Sequence variation at 8q24.21 and risk of back pain"</p>
Pain in patients with Type 2 diabetes-related polyneuropathy is associated with vascular events and mortality
<p>Type 2 diabetes–related polyneuropathy (DPN) is associated with increased vascular events and mortality, but determinants and outcomes of pain in DPN are poorly understood. We sought to examine the effect of neuropathic pain on vascular events and mortality in patients without DPN, DPN with pain (DPN + P), and DPN without pain (DPN-P). A retrospective cohort study was conducted within a large health system of adult patients with type 2 diabetes from January 1, 2009 through December 31, 2016. Using an electronic algorithm, patients were classified as no DPN, DPN + P, or DPN-P. Primary outcomes included number of vascular events and time to mortality. Independent associations with DPN + P were evaluated using multivariable negative binomial and Cox proportional hazards regression models, adjusting for demographics, socioeconomic characteristics, and comorbidities. Of 43 945 patients with type 2 diabetes (age 64.6 ± 14.0 years; 52.1% female), 13 910 (31.7%) had DPN: 9104 DPN + P (65.4%) vs 4806 DPN-P (34.6%). Vascular events occurred in 4538 (15.1%) of no DPN patients, 2401 (26.4%) DPN + P, and 1006 (20.9%) DPN-P. After adjustment, DPN + P remained a significant predictor of number of vascular events (incidence rate ratio [IRR] = 1.55, 95% CI, 1.29-1.85), whereas no DPN was protective (IRR = 0.70, 95% CI, 0.60-0.82), as compared to DPN-P. Compared to DPN-P, DPN + P was also a significant predictor of mortality (hazard ratio = 1.42, 95% CI, 1.25-1.61). Our study found a significant association between pain in DPN and an increased risk of vascular events and mortality. This observation warrants longitudinal study of the risk factors and natural history of pain in DPN.</p> <p> </p>
Data from: Scrambler therapy improves pain in neuromyelitis optica: a randomized controlled trial
<p>Objective: The primary objective aimed to determine if Scrambler therapy is an effective, acceptable and feasible treatment of persistent central neuropathic pain in patients with neuromyelitis optica spectrum disorder (NMOSD). The secondary objective explored the effect of Scrambler therapy on co-occurring symptoms.</p> <p>Methods: We conducted a randomized single blind, sham-controlled trial in patients with NMOSD who have central neuropathic pain using Scrambler therapy for 10 consecutive weekdays. Pain severity, pain interference, anxiety, depression and sleep disturbance were assessed at baseline, end of treatment, and at 30- and 60-day follow-up.</p> <p>Results: Twenty-two patients (11 per arm) were enrolled into and completed this trial. The median baseline NRS pain score decreased from 5.0 to 1.5 following 10 days of treatment with Scrambler therapy, whereas the median NRS score did not significantly decrease in the sham arm. Depression was also reduced in the treatment arm, and anxiety was decreased in a subset of patients who responded to treatment. These symptoms were not impacted in the sham arm. The safety profiles were similar between groups.</p> <p>Conclusions: Scrambler therapy is an effective, feasible and safe intervention for central neuropathic pain in patients with NMOSD. Decreasing pain with Scrambler therapy may additionally improve depression and anxiety. Clinicaltrials.gov identifier NCT03452176 Classification of Evidence This study provides Class II evidence for patients with NMOSD and persistent central neuropathic pain that Scrambler therapy significantly reduces pain.</p>
Data from: BCI training to move a virtual hand reduces phantom limb pain: a randomized crossover trial
<p>Objective: To determine whether training with a brain–computer interface (BCI) to control an image of a phantom hand, which moves based on cortical currents estimated from magnetoencephalographic signals, reduces phantom limb pain.</p> <p>Methods: Twelve patients with chronic phantom limb pain of the upper limb due to amputation or brachial plexus root avulsion participated in a randomized single-blinded crossover trial. Patients were trained to move the virtual hand image controlled by the BCI with a real decoder, which was constructed to classify intact hand movements from motor cortical currents, by moving their phantom hands for 3 days ("real training"). Pain was evaluated using a visual analogue scale (VAS) before and after training, and at follow-up for an additional 16 days. As a control, patients engaged in the training with the same hand image controlled by randomly changing values ("random training"). The two trainings were randomly assigned to the patients. This trial is registered at UMIN-CTR (UMIN000013608).</p> <p>Results: VAS at day 4 was significantly reduced from the baseline after real training (45.3 [24.2] to 30.9 [20.6], 1/100mm, mean [SDs]; P=0.009<0.025), but not after random training (P=0.047>0.025). Compared to VAS at day 1, VAS at days 4 and 8 was significantly reduced by 32% and 36%, respectively, after real training and was significantly lower than VAS after random training (P<0.01).</p> <p>Conclusion: Three-day training to move the hand images controlled by BCI significantly reduced pain for one week.<br> Classification of evidence: This study provides Class &#8546; evidence that BCI reduces phantom limb pain.</p> <p> </p>
FIGURE 33–36. 33 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 33–36. 33—overview of karst of Pains; 34—main conduit of the Brega cave, type locality of the new specie; 35—Eidmanacris sp., species that co-occurs with Endecous (Endecous) painensis n. sp. in several caves of the region. 36—region near to entrance of the Brega cave.
FIGURE 37 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 37. Distribution of trait averages referring to the difference of (R and L) of each population of Endecous (Endecous) painensis n. sp. ♀♀ mensured. Legend: (*) — p> 0.05* represent normal distribution, for Shapiro-Wilk test; I, II and III—length of the first, second and third segments present in the apical portion of the maxillary palp; IV—compound eyes area; V—tympanum area; VI—femur III length; VII—tibia III length.
FIGURES 31–32. 31–32 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURES 31–32. 31–32. Endecous (Endecous) painensis n. sp. in situ inside the Brega cave. 31—adult male, 32—adult female.
FIGURE 19 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 19. Endecous (Endecous) painensis n. sp. holotype legs morphology (ISLA 59121). I–II—first right leg, in interior and exterior view respectively, tympanum (t) highlighted in yellow; III–IV—second right leg, in interior and exterior view respectively, (μ) and (λ) littles spurs at the apex of the tibia; V–VI—third right leg, in interior and exterior view respectively, spurs subapical and apical are highlighted in yellow.
FIGURES 5–10 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURES 5–10. Endecous (Endecous) painensis n. sp. phallic sclerite and copulatory papilla of the paratypes ♂ (ISLA 59126) and ♀ (ISLA 59132). 5—dorsal view (the blue arrow below the endophallic sclerite posterior portion (End.Sc.p) indicates a small region that forms an arc partially sclerotized U-shaped); 6—ventral view (the yellow arrow indicates the endophallic apodema), 7—diagonal view; 8—front view; 9—lateral view (the yellow arrow indicates the endophallic apodema); 10—copulatory papilla. a, dorsal view; b, lateral view; c, ventral view. Abbreviations: Ps.arm, pseudepiphallic arm; Ps.db, pseudepiphallic dorsal branch; Ps.im, pseudepiphallic interior projection; Ps.ib, pseudepiphallic sclerite inner bars; Ps.ms, pseudepiphallic membranous shield; A, pseudepiphallic ventral branch (also known as sclerite A (vide Desutter 1990)); Ps.P, pseudepiphallic paramere; Ect.Arc, ectophallic arc; Ect.lb, ectophallic lateral bar; Ect.mp, ectophallic median projection; Ect.Ap, ectophallic apodeme; End.Sc.a, endophallic sclerite anterior portion; End.
FIGURES 11–18 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURES 11–18. Endecous (Endecous) painensis n. sp. holotype morphology (ISLA 59121). 11—12–head in front, lateral and superior view respectively; 13—pronotum, dorsal view; 14—tegmina, dorsal view; 15—right tegmen and pronotum, lateral view; 16—subgenital and supranal plate, phallic sclerite, in lateral view; 17—subgenital plate, ventral view; 18—supranal, dorsal view. Abbreviations: m., mirror; h., harp; b.f., basal field; l.f., lateral field.
FIGURE 2 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 2. Map of the municipality of Pains, with highlight in three caves (red points) where female populations were sampled ♀♀ adults for comparison of fluctuating asymmetry. I and II, Brega cave and Mastodonte cave (relatively distant from the mining areas), III Paranoá cave (next to a mining).
FIGURE 4 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 4. Bilateral structures measured metricament in females ♀♀ adults. Legend: 1–3: length of first, second and third maxillary palpomers; 4—compound eyes area; 5—tympanum area; 6—femur III length; 7—tibia III length.
FIGURE 3 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 3. Illustration drawing of the trap used by us with recyclable plastic bottles, for sampling of crickets Endecous in the caves.
FIGURES 20–25 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURES 20–25. Right tegmen of Endecous (Endecous) painensis n. sp. in dorsal and lateral view. 20—holotype (ISLA 59121); 21—examined individual (ISLA 15349); 22—examined individual (ISLA 59135); 23—examined individual (ISLA 15381); 24examined individual (ISLA 59133); 25—examined individual (ISLA 59134).
FIGURES 26–30 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURES 26–30. Endecous (Endecous) painensis n. sp. ♀ ISLA (59131). 26—ovipositor, lateral view; 27—supranal plate, dorsal view; 28—subgenital plate, ventral view; 29 and 30—ovipositor apex, in lateral and ventral view respectively.
FIGURE 1 in Description and ecology of a new species of the cricket genus Endecous (Orthoptera: Grylloidea: Phalangopsidae) in the speleological province of Arcos-Pains-Doresópolis, Southeastern Brazil
FIGURE 1. (A and B). (A) South America map highlighting the Bambuí carbonatic group which covers the State of Minas Gerais; (B) Caves distributed in the municipalities of Arcos, Córrego Fundo, Doresópolis and Pains where the species co-occur Endecous painensis n. sp. and Eidmanacris sp.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.