Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
18,654
datasets available to search
ShareScore release 0.9.0
Dataset results
18,654 results for “Pain”
Data from: Randomized study of the impact of a therapeutic education program on patients suffering from chronic low-back pain who are treated with transcutaneous electrical nerve stimulation
Background: Transcutaneous electrical nerve stimulation (TENS) is often used for the treatment of low-back pain (LBP). However, its effectiveness is controversial. Objective: To determine the efficacy of TENS in the treatment LBP when associated to a therapeutic education program (TEP). Design: Open randomized monocentric study. Setting: University hospital between 2010 and 2014. Patients: A total of 97 patients suffering from LBP. Interventions: Routine care (TENS group) or routine care plus a therapeutic education program (TENS-TEP group) based on consultation support by a pain resource nurse Main outcome measures: EIFEL and Dallas Pain Questionnaire scores. Results: Twenty-two patients (44%) were still assessable at the end-of-study visit, whereas 33 (70%) were assessable at the same time point in the TENS-TEP group (P = 0.013). The EIFEL score and the Dallas score had a similar evolution over time between groups (p = 0.18 and p = 0.50 respectively). Similarly, there were no significant differences between the groups with respect to resting pain scores (p = 0.94 for back pain and p = 0.16 for leg pain) and movement pain scores (p = 0.52 for back pain and p = 0.56 for leg pain). At Month 6, there was no significant difference between the groups (p = 0.85) with regard to analgesics and social impact. Two patients presented a serious adverse event during the study (one in each group) but non-attributable to the treatment studied. Conclusion: This study does not support the use of TENS in the treatment of patients with chronic LBP even though patients benefited from a therapeutic education program by a pain resource nurse. However, the higher number of premature withdrawals in the TENS group may be due to early withdrawal of patients who did not experience improvement of their symptoms.
Data from: Primary care follow-up and measured mental health outcomes among women referred for ultrasound assessment of pain and/or bleeding in early pregnancy: a quantitative questionnaire study
Objectives To examine the extent of primary care follow-up and mental health outcomes among women referred for ultrasound assessment of pain and/or bleeding in early pregnancy, including those whose pregnancy is found to be viable on ultrasound assessment. Design Questionnaire study with prospective follow-up. Setting Urgent gynaecology clinic in secondary care, England. Participants 57 women participated in the study. Entry criteria: referral to the urgent gynaecology clinic with pain and/or bleeding in early pregnancy; gestation less than 16 weeks (the clinic's own 'cut-off'); no previous attendance at the clinic during the current pregnancy. Exclusion criteria: inability to understand English or to provide informed consent. Primary and secondary outcome measures Incidence of primary care follow-up among women referred to the urgent gynaecology clinic; incidence of women with measured mental health scores suggesting significant symptoms of distress. Results Fewer than 1 in 10 women referred for ultrasound assessment of pain and/or bleeding in early pregnancy had follow-up arrangements made with their general practitioner (GP). Most women who had GP follow-up found it helpful and a significant minority of women who did not have GP follow-up felt that it would have been helpful. Following ultrasound assessment, more than one-third of women had significant symptoms of distress. Symptoms of distress, particularly anxiety, were present among those women found to have viable pregnancies, as well as among those with non-viable pregnancies. Conclusions GPs are advised to consider offering follow-up to all women referred for ultrasound assessment of pain and/or bleeding in early pregnancy. Researchers in this area are advised to consider the experiences of women with pain and/or bleeding in early pregnancy whose pregnancies are ultimately found to be viable on ultrasound scan.
Data from: Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: disassembling the percept of pain
Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods: Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results: Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09–3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions: ACC- and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se.
Data from: Musculoskeletal pain as a marker of health quality. Findings from the epidemiological sleep study among the adult population of São Paulo city
Background: We are witnessing the growth of urban populations, particularly in the developing world. São Paulo, the largest city in South America, continues to grow, and this growth is dramatically effecting the environment and human health. The aim of this study was to estimate the point prevalence of chronic pain in São Paulo city dwellers and to explore the influence of aspects related to urbanicity. Methods: A two-stage cluster randomized sample included 1100 individuals of the city of Sao Paulo, representing the population proportionally in terms of gender, age and social classes in 2007. For this observational cross-sectional study, the household sample was interviewed using validated questionnaires for sociodemographic aspects, the Beck inventories for anxiety and depression, the WHOQoL-REF for quality of life, the Chalder Fatigue Scale. Musculoskeletal pain was defined as diffuse pain or pain located in the back, joints or limbs. Data regarding sleep complaints and polysomnography were obtained from the Epidemiologic Sleep Study conducted in São Paulo city in 2007. Results: The prevalence estimate of chronic musculoskeletal pain was approximately 27%, with a female/male ratio of approximately 2.6/1. The predictors were being in the age-range of 30–39 years, low socioeconomic and schooling levels, obesity, sedentarism, fatigue, non-restorative sleep, daytime sleepiness, poor sleep quality, poor life quality, anxiety and depression symptoms. Psychological wellbeing was the main discriminator between responders with chronic musculoskeletal pain and the controls, followed by depression for the participants with poor psychological wellbeing, and fatigue, for the remaining ones. Insomnia syndrome was the third-level discriminator for those with fatigue, whereas sleep quality for those without fatigue. Conclusions: Musculoskeletal pain was frequently reported by São Paulo city dwellers and its correlates with psychological and sleep aspects are suggestive of a response to urbanicity. Trial Registration: ClinicalTrials.gov NCT00596713
Data from: The Fear Reduction Exercised Early (FREE) approach to management of low back pain in general practice: a pragmatic cluster-randomised controlled trial
Background: Effective and cost-effective primary care treatments for low back pain (LBP) are required to reduce the burden of the world's most disabling condition. This study aimed to compare the clinical effectiveness and cost-effectiveness of the Fear Reduction Exercised Early (FREE) approach to LBP (intervention) with usual general practitioner (GP) care (control). Methods and findings: This pragmatic, cluster-randomised controlled trial with process evaluation and parallel economic evaluation was conducted in the Hutt Valley, New Zealand. Eight general practices were randomly assigned (stratified by practice size) with a 1:1 ratio to intervention (4 practices; 34 GPs) or control group (4 practices; 29 GPs). Adults presenting to these GPs with LBP as their primary complaint were recruited. GPs in the intervention practices were trained in the FREE approach, and patients presenting to these practices received care based on the FREE approach. The FREE approach restructures LBP consultations to prioritise early identification and management of barriers to recovery. GPs in control practices did not receive specific training for this study, and patients presenting to these practices received usual care. Between 23 September 2016 and 31 July 2017, 140 eligible patients presented to intervention practices (126 enrolled) and 110 eligible patients presented to control practices (100 enrolled). Patient mean age was 46.1 years (SD 14.4), and 46% were female. The duration of LBP was less than 6 weeks in 88% of patients. Primary outcome was change from baseline in patient participant Roland Morris Disability Questionnaire (RMDQ) score at 6 months. Secondary patient outcomes included pain, satisfaction, and psychosocial indices. GP outcomes included attitudes, knowledge, confidence, and GP LBP management behaviour. There was active and passive surveillance of potential harms. Patients and outcome assessors were blind to group assignment. Analysis followed intention-to-treat principles. A total of 122 (97%) patients from 32 GPs in the intervention group and 99 (99%) patients from 25 GPs in the control group were included in the primary outcome analysis. At 6 months, the groups did not significantly differ on the primary outcome (adjusted mean RMDQ score difference 0.57, 95% CI −0.64 to 1.78; p = 0.354) or secondary patient outcomes. The RMDQ difference met the predefined criterion to indicate noninferiority. One control group participant experienced an activity-related gluteal tear, with no other adverse events recorded. Intervention group GPs had improvements in attitudes, knowledge, and confidence compared with control group GPs. Intervention group GP LBP management behaviour became more guideline concordant than the control group. In cost-effectiveness, the intervention dominated control with lower costs and higher Quality-Adjusted Life Year (QALY) gains. Limitations of this study were that although adequately powered for primary outcome assessment, the study was not powered for evaluating some employment, healthcare use, and economic outcomes. It was also not possible for research nurses (responsible for patient recruitment) to be masked on group allocation for practices. Conclusions: Findings from this study suggest that the FREE approach improves GP concordance with LBP guideline recommendations but does not improve patient recovery outcomes compared with usual care. The FREE approach may reduce unnecessary healthcare use and produce economic benefits. Work participation or health resource use should be considered for primary outcome assessment in future trials of undifferentiated LBP.
Management of persistent non-specific low back pain in primary care: A review of current guideline recommendations
<p>AGREE II Summary Score Sheets</p>
Comparative study between Dexmedetomidine with Bupivacaine and Bupivacaine alone in erector spinae plane block for postoperative pain control of posterior lumbosacral spine fixation surgeries: A randomized controlled trial
<p><strong><span>2. </span></strong><strong><span>Materials and Methods</span></strong></p> <p><strong><span>2.1. Participants</span></strong></p> <p><span>Patients above 18 years old of either sex submitted for elective posterior lumbosacral spine fixation and fusion surgery were eligible to participate if they were classified as ASA I-III according to the American Society of Anesthesiologists (ASA) classification. The surgery was done on all the patients by the same neurosurgical team and using the same surgical techniques. The exclusion criteria included patient refusal, hypersensitivity to the drugs used in the study, patients with any contraindication to regional anesthesia, such as skin infections at the site of the block, and patients with a history of bleeding disorders or receiving anticoagulant medications. All patients were screened for eligibility criteria. Eligible patients were asked for voluntary informed consent to participate in the trial.</span></p> <p><strong><span>2.2 Study design</span></strong></p> <p><span>This double-blind, randomized controlled trial was carried out on 90 patients on October 6 University Hospitals. It was conducted from November 2022 to July 2023. The study was approved by the Clinical Research Ethical Committee of October 6 University Hospitals (approval number PRC-Me-2210035). It was registered online at ClinicalTrials.gov Identifier: NCT05590234. All patients who participated in this study had to sign a detailed, informed, written anesthesia and surgery consent. </span></p> <p><strong><span>2.3. Randomization and allocation </span></strong></p> <p><span>Patients were randomly allocated using a random allocation sequence by a web-based program. Participants were randomized to three groups in a 1:1:1 ratio. Each group consisted of 30 patients. Dexmedetomidine Bupivacaine ESPB group (<a name="_Hlk145148479"></a>DB group) receive <a name="_Hlk145148507"></a>0.5 ug/kg dexmedetomidine plus 20 mL of bupivacaine 0.25%, Bupivacaine ESPB group (<a name="_Hlk145148593"></a>B group) receive 20 mL of bupivacaine 0.25%, and Saline ESPB (S group) which is the Control group receive 20 ml of normal saline 0.9%. The block procedure was done bilaterally in the three groups. Neither patients nor investigators knew the group in which the patients were placed, and the type of intervention received.</span></p> <p><strong><span>2.4. Preoperative management</span></strong></p> <p><span>All patients were assessed clinically before surgery, including full history, thorough clinical examination, and laboratory investigations. On arrival at the operating suite, patients were fully monitored (5 leads ECG, noninvasive blood pressure, and pulse oximetry). Basal readings of vital data were recorded. Intravenous access was established.</span></p> <p><strong><span>2.5. Anesthetic management</span></strong></p> <p><span>Midazolam 3 mg IV was given for sedation. Induction of anesthesia was performed with IV propofol (2mg/kg), fentanyl (1.5–2 µg/kg), and rocuronium bromide (0.6 mg/kg). Maintenance of anesthesia was done by isoflurane. The prone position was established immediately after the intubation of anesthesia. Intraoperatively, the data of (peripheral oxygen saturation, heart rate, noninvasive arterial blood pressure, and end-tidal carbon dioxide level) were recorded every five minutes throughout the operation. </span></p> <p><span>Any decrease in heart rate below 50 beats per minute was treated with intravenous atropine, according to the response. A reduction in mean blood pressure below 20% of the basal reading or systolic BP below 90 mmHg was treated with 5 mg increments of intravenous ephedrine. After the induction of anesthesia and putting the patients in the prone position, the US-guided ESPB was performed in the three groups.</span></p> <p><span>The study was conducted in a double-blind fashion where the attending anesthetist who performed the ESPB and the neurosurgical team were blind entirely to the content of the injected solution composition. The responsible anesthetist in this study was the only one not blind to the injected solution composition but was not involved in the postoperative patient assessment.<span> </span></span></p> <p><strong><span><span> </span>2.6. ESPB technique</span></strong></p> <p><span>Under strict aseptic technique, the ESPB was done in the prone position for all patients of the three groups. A sterile ultrasound curved probe (Philips ultrasound machine HD7 XE C153160013, Philips and Neusoft Medical Systems Co., Ltd. China.) was used for the technique. The ultrasound probe was placed on the third lumbar vertebral body level in the parasagittal plane. When the spinous process was first seen, the probe was moved laterally from the midline, and then the transverse process of L3 and erector spinae muscle was observed at about 2 to 3 cm from the midline (Figure 1). </span></p> <p><span>A 22 gauge/ 8 cm ultrasound-visible needle (Stimuplex, Braun AG, Melsungen, Germany) was used to make a puncture using the in-plane technique. The direction of the needle was craniocaudal, and the proper position of the needle was confirmed by injecting 2 ml of saline solution. After ensuring the position of the needle, 20 ml of 0.25% bupivacaine plus 0.5 ug/kg dexmedetomidine was administered to the DB group. The same ESPB procedure was done on the other side with the same drugs and volume. In total, 40 ml of 0.25% bupivacaine plus 1 ug/kg dexmedetomidine was administered.</span></p> <p><span>The same block procedure was done in the B group with only 20 ml of 0.25% bupivacaine on both sides (with a total volume of 40 ml). In the S group (control group), the same block procedure was done with 20 ml of 0.9% normal saline on both sides (40 ml total volume).</span></p> <p><strong><span> </span></strong></p> <p><strong><span> </span></strong></p> <p><strong><span> </span></strong></p> <p><strong><span> </span></strong></p> <p><strong><span>Figure 1. </span></strong><strong><span>Ultrasound image of ESPB.</span></strong></p> <p><strong><span> </span></strong></p> <p><span>At the end of surgery, 1 gm of paracetamol IV and 30 mg of ketorolac IV infusion were given to all the patients of the three groups. The patients were extubated after efficient spontaneous breathing and transported to the post-anesthesia care unit (PACU). Patients were discharged from the PACU to the ward with a modified Aldrete score of 12.</span></p> <p><strong><span>2.7. Postoperative pain management</span></strong></p> <p><span>The postoperative analgesic management was done using the classical protocol of our department to all patients of the three groups, which included a PCA (patient-controlled analgesia) device, and an IV of one gm paracetamol was given every eight hours for the first 48 hours postoperatively. The PCA device (Accufuser Plus <sup>®</sup><sub>REF,</sub> manufactured by Woo Young Medical Co., Ltd. Korea) has a silicon balloon infuser with a total volume of 300 ml, basal rate of 5 ml per hour, bolus 1 ml, and lockout interval every 15 minutes. </span></p> <p><span>A PCA device with morphine was attached to all the patients. The PCA infusion (300ml) consisted of 60 mg of morphine with 2 mg of granisteron and 180 mg of ketorolac. The concentration of morphine was set to 0.2 mg/ml, the loading dose was 1 mg (5 ml), the lockout interval was 15 min (bolus of 1ml/15 min), and a 1 mg/h (5ml/hr) continuous infusion was maintained for 48 hrs. IV one gm paracetamol was given every eight hours postoperatively.</span></p> <p><span>A nurse blind to the study used the visual analog scale (VAS; zero, no pain, ten = the most severe pain) to evaluate and record the pain scores and recorded the opioid consumption of the patients. The nurse recorded passive (at rest) and active (while mobilization) VAS scores at intervals of every two hours in the first 24 hours and every 4 hours in the second 24 hours and total opioid consumption for the first 48 hours postoperatively. Rescue analgesic medication was done using pethidine 50 mg IM when passive VAS pain score > 6. </span></p> <p><span>Patients who experienced pruritis, nausea, vomiting, or respiratory depression (opioid-related adverse effects) were recorded. On the first day postoperative, all patients were encouraged to ambulate in the ward after wearing lumbosacral support. The subcutaneous closed suction drainage system was removed after 36 hours. All patients were discharged home after 48 hours.</span></p> <p><strong><span>2.8. Outcome measurements</span></strong></p> <p><span>The primary clinical outcome measures were active (while mobilization) and passive (at rest) visual analog scale (VAS) pain score at the first 48 hours, measured every 2 hours in the first 24 hours and every 4 hours in the second 24 hours. </span></p> <p><span>Other clinical outcomes included opioid consumption (the number of PCA presses), the need for rescue analgesia, postoperative opioid side effects, and intraoperative dexmedetomidine side effects such as bradycardia and hypotension.</span></p> <p><strong><span>2. 9. Sample size calculation </span></strong></p> <p><span>As we have three treatment groups (S, B, DB), we performed a one-way analysis of variance (ANOVA) to assess effect size and the required number of patients per group based on the overall difference of total Fentanyl consumption (µg) means (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908442/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908442/</a>).<span> </span>The effect size for ANOVA is typically measured using <span>Cohen's<em><span> d</span></em> = <em><span>M</span></em><sub>1</sub> - <em><span>M</span></em><sub>2</sub> / s<sub>pooled</sub></span>, <span>where s<sub>pooled</sub> =&radic; [(s <sub>1</sub><sup>2</sup>+ s <sub>2</sub><sup>2</sup>) / 2]</span> and <strong><span>effect-size</span></strong><span> <em><span>r</span></em>= d / √ (d<sup>2</sup> + 4)[</span><a href="https://lbecker.uccs.edu/#means%20and%20standard%20deviations">https://lbecker.uccs.edu/#means%20and%20standard%20deviations</a><span>].<span> </span></span></span></p> <p><span>Given the following values: </span></p> <p><span><span>·<span> </span></span></span><span>Mean 1: 820 SD1: 102</span></p> <p><span><span>·<span> </span></span></span><span>Mean2: 641 SD2: 140</span></p> <p><span><span>·<span> </span></span></span><span>α=0.05</span></p> <p><span><span>·<span> </span></span></span><span>β=0.05 (implying a power of 0.95)</span></p> <p><strong><span>Then, Cohen's </span></strong><em><span>d: -1.46<span> </span>&<span> </span></span></em><strong><span>effect-size</span></strong><span> <em><span>r: -0.58</span></em></span></p> <p><span>In addition,</span><span> the required sample size per group is <strong>17</strong> based on the following online tool [https://homepage.univie.ac.at/robin.ristl/samplesize.php?test=anova] for </span><span>s</span><span>ample size for one-way analysis of variance.</span><span> </span></p> <p><strong><span>2.10. Statistical analysis</span></strong></p> <p><span>Data were analyzed using the statistical package for social sciences, version 20.0 (SPSS Inc., Chicago, Illinois, USA). We conducted the Shapiro-Wilk test to assess whether the numeric data followed a normal distribution or not. Quantitative normal distributed data were expressed as mean± standard deviation (SD). Qualitative data were expressed as frequency and percentage. The following tests were used: A one-way analysis of variance (ANOVA) when comparing between more than two means, Post Hoc test: Least Significant Difference (LSD) was used for multiple comparisons between different variables, and Chi-square (X<sup>2</sup>) test of significance was used to compare proportions between two qualitative parameters.<a name="2et92p0"></a><a name="3znysh7"></a> Furthermore, we performed linear and binary regression analyses to elucidate the relationship between the primary outcomes and the intervention groups (S, D, DB).</span></p> <p><span>The confidence interval was set to 95%, and the margin of error accepted was set to 5%. So, the p-value was considered non-significant when the P-value > 0.05, significant if < 0.05, and highly significant if <0.001.</span></p>
Decoding Pain: Uncovering the Factors that Affect Performance of Neuroimaging-Based Pain Models
<p>This repository contains the codes and data which are used in the following paper.</p> <blockquote> <p>Dong Hee Lee, Sungwoo Lee, Choong-Wan Woo, Decoding Pain: Uncovering the Factors that Affect Performance of Neuroimaging-Based Pain Models, 2023, bioRxiv (<a href="https://doi.org/10.1101/2023.12.22.573021" target="_blank" rel="noopener">link</a>)</p> </blockquote> <h2>Dependencies</h2> <ol> <li>CanlabCore toolbox (<a href="https://github.com/canlab/CanlabCore" target="_blank" rel="noopener">link</a>)</li> <li>Mediation toolbox (<a href="https://github.com/canlab/MediationToolbox" target="_blank" rel="noopener">link</a>)</li> <li>SPM12 (<a href="https://www.fil.ion.ucl.ac.uk/spm/software/spm12/" target="_blank" rel="noopener">link</a>)</li> <li>MATLAB Statistics and Machine Learning Toolbox (<a href="https://www.mathworks.com/products/statistics.html" target="_blank" rel="noopener">link</a>)</li> </ol> <h2><strong>Usage</strong></h2> <p>Below are the codes that allow you to generate the main figures in the manuscript.</p> <ul> <li><code>fig_3_litearture_survey.m</code></li> <li><code>fig_4_literature_survey.R</code></li> <li><code>fig_5_litearture_survey.m</code></li> <li><code>fig_7_benchmarking_analysis.m</code></li> <li><code>fig_8_benchmarking_analysis.m</code></li> <li><code>fig_9_benchmarking_analysis.m</code></li> <li><code>fig_10_benchmarking_analysis.m</code></li> </ul> <p>To use these scripts, download all files and unzip the zipfile (i.e. <code>data.zip</code>). Open the script that you want to run in Matlab or R and set the current folder to the working directory. Add the paths for the dependencies. The other functions (e.g., <code>lpp_plot_boxplot.m</code>) are necessary to create the main figures. Make sure that the functions have to be saved in the same directory with the main scripts.</p>
Single exercise into pain versus SUMS dataset
Open the record for dataset details and reuse information.
Dataset for Effects Effects of Soft Tissue Mobilization with TECAR Therapy Using Bracelet Electrodes in Women with Chronic Non-specific Neck Pain
<p>This dataset contains anonymized data from a randomized controlled trial (RCT) evaluating the effectiveness of combining Soft Tissue Mobilization Techniques (STMT) with Capacitive and Resistive Electric Transfer Therapy (TECAR) in women with Chronic Non-Specific Neck Pain (CNSNP). Data include assessments at baseline, the 5th week, and the 6th-month follow-up for variables related to pain intensity, disability, and range of motion (ROM).</p>
Dataset for HomoLateral Neuropathic Pain (HLNP)
<p>The study data has been updated for public sharing in accordance with the recommendation.</p> <p>Minor errors have been corrected.</p>
Data from: Self-myofascial release decreased pain intensity and improved conditioned pain modulation response in patients with myofascial pain syndrome: a single-blind RCT study
<p>Objective: The present study investigated the effects of self-myofascial release (SMFR) on pain perception, myofascial trigger point (MTrP) activity, and conditioned pain modulation (CPM) response in patients with myofascial pain syndrome (MPS).</p> <p>Methods: A total of 32 MPS patients with a visual analog scale (VAS) score greater than 30/100 mm were enrolled and randomly assigned to 3 groups of 4 weeks of intervention – A) SMFR with a 60 s period (n=11), B) SMFR with a 30 s period (n=10) and C) conventional myofascial release (MFR) performed by the physiotherapist (n=11). Pressure pain threshold (PPT), VAS, resting-state electromyography amplitude (rAEMG) and conditioned pain modulation response (CPM-R) were assessed before, 1 week, 2 weeks and 4 weeks during the intervention.</p> <p>Results: Compared with baseline, VAS and rAEMG levels in were significantly decreased, while the PPT and CPM-R values were significantly increased in all groups after 4 weeks' intervention without significant difference between groups.</p> <p>Conclusion: Both SMFR and MFR techniques with a single pressing duration of 60s and 30s had significant therapeutic effects on chronic myofascial pain, with the decrease of VAS and rAEMG, the increase of PPT and CPM-R values, indicating that SMFR could activate and restore the function of descending pain modulation.</p>
Bracing adults with chronic low back pain secondary to severe scoliosis: six months results of a prospective pilot study.
<p>Dataset from the paper: Bracing adults with chronic low back pain secondary to severe scoliosis: six months results of a prospective pilot study. Eur Spine J. 2021 Oct;30(10):2962-2966. doi: 10.1007/s00586-021-06808-1. Epub 2021 Mar 17. PMID: 33733328.</p> <p>Abstract</p> <p><strong>Purpose: </strong>Adult scoliosis is sometimes associated with back pain and severe curves can progress over time. Despite scoliosis has been estimated to affect up to 68% of the population over 60, there is scant literature about conservative treatment for adult scoliosis. Recently, we tested a new brace designed to alleviate pain for adult patients with chronic pain secondary to scoliosis. The study aims to test the efficacy of a prefabricated brace in reducing pain in adult scoliosis patients.</p> <p><strong>Methods: </strong>Twenty adults (age 67.8 ± 10.5, curve 61.9 ± 12.6° Cobb) with chronic low back pain (cLBP) secondary to Idiopathic Scoliosis (IS) were included. Patients were evaluated at baseline immediately before starting with the brace and after 6 months. Outcome measures were GRS, Oswestry Disability Index (ODI), Roland Morris Questionnaire (RM), COMI. The paired t test, ANOVA and Wilcoxon tests were used for statistical analysis RESULTS: At six months, worst pain, leg pain and back pain were significantly improved: from 7.15 to 5.60, from 5.65 to 4.35 and from 6.55 to 5.25 (p < 0.05). Sixty-five percent of patients achieved the minimal clinically important difference of 2 points for worst pain and leg pain, 55% for back pain. RM and COMI improved (p < 0.05), no differences for ODI.</p> <p><strong>Conclusion: </strong>The prefabricated brace showed a significant improvement at 6 months of worst, leg and back pain in most patients in a group of adult women with IS and cLBP. The quality of life didn't change in a clinically significant way even if the patients reported satisfaction with the treatment. Trial registration number and date of registration: ClinicalTrials.gov Identifier: <a href="http://clinicaltrials.gov/show/NCT02643290">NCT02643290</a>, December 31, 2015.</p>
Dataset of the study "Psychological factors and trajectories of post-surgical pain: A longitudinal prospective study"
<p>Dataset of the study "Psychological factors and trajectories of post-surgical pain: A longitudinal prospective study" published in Pain Practice, 2022 Feb; 22(2): 159-170. doi: 10.1111/papr.13074</p>
Dataset of the study "Factor Structure, Validity, and Reliability of the STarT Back Screening Tool in Italian Obese and Non-obese Patients With Low Back Pain"
<p>Dataset of the study "Factor Structure, Validity, and Reliability of the STarT Back Screening Tool in Italian Obese and Non-obese Patients With Low Back Pain" published in Frontiers in Psychology 20 October 2021 12:740851, doi: 10.3389/fpsyg.2021.740851</p>
Developing an in-depth understanding of the prevalence, risk factors and treatment recommendations for phantom limb pain, and patient-generated care priorities for people who have undergone lower limb amputations.
<p>The file holds data collected for a series of four studies on phantom limb pain. </p>
abnormal CT findings among patients with abdominal pain in the radiology department of a teriary care center
<p>These are Data were collected from the hospital system regarding demographic characteristics, past medical and surgical history, symptom description and physical examination findings, diagnosis (both initial and final), laboratory tests, CT findings, and results from other requested radiology modalities. All information was obtained after obtaining ethical approval.</p>
Development of chronic pain after posterolateral and axillary approaches for thoracic surgery: A prospective monocentric observational study
<p class="MDPI17abstract"><span>Mini-invasive thoracotomies may reduce chronic</span><span> pain and pain-related functional impairment. The aims of part 2 of the study were to assess their incidence after posterolateral and axillary thoracotomies and to identify potential factors of chronic pain. Patients undergoing a posterolateral (79 patients) or axillary (79 patients) thoracotomy between July 2014 and November 2015 were analyzed in this prospective monocentric cohort study. At the 4-month assessment, more patients had chronic pain in the posterolateral group (60.8% vs 40.5%; p=0.017). There was a significant difference between groups favoring the axillary group: less level of catastrophism (p=0.021) and less impact of pain on daily activities (globally, p=0.009; routine activities subscore, p=0.010, chosen activity subscore, p=0.030). According to a multinomial logistic model multivariable, three factors are associated with the presence of chronic pain: the presence of pain before surgery (OR=2.36, CI 95% [1.03-5.39]), a large posterolateral incision (OR=4.14 [1.25-13.72]) and the intensity of pain during mobilization of the ipsilateral shoulder at postoperative day 6 (OR=1.37 [1.10-1.70]). In conclusion, chronic pain is less frequent after an axillary approach than after a posterolateral one. Identified risk factors for chronic pain should lead to more aggressive management of preoperative and early postoperative pain and favor the mini-invasive approach.</span></p>
Early postoperative pain trajectories after posterolateral and axillary approaches for thoracic surgery: A prospective monocentric observational study
<p class="MDPI17abstract"><span>Less invasive thoracotomies may reduce early postoperative pain. The aims of this study were to identify pain trajectories from postoperative day 0 to 5 after posterolateral and axillary thoracotomies and identify potential factors related to the worst" trajectory. Patients undergoing a posterolateral (92 patients) or axillary (89 patients) thoracotomy between July 2014 and November 2015 were analyzed in this prospective monocentric cohort study. The best-fitting model resulted in four pain trajectory groups: trajectory 1, the "worst", with 29.8% of the patients with permanent significant pain; trajectory 2 with patients with low pain (32.6%), trajectory 3 with patients with a steep decrease in pain (22.7%), trajectory 4 with patients with a steep increase (14.9%). According to a multinomial logistic model multivariable analysis, some predictive factors allow differentiation between trajectory groups 1 and 2. Risk factors for permanent pain are the existence of preoperative pain (OR =6.94, CI 95% [1.54-31.27]) and scar length (OR=1.20 [1.05-1.38])). In contrast, ASA class III is a protective factor to be in group 1 (OR=0.02 [0.001-0.52]). In conclusion, early postoperative pain can be characterized by four trajectories and preoperative pain is the major factor for the worst trajectory of early postoperative pain.</span></p>
FIGURE 1 in Alloionema californicum Nermuť, Půža, Mráček & Lewis, 2016 is a junior synonym of Alloionema similis Holovachov, Boström, Tandingan De Ley, Mc Donnell, Alvarado, Paine & De Ley, 2016 (Nematoda: Alloionematidae)
FIGURE 1. Phylogenetic position of Alloionema similis and Alloionema californicum based on analysis of SSU (A), partial LSU (B) and ITS (C) regions of the rDNA. Toxocara cati, Steinernema glaseri and Steinernema monticolum, respectively, were used as outgroup taxa. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (10000 replicates) are shown next to the branches. Branch lengths indicate evolutionary distances expressed as the number of base differences per site.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.