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13,587
datasets available to search
ShareScore release 0.9.0
Dataset results
13,587 results for “specification”
Identification of spondylarthropathy-specific genes in BALB/c mice with proteoglycan-induced spondylitis (PGIS)
GEO Series GSE13782. Mus musculus. 8 samples. Type: Expression profiling by array.
ChIP Seq of influenza specific primary, memory and secondary CD4+ T cells
GEO Series GSE135250. Mus musculus. 40 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Isolate specific transcriptome changes exerted by isavuconazole treatment in Candida auris
GEO Series GSE275177. Candidozyma auris. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of hepatic genes in pair-fed and ethanol-fed wild type and Sirt6 liver-specific knockout mice
GEO Series GSE129370. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Subtype-specific regulatory network rewiring in acute myeloid leukemia [DNase-Hypersensitivity]
GEO Series GSE108246. Homo sapiens. 33 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Disease-specific exhaustion features and PD-1 immunotherapy responsiveness of antigen-specific CD8+ T cells at single-cell resolution
GEO Series GSE152628. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Subtype-specific regulatory network rewiring in acute myeloid leukemia [RNA-seq]
GEO Series GSE108266. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor specific genomic imbalances, despite random chromosomal instability
GEO Series GSE102647. Homo sapiens. 24 samples. Type: Expression profiling by array.
Induction of epididymis specific G-protein coupled receptor-64 (GPR64) in Ewing Tumors supports invasiveness and metastatic spread
GEO Series GSE23058. Homo sapiens. 10 samples. Type: Expression profiling by array.
The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression
Background: ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL) and also most likely the crucial factor for disease initiation, whereas its role in leukemia propagation and maintenance remains largely elusive. To address this issue we performed a shRNA-mediated knock-down (KD) of the E/R fusion gene and investigated the ensuing consequences on genome-wide gene expression patterns and deducible regulatory functions in two E/R-positive leukemic cell lines. Findings: Microarray analyses identified 777 genes whose expression was substantially altered. Although approximately equal proportions were either up- (KD-UP) or down-regulated (KD-DOWN), the effects on biological processes and pathways differed considerably. The E/R KD-DOWN set was significantly enriched for genes included in the cell activation, immune response, apoptosis, signal transduction and development and differentiation categories, whereas in the E/R KD-UP set only the PI3K/AKT/mTOR signaling and hematopoietic stem cells categories became evident. Comparable expression signatures obtained from primary E/R-positive ALL samples underline the relevance of these pathways and molecular functions. We also validated six differentially expressed genes representing the categories stem cell properties, B-cell differentiation, immune response, cell adhesion and DNA damage with RT-qPCR. Conclusion: The results of our analyses provide the first preliminary evidence that the continuous expression of the E/R fusion gene interferes with regular B-cell development by repressing key functions that are necessary under physiological circumstances. E/R may thus constitute also the essential driving force for the propagation and maintenance of the leukemic process irrespective of potential consequences of associated secondary changes. Finally, these findings may also provide a valuable source of potentially attractive therapeutic targets.
A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver [Altre-WT and Altre-KO]
GEO Series GSE227799. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling
GEO Series GSE110783. Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling (RNA-seq data set)
GEO Series GSE110782. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Treatment of human AML cell lines MOLM-14 and THP-1 with MUC1 specific shRNA
GEO Series GSE99510. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Mechanical stretch differentially regulates the expression of specific miRNA in the extracellular vesicles released from lung epithelial cells
GEO Series GSE131645. Mus musculus; synthetic construct. 16 samples. Type: Non-coding RNA profiling by array.
Single-cell multiomics study of cell-type-specific neuron activation unravels context-dependent gene regulation of brain disorders [029]
GEO Series GSE289518. Homo sapiens. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
An endothelial subtype-specific communication network orchestrates capillarization in liver tumorigenesis via the Hgf/c-Met pathway
GEO Series GSE128047. Mus musculus. 50 samples. Type: Expression profiling by array.
Dataset related to article "p2PSA for predicting biochemical recurrence of prostate cancer earlier than total prostate-specific antigen after radical prostatectomy: an observational prospective cohort study."
<p>BACKGROUND:</p> <p>There is an unmet clinical need for more biochemical specific tests that may detect clinically significant recurrent PCa at an early stage after radical prostatectomy (RP). Our purpose is to test the hypothesis that p2PSA (Index test) detects prostate cancer relapse (BCR) earlier than the current Reference Standard Test (total prostate-specific antigen [tPSA]) in patients who underwent RP for localized PCa.</p> <p>METHODS:</p> <p>This is an observational, prospective, cohort, follow-up study in patients subjected to RALP (robotic assisted laparoscopic radical prostatectomy) for clinically localized PCa from January 2013 to July 2013 at a high-volume Institution (450 average RP/year). A blood sample, for tPSA and p2PSA, was prospectively drawn after 3, 6, and 12 months and then every 6 months during the following two years. The primary outcome is to determine whether or not kinetics in rising of p2PSA significantly anticipates the tPSA kinetics. Exploratory data analysis was used to identify relationship between different variables.</p> <p>RESULTS:</p> <p>Over 134 patients 20 BCRs were detected according to tPSA cut-off. Five patients showed a contemporary increase of tPSA and p2PSA, 11 presented a p2PSA increase earlier than tPSA increase (13.9 months ±9.7). In four patients, the increase of PSA was not associated with a p2PSA>0.8 pg/mL. The correlation between tPSA and p2PSA according to Sperman's rho coefficient was statistically significant at 3, 6, 18 and 30 months: 0.416 (P<0.01), 0.255 (P<0.01), 0.359 (P<0.01) and 0.413 (P<0.01) respectively. When subjects were stratified according to stage/grade and margins (positive vs. negative), patients with higher stage and positive surgical margins could be considered the target categories. The low rate of observed BCR and high rate of p2PSA false positive are the main limitations.</p> <p>CONCLUSIONS:</p> <p>The current findings showed that p2PSA might be more sensitive than tPSA in detecting earlier BCR within 3-year follow-up. Further studies with a longer follow-up and larger population remain mandatory before considering p2PSA for clinical decision-making.</p>
Data set from the article Prinzivalli M, Sammarco G, Rampoldi B, Costa E, Corsi Romanelli MM. Comparison between specific and nonspecific assay in the evaluation of the anticoagulant effect of the Direct Oral Anticoagulants: Our experience in a cardiovascular hospital. Eur J Intern Med. 2019;60:e20‐e22. doi:10.1016/j.ejim.2018.10.005
<p>Data set from the article Prinzivalli M, Sammarco G, Rampoldi B, Costa E, Corsi Romanelli MM. Comparison between specific and nonspecific assay in the evaluation of the anticoagulant effect of the Direct Oral Anticoagulants: Our experience in a cardiovascular hospital. <em>Eur J Intern Med</em>. 2019;60:e20‐e22. doi:10.1016/j.ejim.2018.10.005</p>
Cancer-specific Survival of Uveal Melanoma Patients by Diagnosis Era (A, C, D, E) and Tumor Stage (B, F,G,H)
<p>Cancer-specific Survival of Uveal Melanoma Patients by Diagnosis Era (A, C, D, E) and Tumor Stage (B, F,G,H)</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.