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13,587 results for “specification”
Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias
<p>Neural circuit alterations, although laying at the core of brain physiopathology, are usually hard to unveil in living subjects. Virtual brain modelling (TVB), by leveraging structural and functional MRI to simulate brain dynamics, can yield mesoscopic parameters of connectivity and synaptic transmission including excitatory and inhibitory coupling and recurrent excitation. In this work, we used TVB to simulate resting-state network dynamics in Alzheimer disease (AD) and Frontotemporal Dementia (FTD) patients and compared them to healthy controls (HC). The simulated parameter patterns differed between AD and FTD networks. Individual subjects, even when belonging to the same group (e.g., AD, FTD, or HC), presented subtle differences in network parameter patterns that significantly correlated with their own neuropsychological, clinical, and pharmacological profiles.</p> <p>This database includes structural and functional connectivity matrices estimated from tractography and rs-fMRI time-series of each subject analyzed (10 HC, 16 AD, 7 FTD). An ad-hoc grey matter (GM) parcellation atlas has been created combining 93 cerebral (including cortical/subcortical structures) and 31 cerebellar labels. Each GM parcellation is reported as a node in the connectivity matrices. Two types of SC matrices are reported: a distance matrix containing the length of tracts connecting each pair of nodes and a weight matrix in which connections strengths (number of streamlines) are normalized by the maximum value per each subject. The time-course of BOLD signals has been extracted for each node. To perform brain dynamics simulations in multiple functional networks a subset of nodes and connections need to be extracted from whole-brain SC and FC matrices and used as an input for TVB.</p>
Drosophila suzukii and Drosophila melanogaster demonstrate distinct preferences for specific natural aroma compounds in beer
<p>Raw Data sets of behavioral responses of <em>Drosophila suzukii</em> and <em>Drosophila melanogaster</em> towards specific beers, compounds found in beer, and lures spiked with specific compounds, calcium imaging responses. File names refer to the specific figures in manuscript that were created with this data.</p> <p> </p>
Targeted DamID Detects Cell Type Specific Histone Modifications in intact tissues or organisms
GEO Series GSE278272. Drosophila melanogaster; Xenopus laevis; Mus musculus. 47 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Rapid intrahepatic and peripheral blood HCV RNA decline and HCV-specific immune response increase during IFN-free DAA therapy in HCV treatment-naïve patients [exp2]
GEO Series GSE113420. Homo sapiens. 44 samples. Type: Expression profiling by array.
A coordinated attack by a bacterial secretion system and a small molecule drives prey specificity
GEO Series GSE270023. Vibrio parahaemolyticus; Aeromonas dhakensis. 10 samples. Type: Expression profiling by high throughput sequencing.
Trithorax balances ISC fate decisions via Ptx1-mediated repression of EE specification [ATAC-seq]
GEO Series GSE311542. Drosophila melanogaster. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer’s disease neuropathology [scRNA-seq]
GEO Series GSE287652. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Cell type-specific regulation by intragenic CpG islands [WGBS]
GEO Series GSE82125. Mus musculus. 4 samples. Type: Methylation profiling by high throughput sequencing.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity [human]
GEO Series GSE98814. Homo sapiens. 2 samples. Type: Expression profiling by array.
Myeloid-specific ferritin light chain deletion does not confer renal protection in sepsis-associated acute kidney injury
GEO Series GSE255281. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Selective requirement of 3D genomic organization for the Mdm1-Il22-Ifng locus regulation in initial Th1 cell lineage specification and differentiation
GEO Series GSE215179. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Meyoid-specific deficiency of Glutamine Synthetase Aggravates LPS/D-GalN-induced liver injury via the activation of monocyte-derived macrophages
GEO Series GSE229818. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Mating-type specific gene expression in the filamentous ascomycete Neurospora tetrasperma
GEO Series GSE26798. Neurospora crassa; Neurospora tetrasperma. 36 samples. Type: Expression profiling by array.
TCRseq of Rpl18*-specific T cells from MC38 tumor and draining lymph node
GEO Series GSE302185. Mus musculus. 12 samples. Type: Other.
Single-cell transcriptional logic of cell-fate specification and axon guidance in early born retinal neurons
GEO Series GSE126820. Mus musculus. 802 samples. Type: Expression profiling by high throughput sequencing.
To identify specific glycosylated structures on brain endothelial cells that mediate rolling, adhesion, and diapedesis of leukocytes in the brain
GEO Series GSE29932. Homo sapiens. 10 samples. Type: Expression profiling by array.
Retinoic acid and TGF-β orchestrate organ-specific programs of tissue-residency
GEO Series GSE277120. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level [RNA-Seq]
GEO Series GSE243795. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
The role of glycans and glycosylation in cell-type specific effects on viral infectivity
GEO Series GSE29924. Homo sapiens. 4 samples. Type: Expression profiling by array.
Promoter G-quadruplex structures regulate tissue-specific gene expression and functional differentiation in Bombyx mori [CUT&Tag]
GEO Series GSE303268. Bombyx mori. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.