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18,654 results for “Pain”
A deep learning framework combining molecular image and protein structural representation identifies candidate drugs for chronic pain
<p>Official dataset for <i>A deep learning framework combining molecular image and protein structural representation identifies candidate drugs for chronic pain</i>. </p><p>The related code can be found at <a href="https://github.com/yuxin212/GPCR-public">here</a> and <a href="https://github.com/ChengF-Lab/LISA-CPI">here</a>. </p><p>The dataset is now public. </p>
Recurrent pain symptoms in adolescents with generalized and specific problematic Internet use: Associations analysis, confounding and mediating effects of comorbid psychosocial problems
<p>Problematic Internet use (PIU) in adolescents is a global public health issue especially exacerbated by the restrictions caused by the COVID-19 epidemic. The authors assume a negative impact of PIU not only in relation to adolescents' mental health and social behaviour but also relative to somatic components of their health, particularly concerning the occurrence of pain symptoms – recurrent headache (RH), recurrent abdominal pain (RAP), and recurrent back pain (RBP). The present study aims to identify the associations between different types of PIU (generalized PIU – PIUgen, problematic computer game use – PUgame, and problematic social media use – PUsocial), and pain symptoms (RH, RAP and RBP), and to determine the role of psychosocial factors in the emergence of these associations.</p> <p><strong>Methods: </strong>The<strong> </strong>research represents a one-stage observational study of 4,411 adolescents (53.6% girls; Mage = 14.53±1.52) in an unbiased school sample, held in three large cities of Central Siberia. The frequency and intensity of pain symptoms over the past three months were ascertained by completing a number of questionnaires. The following questionnaires were used to identify PIU and its types: the Chen Internet Addiction Scale (CIAS for PIUgen), the Game Addiction Scale for Adolescents (GASA for PUgame), and The Social Media Disorder Scale (SMDS for PUsocial). The psychological problems were assessed using The Strengths and Difficulties Questionnaire (SDQ). Logistic and linear regression, as well as mediation analysis, were used.</p> <p><strong>Results:</strong> Considering both the frequency and intensity of pain, along with the presence of psychosocial problems as a confounder, a direct association of RH with PUsocial only was revealed (OR = 1.68, CI = 1.33–2.11). Using the same criteria, RAP in this sample was associated with PIUgen and PUsocial (OR = 1.99, CI = 1.51–2.62 and 2.10, CI = 1.62–2.72, respectively). RBP, according to the obtained data, was also associated with PIUgen and PUsocial both in terms of pain frequency (OR = 1.99, CI = 1.53–2.57 and OR = 2.20, CI = 1.44–3.38, respectively) and intensity. PUgame was weakly associated only with RAP and showed no significant association with RH and RBP. The mediation analysis indicated that the revealed positive associations were largely mediated by psychosocial problems comorbid for PIUgen and PUsocial (but not PUgame).</p> <p><strong>Conclusions: </strong>The<strong> </strong>frequently reported association of recurrent pain symptoms with PIU in adolescents is largely mediated by comorbid psychosocial problems. The direct effect of excessive Internet use on somatic pain symptoms in adolescents is mild-to-moderate and depends on the content predominantly consumed.</p>
Riskfactors of Post-operative Pain and Nausea After Ambulatory Gynaecological Laparocopy.
ClinicalTrials.gov study NCT05050708. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Adrenocorticotropic Axis and Neuropathic Pain
ClinicalTrials.gov study NCT01543425. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery
ClinicalTrials.gov study NCT07291089. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Vibration for Pain Reduction During Trigger Point Injection
ClinicalTrials.gov study NCT03365674. IPD Sharing: NO. Countries: 1. Publications: 4.
Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
ClinicalTrials.gov study NCT01843010. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Flecainide in Treating Patients With Chronic Neuropathic Pain
ClinicalTrials.gov study NCT00002996. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of the Effect of Propacetamol, Ibuprofen or Their Combination on Postoperative Pain and Quality of Recovery After Laparoscopic Hernia Repair in Children
ClinicalTrials.gov study NCT03352362. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Self-Acupressure on Pain and Sleep in Coronary Artery Patients
ClinicalTrials.gov study NCT04934241. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparing Different Physiotherapy Interventions on APT in Non Specific Low Back Pain
ClinicalTrials.gov study NCT07098741. IPD Sharing: NO. Countries: 1. Publications: 9.
Effectiveness of Radial Extracorporeal Shockwave Therapy in Patients With Chronic Low Back Pain
ClinicalTrials.gov study NCT05308641. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Flexible Attention Sensory Training for Youth with Chronic Pain
ClinicalTrials.gov study NCT06051305. IPD Sharing: NO. Countries: 1. Publications: 9.
Group Acupuncture Treatment Effects for Painful Diabetic Neuropathy (GATE-PDN)
ClinicalTrials.gov study NCT02104466. IPD Sharing: Not stated. Countries: 1. Publications: 11.
The Effect of Hybrid Tele-rehabilitation Versus In Person Rehabilitation on Pain and Function in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT06956222. IPD Sharing: YES. Countries: 1. Publications: 1.
A Pilot Study Evaluating a Multidisciplinary Chronic Pain Group Therapy in a Primary Care Setting
ClinicalTrials.gov study NCT01517256. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Local Anesthetic Nebulization and Instillation for Pain Control After Laparoscopic Surgery
ClinicalTrials.gov study NCT01248819. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy of Platelet Rich Plasma vs. Corticosteroid Injections for Treating Greater Trochanteric Pain Syndrome
ClinicalTrials.gov study NCT02031367. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain in Maxillary Premolars With Acute Irreversible Pulpitis
ClinicalTrials.gov study NCT07250399. IPD Sharing: NO. Countries: 1. Publications: 2.
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
ClinicalTrials.gov study NCT06945263. IPD Sharing: NO. Countries: 1. Publications: 17.
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