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247
datasets available to search
ShareScore release 0.7.1
Dataset results
247 results for “CRISPR/Cas9”
An organoid-based CRISPR/Cas9 screen for regulators of intestinal epithelial maturation
GEO Series GSE221278. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Linking CRISPR/Cas9 double-strand break profiles to gene editing precision with BreakTag
GEO Series GSE223772. Homo sapiens. 220 samples. Type: Other.
Enabling multiplexed CRISPR/Cas9 screening via massively parallel in-library ligation
GEO Series GSE149945. Homo sapiens; Escherichia coli. 9 samples. Type: Other.
Genome-wide CRISPR/Cas9 library screening identified OGDH as a regulator of disease progress and HMAs-resistance in MDS by reprogramming glutamine metabolism
GEO Series GSE273914. Homo sapiens. 5 samples. Type: Other.
SETDB1-TRIM28 complex suppresses antitumor immunity [CRISPR/Cas9 screen]
GEO Series GSE182197. Mus musculus. 1 samples. Type: Other.
Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [scRNA-seq]
GEO Series GSE237569. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
CRISPR/Cas9 Screens Reveal Epstein-Barr virus Synthetic Lethal Targets
GEO Series GSE93681. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Efficient Genome Editing in Bacillus licheniformis Mediated by a Conditional CRISPR/Cas9 System
<p>The sequencing results of the positive transformants. The lack of a 484-bp fragment indicates successful disruption of the amyL gene</p>
CRISPR/Cas9 genome-wide screens for sensitisers and suppressors of AZD6738 efficacy in Atm WT and Atm KO mESCs
<p>The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in the related kinase ATM. However, it still remains unclear which functions and pathways dominate long-term ATRi efficacy, and how these vary between clinically relevant genetic backgrounds. Elucidating common and genetic-background specific mechanisms of ATRi efficacy could therefore assist patient stratification and pre-empting drug resistance. Here, we use CRISPR-Cas9 genome-wide screening in ATM-deficient and proficient mouse embryonic stem cells to interrogate cell fitness following treatment with the ATRi, ceralasertib (AZD6738). We identify factors that enhance or suppress ATRi efficacy, with a subset of these requiring intact ATM signalling. Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and suggests new ATM-dependent pathways that compensate in the absence of functional ATR.</p>
CRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC Mutation
ClinicalTrials.gov study NCT06465537. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mitochondrial RNA cytosolic leakage drives the SASP [CRISPR/Cas9]
GEO Series GSE306957. Homo sapiens; Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of ETV6/RUNX1 KO lymphoid cell line generated by CRISPR/Cas9 showed a distinct expression signature and a deregulation of its downstream signaling genes
GEO Series GSE140980. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification and Characterization of the Determinants of Copper Resistance in the Acidophilic Fungus Acidomyces richmondensis MEY-1 Using the CRISPR/Cas9 System
GEO Series GSE217610. Acidomyces sp. 'richmondensis'. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification of genes involved in class switch recombination by genome-wide CRISPR/Cas9 knock-out screen
GEO Series GSE184145. Mus musculus. 8 samples. Type: Other.
RNA-Seq of brain metastatic breast cancer cell lines after knockout of lipid metabolism genes using CRISPR/Cas9 gene editing
GEO Series GSE148372. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Linking CRISPR/Cas9 double-strand break profiles to gene editing precision with BreakTag [hiplex2]
GEO Series GSE223770. Homo sapiens. 10 samples. Type: Other.
Pooled CRISPR/Cas9 screen for genes that contribute to ribosome biogenesis and turnover
GEO Series GSE197277. Homo sapiens. 4 samples. Type: Other.
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing [MeDIP-Seq]
GEO Series GSE96577. Homo sapiens. 5 samples. Type: Methylation profiling by high throughput sequencing.
Cellular Indexing of Transcriptomes and epitopes sequencing (CITE-seq) analysis to investigate the impact of granulocyte-colony stimulating factor on CRISPR/Cas9 gene edited human hematopoietic stem c
GEO Series GSE230182. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
A CRISPR/Cas9 library screening identified CARM1 as a critical inhibitor for Sorafenib-induced ferroptosis in hepatocellular carcinoma cells [CRISPR screen]
GEO Series GSE215909. Homo sapiens. 5 samples. Type: Other.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.