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758 results for “Candida”
A Multicenter Observational Study of Invasive Candida Infections Among ICU Patients in China
ClinicalTrials.gov study NCT01253954. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week
ClinicalTrials.gov study NCT00537888. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074)
ClinicalTrials.gov study NCT01165320. IPD Sharing: YES. Countries: 0. Publications: 1.
Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation
ClinicalTrials.gov study NCT03140748. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Candida Antigen and Bivalent HPV Vaccine in the Treatment of Multiple Warts
ClinicalTrials.gov study NCT05291845. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Intraspecific phenotypic variation and morphological divergence of strains of Folsomia candida (Willem) (Collembola: Isotomidae), the "standard" test springtail
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Data from: Multilocus microsatellite markers for molecular typing of Candida tropicalis isolates
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Data from: Host-induced genome instability rapidly generates phenotypic variation across Candida albicans strains and ploidy states
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Data from: Interactive effects of soil moisture, air temperature and litter nutrient diversity on soil microbial communities and Folsomia candida population
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Data from: Decrease in ribosomal RNA in Candida albicans induced by serum exposure
Candida albicans is an important polymorphic human pathogen. It can switch from a unicellular yeast form to germinating hypha, which may play a role in making it the successful pathogen it is. This hyphal transformation can be triggered by various extracellular stimuli, the most potent one being serum from any source. We have previously reported that Candida albicans transiently polyadenylates portions of both the large and small subunits of ribosomal RNA, shortly after serum exposure. Northern blots at the same time suggested that serum might induce a decrease in total ribosomal RNA. We have carried out a number of experiments to carefully assess this possibility and now report that serum significantly reduces ribosomal RNA in Candida albicans. Fluorometric measurements, Northern blotting and quantitative RT-PCR, have all confirmed this decrease. Timed experiments show that serum induces this decrease rapidly, as it was seen in as early as five minutes. Cell mass is not decreased as total cellular protein content remains the same and metabolic activity does not appear to slow, as assessed by XTT assay, and by the observation that cells form hyphal structures robustly. Another hyphal inducer, N-acetylglucosamine, also caused RNA decrease, but to a lesser extent. We also observed it in non-germinating yeast, such as Candida glabrata. The reason for this decrease is unknown and overall our data suggests that decrease in rRNA does not play a causal role in hyphal transformation. Rapid and significant decrease in a molecule so central to the yeast's biology is of some importance, and further studies, such as its effect on protein metabolism, will be required to better understand its purpose.
Finding Candida auris in public metagenomic repositories
<p><i>Candida auris</i> is a newly emerged multidrug-resistant fungus capable of causing invasive infections with high mortality. Despite intense efforts to understand how this pathogen rapidly emerged and spread worldwide, its environmental reservoirs are poorly understood. Here, we present a collaborative effort between the U.S. Centers for Disease Control and Prevention, the National Center for Biotechnology Information, and GridRepublic (a volunteer computing platform) to identify <i>C. auris</i> sequences in publicly available metagenomic datasets. We developed the MetaNISH pipeline that uses SRPRISM to align sequences to a set of reference genomes and computes a score for each reference genome. We used MetaNISH to scan ~300,000 SRA metagenomic runs from 2010 onwards and identified five datasets containing <i>C. auris</i> reads. Finally, GridRepublic has implemented a prospective <i>C. auris </i>molecular monitoring system using MetaNISH and volunteer computing.</p>
Data for / Comparison of Antifungal Activity of Thymus Vulgaris Essential Oil and Triple Antibiotic Paste Against Candida Albicans Isolated from Root Canal (In Vitro Study)
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Antibacterial effect of Hibiscus sabdariffa (Roselle) extract in synergism with voriconazole and fluconazole against fluconazole-resistant Candida albicans isolates: An in vitro study.
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FIGURE 4 in Hidden in plain sight: the identity of the white-leaved snakewood species from southeastern Brazil, Cecropia candida Snethl. and Cecropia hololeuca Miq. (Urticaceae)
FIGURE 4. Geographic distribution of Cecropia candida.
FIGURE 3 in Hidden in plain sight: the identity of the white-leaved snakewood species from southeastern Brazil, Cecropia candida Snethl. and Cecropia hololeuca Miq. (Urticaceae)
FIGURE 3. Lectotype of Cecropia candida (HBG513206).
Protective efficacy of anti-Hyr1p monoclonal antibody against systemic candidiasis due to multi-drug resistant Candida auris
<p>Supplementary data set </p>
Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans
<p>Fungal pathogens like Candida albicans can cause devastating human disease. Treatment of candidemia is complicated by the high rate of resistance to common antifungal therapies. Additionally, there is host toxicity associated with many antifungal compounds due to the conservation between essential mammalian and fungal proteins. An attractive new approach for antimicrobial development is to target virulence factors: non-essential processes that are required for the organism to cause disease in human hosts. This approach expands the potential target space while reducing the selective pressure towards resistance, as these targets are not essential for viability. In C. albicans, a key virulence factor is the ability to transition to hyphal morphology. We developed a high-throughput image analysis pipeline to distinguish between yeast and filamentous growth in C. albicans at the single cell level. Based on this phenotypic assay, we screened the FDA drug repurposing library of 2,017 compounds for their ability to inhibit filamentation and identified 33 compounds that block the hyphal transition in C. albicans with IC50 values ranging from 0.2 to 150 µM. Multiple compounds showed a phenyl vinyl sulfone chemotype, prompting further analysis. Of these phenyl vinyl sulfones, NSC 697923 displayed the most efficacy, and by selecting for resistant mutants, we identified eIF3 as the target of NSC 697923 in C. albicans. </p>
Fig. 9 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities
Fig. 9. ORTEP drawing of the X-ray structures of haemanthamine (18) and (+)-tazettine (24).
Fig. 1 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities
Fig. 1. Chemical structures of the isolated alkaloids 1–26.
Fig. 5 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities
Fig. 5. Proposed biosynthetic pathway of zephyranine A (1).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.