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636 results for “Chimerism”
CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies
ClinicalTrials.gov study NCT02965092. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults w/ Recurrent or Refractory B Cell Malignancies
ClinicalTrials.gov study NCT03241940. IPD Sharing: NO. Countries: 1. Publications: 2.
Her2 Chimeric Antigen Receptor Expressing T Cells in Advanced Sarcoma
ClinicalTrials.gov study NCT00902044. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Anti-Lewis Y Chimeric Antigen Receptor-T Cells (LeY-CAR-T) in Patients With Solid Tumours
ClinicalTrials.gov study NCT03851146. IPD Sharing: NO. Countries: 1. Publications: 1.
CD38-targeted Chimeric Antigen Receptor T Cell (CART) in Relapesd or Refractory Acute Myeloid Leukemia
ClinicalTrials.gov study NCT04351022. IPD Sharing: NO. Countries: 1. Publications: 2.
Chimeric inheritance and crown-group acquisitions of Carbon fixation genes within Chlorobiales
Open the record for dataset details and reuse information.
Data from: ITS all right mama: Investigating the formation of chimeric sequences in the ITS2 region by DNA metabarcoding analyses of fungal mock communities of different complexities
Open the record for dataset details and reuse information.
Data from: Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns
Ferns are well known for their shade-dwelling habits. Their ability to thrive under low-light conditions has been linked to the evolution of a novel chimeric photoreceptor—neochrome—that fuses red-sensing phytochrome and blue-sensing phototropin modules into a single gene, thereby optimizing phototropic responses. Despite being implicated in facilitating the diversification of modern ferns, the origin of neochrome has remained a mystery. We present evidence for neochrome in hornworts (a bryophyte lineage) and demonstrate that ferns acquired neochrome from hornworts via horizontal gene transfer (HGT). Fern neochromes are nested within hornwort neochromes in our large-scale phylogenetic reconstructions of phototropin and phytochrome gene families. Divergence date estimates further support the HGT hypothesis, with fern and hornwort neochromes diverging 179 Mya, long after the split between the two plant lineages (at least 400 Mya). By analyzing the draft genome of the hornwort Anthoceros punctatus, we also discovered a previously unidentified phototropin gene that likely represents the ancestral lineage of the neochrome phototropin module. Thus, a neochrome originating in hornworts was transferred horizontally to ferns, where it may have played a significant role in the diversification of modern ferns.
Data from: Chimeric antigen receptors that trigger phagocytosis
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may be beneficial. Here, we engineered a family of Chimeric Antigen Receptors for Phagocytosis (CAR-Ps) that direct macrophages to engulf specific targets, including cancer cells. CAR-Ps consist of an extracellular antibody fragment, which can be modified to direct CAR-P activity towards specific antigens. By screening a panel of engulfment receptor intracellular domains, we found that the cytosolic domains from Megf10 and FcRɣ robustly triggered engulfment independently of their native extracellular domain. We show that CAR-Ps drive specific engulfment of antigen-coated synthetic particles and whole human cancer cells. Addition of a tandem PI3K recruitment domain increased cancer cell engulfment. Finally, we show that CAR-P expressing murine macrophages reduce cancer cell number in co-culture by over 40%.
Data to accompany Structural prediction of chimeric immunogens to elicit targeted antibodies against betacoronaviruses
<p>This dataset contains predicted chimera structures, NanoDSF data on thermal stability of expressed chimeras on the surface of pseudoviruses, and immunofluorescence data on expressed chimeras on the surface of pseudoviruses as described in the manuscript.</p>
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
<p>Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. This approach may still be limited by the presence of immunosuppressive myeloid populations. Here we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. Treatment of xenograft tumors resulted in PD-L1 dependent tumor growth inhibition. PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. The clinical study of PD-L1 CAR haNKs is warranted.</p>
FIGURE 1 in The chimeric Onobrychis tenoreana (Fabaceae) and lectotypification of the names O. laconica and O. pentelica
FIGURE 1. Lectotype of the name Onobrychis tenoreana (BM!, without barcode).
Figure 1 from: Hughes KW, Morris SD, Reboredo-Segovia A (2015) Cloning of ribosomal ITS PCR products creates frequent, non-random chimeric sequences – a test involving heterozygotes between Gymnopus dichrous taxa I and II. MycoKeys 10: 45-56. https://doi.org/10.3897/mycokeys.10.5126
Figure 1 - The ITS2 region of two haplotypes of Gymnopus dichrous: Haplotypes DI (represented by TENN68084) and DII (represented by TENN68078). The TC pair at position 15 and the indel at position 25 were used to determine which the haplotype was represented by the 5' end of a cloned sequence. Bases in red are points where DI and DII haplotypes differ in sequence and were used to determine if template switching had occurred in a cloned PCR product. Eight base pairs at which template switching can be detected are indicated by numbers 1-8. The possible area in which template switching (ts) could have occurred is indicated by vertical arrows and the number of observed template switching events is given above the vertical arrow. Bases that may be involved in intra-strand base pairing as determined by MFOLD are outlined with black boxes. Ambiguity codes indicate intraspecific variation.
Figure 3 from: Molino J, Lubiana Alves T, Ferreira-Camargo L, Croce M, Tanaka A, Buson F, Ribeiro P, Campos-Salazar A, Antonio E, Maizel A, Siratuti V, Costa C, Wlodarczyk S, de Souza Lima R, Mello F, Mayfield S, Carvalho J (2016) Chimeric spider silk production in microalgae: a modular bionanomaterial. Research Ideas and Outcomes 2: e9342. https://doi.org/10.3897/rio.2.e9342
Figure 3 - Cassette construction to be inserted in C. renhardtii nuclear genome for the expression of desired proteins. Promoter hsp70A/rbcs2: fusion of the promoters hsp70A and rbcs2 (Eichler-Stahlberg et al. 2009, Schroda et al. 2000). Sh-Ble: gene that gives resistance to Zeomycin. 2A: self-cleavage peptide obtained from Foot and Mouth Disease Virus (FMDV) (Rasala et al. 2012). PS: Secretion signal peptide of the gene Ars1. GOI: gene of interest coding the proteins to be used in the project. His: coding sequence of six histidines (histidine tag). RbcS2 3'UTR: terminal sequence (untranslated region) of the gene RbcS2 (Fuhrmann et al. 1999)
Figure 1 from: Molino J, Lubiana Alves T, Ferreira-Camargo L, Croce M, Tanaka A, Buson F, Ribeiro P, Campos-Salazar A, Antonio E, Maizel A, Siratuti V, Costa C, Wlodarczyk S, de Souza Lima R, Mello F, Mayfield S, Carvalho J (2016) Chimeric spider silk production in microalgae: a modular bionanomaterial. Research Ideas and Outcomes 2: e9342. https://doi.org/10.3897/rio.2.e9342
Figure 1 - Project overview. Schematic representation of spider web structure from macro to nano scale. A representation of: enzybiotic protein from a bacteriophage; a spider silk protein with repetitive domains and N and C terminals; host expression system Chlamydomonas reinhardtii and a chimeric protein envisioned in this project; and the final product, a biopatch produced from recombinant silk proteins and chimeric proteins.
Figure 2 from: Molino J, Lubiana Alves T, Ferreira-Camargo L, Croce M, Tanaka A, Buson F, Ribeiro P, Campos-Salazar A, Antonio E, Maizel A, Siratuti V, Costa C, Wlodarczyk S, de Souza Lima R, Mello F, Mayfield S, Carvalho J (2016) Chimeric spider silk production in microalgae: a modular bionanomaterial. Research Ideas and Outcomes 2: e9342. https://doi.org/10.3897/rio.2.e9342
Figure 2 - Schematic representation of spider silk proteins and chimeric protein. A: MaSp1 - Major ampullate spidroin 1, MaSp2 - Major ampullate spidroin 2 B: Chimeric protein of a enzybiotic with N and C terminals domains of spider silk proteins.
Figure 4 from: Molino J, Lubiana Alves T, Ferreira-Camargo L, Croce M, Tanaka A, Buson F, Ribeiro P, Campos-Salazar A, Antonio E, Maizel A, Siratuti V, Costa C, Wlodarczyk S, de Souza Lima R, Mello F, Mayfield S, Carvalho J (2016) Chimeric spider silk production in microalgae: a modular bionanomaterial. Research Ideas and Outcomes 2: e9342. https://doi.org/10.3897/rio.2.e9342
Figure 4 - Experimental Flowchart. (A) Wild Cells incubated with built vectors. (B) Wild-cell transformation by electroporation. (C) Selection of mutants resistant to Zeocin. (D) Screening of antibiotic resistant cells by PCR. (E) Cultivation of PCR positive cells. (F) Fractions to be tested for the presence of recombinant proteins. (G) Detection of recombinant proteins present in the fractions by Western Blot. (H) Protein Purification. (I) Quantification via ELISA. (J) Spider silk polymerization reaction.
Immunomics datasets: to identify potential candidates for chimeric vaccine design to cervix papilloma
<p>Immunomics datasets: to identify potential candidates for chimeric vaccine design to cervix papilloma</p>
Long-term Follow-up of Immunogenicity of a Single Dose of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Toddlers
ClinicalTrials.gov study NCT01001988. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Treatment of Patients With Advanced Renal Cancer With a Radiolabeled Antibody, Yttrium-90 Conjugated Chimeric G250
ClinicalTrials.gov study NCT00199875. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.