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Dataset results
317 results for “Histone deacetylase”
Development of miRNA expression signatures for induction of histone deacetylase inhibitor (part 2)
GEO Series GSE69488. Homo sapiens. 2 samples. Type: Non-coding RNA profiling by array.
Histone deacetylase inhibition in triple-negative breast cancer
GEO Series GSE92911. Homo sapiens. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing.
The Pelvic Radiation and Vorinostat (PRAVO) Study - Histone Deacetylase Inhibitor Activity
GEO Series GSE46703. Homo sapiens. 42 samples. Type: Expression profiling by array.
Polycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
GEO Series GSE59442. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The growth factor FGF21 maintains neuromuscular junction through histone deacetylase HDAC4 in denervation-induced skeletal muscle atrophy
GEO Series GSE303861. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Histone deacetylase-1 is required for epigenomic stability in Neurospora crassa [HiC]
GEO Series GSE286537. Neurospora crassa. 2 samples. Type: Other.
Development of miRNA expression signatures for induction of histone deacetylase inhibitor (part 1)
GEO Series GSE69487. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by array.
Data from: Genome-wide mapping of targets of maize histone deacetylase hda101 reveals its function and regulatory mechanism during seed development
Histone deacetylases (HDACs) control histone acetylation levels by removing acetyl group from lysine residues. Maize (Zea mays) HDAC HDA101 influences several aspects of development, including kernel size; however, the molecular mechanism by which HDA101 affects kernel development remains unknown. In this study, we find HDA101 regulates the expression of transfer cell-specific genes, suggesting their mis-regulation may be associated with defects in differentiation of transfer cells and smaller kernels of hda101 mutants. To investigate HDA101 function during early stages of seed development, we performed genome-wide mapping of HDA101 binding sites. We observed that HDA101 mainly targets highly and intermediately expressed genes. Although loss of HDA101 can induce histone hyper-acetylation of its direct targets, this often does not involve variation in transcription. A small subset of inactive genes that must be negatively regulated during kernel development are also targeted by HDA101 and its loss leads to hyper-acetylation and increased expression of these genes. Finally, we report HDA101 interacts with members of different chromatin remodeling complexes, such as NFC103/MSI1 and SNL1/SIN3-like co-repressors. Taken together, our results reveal a complex genetic network regulated by HDA101 during seed development and provide insights into the different mechanisms of HDA101-mediated regulation of transcriptionally active and inactive genes.
Dataset of docked structures for Topoisomerases-Histone Deacetylase-Dual Targeted Quinoline-Bridged Hydroxamates as Anticancer Agents
<p>The dataset contains docking poses of inhibitors 5C and 5G in the binding site of human TopoIIα, docking poses of inhibitors 5C and 5G in the binding site of human TopoI-DNA complex, docking poses of inhibitors 5C and 5G in the binding sites of HDAC1, HDAC6 and HDAC8 and protein-protein docking poses of hTopoIIα and HDAC1. All files are provided in pdb format. </p>
Oral Histone Deacetylase Inhibitor 4SC-202 in Patients With Advanced Hematologic Malignancies (TOPAS)
ClinicalTrials.gov study NCT01344707. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Histone Deacetylase Inhibitor (HDACi) Quisinostat (JNJ-26481585) in Patients With Previously Treated Stage Ib-IVa Cutaneous T-cell Lymphoma
ClinicalTrials.gov study NCT01486277. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Histone Deacetylases - Gastric Cancer (HDAC-GaCa-2008)
ClinicalTrials.gov study NCT01528501. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Imatinib, a Platelet-derived Growth Factor Receptor Inhibitor, and LBH589, a Histone Deacetylase Inhibitor, in the Treatment of Newly Diagnosed and Recurrent Chordoma
ClinicalTrials.gov study NCT01175109. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Histone-deacetylase Inhibitor JNJ-26481585 in Patients With Advanced or Refractory Leukemia or Myelodysplastic Syndrome
ClinicalTrials.gov study NCT00676728. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase II Study of Histone-deacetylase Inhibitor ITF2357 in Refractory/Relapsed Lymphocytic Leukemia
ClinicalTrials.gov study NCT00792831. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anti-PD-1 Antibody Combined With Histone Deacetylase Inhibitor in Patients With Advanced Cervical Cancer
ClinicalTrials.gov study NCT04651127. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Quisinostat, a Histone Deacetylase Inhibitor, in Combination With Chemotherapy
ClinicalTrials.gov study NCT02948075. IPD Sharing: NO. Countries: 1. Publications: 0.
Imaging Histone Deacetylase in the Heart
ClinicalTrials.gov study NCT03549559. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours
ClinicalTrials.gov study NCT00697879. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Safety, Tolerability and Pharmacokinetics of Quisinostat, a Histone Deacetylase Inhibitor, in Combination With Chemotherapy
ClinicalTrials.gov study NCT02728492. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.