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5,328 results for “MicroRNAs”
Raw data for the article: 3D Culture and Interferon-? Priming Modulates Characteristics of Mesenchymal Stromal/Stem Cells by Modifying the Expression of Both Intracellular and Exosomal microRNAs
<p>Mesenchymal stromal/stem cells (MSCs) have emerged as a therapeutic tool in regenerative medicine. Recent studies have shown that exosome (EXO)-derived microRNAs (miRNAs) play a crucial role in mediating MSC functions. Additionally, intracellular miRNAs have been found to regulate MSC therapeutic capacities. However, the molecular mechanisms underlying miRNA-mediated MSC effects are not fully understood. We used 3D culture and IFN-γ to prime/enhance the MSC therapeutic effects in terms of functional miRNAs. After priming, our analysis revealed stable variations in intracellular miRNA among the MSC biological replicates. Conversely, a significant variability of miRNA was observed among EXOs released from biological replicates of the priming treatment. For each priming, we observed distinct miRNA expression profiles between the MSCs and their EXOs. Moreover, in both types of priming, gene ontology (GO) analysis of deregulated miRNAs highlighted their involvement in tissue repair/regeneration pathways. In particular, the 3D culture enhanced angiogenic properties in both MSCs and EXOs, while IFN-γ treatment enriched miRNAs associated with immunomodulatory pathways. These findings suggest that 3D culture and IFN-γ treatment are promising strategies for enhancing the therapeutic potential of MSCs by modulating miRNA expression. Additionally, the identified miRNAs may contribute to understanding the molecular mechanisms underlying the miRNA-mediated therapeutic effects of MSCs.</p>
Associated data for "SOX10, MITF, and microRNAs: decoding their interplay in regulating melanoma plasticity (doi: 10.1002/ijc.35499)".
<p>This deposit contains the data and analysis to recreate the results in the paper- <span>Lai X</span>, <span>Luan C</span>, <span>Zhang Z</span>, et al. <span>SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity</span>. <em>Int J Cancer</em>. <span>2025</span>; <span>1</span>-<span>17</span>. doi: <a title="Link to external resource: 10.1002/ijc.35499" href="https://doi.org/10.1002/ijc.35499" target="_blank" rel="noopener">10.1002/ijc.35499.</a></p> <p>If you have used the data for your research, please cite the original publication. Thank you very much.</p> <p> </p> <p> </p>
Data for Fluorescein-switching-based lateral flow assay for the detection of microRNAs
<p>Data for Fluorescein-switching-based lateral flow assay for the detection of microRNAs</p>
Data from: Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
Exosomes are small vesicles that are secreted from metazoan cells and may convey selected membrane proteins and small RNAs to target cells for the control of cell migration, development and metastasis. To study the mechanisms of RNA packaging into exosomes, we devised a purification scheme based on the membrane marker CD63 to isolate a single exosome species secreted from HEK293T cells. Using immunoisolated CD63-containing exosomes we identified a set of miRNAs that are highly enriched with respect to their cellular levels. To explore the biochemical requirements for exosome biogenesis and RNA packaging, we devised a cell-free reaction that recapitulates the species-selective enclosure of miR-223 in isolated membranes supplemented with cytosol. We found that the RNA-binding protein Y-box protein I (YBX1) binds to and is required for the sorting of miR-223 in the cell-free reaction. Furthermore, YBX1 serves an important role in the secretion of miRNAs in exosomes by HEK293T cells.
Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization
<p>Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization</p>
Raw data - Digital scans - Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses
<p>Raw data of the manuscript "<em>Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses" </em>as published in Scientific Reports (https://doi.org/10.1038/s41598-025-17319-0) are included. Types of included data are:</p> <p> </p> <p>- NDPI files of digital scans showing miRNA in situ hybridization in mouse kidney</p>
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
ClinicalTrials.gov study NCT02418195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer
ClinicalTrials.gov study NCT07297134. IPD Sharing: NO. Countries: 1. Publications: 0.
Diagnostic and Prognostic Value of MicroRNA in Breast Cancer Patients
ClinicalTrials.gov study NCT04778202. IPD Sharing: Not stated. Countries: 0. Publications: 1.
microRNA Profile in Early-stage Cervical Cancer
ClinicalTrials.gov study NCT04087785. IPD Sharing: NO. Countries: 0. Publications: 10.
Circulating microRNAs and Response to Neoadjuvant Chemotherapy in Breast Cancer
ClinicalTrials.gov study NCT07289282. IPD Sharing: NO. Countries: 0. Publications: 0.
microRNA Profiles Identification in Adeno Carcinoma Prostate Cancer
ClinicalTrials.gov study NCT02964351. IPD Sharing: NO. Countries: 0. Publications: 7.
Carbohydrate Availability and microRNA Expression
ClinicalTrials.gov study NCT03250234. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer
ClinicalTrials.gov study NCT02127073. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Measurement of Serum microRNA in Acne Vulgaris Patient
ClinicalTrials.gov study NCT05885217. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Role of microRNAs in T Cell-Driven Inflammation in Asthma
ClinicalTrials.gov study NCT01484691. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MicroRNA-150 and microRNA-155 in Multiple Sclerosis
ClinicalTrials.gov study NCT04300543. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Effect of Food Consumption on microRNA Related to Metabolic Syndrome
ClinicalTrials.gov study NCT02606812. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Tocilizumab Effect on microRNA Expression and Adipokine Levels in Rheumatoid Arthritis Patients
ClinicalTrials.gov study NCT03149796. IPD Sharing: YES. Countries: 0. Publications: 22.
Circulating microRNAs as Novel Prognosis Biomarkers for Rheumatoid Arthritis
ClinicalTrials.gov study NCT03719469. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.