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175
datasets available to search
ShareScore release 0.9.0
Dataset results
175 results for “Single-molecule”
Data from: Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species, which occurs after ten cell divisions in zebrafish embryos. How transcription factor (TF)-chromatin interactions evolve during early development to support ZGA is largely unknown. We establish single molecule tracking in live developing zebrafish embryos using reflected light-sheet microscopy to visualize two fluorescently labeled TF species, mEos2-TBP and mEos2-Sox19b. We further develop a data acquisition and analysis scheme to extract quantitative information on binding kinetics and bound fractions during fast cell cycles. The chromatin-bound fraction of both TFs increases during early development, as expected from a physical model of TF-chromatin interactions including a decreasing nuclear volume and increasing DNA accessibility. For Sox19b, data suggests the increase is mainly due to the shrinking nucleus. Our single molecule approach provides quantitative insight into changes of TF-chromatin associations during the developmental period embracing ZGA.
Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase
<p>Single-molecule data files, surface plasmon resonance data files and raw images of ensemble assays presented in "Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase". </p>
Data belonging to "DNA-PAINT single-particle tracking (DNA-PAINT-SPT) enables extended single-molecule studies of membrane protein interactions"
<p>Source data for "DNA-PAINT single-particle tracking (DNA-PAINT-SPT) enables extended single-molecule studies of membrane protein interactions"</p>
Versatile Ampification Single-Molecule Detection in Liquid Biopsy
ClinicalTrials.gov study NCT05940311. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Application of Quantum Detection-Driven Artificial Intelligence Algorithms for Single-Molecule cfDNA Characterization in the Early Diagnosis of Prostate Cancer
ClinicalTrials.gov study NCT07238959. IPD Sharing: NO. Countries: 1. Publications: 0.
Heterogeneous single-molecule packaging of human mitochondrial nucleoids
GEO Series GSE249742. Drosophila melanogaster. 12 samples. Type: Other.
Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids
GEO Series GSE287653. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the transcriptome response to drought in Larix kaempferi using single-molecule long read isoform sequencing with de novo RNA-seq reads [RNA-Seq]
GEO Series GSE154534. Larix kaempferi. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
Open the record for dataset details and reuse information.
Transcriptomic analysis of testis and epididymis tissues from Banna mini-pig inbred line (BMI) boars with single-molecule long-read sequencing
GEO Series GSE193976. Sus scrofa. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Single-molecule regulatory architectures captured by chromatin fiber sequencing [Dm Fiber-seq]
GEO Series GSE146940. Drosophila melanogaster. 4 samples. Type: Other.
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer/promoter dynamics [ChIP-seq]
GEO Series GSE147789. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm
GEO Series GSE137490. Homo sapiens; Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Long-range single-molecule mapping of chromatin accessibility in eukaryotes
GEO Series GSE128290. Saccharomyces cerevisiae. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Single-molecule chromatin configurations link transcription factor binding to expression in human cells [ATAC-seq]
GEO Series GSE276513. Homo sapiens. 44 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing I
GEO Series GSE210136. Homo sapiens. 11 samples. Type: Other.
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing IV
GEO Series GSE245946. Mus musculus. 1 samples. Type: Other.
Fingerprinting tertiary structure in complex RNAs using single-molecule correlated chemical probing
GEO Series GSE278422. Enterococcus faecalis. 15 samples. Type: Other.
Single-molecule nascent RNA sequencing reveals regulatory domain architecture ant promoters and enhancers
GEO Series GSE116472. Homo sapiens; Mus musculus. 14 samples. Type: Other; Expression profiling by high throughput sequencing.
The single-molecule accessibility landscape of newly replicated mammalian chromatin
GEO Series GSE245558. Homo sapiens; Mus musculus. 176 samples. Type: Other.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.