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468 results for “Spikes”
Laminar phase coupling data for: Spike-phase coupling patterns reveal laminar identity in primate cortex
<p><span>The cortical column is one of the fundamental computational circuits in the brain. In order to understand the role neurons in different layers of this circuit play in cortical function it is necessary to identify the boundaries that separate the laminar compartments. While histological approaches can reveal ground truth they are not a practical means of identifying cortical layers <em>in</em> <em>vivo</em>. The gold standard for identifying laminar compartments in electrophysiological recordings is current-source density (CSD) analysis. However, laminar CSD analysis requires averaging across reliably evoked responses that target the input layer in cortex, which may be difficult to generate in less well-studied cortical regions. Further, the analysis can be susceptible to noise on individual channels resulting in errors in assigning laminar boundaries. Here, we have analyzed linear array recordings in multiple cortical areas in both the common marmoset and the rhesus macaque. We describe a pattern of laminar spike-field phase relationships that reliably identifies the transition between input and deep layers in cortical recordings from multiple cortical areas in two different non-human primate species. This measure corresponds well to estimates of the location of the input layer using CSDs but does not require averaging or specific evoked activity. Laminar identity can be estimated rapidly with as little as a minute of ongoing data and is invariant to many experimental parameters. This method may serve to validate CSD measurements that might otherwise be unreliable or to estimate laminar boundaries when other methods are not practical. </span></p>
Motor cortex analogue neurons in songbirds utilize Kv3 subunits to generate ultranarrow spikes
<p>Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels involved, we conducted a thorough study of the excitability of upper motor neurons controlling somatic motor function in the zebra finch. We found that robustus arcopallialis projection neurons (RAPNs), key command neurons for song production, exhibit ultranarrow spikes and higher firing rates compared to neurons controlling non-vocal somatic motor functions (AId neurons). Pharmacological and molecular data indicate that this striking difference is associated with the higher expression in RAPNs of high threshold, fast-activating voltage-gated Kv3 channels likely containing Kv3.1 subunits. The spike waveform and Kv3.1 expression in RAPNs mirror properties of Betz cells, specialized upper motor neurons involved in fine digit control in humans and other primates but absent in rodents. Our study thus provides evidence that songbirds and primates have convergently evolved the use of Kv3.1 to ensure precise, rapid AP firing in upper motor neurons controlling fast and complex motor skills.</p>
Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes - dataset
<p>Dataset used in Someck et al., 2023, "Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes." Structure contains 9160 units. Details and code are available at https://github.com/EranStarkLab/NonNegativeSpikes.</p>
SARS-CoV-2 spike protein complexes and their contacts
<p>This archive contains protein complex structures containing SARS-CoV-2 spike protein as well as derived data.</p>
Guerrero Two Copper Spikes in Bedrock (2019)
Site 2-04-8MO02343: Two copper spikes and a smaller variety of fastener are embedded in the bedrock at a shipwreck site thought to be that of the 1827 pirate slave ship *Guerrero*. These spikes are part of a broader feature of copper sheeting and spikes found along the east side of the site (see https://skfb.ly/6SCKy). Model created June, 2019. Scale = 5 centimeters. Source: Objaverse 1.0 / Sketchfab
Fantasy Sword, thorn spikes
This sword of unknown design and origin is as stylish as it is impractical. Very spiky in a rose thorn sort of way. The inward-facing spikes on the pommel would make it terrible to use, and the pommel plates are so large that it would be really difficult to strike with as well. Like this model, but need something a bit different? I take commissions! http://peripheralarbor.com/commission/ Actual license is "Public Domain" see details here https://ip.tryop.com/ Source: Objaverse 1.0 / Sketchfab
Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo
<p>Neuropixels data for investigating short-term plasticity in the mouse retinocollicular pathway. </p> <p>Paper (bioRxiv): <a href="https://www.biorxiv.org/content/10.1101/2024.01.17.576068v1">Differential Short-Term Facilitation Of Synaptic Inputs And Spike Transmission At The Retinocollicular Synapse In Vivo</a></p> <p>Full data will be availale upon publication of the paper.</p>
Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome
ClinicalTrials.gov study NCT02904265. IPD Sharing: NO. Countries: 1. Publications: 6.
COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household
ClinicalTrials.gov study NCT04452318. IPD Sharing: YES. Countries: 3. Publications: 8.
A Trial Looking at the Use of Camostat in People Who Have Tested Positive for Coronavirus (COVID-19) (SPIKE-1)
ClinicalTrials.gov study NCT04455815. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19
ClinicalTrials.gov study NCT04425629. IPD Sharing: YES. Countries: 3. Publications: 7.
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
ClinicalTrials.gov study NCT04426695. IPD Sharing: YES. Countries: 6. Publications: 5.
The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein
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Stimulus presentation can enhance spiking irregularity across subcortical and cortical regions
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Motor cortex analogue neurons in songbirds utilize Kv3 subunits to generate ultranarrow spikes
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Laminar phase coupling data for: Spike-phase coupling patterns reveal laminar identity in primate cortex
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Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe
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Alpha modulation of spiking activity across multiple brain regions in mice performing a tactile selective detection task
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Data from: Cerebellar complex spikes multiplex complementary behavioral information
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Spiking activity in the ventral visual pathway under delayed match-to-sample task
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.