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1,456 results for “Weight loss”
Data from: Obesity-induced decreases in muscle performance are not reversed by weight loss
BACKGROUND/OBJECTIVES: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss. SUBJECTS/METHODS: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain (MHC) composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction. RESULTS: Obesity increased resting metabolic rates (Po0.001) and decreased maximal metabolic rates (P = 0.030), but these changes were reversible by weight loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (P = 0.0034), and isolated muscle isometric stress (P = 0.01), work-loop power output (Po0.001) and relaxation rates (P = 0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow MHCs, and a shift toward fast MHCs were not reversed by weight loss. CONCLUSION: Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
Behavioural Weight Loss Treatment Plus Motivational Interviewing versus Attention Control: A Randomized Controlled Trial
<p>Studies evaluating the benefit of adding motivational interviewing (MI) to behavioural weight loss programs (BWLPs) have yielded mixed findings. The aims of this randomized controlled trial were to: (1) assess the efficacy of adding MI to a BWLP on weight loss and adherence among 135 overweight and obese individuals (77.8% female; mean BMI = 33.6 kg/m<sup>2</sup>) enrolled in a 12-week BWLP, and (2) explore levels of importance, confidence, and readiness for change ratings. Participants, who were randomized to receive 2 MI sessions or 2 attention control sessions, were assessed at baseline, end of BWLP, and 6 months post-BWLP. Both groups decreased their weight from baseline to end of the BWLP; however, there was no weight change from baseline to 6 months post-BWLP in either group. We observed no group differences in importance, confidence, and readiness for change after each session. Participants may not have benefited from MI because they were already highly motivated to change. These findings suggest that pre-treatment assessment and treatment monitoring may help enhance MI+BWLP efficacy by guiding a stepped-care approach that identifies individuals for whom additional MI sessions are needed, and when. A focus on refining elements of treatment remains an important direction for effective obesity treatment.</p>
Dataset for a physics informed deep learning method with adaptively weighted loss for modeling soil water flows
<p>The data for the 11 scenarios generated by Hydrus-1D is located in data.zip</p> <p>The code for the physics-informed neural networks with adaptively weighted loss used to simulate water flow in loam soils is located at PINN_adaptively_weighted_loss_loam.zip</p>
Metabolic profiles of obese soldiers before and after passing an intense 60-days weight-loss course (SEDENA)
<p>Untargeted metabolomics data (HPLC-MS, high resolution) of urine of obese soldiers that participated successfully in a 60-day course for losing weight, in a training center of the Mexican army (SEDENA).</p> <p>The sample names with the ending -2 represent data after the treatment; without this ending, before the treatment. The raw data were converted to .mzML using the ProteoWizard, and compressed to .zip files which can be directly uploaded to the MetaboAnalyst.ca website.</p>
Comparison of Weight Loss Programs for Individuals With Severe Obesity
ClinicalTrials.gov study NCT01330329. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Skeletal Muscle Lipid and Insulin Resistance: Effects of Physical Activity and Weight Loss
ClinicalTrials.gov study NCT00766298. IPD Sharing: NO. Countries: 1. Publications: 6.
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
ClinicalTrials.gov study NCT07224087. IPD Sharing: NO. Countries: 1. Publications: 1.
A Weight Loss Trial for Emotional Eating
ClinicalTrials.gov study NCT02055391. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Glucosamine and Chondroitin Supplementation in Women With Knee Osteoarthritis Participating in an Exercise and Weight Loss Program
ClinicalTrials.gov study NCT01271218. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Short Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients
ClinicalTrials.gov study NCT03034941. IPD Sharing: YES. Countries: 1. Publications: 3.
Macronutrient Relations and Weight Loss in Obese Subjects
ClinicalTrials.gov study NCT00868387. IPD Sharing: NO. Countries: 1. Publications: 1.
Role of Parenting Skills and Parenting Style in Pediatric Weight Loss Programs
ClinicalTrials.gov study NCT01004341. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Weight Loss and Exercise in Obese, Physically Limited, Older Women and Men
ClinicalTrials.gov study NCT00146107. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Does Motivational Interviewing Improve Behavioral Weight Loss Outcomes for Obesity?
ClinicalTrials.gov study NCT02649634. IPD Sharing: YES. Countries: 0. Publications: 10.
Evaluating the Efficacy of AI-Guided (GenAIS TM) vs. Standard Physician-Guided Dietary Supplement Prescriptions for Weight Loss in Obese Patients
ClinicalTrials.gov study NCT06458296. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches
ClinicalTrials.gov study NCT05929469. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
ClinicalTrials.gov study NCT02218112. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Testosterone and Weight Loss
ClinicalTrials.gov study NCT01616732. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Physiological Factors That Influence Maintenance of Lifestyle Changes and Weight Loss - a Longitudinal Study
ClinicalTrials.gov study NCT01997060. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Pounds Off Digitally (POD): The Use of Podcasting and Mobile Media to Promote Weight Loss
ClinicalTrials.gov study NCT01139255. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.