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256 results for “Working memory”
Multisensory modalities increase working memory for mating signals in a treefrog
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Data from: Cross-frequency synchronization connects networks of fast and slow oscillations during visual working memory maintenance
Neuronal activity in sensory and fronto-parietal (FP) areas underlies the representation and attentional control, respectively, of sensory information maintained in visual working memory (VWM). Within these regions, beta/gamma phase-synchronization supports the integration of sensory functions, while synchronization in theta/alpha bands supports the regulation of attentional functions. A key challenge is to understand which mechanisms integrate neuronal processing across these distinct frequencies and thereby the sensory and attentional functions. We investigated whether such integration could be achieved by cross-frequency phase synchrony (CFS). Using concurrent magneto- and electroencephalography, we found that CFS was load-dependently enhanced between theta and alpha–gamma and between alpha and beta-gamma oscillations during VWM maintenance among visual, FP, and dorsal attention (DA) systems. CFS also connected the hubs of within-frequency-synchronized networks and its strength predicted individual VWM capacity. We propose that CFS integrates processing among synchronized neuronal networks from theta to gamma frequencies to link sensory and attentional functions.
Data from: The influence of a working memory task on affective perception of facial expressions
In a dual-task paradigm, participants performed a spatial location working memory task and a forced two-choice perceptual decision task (neutral vs. fearful) with gradually morphed emotional faces (neutral ~ fearful). Task-irrelevant word distractors (negative, neutral, and control) were experimentally manipulated during spatial working memory encoding. We hypothesized that, if affective perception is influenced by concurrent cognitive load using a working memory task, task-irrelevant emotional distractors would bias subsequent perceptual decision-making on ambiguous facial expression. We found that when either neutral or negative emotional words were presented as task-irrelevant working-memory distractors, participants more frequently reported fearful face perception - but only at the higher emotional intensity levels of morphed faces. Also, the affective perception bias due to negative emotional distractors correlated with a decrease in working memory performance. Taken together, our findings suggest that concurrent working memory load by task-irrelevant distractors has an impact on affective perception of facial expressions.
Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory
<p><span>Humans show a pervasive bias for processing self- over other-related information, including in working memory (WM), where people prioritize the maintenance of self- (over other-) associated cues. To elucidate the neural mechanisms underlying this self-bias, we paired a self- vs. other-associated spatial WM task with functional magnetic resonance imaging (fMRI) and transcranial direct current stimulation (tDCS). Maintaining self- (over other-) associated cues resulted in enhanced delay-period activity in classic WM regions (frontoparietal cortex), and in superior multivoxel pattern decoding of the cue locations from visual cortex. Moreover, ventromedial prefrontal cortex (VMPFC) displayed enhanced functional connectivity with WM regions during maintenance of self-associated cues, which predicted individuals' behavioral self-prioritization effects. In a follow-up tDCS experiment, we targeted VMPFC with either excitatory (anodal), inhibitory (cathodal), or sham tDCS. Cathodal tDCS eliminated the self-prioritization effect. These findings provide strong converging evidence for a causal role of VMPFC in driving self-prioritization effects in WM.</span></p>
TZO - Working memory performance in glioma patients is associated with functional connectivity between the right dorsolateral prefrontal cortex and default mode network
<p>Data files hosted on Figshare for "Working memory performance in glioma patients is associated with functional connectivity between the right dorsolateral prefrontal cortex and default mode network".</p> <p>Contains functional connectivity matrices, clinical variables, and working memory performance scores of 45 glioma patients.</p>
Data from: Effect of mild thyrotoxicosis on performance and brain activations in a working memory task
Aims: Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. The aim of this study was to evaluate effects of mild induced thyrotoxicosis on working memory and its neural correlates. Methods: Twenty-nine healthy, male subjects with normal thyroid state participated in the study. Functional MRI was acquired during a working memory task (n-back task) before and after ingesting 250 μg L-thyroxin per day for a period of eight weeks. In addition, neuropsychological tests were performed. Results: In the hyperthyroid condition the subjects showed slower reaction times, but a higher accuracy in the 0-back version of the memory tasks. Fewer differences between euthyroid and hyperthyroid state were seen for the more difficult conditions of the n-back task. FMRI revealed effects of difficulty in the parahippocampal gyrus, supplementary motor area, prefrontal cortex, anterior cingulate cortex, posterior cerebellum, rolandic operculum and insula (p<0.05, FWE corrected). When comparing euthyroid and hyperthyroid condition in relation to task-induced activation, differences of activation were found in the right prefrontal cortex as well as in the right parahippocampal area. In the psychological assessment, the alerting effect in the Attention Network Task (ANT) and four out of five parameters of the auditory verbal learning test (AVLT) showed an increase from euthyroid to hyperthyroid state. Conclusions: It can be concluded that even a short-term intake of thyroid hormones leads to an activation of brain areas associated with working memory and to an improvement of accuracy of working memory tasks.
Data from: Concurrent visual and motor selection during visual working memory guided action
Visual working memory enables us to hold onto past sensations in anticipation that these may become relevant for guiding future actions. Yet laboratory tasks have treated visual working memories in isolation from their prospective actions and have focused on the mechanisms of memory retention rather than utilization. To understand how visual memories become used for action, we linked individual memory items to particular actions and independently tracked the neural dynamics of visual and motor selection when memories became used for action. This revealed concurrent visual-motor selection, engaging appropriate visual and motor brain areas at the same time. Thus we show that items in visual working memory can invoke multiple, item-specific, action plans that can be accessed together with the visual representations that guide them, affording fast and precise memory-guided behavior.
Data from: The expression of established cognitive brain states stabilizes with working memory development
We present results from a longitudinal study conducted over 10 years in a sample of 126 8-33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal that putative gain signals affecting maintenance and retrieval aspects of working memory processing stabilize during adolescence, while those affecting sensorimotor processes do not. We show that trial-to-trial variability in the reaction time and accuracy of eye-movements during a memory guided saccade task are related to fluctuations in the amplitude of expression of task-related brain states, or brain state variability, and also provide evidence that individual developmental trajectories of reaction time variability are related to individual trajectories of brain state variability. These observations demonstrate that underlying the maturation of cognition through adolescence is the stabilization of widespread gain signals affecting already available cognitive processes.
Working Memory Training on Delay Discounting Among Cigarette Smokers
ClinicalTrials.gov study NCT05210608. IPD Sharing: NO. Countries: 1. Publications: 0.
Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory
ClinicalTrials.gov study NCT03032796. IPD Sharing: NO. Countries: 1. Publications: 0.
Eye-tracking Working Memory Training in Children and Youth With Severe Cerebral Palsy
ClinicalTrials.gov study NCT06918379. IPD Sharing: NO. Countries: 1. Publications: 0.
Genetic Modulation of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
ClinicalTrials.gov study NCT01351272. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
ClinicalTrials.gov study NCT04002167. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Pilot Trial of Acute N-Acetylcysteine Effects on Working Memory and Other Cognitive Functions in Schizophrenia
ClinicalTrials.gov study NCT01232790. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Application of VR-based Working Memory Screening Test
ClinicalTrials.gov study NCT04600726. IPD Sharing: NO. Countries: 0. Publications: 4.
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
ClinicalTrials.gov study NCT06783283. IPD Sharing: YES. Countries: 1. Publications: 0.
Pilot Study of the Feasibility and Efficacy of Working Memory Training in Children With Cochlear Implants
ClinicalTrials.gov study NCT00763243. IPD Sharing: NO. Countries: 1. Publications: 0.
Modulating Oscillations and Working Memory in Patients With Subdural Electrodes
ClinicalTrials.gov study NCT03111290. IPD Sharing: YES. Countries: 0. Publications: 1.
CDP-Choline and Working Memory After TBI: A Neuroimaging Study
ClinicalTrials.gov study NCT00727246. IPD Sharing: NO. Countries: 1. Publications: 0.
Working Memory Functioning in Alzheimer's Disease and Vascular Dementia
ClinicalTrials.gov study NCT06321380. IPD Sharing: NO. Countries: 0. Publications: 22.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.