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287
datasets available to search
ShareScore release 0.9.0
Dataset results
287 results for “adenosine”
The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
GEO Series GSE188854. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase I
GEO Series GSE208401. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Effect of FSH on the gene expression profile of cumulus cells in vitro cultured as cumulus-oocyte complexes in presence of adenosine for 6 h
GEO Series GSE119803. Bos indicus; Bos taurus. 8 samples. Type: Expression profiling by array.
The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells [RNA-seq]
GEO Series GSE188814. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana [smallRNAs]
GEO Series GSE122526. Arabidopsis thaliana. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana [m6A_IP]
GEO Series GSE122525. Arabidopsis thaliana. 4 samples. Type: Expression profiling by high throughput sequencing.
Profiling of N6-Adenosine (m6A) methylation in HCCLM3 cells with shCtrl or shKIAA1429
GEO Series GSE134630. Homo sapiens. 6 samples. Type: Other.
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases
GEO Series GSE123905. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
RNAseq transcriptomic profile of glioblastoma stem-like cells derived from U87MG cell line treated with a selective A3 adenosine receptor antagonist (MRS1220) under hypoxia
GEO Series GSE100146. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide CRISPR Knockout Screen in HAP1 MTHFD1-K56R cells to identify genes which confer to resistance to adenosine toxicity
GEO Series GSE306775. Homo sapiens. 4 samples. Type: Other.
Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer
GEO Series GSE99789. Homo sapiens. 3 samples. Type: Other.
N6-Adenosine methylation regulates the translation of insulin mRNA
GEO Series GSE207547. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.
GEO Series GSE138729. Mus musculus; Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Adenosine DeAminase-1 (ADA-1) improves Follicular helper T cell function and vaccine response [2]
GEO Series GSE99781. Homo sapiens. 22 samples. Type: Expression profiling by array.
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells.
GEO Series GSE302191. Homo sapiens. 12 samples. Type: Expression profiling by array.
Ecto-5’-Nucleotidase (Nt5e/CD73)-Mediated Adenosine Signaling Attenuates TGFβ-2 Induced Elastin and Cellular Contraction
GEO Series GSE216727. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
AMPK signaling downstream of adenosine 2A receptor represses Th17 cell pathogenicity through epigenetic and metabolic reprogramming.
GEO Series GSE284714. Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Depletion of AUF1 from myeloid cells protects from allergic airway and tumor infiltration and alters pro-angiogenic macrophage polarization by adenosines
GEO Series GSE181222. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Additional insights into Key Determinants for Adenosine 1 Receptor Antagonists Selectivity using Supervised Molecular Dynamics Simulations
<p>Adenosine receptors (ARs), like many other G protein-coupled receptors (GPCRs), are targets of primary interest in drug design. However, one of the main limits for the development of drugs for this class of GPCRs is the complex selectivity profile usually displayed by ligands. Numerous efforts have been done for clarifying the selectivity on ARs, leading to the development of many ligand-based models. The structure of the AR subtype A<sub>1</sub> (A<sub>1</sub>AR) has been recently solved, providing important structural insights. In the present work, we rationalized the selectivity profile of two selective A<sub>1</sub>AR and A<sub>2A</sub>AR antagonist investigating their recognition trajectories obtained by Supervised Molecular Dynamics from unbound state and monitoring the role of the water molecules in the binding site.</p>
Data from: Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment
OBJECTIVES: We compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) #0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). BACKGROUND: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR. METHODS: We recruited patients undergoing routine FFR assessment and made paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, cFFR, and FFR). Contrast medium and dose were per local practice, as was the dose of intracoronary adenosine. Operators were encouraged to perform both intracoronary and intravenous adenosine assessments and a final drift check to assess wire calibration. A central core lab analyzed blinded pressure tracings in a standardized fashion. RESULTS: A total of 763 subjects were enrolled from 12 international centers. Contrast volume was 8 +- 2 ml per measurement, and 8 different contrast media were used. Repeated measurements of each metric showed a bias <0.005, but a lower SD (less variability) for cFFR than resting indexes. Although Pd/Pa and iFR demonstrated equivalent performance against FFR #0.8 (78.5% vs. 79.9% accuracy, p ¼ 0.78; area under the receiver-operating characteristic curve: 0.875 vs. 0.881, p ¼ 0.35), cFFR improved both metrics (85.8% accuracy and 0.930 area, p < 0.001 for each) with an optimal binary threshold of 0.83. A hybrid decision-making strategy using cFFR required adenosine less often than when based on either Pd/Pa or iFR. CONCLUSIONS: cFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only ~85% agreement.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.