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837 results for “associational effects”
Mediating effects of Trait Emotional Intelligence on the association between Adverse Childhood Experiences (ACEs) and Self-reported Health
<p>Data for two studies which investigate the role of trait emotional intelligence in resilience following adverse childhood experiences. </p>
The effect of dietary supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on gene expression associated with glucose metabolism in skeletal muscle obtained from a high-fat-high-carbohydrate diet induced obesity model
<p><span>Obesity is a leading global health problem contributing to various chronic diseases, including type II diabetes mellitus</span> <span>(T2DM). The aim of this study was to investigate whether blueberries, yoghurt, and their respective bioactive components, Cyanidin-3-O-β-glucoside (C3G) and peptides alone or in combinations, alter the expression of genes related to glucose metabolism in skeletal muscles from diet-induced obese mice. In extensor digitorum longus (EDL), yoghurt up-regulated the expression of activation of 5'adenosine monophosphate-activated protein kinase (AMPK), insulin receptor substrate-1 (IRS-1), phosphatidylinositol-3 kinase (PI3K) and glucose transporter 4 (GLUT4), and down-regulated the expression of angiotensin II receptor type 1 (AGTR-1). The combination of blueberries and yoghurt down-regulated the mRNA expression of AGTR-1 and Forkhead box protein O1 (FoxO1) in the EDL. Whereas the combination of C3G and peptides down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression in the EDL. In the soleus, blueberries and yoghurt alone, and their combination down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression. In summary blueberries and yoghurt, regulated multiple genes associated with glucose metabolism in skeletal muscles, and therefore may play a role in the management and prevention of T2DM.</span></p>
Effects of individual traits vs. trait syndromes on assemblages of various herbivore guilds associated with central European Salix
<p><span>Data on studied willows, their traits, associated arthropod herbivore species, and script to perform analyses for the manuscript: "Effects of individual traits vs. trait syndromes on assemblages of various herbivore guilds associated with central European <em>Salix</em>".</span></p>
Large-eddy simulation of an atmospheric bore and associated gravity wave effects on wind farm performance in the Southern Great Plains
<p>Animations from weather radars (observations) and simulations (modeling) of an atmospheric bore and associated gravity waves during the AWAKEN field campaign from a case study on 06 June 2023. The first animation is reflectivity from the NEXRAD WSR-88D system at the Oklahoma City radar site (KTLX) operated by the National Weather Service. The second animation is wind speed at 95, 145, and 270 m agl from the Texas Tech X-Band radars at the AWAKEN site. The third and fourth animations are for simulation results using the Weather Research and Forecasting model (WRF) with two domains. The third animation is vertical velocity at 1 km agl and potential temperature at 200 m agl on domain d01, which has a horizontal grid spacing of 300 m. The fourth animation is hub-height wind speed and perturbation pressure along with simulated power output for 3 wind turbines in each of the four rows on domain d01, which has a horizontal grid spacing of 20 m. The wind turbines are NREL 2.8 MW turbines parameterized using a generalized actuator disk. </p> <p>These animations are included as supplementary material for the manuscript "Large-eddy simulation of an atmospheric bore and associated gravity wave effects on wind farm performance in the Southern Great Plains" submitted to <em>Wind Energy Science</em>. </p>
Repository associated with "Quantifying CO2 forcing effects on lightning, wildfires, and climate interactions"
<p>Results of CESM2 simulation runs.<br>See readme file for details.</p>
Data from: Effects of landscape complexity on pollinators are moderated by pollinators' association with mass-flowering crops
Conserving and restoring semi-natural habitat, i.e. enhancing landscape complexity, is one of the main strategies to mitigate pollinator decline in agricultural landscapes. However, we still have limited understanding of how landscape complexity shapes pollinator communities in both crop and non-crop habitat, and whether pollinator responses to landscape complexity vary with their association with mass-flowering crops. Here, we surveyed pollinator communities on mass-flowering leek crops and in nearby semi-natural habitat in landscapes of varying complexity. Surveys were done before and during crop bloom and distinguished between pollinators that visit the crop frequently (dominant), occasionally (opportunistic) or not at all (non-crop). Forty-four percent of the species in the wider landscape were also observed on leek flowers. Crop pollinator richness increased with local pollinator community size and increasing landscape complexity, but relationships were stronger for opportunistic than for dominant crop pollinators. Relationships between pollinator richness in semi-natural habitats and landscape complexity differed between groups with the most pronounced positive effects on non-crop pollinators. Our results indicate that while dominant crop pollinators are core components of crop pollinator communities in all agricultural landscapes, opportunistic crop pollinators largely determine species-richness responses and complex landscapes are local hotspots for both biodiversity conservation and potential ecosystem service-provision.
Data from: Host species and environmental effects on bacterial communities associated with Drosophila in the laboratory and in the natural environment
The fruit fly Drosophila is a classic model organism to study adaptation as well as the relationship between genetic variation and phenotypes. Although associated bacterial communities might be important for many aspects of Drosophila biology, knowledge about their diversity, composition, and factors shaping them is limited. We used 454-based sequencing of a variable region of the bacterial 16S ribosomal RNA gene to characterize the bacterial communities associated with wild and laboratory Drosophila isolates. In order to specifically investigate effects of food source and host species on bacterial communities, we analyzed samples from wild Drosophila melanogaster and D. simulans collected from a variety of natural substrates, as well as from adults and larvae of nine laboratory-reared Drosophila species. We find no evidence for host species effects in lab-reared flies; instead, lab of origin and stochastic effects, which could influence studies of Drosophila phenotypes, are pronounced. In contrast, the natural Drosophila–associated microbiota appears to be predominantly shaped by food substrate with an additional but smaller effect of host species identity. We identify a core member of this natural microbiota that belongs to the genus Gluconobacter and is common to all wild-caught flies in this study, but absent from the laboratory. This makes it a strong candidate for being part of what could be a natural D. melanogaster and D. simulans core microbiome. Furthermore, we were able to identify candidate pathogens in natural fly isolates.
Figure 3 in Nest-site microhabitat association of red-billed leiothrix in subtropical fragmented forest in central China: evidence for a reverse edge effect on nest predation risk?
Figure 3. Nonmetric multidimensional scaling (NMS) ordination of 237 sample units of microhabitat characteristics in the forest, and the joint plot of NMS scores with important microhabitat variables (r2> 0.2). The first and third axes represent 30% and 46% of the total variation, respectively.
Figure 4 in Nest-site microhabitat association of red-billed leiothrix in subtropical fragmented forest in central China: evidence for a reverse edge effect on nest predation risk?
Figure 4. Nonmetric multidimensional scaling (NMS) ordination of 134 sample units of microhabitat characteristics in the scrub-grassland, and the joint plot of NMS scores with important microhabitat variables (r2> 0.2). The first and second axes represent 78% and 15% of the total variation, respectively.
Figure 1 in Nest-site microhabitat association of red-billed leiothrix in subtropical fragmented forest in central China: evidence for a reverse edge effect on nest predation risk?
Figure 1. Study areas and vegetation types for nest-site selection of the red-billed leiothrix in Daweishan Nature Reserve (DSNR; 28°20′54″–28°28′47″N, 114°01′51″–114°12′52″E), Hunan Province, China.
Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives
<pre>Hypercalciuria in postmenopausal women with reduced bone mineral density is associated with different mineral metabolic profiles: effects of treatment with thiazides and anti-resorptives</pre>
Data for: Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition
<p>Whether, when, and how genetic diversity buffers individuals and populations against infectious disease risk is a critical and open question for understanding wildlife disease and zoonotic disease risk. Several, but not all, studies have found negative relationships between infection and heterozygosity in wildlife. Since they can host multiple zoonotic infections, we sampled a population of wild deer mice (<em>Peromyscus maniculatus</em>), sequenced their genomes, and examined their fecal samples for coccidia and nematode eggs. We analyzed coccidia infection status, abundance, and coinfection status in relation to per-locus and per-individual measures of heterozygosity, as well as identified SNPs associated with infection status. Since heterozygosity might affect host condition, and condition is known to affect immunity, it was included as a co-variate in the per-individual analyses and as response variable in relation to heterozygosity. Not only did coccidia-infected individuals have lower levels of genome-wide per-locus diversity across all metrics, but we found an inverse relationship between genomic diversity and severity of coccidia infection. We also found weaker evidence that coinfected individuals had lower levels of private allelic variation than all other groups. In the per-individual analyses, relationships between heterozygosity and infection were marginal but followed the same negative trends. Condition was negatively correlated with infection, but was not associated with heterozygosity, suggesting that effects of heterozygosity on infection were not mediated by host condition in this system. Association tests identified multiple loci involved in the inflammatory response, with a particular role for NF-κB signaling, supporting previous work on the genetic basis of coccidia resistance. Taken together, we find that increased genome-wide neutral diversity, the presence of specific genetic variants, and improved condition positively impact infection status. Our results underscore the importance of considering host genomic variation as a buffer against infection, especially in systems that can harbor zoonotic diseases.</p>
Supporting data for "The ionospheric effects of the 2022 Hunga Tonga Volcano eruption and the associated impacts on GPS Precise Point Positioning across the Australian region"
<p>This dataset contains the GPS Vertical Total Electron Content (TEC) data, the Rate of TEC, and the GPS Precise Point Positioning convergence time results as presented in Carter et al. (2023). For access to the raw datasets used in the analysis, the reader is referred to details in Carter et al. (2023).</p> <p>Carter, B. A., R. Pradipta, T. Dao, J. L. Currie, S. Choy, P. Wilkinson, P. Maher, R. Marshall, K. Harima, M. LeHuy, T. Nguyen Chien, T. Nguyen Ha, T. J. Harris (2023) The ionospheric effects of the 2022 Hunga Tonga Volcano eruption and the associated impacts on GPS Precise Point Positioning across the Australian region, Submitted to Space Weather, March, 2023.</p>
Recurrent pain symptoms in adolescents with generalized and specific problematic Internet use: Associations analysis, confounding and mediating effects of comorbid psychosocial problems
<p>Problematic Internet use (PIU) in adolescents is a global public health issue especially exacerbated by the restrictions caused by the COVID-19 epidemic. The authors assume a negative impact of PIU not only in relation to adolescents' mental health and social behaviour but also relative to somatic components of their health, particularly concerning the occurrence of pain symptoms – recurrent headache (RH), recurrent abdominal pain (RAP), and recurrent back pain (RBP). The present study aims to identify the associations between different types of PIU (generalized PIU – PIUgen, problematic computer game use – PUgame, and problematic social media use – PUsocial), and pain symptoms (RH, RAP and RBP), and to determine the role of psychosocial factors in the emergence of these associations.</p> <p><strong>Methods: </strong>The<strong> </strong>research represents a one-stage observational study of 4,411 adolescents (53.6% girls; Mage = 14.53±1.52) in an unbiased school sample, held in three large cities of Central Siberia. The frequency and intensity of pain symptoms over the past three months were ascertained by completing a number of questionnaires. The following questionnaires were used to identify PIU and its types: the Chen Internet Addiction Scale (CIAS for PIUgen), the Game Addiction Scale for Adolescents (GASA for PUgame), and The Social Media Disorder Scale (SMDS for PUsocial). The psychological problems were assessed using The Strengths and Difficulties Questionnaire (SDQ). Logistic and linear regression, as well as mediation analysis, were used.</p> <p><strong>Results:</strong> Considering both the frequency and intensity of pain, along with the presence of psychosocial problems as a confounder, a direct association of RH with PUsocial only was revealed (OR = 1.68, CI = 1.33–2.11). Using the same criteria, RAP in this sample was associated with PIUgen and PUsocial (OR = 1.99, CI = 1.51–2.62 and 2.10, CI = 1.62–2.72, respectively). RBP, according to the obtained data, was also associated with PIUgen and PUsocial both in terms of pain frequency (OR = 1.99, CI = 1.53–2.57 and OR = 2.20, CI = 1.44–3.38, respectively) and intensity. PUgame was weakly associated only with RAP and showed no significant association with RH and RBP. The mediation analysis indicated that the revealed positive associations were largely mediated by psychosocial problems comorbid for PIUgen and PUsocial (but not PUgame).</p> <p><strong>Conclusions: </strong>The<strong> </strong>frequently reported association of recurrent pain symptoms with PIU in adolescents is largely mediated by comorbid psychosocial problems. The direct effect of excessive Internet use on somatic pain symptoms in adolescents is mild-to-moderate and depends on the content predominantly consumed.</p>
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
ClinicalTrials.gov study NCT07309094. IPD Sharing: NO. Countries: 1. Publications: 15.
The Effect of Dietary Fat Modification on Risk Factors Associated With the Metabolic Syndrome
ClinicalTrials.gov study NCT00429195. IPD Sharing: Not stated. Countries: 1. Publications: 18.
The Effect of Prone Position Use Ventilator-Associated Pneumonia in Intensive Care Patients
ClinicalTrials.gov study NCT05760716. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Association Between Sarcopenia and Urinary Incontinence And Effect Of Physical Activity Among Over 50 Years Old Adults
ClinicalTrials.gov study NCT05313360. IPD Sharing: NO. Countries: 1. Publications: 1.
Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators
ClinicalTrials.gov study NCT03664466. IPD Sharing: NO. Countries: 1. Publications: 49.
Effect of Anti TNFa Upon Deep Endometriosis Associated Pain
ClinicalTrials.gov study NCT00604864. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.