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Dataset results
146 results for “brain size”
The evolutionarily conserved zebrafish choroid plexus maintains the size of brain ventricles
GEO Series GSE246851. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
Neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and brain size in Xenopus embryos
GEO Series GSE149538. Xenopus tropicalis. 6 samples. Type: Expression profiling by high throughput sequencing.
A human tissue screen identifies a regulator of ER secretion as a brain size determinant [organoid - screen]
GEO Series GSE151382. Homo sapiens. 1 samples. Type: Other.
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
GEO Series GSE220462. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
A human tissue screen identifies a regulator of ER secretion as a brain size determinant [organoid - lineage tracing]
GEO Series GSE151383. Homo sapiens; Mus musculus. 2 samples. Type: Other.
Data from: Rethinking the effects of body size on the study of brain size evolution
Body size correlates with most structural and functional components of an organism's phenotype – brain size being a prime example of allometric scaling with animal size. Therefore, comparative studies of brain evolution in vertebrates rely on controlling for the scaling effects of body size variation on brain size variation by calculating brain weight/body weight ratios. Differences in the brain size-body size relationship between taxa are usually interpreted as differences in selection acting on the brain or its components, while selection pressures acting on body size, which are among the most prevalent in nature, are rarely acknowledged, leading to conflicting and confusing conclusions. We address these problems by comparing brain-body relationships from across >1,000 species of birds and non-avian reptiles. Relative brain size in birds is often assumed to be 10 times larger than in reptiles of similar body size. We examine how differences in the specific gravity of body tissues and in body design (e.g., presence/absence of a tail or a dense shell) between these two groups can affect estimates of relative brain size. Using phylogenetic comparative analyses, we show that the gap in relative brain size between birds and reptiles has been grossly exaggerated. Our results highlight the need to take into account differences between taxa arising from selection pressures affecting body size and design, and call into question the widespread misconception that reptile brains are small and incapable of supporting sophisticated behavior and cognition.
Data from: Brain size and the risk of getting shot
Hunting kills hundreds of millions of animals annually, potentially constituting an important selection pressure on hunted species. We hypothesized that hunted individuals differing from survivors by having better ability to distinguish between dangerous humans and other human beings would be at a selective advantage. We tested whether shot individual birds had smaller brains than survivors, under the assumption that individuals with larger brains had superior escape ability. We used a large database on birds from Denmark to test whether getting shot was predicted by brain mass, while controlling statistically for the potentially confounding effects of age, sex, body mass and body condition. Analyses based on all species, or only species that were hunted, while controlling for differences in sampling effort in random effects models, showed consistently that shot individuals had smaller brains than survivors.
Data from: Selection for brain size impairs innate, but not adaptive immune responses
The brain and the immune system are both energetically demanding organs, and when natural selection favors increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over eight days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared to large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
Data from: Brain size in birds is related to traffic accidents
Estimates suggest that perhaps a quarter of a billion birds are killed by traffic annually across the world. This is surprising because birds have been shown to learn speed limits. Birds have also been shown to adapt to the direction of traffic and lane use, and this apparently results in reduced risks of fatal traffic accidents. Such behavioural differences suggest that individual birds that are not killed in traffic should have larger brains for their body size. We analysed the link between being killed by traffic and relative brain mass in 3521 birds belonging to 251 species brought to a taxidermist. Birds that were killed in traffic indeed had relatively smaller brains, while there was no similar difference for liver mass, heart mass or lung mass. These findings suggest that birds learn the behaviour of car drivers, and that they use their brains to adjust behaviour in an attempt to avoid mortality caused by rapidly and predictably moving objects.
Intra-operative Variation in Size of Brain Tumors After Craniotomy
ClinicalTrials.gov study NCT04365647. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
ClinicalTrials.gov study NCT07227610. IPD Sharing: YES. Countries: 1. Publications: 0.
A human tissue screen identifies a regulator of ER secretion as a brain size determinant
GEO Series GSE151384. Homo sapiens; Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing; Other.
Data from: Selection for brain size impairs innate, but not adaptive immune responses
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Data from: Brain size in birds is related to traffic accidents
Open the record for dataset details and reuse information.
Data from: Rethinking the effects of body size on the study of brain size evolution
Open the record for dataset details and reuse information.
Data from: Brain size and the risk of getting shot
Open the record for dataset details and reuse information.
A human tissue screen identifies a regulator of ER secretion as a brain size determinant [scRNA-Seq]
GEO Series GSE151381. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Wild mice with different social network sizes vary in brain gene expression
GEO Series GSE148075. Mus musculus. 86 samples. Type: Expression profiling by high throughput sequencing.
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (RNA-seq NPC)
GEO Series GSE220459. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (scRNA-seq)
GEO Series GSE220461. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.