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252
datasets available to search
ShareScore release 0.9.0
Dataset results
252 results for “disease invasion”
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
GEO Series GSE285645. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
GEO Series GSE285641. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Circulating microRNAs associated to cerebrospinal fluid amyloid-β and phosphorylated tau levels as potential non-invasive biomarkers for mild cognitive impairment and Alzheimer’s disease
GEO Series GSE215789. Homo sapiens. 217 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
GEO Series GSE285647. Mus musculus; Homo sapiens. 102 samples. Type: Expression profiling by high throughput sequencing.
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
GEO Series GSE285642. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
GEO Series GSE285643. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Identifying urinary RNA as non-invasive biomarkers for progression of chronic kidney disease
GEO Series GSE121978. Homo sapiens. 80 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Non-invasive stratification of non-alcoholic fatty liver disease by whole-transcriptome cell-free mRNA characterization
<p>Hepatic fibrosis stage is the most important determinant of outcomes in patients with non-alcoholic fatty liver disease (NAFLD). There is an urgent need for non-invasive tests that can accurately stage fibrosis and determine efficacy of interventions. Here we describe a novel cf-mRNA-Sequencing approach that can accurately and reproducibly profile low levels of circulating mRNAs and evaluate the feasibility of developing a cf-mRNA-based NAFLD fibrosis classifier. Using separate discovery and validation cohorts with biopsy-confirmed NAFLD (n=176 and 59, respectively) and healthy subjects (n=23), we performed serum cf-mRNA RNA-Seq profiling. Differential expression analysis identified 2498 dysregulated genes between NAFLD and healthy subjects and 134 fibrosis-associated genes in NAFLD patients. Comparison between cf-mRNA and liver tissues transcripts revealed significant overlap of fibrosis associated genes and pathways indicating that the circulating cf-mRNA transcriptome reflects molecular changes in the livers of NAFLD patients. In particular, metabolic and immune pathways reflective of known underlying steatosis and inflammation were highly dysregulated in the cf-mRNA profile of patients with advanced fibrosis. Finally, we used an elastic net ordinal logistic model to develop a classifier that predicts clinically significant fibrosis (F2-4). In an independent cohort, the cf-mRNA classifier was able to identify 50% of patients with at least 90% probability of clinically significant fibrosis. We demonstrate<b> </b>a<b> </b>novel and robust cf-mRNA-based RNA-Seq platform for non-invasive identification of diverse hepatic molecular disruptions and for fibrosis staging with promising potential for clinical trials and clinical practice.</p>
Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease
ClinicalTrials.gov study NCT04873258. IPD Sharing: NO. Countries: 1. Publications: 0.
Non-invasive Measures of Distal Lung Disease in Asthmatics
ClinicalTrials.gov study NCT00250341. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
ClinicalTrials.gov study NCT07067229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Non-Invasive Tests for Metabolic Liver Disease
ClinicalTrials.gov study NCT07122700. IPD Sharing: YES. Countries: 1. Publications: 0.
Effect Mechanism Investigation of a Non-invasive Stimulation Device for Rapid Alleviation of Parkinson's Disease Symptoms
ClinicalTrials.gov study NCT03320681. IPD Sharing: NO. Countries: 1. Publications: 0.
Non-Invasive Biomarkers in Prostate Cancer Disease Management
ClinicalTrials.gov study NCT06144619. IPD Sharing: NO. Countries: 1. Publications: 0.
Observational Study of Effectiveness and Safety of Trastuzumab Emtansine (T-DM1) in HER2-positive Breast Cancer Patients With Residual Invasive Disease Following Neoadjuvant Chemotherapy and Anti-HER2
ClinicalTrials.gov study NCT05754502. IPD Sharing: NO. Countries: 1. Publications: 0.
Bleeding in Hospitalized Patients With Liver Disease Undergoing Invasive Procedures
ClinicalTrials.gov study NCT04076605. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non Invasive Prenatal Test of Rare Genetic Diseases: Application to Rare Intellectual Disabilities
ClinicalTrials.gov study NCT03688594. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non-invasive Solution for Periodontal and Peri-implant Diseases (INPERIO)
ClinicalTrials.gov study NCT03977714. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Studying Blood and Tumor Tissue Samples in Women With Invasive Breast Cancer, Ductal or Lobular Carcinoma in Situ, or Benign Breast Disease
ClinicalTrials.gov study NCT00898508. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Application and Outcome of Non-invasive Ventilation in Different Chest Diseases
ClinicalTrials.gov study NCT03169452. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.