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Dataset results
1,274 results for “disease models”
Data associated to the study entitled:"Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI"
<p>Parkinson’s disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology.</p> <p>We performed a unilateral injection of 6-OHDA in the striatum of Sprague Dawley rats to produce retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta. We carried out a longitudinal study with a multi-modal approach combining structural and functional MRI together with quantitative histological validation to follow the effects of the lesion. Functional and structural connectivity were assessed in the brain of 6-OHDA rats and sham rats (NaCl injection) at 3 and 6 weeks post-lesioning using resting-state functional MRI and diffusion-weighted.</p> <p>The shared datafile corresponds to the MRI biomarkers extracted from diffusion and functional acquisitions as well as from histological mesaurements within striatum and substantia nigria.</p>
A Model for the Development of Alzheimer's Disease
<p>Here is the code and supplementary data for the paper "A Model for the Development of Alzheimer’s Disease". The file Alzheimer-model.code.tar.gz contains the code. Supplementary Data.rar includes supplementary data S1 to S7. Supplementary data S1 contains all transcript sequences of the groups, supplementary data S2 contains the genome annotation file assembled by StringTie, supplementary data S3 contains the TPM expression files of all assembled transcripts, supplementary data S4 contains the differential transcripts files, supplementary data S5 contains the functional annotation files of protein-coding transcripts, supplementary data S6 contains the pathways enriched by all differential transcripts, and supplementary data S7 contains information of all samples.</p>
Understanding the Rare Inflammatory Disease Using Large Language Models and Social Media Data
Open the record for dataset details and reuse information.
Global Transcriptomic Analysis of Topical Sodium Alginate Protection Against Peptic Damage in An In Vitro Model of Treatment-Resistant Gastroesophageal Reflux Disease
<p>PA= pepsin + Acid; "Sham + PA" means "Pretreatment + Treatment"</p> <p><span>Breakthrough symptoms </span>are thought to occur in roughly half of <span>all </span>gastroesophageal reflux disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) therapy. Topical alginates have recently been shown to enhance mucosal defense against acid-pepsin insult during GERD. We aimed to examine potential alginate protection of transcriptomic changes in a cell culture model of PPI recalcitrant GERD. Immortalized normal-derived human esophageal epithelial cells underwent pretreatment with commercial alginate-based anti-reflux medications (Gaviscon Advance or Gaviscon Double Action), a matched-viscosity placebo control, or pH 7.4 buffer (sham) alone for 1 minute, followed by exposure to pH 6.0+pepsin or buffer alone for 3 minutes. RNA sequencing was conducted, and Ingenuity Pathway Analysis was performed with a false discovery rate of ≤0.01, and absolute fold-change of ≥<span>1.3. Pepsin-acid exposure disrupted gene expressions associated with epithelial barrier function, chromatin structure</span>, carcinogenesis, and inflammation<span>. Alginate formulations demonstrated protection by mitigating these changes and promoting extracellular matrix repair, downregulating proto-oncogenes, and enhancing tumor suppressor expression. </span>These data suggest molecular mechanisms by which alginates provide topical protection against injury during weakly acidic reflux and support a potential role for alginates in prevention of GERD-related carcinogenesis.</p>
Dataset supporting the manuscript "Establishment of a Newborn Lamb Gut-Loop Model to Evaluate New Methods of Enteric Disease Control and Reduce Experimental Animal Use" (Baillou, Kasal-Hoc et al, Veterinary Sciences, 2021)
<p>These are the data supporting reported results in the publication "Establishment of a Newborn Lamb Gut-Loop Model to Evaluate New Methods of Enteric Disease Control and Reduce Experimental Animal Use" (Baillou, A, Kasal-Hoc N. et al, Veterinary Sciences, 2021). DOI not yet available.</p>
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic
<p>These are pseudo-randomized data from the MISTRAL study: "Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho during almost two years of pandemic". The data dictionary explains the data. Between December 2020 and August 2022, 4371 individuals with either COVID symptoms or contact with a COVID-positive case were included from two hospitals in Lesotho. </p>
rMATS analysis of alternative splicing events in a mouse model of environmental liver disease
<p>rMATS (https://rnaseq-mats.sourceforge.io/) was used to identify differential alternative splicing events (ASEs) corresponding to all five major types of AS patterns, <em>i.e</em>., skipped exon (SE), mutually exclusive exons (MXE), alternative 3’ splice site (A3SS), alternative 5’ splice site (A5SS), and retained intron (RI), in the HFD-fed mouse livers exposed to Ar1260, PCB126, or Ar1260 + PCB126 co-exposure compared to vehicle control This dataset identifies differential ASEs corresponding to all five major types of AS patterns [<em>i.e.,</em> skipped exon (SE), mutually exclusive exons (MXE), alternative 3’ splice site (A3’SS), alternative 5’ splice site (A5’SS), and retained intron (RI)], between Ar1260, PCB126, and Ar1260 + PCB126-exposed samples and vehicle control. For each ASE, the estimation of the alternatively spliced region usage is defined as percent-spliced in (ψ or PSI). Each comparison was made to identify differential ASEs with an associated change in exon usage (∆ψ). Differential ASEs were detected with an FDR of <0.05 and |∆ψ| of≥5%. The difference in the proportion of the two isoforms of the transcript was expressed as the change in mean percentage spliced-inform included (mean ∆ψ).</p>
Use of Three-Dimensional Printed Models for Endovascular Planning and Follow-up in Patients Affected by Aorto-Iliac-Femoral-Popliteal Arterial Disease Undergoing Balloon Angioplasty. A Single-center,
ClinicalTrials.gov study NCT07000097. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Incentive Integrated E-IBD Chronic Disease Management Model on the Quality of Life in IBD Patients
ClinicalTrials.gov study NCT05719766. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prediction Model of Cardiac Risk for Dental Extraction in Elderly Patients With Cardiovascular Diseases
ClinicalTrials.gov study NCT03211312. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Modeling Patient Response to a Therapeutic Diet in Crohn's Disease
ClinicalTrials.gov study NCT04596566. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluating the Potential of Large Language Models for Respiratory Disease Consultations
ClinicalTrials.gov study NCT06457269. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Research on the Diagnostic Value of Machine Learning Model Based on Clinical Data in Patients With Coronary Heart Disease
ClinicalTrials.gov study NCT05018715. IPD Sharing: NO. Countries: 1. Publications: 1.
Develop a Risk Prediction Model for Phthalate-ester-induced Diseases
ClinicalTrials.gov study NCT05892029. IPD Sharing: NO. Countries: 1. Publications: 1.
Tissue Models for Invasive Disease (TIMID)
ClinicalTrials.gov study NCT04620824. IPD Sharing: NO. Countries: 1. Publications: 1.
Tissue Models for Liver Disease
ClinicalTrials.gov study NCT05255042. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi
ClinicalTrials.gov study NCT05510973. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigation of the Effectiveness of a Biopsychosocial-Based Exercise Model in Rheumatic Diseases: A Mixed Methods Research With Patients' Perspectives
ClinicalTrials.gov study NCT05344131. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Application of Wearable Devices to Build a Self-Management Model in Chronic Kidney Disease Patients
ClinicalTrials.gov study NCT04617431. IPD Sharing: NO. Countries: 1. Publications: 1.
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
ClinicalTrials.gov study NCT06529744. IPD Sharing: NO. Countries: 1. Publications: 33.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.