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34,778 results for “diseases”
Data from Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies
<p>This dataset contains three text files in RIS format. They represent the screening process during study selection for "Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies" (<a href="https://doi.org/10.1111/liv.14179">https://doi.org/10.1111/liv.14179</a>). The file DOKU_All TiAb-Screening_20200116_cap contains all 3453 records (merged from original and update search) that were subjected to title-abstract screening. The file DOKU_All FT-Screening_20200116_cap contains all 174 records that were subjected to full-text screening. The file DOKU_All Included_20200116_cap contains all 26 records that were included into the final review.</p> <p>In addition, a PRISMA flow diagram (Fig. 1 in the paper) is available in TIF format.</p>
Summary statistics data for "Genetic Analyses Support the Contribution of mRNA N6-methyladenosine (m6A) Modification to Human Diseases Heritability"
<p>We included the summary statistics data associated with our manuscript "<strong>Genetic Analyses Support the Contribution of mRNA <em>N</em><sup>6</sup>-methyladenosine (m<sup>6</sup>A) Modification to Human Diseases Heritability". </strong></p> <p>We also included the newly imputed genotype data for the 60 YRI individuals involved in our study, the joint m<sup>6</sup>A peaks tested (locations of the molecular phetnotype in BED12 format) and normalized log odds ratio (enrichment) of these joint peaks (molecular phenotype data). </p>
Data from: Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats
Vaccines that autonomously transfer among individuals have been proposed as a strategy to control infectious diseases within wildlife populations. However, understanding rates of spread and epidemiological efficacy in real world systems remain elusive. Here, we investigated whether topical vaccines that transfer among bats through social contacts can control vampire bat rabies, a medically and economically important zoonosis in Latin America. Field experiments in 3 Peruvian bat colonies which used fluorescent biomarkers as a proxy for the bat-to-bat transfer and ingestion of an oral vaccine revealed that vaccine transfer would increase population-level immunity up to 2.6 times beyond the same effort using conventional, non-spreadable vaccines. Mathematical models demonstrated that observed levels of vaccine transfer would reduce the probability, size, and duration of rabies outbreaks, even at low, but realistically achievable levels of vaccine application. Models further predicted that existing vaccines provide substantial advantages over culling bats, the policy currently implemented in North, Central, and South America. Linking field studies with biomarkers to mathematical models can inform how spreadable vaccines may combat pathogens of health and conservation concern prior to costly investments in vaccine design and testing.
A protocol to assess the risk of dementia among patients with coronary artery diseases using CAIDE score-Extended Data
<p>The contents of this extended data file are-<br> 01. Consent form (English & Bengali Version)<br> 02. Interview Questionnaire (English & Bengali Version)<br> These contents will help to address the objectives of the study that attempted to identify the risk of long-term dementia among coronary artery disease patients in Bangladesh.</p>
Disease and lesion maps - part of the Scientific opinion on the evaluation of public and animal health risks in case of a delayed post-mortem inspection in ungulates
<p>EFSA was requested to assess the impact on effectiveness of <em>post-mortem</em> inspection in terms of any change in the sensitivity of detection of animal diseases of domestic and wild ungulates listed according to Article 5 of Regulation (EC) No 2016/429 and septicaemia, pyaemia, toxaemia or viraemia, when carried out after up to 24 hours or up to 72 hours after slaughter in comparison to when it is carried out immediately after slaughter. In order to identify the main lesions associated with the target diseases, a so called “disease map” was built, with the information about the clinical forms of the diseases (acute, subacute, chronic, or latent forms) and clinical signs, as well as potential lesions that could be observed on the respective diseased animals.</p> <p>The following information is indicated for each disease/condition in the disease map:</p> <ol> <li>The susceptible animal species</li> <li>Whether there is any surveillance programme in place in the EU</li> <li>The signs associated with the disease that could be detected at <em>ante mortem </em>inspection;</li> <li>The lesions associated with the disease that could be detected at <em>post mortem</em> inspection</li> <li>The probability of detecting the disease during the PMI as normally carried out.</li> <li>Whether carcass swabbing and/or laboratory tests are normally carried out.</li> </ol> <p>From the disease map, the list of organs to be considered at <em>post mortem</em> inspection and the lesions, a “lesion map” was built by connecting animal species with organs, lesions and corresponding disease. This was done to facilitate the construction of a questionnaire where, for each organ and the five types of lesions, the respondents (meat inspectors) had to provide a numerical answer about how many carcasses out of 100 with the given lesion, will be still detected after 24- or 72-h of refrigerated storage.</p>
Biochemical Characterization of Mouse Retina of an Alzheimer's Disease Model by Raman Spectroscopy
<p>Raman raw data for the paper "Biochemical Characterization of Mouse Retina of an Alzheimer’s Disease Model by Raman Spectroscopy"</p> <ul> <li>two datasets of Raman images from cross-sectional and en face mouse retinas without processing</li> </ul>
Resting-State High-Density EEG using EGI GES 300 with 256 Channels of Healthy Elders, People with Subjective and Mild Cognitive Impairment and Alzheimer's Disease
<p>This repository contains Matlab files including 4 samples of resting-state EEG recording for Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), and Healthy Controls (HC) using the HD-EEG EGI GES 300.</p> <p><strong>[AD: i108, MCI: i100, SCD: i090, HC: s055]</strong></p> <p> </p> <p><strong>Participants & Settings</strong></p> <p>In total 230 participants have been recruited from the memory and dementia clinic of the Greek Association of Alzheimer’s Disease and Related Disorders (GAADRD) and the 1st Department of Neurology, U.H. AHEPA, Aristotle University of Thessaloniki, Greece.</p> <p>The full dataset includes:</p> <p><strong>Healthy Controls Elders (60+ years old)</strong>: 33 participants</p> <p><strong>Subjective Cognitive Decline:</strong> 34 participants</p> <p><strong>Mild Cognitive Impairment</strong>: 79 participants</p> <p><strong>Alzheimer's Disease</strong>: 48 participants</p> <p><strong>Healthy Young (25-40 years old):</strong> 36 participants</p> <p>The study was carried out in accordance with the Declaration of Helsinki and received approval by the Scientific and Ethics Committee of GAADRD (No56_27/11/2016), and written informed consent was obtained from all participants prior to their participation in the study. The diagnosis of AD was conducted by a neuropsychiatrist according to their medical history, neuropsychological performance, structural magnetic resonance imaging (MRI), and clinical and neurological examinations.</p> <p>Participants with AD fulfilled the National Institute of Neurological and Communication Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable AD, as well as the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria for dementia of Alzheimer’s type (American Psychological Association, 1994). On the other hand, the MCI participants fulfilled the Petersen criteria, while the SCD group met International Working Group-2 guidelines and the recent National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease (NI-AA), as well as the SCD-I Working Group instructions. </p> <p><strong>Resting-State EEG Recording</strong></p> <p>Fifteen-minute resting EEG activity was recorded for all the participants. For the whole duration of the resting state EEG recording, participants were advised to keep themselves relaxed as much as possible, close their eyes and open them after the researcher’s demand, sit still, minimize blinking or mouth movements and let their mind wander. The experimental procedure was monitored by a research assistant aiming to identify cases of horizontal eye movements, continued blinking, or excessive movement by visually inspecting the EEG traces during the experiment. More specifically, an EEG was registered for both resting conditions (eyes open, EO and eyes closed, EC) for at least 2–3 min for each period.</p> <p><strong>EEG Data Acquisition</strong></p> <p>The EEG data were collected by using the EGI 300 Geodesic EEG system (GES 300, CERTH-ITI, Thessaloniki, Greece) with a 256-channel HydroCel Geodesic Sensor Net (HCGSN) and a sampling rate of 250 Hz (EGI Eugene, OR). Moreover, the researcher placed the electrodes in accordance with the 256 HCGSN adult 1.0 montage system, while the signals were recorded relative to a vertex reference electrode (Cz), with AFz as the ground electrode with the electrodes’ impedance below 50 kΩ throughout the experimental procedure, as recommended for the high-input impedance amplifier. In detail, the HD-EEG data were analyzed offline in order to detect any artifact, as well as to conduct pre-processing (filtering, segmentation, bad channel replacement) using Net Station 4.3 software (EGI). HD-EEG data were initially filtered with a 5th-order bandpass Butterworth IIR filter of 0.3–30 Hz. Once the segmentation was completed, the detection of artifacts was performed by using the Net Station artifact detection tool for the automatic detection of excessive eye blinking and movement. Afterward, the signals were baseline corrected using 200 msec before the start of the experiment period and average re-referenced to transform them into reference-independent values.</p> <p> </p> <p><strong>Full Dataset Access</strong></p> <p>More information about the sample dataset and access to the full dataset can be available after request via e-mail:</p> <p><strong>Ioulietta Lazarou</strong> BSc, MSc, PhD candidate</p> <p>Neuropsychologist - Clinical Research Associate </p> <p>Centre for Research and Technology Hellas (CERTH), Information Technologies Institute (ITI)</p> <p>6th km Charilaou-Thermi Road, P.O. Box 60361, 57001 Thermi-Thessaloniki, Greece</p> <p>E-mail: <a href="mailto:iouliettalaz@iti.gr">iouliettalaz@iti.gr</a></p>
Identification of co-infections in a cohort of patients diagnosed with Lyme Disease
<p>Serlogy test data used in the study: Identification of co-infections in a cohort of patients diagnosed with Lyme Disease</p>
Sign-specific stimulation "hot" and "cold" spots in Parkinson's disease validated with machine learning
<p><strong>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become a standard therapy for Parkinson’s disease (PD). Despite extensive experience, however, the precise target of optimal stimulation and the relationship between site of stimulation and alleviation of individual signs remains unclear. We examined whether machine learning could predict the benefits in specific parkinsonian signs when informed by precise locations of stimulation.</strong></p> <p> </p> <p><strong>We studied 275 PD patients who underwent STN-DBS between 2003 and 2018. We selected pre-DBS and best available post-DBS scores from motor items of the Unified Parkinson's Disease Rating Scale (UPDRS-III) to discern sign-specific changes attributable to DBS. Volumes of tissue activated (VTAs) were computed and weighted by i) tremor, ii) rigidity, iii) bradykinesia, and iv) axial signs changes. Then, sign-specific sites of optimal (“hot spots”) and suboptimal efficacy (“cold spots”) were defined. These areas were subsequently validated using machine learning prediction of sign-specific outcomes with in-sample and out-of-sample data (n=51 STN-DBS patients from another institution).</strong></p> <p><strong> </strong></p> <p><strong>Tremor and rigidity hot spots were largely located outside and dorsolateral to STN whereas hot spots for bradykinesia and axial signs had larger overlap with STN. Using VTA overlap with sign-specific hot and cold spots, support vector machine (SVM) classified patients into quartiles of efficacy with ≥92% accuracy. The accuracy remained high (68-98%) when only considering VTA overlap with hot spots but was markedly lower (41-72%) when only using cold spots. The model also performed poorly (44-48%) when using only stimulation voltage, irrespective of stimulation location. Out-of-sample validation accuracy was ≥96% when using VTA overlap with the sign-specific hot and cold spots.</strong></p> <p><br> <strong>In two independent datasets, distinct brain areas could predict sign-specific clinical changes in PD patients with STN-DBS. With future prospective validation, these findings could individualize stimulation delivery to optimize quality of life improvement. </strong></p> <p><strong>Hot and cold spots for each sign are publicly available as binary labels in NIfTI format. </strong></p>
Supplementary material: Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis
<p>Supplementary material for Cochrane review: Janjua S , Mathioudakis AG , Fortescue R , Walker RAE , Sharif S , Threapleton CJD , Dias S . Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta-analysis. Cochrane Database of Systematic Reviews 2021, Issue 1. Art. No.: <a href="https://archie.cochrane.org/sections/documents/CD013198">CD013198</a>. DOI: <a href="https://archie.cochrane.org/sections/documents/10.1002/14651858.CD013198.pub2">10.1002/14651858.CD013198.pub2</a>.</p>
Experiment data in support of "Segmentation analysis and the recovery of queuing parameters via the Wasserstein distance: a study of administrative data for patients with chronic obstructive pulmonary disease"
<p>This archive contains a ZIP archive, `data.zip`, that itself contains the data used in the final sections of the paper. The remainder of the paper's supporting files are available at <a href="https://github.com/daffidwilde/copd-paper/">github.com/daffidwilde/copd-paper/</a></p> <p>The ZIP archive is structured as follows:</p> <ul> <li>There is a directory, `wasserstein`, for the parameter sweep described in the model construction section of the paper. Its contents are: (i) a file, `main.csv`, describing each parameter and their maximal Wasserstein distance to the observed data, and (ii) three directories, `best`, `median` and `worst`, each containing the simulated queuing results (in `main.csv`) from that sweep with the best, median and worst found parameter sets, respectively (in `params.txt`).</li> <li>The remaining three directories correspond to the experiments conducted in the final section of the paper. Each directory contains two files: (i) `system_times.csv` which holds trial parameters and system time records for every patient to pass through the model in that experiment, and (ii) `utilisations.csv` which holds trial parameters and utilisations for each server in the model for that experiment.</li> </ul>
A crowdsourced chemical-induced disease relation corpus
<p>A sentence-bound chemical-induced disease relation corpus was produced with crowdsourcing as part of the BioCreative V challenge.</p>
A crowdsourced sentence-bound chemical-induced disease relationship corpus
<p>A set of 3000 abstracts from PubMed were annotated for sentence-bound chemical-induced disease relationships in order to train a machine learning algorithm for the BioCreative V challenge.</p>
Immune repertoire profiling reveals that clonally expanded B and T cells infiltrating diseased human kidneys can also be tracked in the blood
<p>Recent advances in high-throughput sequencing allow for the competitive analysis of the human B and T cell immune repertoire. In this study we compared Immunoglobulin and T cell receptor repertoires of lymphocytes found in kidney and blood samples of 10 patients with various renal diseases based on next-generation sequencing data.</p>
silverCID — a silver standard corpus for Chemical-induced Diseases relation extraction — Edit
<p>silverCID — a silver standard corpus for Chemical-induced Diseases relation extraction — Edit</p>
Example phenopacket containing one disease and two associations
<p>This is an example of a nascent exchange format "Phenopacket". For more information, see github.com/phenopackets</p>
Disease Spread in Age Structured Populations with Maternal Age Effects
<p>Fundamental ecological processes, such as extrinsic mortality, determine population age structure. This influences disease spread when individuals of different ages differ in susceptibility or when maternal age determines offspring susceptibility. We show that Daphnia magna offspring born to young mothers are more susceptible than those born to older mothers, and consider this alongside previous observations that susceptibility declines with age in this system. We used a susceptible- infected compartmental model to investigate how age-specific susceptibility and maternal age effects on offspring susceptibility interact with demographic factors affecting disease spread. Our results show a scenario where an increase in extrinsic mortality drives an increase in transmission potential. Thus, we identify a realistic context in which age effects and maternal effects produce conditions favouring disease transmission. </p> <p>epi model R script.R</p> <p>This is the script for the SIR model as well as the associated script for life history data. </p> <p>main.body size.csv</p> <p>This is the data for the body size data collected in the main experiment. This was measured using imageJ, was recorded in pixels and converted into millimetres. </p> <p>main.exposed.csv</p> <p>This is the proportion of infected/not infected individuals from an exposed treatment group. This was a subset of individuals from the entire experiment. This was the result of the exposures from the main experiment. </p> <p>main.reproduction.csv</p> <p>This document records reproduction for individuals from old or young mothers. It is a count of the offspring born at each reproductive event, which occurs generally every three days, though variation in interclutch interval increases with age. This was from the main experiment. Only those who were unexposed to the parasite, where used for this portion of the experimental work. </p> <p>sm.body size.csv</p> <p>This records body size similarly to above, and was an independent replication of the main experiment. </p> <p>sm.infection status.csv</p> <p>This is infection outcomes of exposures carried out as above, in an independent replication of the main experiment. </p> <p>sm.total babies.csv</p> <p>This is the reproductive output, carried out similarly to above, but in an independent replication of the main experiment. </p>
Figure 3. from: Visual Parkinson's Disease Rating Scale: A Universal Iconic Questionnaire for Epidemiological Studies in India - Research Ideas and Outcomes 2: e8834 (03 May 2016) https://doi.org/10.3897/rio.2.e8834
Figure 3. - TimelineThis Gantt chart provides an estimate of the relative timing and duration for achieving each of the Aims.
Figure 1. from: Visual Parkinson's Disease Rating Scale: A Universal Iconic Questionnaire for Epidemiological Studies in India - Research Ideas and Outcomes 2: e8834 (03 May 2016) https://doi.org/10.3897/rio.2.e8834
Figure 1. - First pass at a VPDRS static graphicFigure 1 corresponds to the first self-administered MDS-UPDRS question:1.7 SLEEP PROBLEMS.Over the past week, have you had trouble going to sleep at night or staying asleep through the night? Consider how rested you felt after waking up in the morning.0: Normal: No problems.1: Slight: Sleep problems are present but usually do not cause trouble getting a full night of sleep.2: Mild: Sleep problems usually cause some difficulties getting a full night of sleep.3: Moderate: Sleep problems cause a lot of difficulties getting a full night of sleep, but I still usually sleep for more than half the night.4: Severe: I usually do not sleep for most of the night."
Figure 2. from: Visual Parkinson's Disease Rating Scale: A Universal Iconic Questionnaire for Epidemiological Studies in India - Research Ideas and Outcomes 2: e8834 (03 May 2016) https://doi.org/10.3897/rio.2.e8834
Figure 2. - Prototype for the mobile phone appThis screen shows a pre-release version of Node, which will support the VPDRS/UPDRS modules. Here we present a means by which a person administering a questionnaire can securely log into and manipulate patient information locally and through cloud services and lastly an example clinician-administered UPDRS question.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.