Find research datasets worth reusing

controlledIPD-YESFeb 2026View details →

A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

ClinicalTrials.gov study NCT03820726. IPD Sharing: YES. Countries: 15. Publications: 1.

Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures

ClinicalTrials.gov study NCT00152516. IPD Sharing: Not stated. Countries: 16. Publications: 1.

Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years

ClinicalTrials.gov study NCT00489268. IPD Sharing: Not stated. Countries: 2. Publications: 3.

3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection

ClinicalTrials.gov study NCT01349465. IPD Sharing: Not stated. Countries: 7. Publications: 1.

closedIPD-NOFeb 2026View details →

Two-way Texting for VMMC Follow-up in Republic of South Africa

ClinicalTrials.gov study NCT04327271. IPD Sharing: NO. Countries: 1. Publications: 6.

Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy

ClinicalTrials.gov study NCT05126693. IPD Sharing: UNDECIDED. Countries: 1. Publications: 10.

opencc-zeroJun 2020View details →

Quit attempts amongst tobacco users identified in the Tamil Nadu Tobacco Survey of 2015-16: A 3 year follow-up mixed methods study

Objectives To determine current tobacco use in 2018-19, quit attempts made and to explore the enablers and barriers in quitting tobacco among tobacco users identified in the Tamil Nadu Tobacco Survey (TNTS) in 2015-16. Setting TNTS was conducted in 2015-16 throughout the state of TN in India covering 111363 individuals. Tobacco prevalence was found to be 5.2% (n=5208) Participants All tobacco users in eleven districts of TN identified by TNTS (n=2909) were tracked after three years by telephone. In-depth interviews (n=26) were conducted in a sub-sample to understand the enablers and barriers in quitting. Primary and Secondary Outcomes Current tobacco use status, any quit attempt and successful quit rate were the primary outcomes, while barriers and enablers in quitting were considered as secondary outcomes. Results Among the 2909 tobacco users identified in TNTS 2015-16, only 724 (24.9%) could be contacted by telephone, of which 555 (76.7%) consented. Of those who consented, 210 (37.8%) were currently not using tobacco (i.e. successfully quit) and 337 (60.7%) continued to use any form of tobacco. Of current tobacco users, 115 (34.1%) never made any quit attempt and 193 (57.3.8%) have made any attempt to quit. Those using smoking form of tobacco products (aRR=1.2, 95% CI: 1.1-1.4) and exposure to smoke at home (aRR=1.2, 95% CI: 1.1-1.3) were found to be positively associated with continued tobacco use (failed or no quit attempt). Support from family and perceived health benefits are key enablers, while peer influence, high dependence and lack of professional help are some of the barriers to quitting. Conclusion Two-thirds of the tobacco users continue to use tobacco in the last 3 years. While tobacco users are well aware of the ill-effects of tobacco, various intrinsic and extrinsic factors play a major role as a facilitator and lack of the same act as a barrier to quit.

opencc-zeroSep 2020View details →

Impact of COVID-19 lockdown on glycemic control in adults with type 1 diabetes mellitus: information and standardized questions regarding follow-up during lockdown

Aim. To examine the impact of the lockdown caused by COVID-19 pandemic on both the glycemic control and the daily habits of a group of patients with type 1 diabetes mellitus (T1DM) using flash continuous glucose monitoring devices (Flash CGM). Methods. Retrospective analysis based on all the information gathered in virtual consultations from a cohort of 50 adult patients with T1DM with follow-up at our site. We compared their CGM metrics during lockdown with their own previous data before the pandemic occurred, as well as the potential psychological and therapeutic changes. Results. We observed a reduction of the average glucose: 160.26 ± 22.55 mg/dl vs. 150 ± 20.96 mg/dl, p=0.0009, estimated HbA1c: 7.21 ± 0.78% vs. 6.83 ± 0.71%, p=000.5, glucose management indicator (GMI) 7.15 ± 0.57 % vs. 6.88 ± 0.49 %, p=0.0003, and glycemic variability (CV): 40.74 ± 6.66 vs. 36.43 ± 6.09 p<0.0001. Time in range showed an improvement: 57.46 ± 11.85% vs a 65.76 ± 12.09%, p<0.0001, without an increase in percentage of time in hypoglycaemia. Conclusions: COVID-19 lockdown was associated with an improvement in glycemic control in patients with T1DM using CGM.

opencc-zeroOct 2020View details →

The association of lactation duration with visceral and pericardial fat volumes in parous women: 25-year follow-up in the CARDIA study

Background: Lactation is associated with lower risks for diabetes and cardiovascular disease (CVD) in women. Organ-related adiposity, which plays a significant role in the development of cardiometabolic diseases, could help explain this observation. Therefore, we evaluated the longitudinal association of lactation duration with visceral and pericardial fat volumes in women. Methods: Data were obtained from 910 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study (1985-86) without diabetes prior to pregnancy who had ≥1 birth during 25 years of follow-up and had visceral (VAT) and pericardial adipose tissue (PAT) measured from computed tomographic scans in 2010-2011. Cumulative lactation duration across all births since baseline was calculated from self-reports collected at periodic exams. Results: At baseline, the average age of women (48% black, 52% white) was 24 ± 3.7 years. After controlling for baseline age, race, smoking status, body mass index, fasting glucose, family history of diabetes, fat intake, total cholesterol, physical activity and follow-up covariates (parity, gestational diabetes), the mean fat volumes across categories of lactation (none (n=221), 1 to 5 months (n=306), 6 to 11 months (n=210), and ≥12 months (n=173)) were 122.0, 113.7 105.0, and 110.1 cm3 for VAT and 52.2, 46.7, 44.5 and 43.4 cm3 for PAT, respectively. No race differences were detected. Changes in body weight from the first post-baseline birth to the end of follow-up mediated 21% and 18% of the associations of lactation with VAT and PAT, respectively. Conclusions: In this prospective study, longer cumulative lactation duration was associated with lower VAT and PAT volumes, with weight gain partially mediating these associations.

opencc-by-4.0Nov 2020View details →

Muscle MRI in two SMA patients on nusinersen treatment: A two years follow-up

Introduction: The effects of nusinersen in adults with SMA rely on neuromotor function scales and qualitative assessments. There are limited clinical or imaging data on muscle changes over time. Methods: Two adult SMA patients underwent clinical assessments including measures of upper and lower limb function with Revised Upper Limb Module (RULM) and Hammersmith Function Motor Scale Expanded (HFMSE); both patients were also studied with whole-body muscle MRI (T1-weighted and Diffusion Tensor Imaging/DTI sequences), at baseline and after 10 and 24 months from the beginning of treatment with nusinersen. Results: After two years of treatment, HFMSE and RULM scores were stable in both patients. DTI sequences revealed an increased number, length and organization of muscle fiber tracks, and Fractional Anisotropy (FA) values showed a significant reduction after 10 and 24 months from baseline, in their corresponding maps. Discussion: Muscle DTI imaging seems to play an interesting role to monitor treatment effects over time in adult SMA patients.

opencc-zeroDec 2014View details →

Data from: Statin use and cognitive function: population-based observational study with long-term follow-up

We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0–10; high performance, 11–12 points) in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N = 1232) or propensity score for statin use (N = 3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p<0.001). The median duration of statin use was 3.8 (interquartile range, 1.6–4.5) years. Unadjusted, statin users had worse cognitive performance than non-users. The mean RFFT score (SD) in statin users and non-users was 58 (23) and 72 (26) points, respectively (p<0.001). VAT performance was high in 261 (29%) statin users and 1351 (43%) non-users (p<0.001). However, multiple regression analysis did not show a significant association of RFFT score with statin use (B, −0.82; 95%CI, −2.77 to 1.14; p = 0.41) nor with statin solubility, statin dose or duration of statin use. Statin users with high doses or long-term use had similar cognitive performance as non-users. This was found in persons with low as well as high cardiovascular risk, and in younger as well as older subjects. Also, the mean RFFT score per quintile of propensity score for statin use was comparable for statin users and non-users. Similar results were found for the VAT score as outcome measure. In conclusion, statin use was not associated with cognitive function. This was independent of statin dose or duration of statin use.

opencc-zeroDec 2012View details →

Data from: Primary care follow-up and measured mental health outcomes among women referred for ultrasound assessment of pain and/or bleeding in early pregnancy: a quantitative questionnaire study

Objectives To examine the extent of primary care follow-up and mental health outcomes among women referred for ultrasound assessment of pain and/or bleeding in early pregnancy, including those whose pregnancy is found to be viable on ultrasound assessment. Design Questionnaire study with prospective follow-up. Setting Urgent gynaecology clinic in secondary care, England. Participants 57 women participated in the study. Entry criteria: referral to the urgent gynaecology clinic with pain and/or bleeding in early pregnancy; gestation less than 16 weeks (the clinic's own 'cut-off'); no previous attendance at the clinic during the current pregnancy. Exclusion criteria: inability to understand English or to provide informed consent. Primary and secondary outcome measures Incidence of primary care follow-up among women referred to the urgent gynaecology clinic; incidence of women with measured mental health scores suggesting significant symptoms of distress. Results Fewer than 1 in 10 women referred for ultrasound assessment of pain and/or bleeding in early pregnancy had follow-up arrangements made with their general practitioner (GP). Most women who had GP follow-up found it helpful and a significant minority of women who did not have GP follow-up felt that it would have been helpful. Following ultrasound assessment, more than one-third of women had significant symptoms of distress. Symptoms of distress, particularly anxiety, were present among those women found to have viable pregnancies, as well as among those with non-viable pregnancies. Conclusions GPs are advised to consider offering follow-up to all women referred for ultrasound assessment of pain and/or bleeding in early pregnancy. Researchers in this area are advised to consider the experiences of women with pain and/or bleeding in early pregnancy whose pregnancies are ultimately found to be viable on ultrasound scan.

opencc-zeroDec 2012View details →

Data from: Long-term benefit of hepatitis C therapy in a safety net hospital system: a cross-sectional study with median 5-year follow-up

Objectives: To demonstrate the effectiveness of hepatitis C virus (HCV) therapy and survival benefit from sustained virologic remission (SVR) in a safety net hospital population with limited resources. Design and setting: We conducted a retrospective cross-sectional study at an urban safety-net hospital in the U.S. Participants and intervention: 242 patients receiving standard HCV therapy between 2001 and 2006. Primary and secondary outcome measures: Response rates, including sustained virologic response (SVR), were recorded for each patient. Univariate and multivariate analyses were performed to identify predictors of SVR and 5 year survival. Results: A total of 242 eligible patients were treated. Treatment was completed in 197 (81%) patients, with 43 patients discontinuing therapy early – 32 due to adverse events and 11 due to non-compliance. Complications on treatment were frequent, including 3 deaths. SVR was achieved in 83 patients (34%). On multivariate analysis, independent predictors of a decreased likelihood of achieving SVR included African American race (OR 0.20, 95% CI 0.07 – 0.54), genotype 1 HCV infection (OR 0.25, 95% CI 0.13 – 0.50) and the presence of cirrhosis (OR 0.26, 95% CI 0.12 – 0.58). Survival was 98% in those achieving SVR (median follow-up 72 months) and 71% in non-responders and those discontinuing therapy (n = 91, median known follow-up 65 and 36 months respectively). On multivariate analysis, the only independent predictor of improved survival was SVR (HR 0.12, 95% CI 0.03 – 0.52). Both cirrhosis and hypoalbuminemia were independent predictors of increased mortality. Conclusions: HCV therapy can be effective despite limited resources. Survival is improved in those achieving SVR. Treatment before histologic cirrhosis develops, in combination with careful selection, may improve long-term outcomes without compromising other health care endeavors in safety net hospitals and areas with financial limitations.

opencc-zeroDec 2023View details →

Flexibilization or biomethane upgrading? Investment preference of German biogas plant operators for the follow-up of guaranteed feed-in tariffs

This dataset reports the results of a discrete choice experiment with 183 German biogas plant operators designed to elicit the respondents' plans for biogas utilization pathways after the end of guaranteed feed-in tariffs. Participants could choose between 'flexibilization' for demand-based electricity generation and conversion to biomethane upgrading for direct feed-in into the natural gas grid. A binomial logit model revealed a 37% probability of switching to biomethane upgrading. These plants are characterized by higher capacities, several involved shareholders, secured succession, costly digestate disposal and belonging to the upper performance quartile. Mixed logit estimations conducted separately for the two investment concepts revealed a very high overall willingness to invest: 71% for flexibilization and 82% for biomethane upgrading. The respondents demand a return on investment of 19% for flexibilization and 26% for biomethane upgrading. Within the flexibilization, twofold overbuilding (installed capacity equals 2 times the rated power) is clearly preferred to fivefold overbuilding. For the biomethane upgrading, private ownership of the upgrading plant is preferred to a joint investment in a central upgrading facility. Limiting the use of energy crops reduces the propensity to invest in both models, while a longer utilization period enhances it. The respondents consider lack of planning reliability as the biggest obstacle to invest, followed by long approval procedures and high investment costs due to restrictive legal requirements.

opencc-by-4.0Mar 2024View details →

Insights from GRBs for optical follow-up of gravitational-wave counterparts

Public data release for the paper "Insights from GRBs for optical follow-up of gravitational-wave counterparts". Includes afterglow lightcurves, skymaps from GW simulations, and scripts for using the scheduler and making figures.

opencc-by-4.0Feb 2022View details →

Serial seroprevalence study: follow-up of immunity to SARS-Cov-2 infection and monitoring of effective vaccination coverage, in three Chilean cities

Population-based serosurvey in Santiago, Talca, and Coquimbo–La Serena

opencc-by-4.0Oct 2022View details →

Appendix for the paper entitled Aerobic Threshold and Point of Maximal Fat Oxidation Agreement: Follow-up on a Systematic Review and Meta-Analysis on Association

This is an appendix with all the data as well as the R software code developed for the multilevel meta-analysis on the agreement

opencc-by-4.0Oct 2024View details →

The SOFIA Massive (SOMA) Star Formation Q-band Follow-up. I. Carbon-Chain Chemistry of Intermediate-Mass Protostars

These figures show spectra obtained by the Yebes 40m telescope toward eleven intermediate-mass protostars. Black lines indicate the observational spectra and red curves indicate the best-fitting models with the MCMC method. Blue curves show the results of the Gaussian fitting.

opencc-by-4.0Dec 2022View details →

Follow-up representative source data of metastatic colorectal cancer patients treated with TAS-102 and regorafenib

Follow-up representative source data of metastatic colorectal cancer patients treated with TAS-102 and regorafenib (date of vital status and tomographic scans).