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2,162 results for “glands”
Figure 2 in Morphology of the arthrodial membrane gland in a Neotropical harvester (Arachnida: Opiliones)
Figure 2. Sections through an arthrodial membrane of the coxa (CX) - trochanter (TR) articulation of a leg IV in a male harvester Mischonyx squalidus: (A) frontal longitudinal section; (B) transversal section between the coxa and the trochanter of leg IV. (AM) Arthrodial membrane, (c) cuticle (sclerite cuticle), (m) muscle.
Figure 4 in Morphology of the arthrodial membrane gland in a Neotropical harvester (Arachnida: Opiliones)
Figure 4. Sagital sections through an arthrodial membrane of the coxa-trochanter articulation of a leg IV in a male harvester Mischonyx squalidus: (A) staining with bromophenol blue; (B) staining with PAS. (AM) Arthrodial membrane, (SC) secretory cells, (cc) cuticular canals.
Transcriptome analysis of anuran breeding glands reveals a surprisingly high expression and diversity of NNMT-like genes
<p><strong>Abstract</strong></p> <p>In many amphibians, males have sexually dimorphic breeding glands, which can produce proteinaceous or volatile pheromones, used for intraspecific communication. In this study we analyse two types of glands in the Mexican treefrog species <em>Ptychohyla macrotympanum </em>(Hylidae) – large ventrolateral glands and small nuptial pads on their fingers – using histology, whole-transcriptome sequencing and phylogenetic analyses. We found strong differences in glandular tissue composition and gene expression patterns between the two breeding gland types. In both glands we only found low expression of protein pheromone candidates. Instead, in the ventrolateral glands, gene expression was strikingly dominated by nicotinamide N-methyltransferase (NNMT)-like genes. Diversity of these genes was remarkably high, with at least 68 distinct NNMT-like genes. Our phylogenetic comparative analysis of the diversity of NNMT-like genes across vertebrates indicates that the extreme diversity of this gene is largely a frog-specific phenomenon and can be traced to large numbers of relatively recent gene duplications occurring independently in many lineages. The strong dominance and astonishing diversity of NNMT-like genes found in anurans in general, and in their sexually dimorphic breeding glands specifically, suggests an important function of NNMT-like proteins for anuran reproduction, possibly being related to volatile pheromone production.In many amphibians, males have sexually dimorphic breeding glands, which can produce proteinaceous or volatile pheromones, used for intraspecific communication. In this study we analyse two types of glands in the Mexican treefrog species <em>Ptychohyla macrotympanum </em>(Hylidae) – large ventrolateral glands and small nuptial pads on their fingers – using histology, whole-transcriptome sequencing and phylogenetic analyses. We found strong differences in glandular tissue composition and gene expression patterns between the two breeding gland types. In both glands we only found low expression of protein pheromone candidates. Instead, in the ventrolateral glands, gene expression was strikingly dominated by nicotinamide N-methyltransferase (NNMT)-like genes. Diversity of these genes was remarkably high, with at least 68 distinct NNMT-like genes. Our phylogenetic comparative analysis of the diversity of NNMT-like genes across vertebrates indicates that the extreme diversity of this gene is largely a frog-specific phenomenon and can be traced to large numbers of relatively recent gene duplications occurring independently in many lineages. The strong dominance and astonishing diversity of NNMT-like genes found in anurans in general, and in their sexually dimorphic breeding glands specifically, suggests an important function of NNMT-like proteins for anuran reproduction, possibly being related to volatile pheromone production.</p> <p> </p> <p><strong>Supplementary datasets accompanying the paper:</strong></p> <p>- final RNAseq assemblies of the ventrolateral glands and the nuptial pads of <em>Ptychohyla macrotympanum</em><br> - fasta-file of all <em>Ptychohyla</em>-NNMT-like genes found in this study</p>
Adult adrenal gland scRNA-seq
<p>Adult adrenal gland scRNA-seq dataset. Gene expression matrices (in dgCMatrix format) are provided as RDS files. Cell annotations (cell types, cortex zonations, and genotypes) are provided in CSV format.</p>
Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy
ClinicalTrials.gov study NCT04299425. IPD Sharing: YES. Countries: 1. Publications: 13.
Lanreotide as Primary Treatment for Acromegalic Patients With Pituitary Gland Macroadenoma
ClinicalTrials.gov study NCT00690898. IPD Sharing: YES. Countries: 9. Publications: 2.
Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy.
ClinicalTrials.gov study NCT04281875. IPD Sharing: YES. Countries: 1. Publications: 7.
Data from: The shape of aroma: Measuring and modeling citrus oil gland distribution
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scRNA-seq of CD45+ cells from salivary gland of Aire-knockout rats
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Single-cell RNA sequencing of human salivary gland derived mesenchymal stromal cells under cytokine treatment conditions
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Bulk RNA sequencing of human mesenchymal stromal cells derived from labial salivary glands, bone marrow, and adipose
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Data from: HIF-signaling in the prothoracic gland regulates growth and development in hypoxia but not normoxia in Drosophila
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Species and sex specific chemical composition in a concealed gland from an internal gland-like tissue of an African frog family
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Dataset related to article "NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation."
<p>Salivary glands (SGs) represent a permissive site for several sialotropic viruses whose persistence is linked to the development of autoimmunity. Natural Killer (NK) cells play a key role in viral clearance but their involvement in viral infection control and in tertiary lymphoid structures (TLS) development within SGs is unknown. By using an inducible model of TLS in the SGs of wild-type C57BL/6 mice, induced by the local delivery of a replication-defective adenovirus (AdV), we demonstrated that circulating NK cells are rapidly recruited to SGs and highly enrich the early inflammatory infiltrate prior to TLS development. NK cells migrating to SGs in response to AdV infection up-regulate NKp46, undergo proliferation, acquire cytotoxic potential, produce Granzyme-B and IFN-γ, and reduce viral load in the acute phase of the infection. Nonetheless, the selective depletion of both circulating and infiltrating NK cells in AdV-infected mice neither affect the development and frequency of TLS nor the onset of autoimmunity. These data demonstrate that, upon local viral delivery of AdV, peripheral NK cells homing to SGs can exert an early control of the viral infection but are dispensable for the formation of TLS and breach of immunologic tolerance.</p> <p> </p> <p>This research used pzf and ets file form extensions, we attach pdfs information about</p>
Figure 1. Iporangaia pustulosa male touching the metatarsal gland IV in Mode of use of sexually dimorphic glands in a Neotropical harvestman (Arachnida: Opiliones) with paternal care
Figure 1. Iporangaia pustulosa male touching the metatarsal gland IV on a leaf (seta).
Figure 2. Iporangaia pustulosa male rubbing the right metatarsus IV in Mode of use of sexually dimorphic glands in a Neotropical harvestman (Arachnida: Opiliones) with paternal care
Figure 2. Iporangaia pustulosa male rubbing the right metatarsus IV against the substrate (seta).
Data from: Innate and adaptive immune proteins in the preen gland secretions of male house sparrows
<p>Recent studies have demonstrated that preen oil acts to reduce or eliminate feather-associated bacteria. The mechanisms underlying this antibacterial activity, however, are incompletely understood. In addition to the activity of alcohols (i.e. 3,7-dimethyloctan-1-ol), recent research has suggested that antimicrobial peptides may underlie the antibacterial activity of preen oil. Here, we document the presence of innate and adaptive immune proteins, lysozyme and immunoglobulin Y (IgY), in the preen oil of house sparrows (<i>Passer domesticus</i>). We suggest lysozyme functions as an antimicrobial agent, with potentially important impacts against Gram-positive feather degrading bacteria. Furthermore, both lysozyme and IgY likely act in local immune defence of the preen gland, and may also play a role in regulating the local microbiome, with potentially important consequences for chemical communication and signalling. Our findings suggest that the preen gland and its secretions should be considered an integral part of the body's first line of defence against invading infections.</p>
Fig. 2 in Cephalic labial gland secretions of males as species recognition signals in bumblebees: are there really geographical variations in the secretions of the Bombus terrestris subspecies? (Hymenoptera: Apidae: Bombus)
Fig. 2: Legends on p. 106
Fig. 1 in Morphometry Of The Digestive Gland Of Terrestrial Mollusks Cornu Aspersum (Gastropoda, Helicidae)
Fig. 1. Specimens of Cornu aspersum.
Data for PNASnexus article Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
<p>Adult salivary stem/progenitor cells (SSPC) have an intrinsic property to self-renew in order to maintain tissue architecture and homeostasis. Adult salivary glands have been documented to harbor SSPC, which have been shown to play a vital role in the regeneration of the glandular structures post radiation damage. We have previously demonstrated that activation of aldehyde dehydrogenase 3A1 (ALDH3A1) after radiation reduced aldehyde accumulation in SSPC, leading to less apoptosis and improved salivary function. We subsequently found that sustained pharmacological ALDH3A1 activation is critical to enhance regeneration of murine submandibular gland after radiation damage. Further investigation shows that ALDH3A1 function is crucial for SSPC self-renewal and survival even in the absence of radiation stress. Salivary glands from <em>Aldh3a1</em>-null mice have fewer acinar structures than wildtype mice. ALDH3A1 deletion or pharmacological inhibition in SSPC leads to a decrease in mitochondrial DNA copy number, lower expression of mitochondrial specific genes and proteins, structural abnormalities, lower membrane potential, and reduced cellular respiration. Loss or inhibition of ALDH3A1 also elevates ROS levels and accumulation of ALDH3A1 substrate 4-hydroxynonenal (4-HNE, a lipid peroxidation product), leading to decreased survival of murine SSPC that can be rescued by treatment with 4-HNE specific carbonyl scavengers. Our data indicate that ALDH3A1 activity protects mitochondrial function and is important for the regeneration activity of SSPC. This knowledge will help to guide our translational strategy of applying ALDH3A1 activators in the clinic to prevent radiation-related hyposalivation in head and neck cancer patients.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.