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431
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ShareScore release 0.9.0
Dataset results
431 results for “kidney functions”
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With
ClinicalTrials.gov study NCT04908436. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Tolerability of Liraglutide in Subjects With Impaired Kidney Function and in Subjects With Normal Kidney Function
ClinicalTrials.gov study NCT01508806. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy(LSG)
ClinicalTrials.gov study NCT06254183. IPD Sharing: NO. Countries: 1. Publications: 6.
Kidney function, kidney function decline, and the risk of dementia in older adults: a registry-based study
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Genetic overlap and causal inferences between kidney function and cerebrovascular disease
<p><u>Objective:</u> Leveraging large-scale genetic data, we aimed to identify shared pathogenic mechanisms and causal relationships between impaired kidney function and cerebrovascular disease phenotypes.</p> <p><u>Methods:</u> We used summary statistics from genome-wide association studies (GWAS) of kidney function traits (<a name="_Hlk536087805">chronic kidney disease (CKD) diagnosis, estimated glomerular filtration rate (eGFR), and Urinary Albumin-to-Creatinine Ratio (UACR)</a>), and of cerebrovascular disease phenotypes: ischemic stroke and its subtypes, intracerebral hemorrhage (ICH), white matter hyperintensities (WMH) on brain MRI. We (i) tested the genetic overlap between them with polygenic risk scores (PRS), (ii) searched for common pleiotropic loci with pairwise GWAS analyses, and (iii) explored causal associations by employing two-sample Mendelian Randomization (MR).</p> <p><u>Results:</u> A PRS for lower eGFR was associated with higher large-artery stroke (LAS) risk (p=1x10<sup>-4</sup>). Multiple pleiotropic loci were identified between kidney function traits and cerebrovascular disease phenotypes, with 12q24 associated with eGFR and both LAS and small-vessel stroke (SVS), and 2q33 associated with UACR and both SVS and WMH. MR revealed associations of both lower eGFR (OR per 1-log decrement=2.10, 95%CI=1.38-3.21) and higher UACR (OR per 1-log increment=2.35, 95%CI=1.12-4.94) with a higher risk of LAS, as well as between higher UACR and higher risk of ICH.</p> <p><u>Conclusions:</u> Impaired kidney function, as assessed by decreased eGFR and increased UACR, may be causally involved in the pathogenesis of LAS. Increased UACR, previously proposed as a marker of systemic small vessel disease, is involved in ICH risk and shares a genetic risk factor at 2q33 with manifestations of cerebral small vessel disease.</p>
Supplementary tables of the research article "Comparative Analysis of Yukmijihwang-tang and Palmijihwang-tang: Lifespan Extension and Kidney Function Improvement in Aging Models"
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Dynamics of glucose metabolism after liver transplantation: Prediabetes as a window of opportunity for patient survival and long‐term kidney function
<p>Posttransplantation diabetes mellitus (PTDM) is a relevant complication following liver transplantation with profound impact on morbidity and mortality. To date, little is known about the evolution and dynamics of glucose metabolism and the impact of prediabetes in long-term follow-up. To address this issue, all consecutive adult liver transplant recipients (n=429) from a European university hospital transplant center between 2007 and 2017 were analyzed retrospectively. In patients without pre-existing diabetes (n=327), we conducted a longitudinal characterization of glucose metabolism. Median follow-up was 37 [9-64, IQR] months. Median prevalence of prediabetes was 39 [37-39]% and of PTDM 21 [17-22]%. Throughout follow-up, intra-individual glucose regulation of patients was highly variable, continuously fluctuating between different states of glucose metabolism (normal glucose tolerance, prediabetes, PTDM). Whereas overall survival and long-term kidney function of patients with PTDM were significantly lower than that of patients with normal glucose metabolism, prediabetes was not associated with adverse outcome. This study provides new insight into the dynamics and impact of glucose metabolism after liver transplantation. Unlike PTDM, prediabetes is not associated with adverse outcome, providing a window of opportunity for targeted intervention. The results underline the need for constant screening and intervention in post-transplant care of liver allograft recipients.</p>
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
ClinicalTrials.gov study NCT04104438. IPD Sharing: NO. Countries: 1. Publications: 0.
Vitamin D and Arterial Function in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT01384539. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of New Test Method to Measure Kidney Function
ClinicalTrials.gov study NCT00026715. IPD Sharing: Not stated. Countries: 1. Publications: 3.
An Observational Study on Renal Function in Kidney Transplant Participants on Immunosuppressive Therapy Containing Mycophenolate Mofetil
ClinicalTrials.gov study NCT01672957. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
ClinicalTrials.gov study NCT01320722. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Daily Use Proton Pump Inhibitors for One Month on Kidney Function
ClinicalTrials.gov study NCT03910647. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Effect of Paracetamol on Kidney Function in Severe Malaria
ClinicalTrials.gov study NCT04251351. IPD Sharing: YES. Countries: 1. Publications: 0.
Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT02031770. IPD Sharing: NO. Countries: 1. Publications: 0.
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
ClinicalTrials.gov study NCT04258423. IPD Sharing: NO. Countries: 1. Publications: 0.
Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT03223883. IPD Sharing: NO. Countries: 1. Publications: 0.
Therapeutic Exercise Programme to Improve the Functional Capacities, Depression and Anxiety of Patients with Chronic Kidney Disease During Haemodialysis Sessions.
ClinicalTrials.gov study NCT06883968. IPD Sharing: NO. Countries: 1. Publications: 0.
Kidney Uptake at F-18 FDG PET/CT Studies and Renal Function Status
ClinicalTrials.gov study NCT06268067. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Protecting Renal Function in Chronic Kidney Disease Patients with Isolated Nighttime Hypertension
ClinicalTrials.gov study NCT06780865. IPD Sharing: NO. Countries: 0. Publications: 6.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.