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237
datasets available to search
ShareScore release 0.9.0
Dataset results
237 results for “mechanism of action”
Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
GEO Series GSE240439. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
GEO Series GSE290022. Mus musculus. 64 samples. Type: Expression profiling by high throughput sequencing.
A plant-derived antimicrobial peptide with multiple mechanisms of action exhibiting antibacterial and antibiofilm activities comparable to or superior to polymyxin B
GEO Series GSE312438. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Thiazolyl Ketone Inhibitors of Cytosolic Phospholipase A2 α: from Synthesis to Chemotherapeutic Mechanism of Action
GEO Series GSE251999. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
Electrical stimulation with a conductive ITO glass promotes neurite outgrowth and its putative mechanisms of action for direct and alternating current in primary cortical neurons
GEO Series GSE207117. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
GEO Series GSE109165. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 6 of 10)
GEO Series GSE33934. Colinus virginianus. 8 samples. Type: Expression profiling by array.
Mechanisms of Action of Fu Fang Gang Liu Liquid in Treating Condyloma Acuminatum by Network Pharmacology and Experimental Validation
GEO Series GSE223380. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms for Krüppel-like factor 13 actions in hippocampal neurons [ChSP-seq]
GEO Series GSE148383. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Supplementary materials-Anti-Insulin Resistance Mechanism of Action of Glycyrrhizic Acid An in Vitro Investigation Based on in Silico Prediction
<p>The supplementary materials of the article "Anti-Insulin Resistance Mechanism of Action of Glycyrrhizic Acid: An <em>in Vitro</em> Investigation Based on <em>in Silico</em> Prediction"</p>
Domain-invariant features for mechanism of action prediction in a multi-cell-line drug screen
<p><strong>Motivation: </strong>As a proxy for diseased cells, a cell line cannot be thought of as a perfect model. Many diseases feature an important molecular heterogeneity. Consequently, a drug may be effective against one molecular subtype of a disease, but less so against another. To characterise drugs with respect to their effect not only on one cell line but on a consensus of several is therefore a promising strategy to streamline the drug discovery process.</p> <p><strong>Results: </strong>The contribution of this paper is twofold. First, we investigate whether we can predict MOA at the molecular level without optimisation of the MOA classes to the screen specificities. To this end, we benchmark a set of algorithms within a conventional pipeline, and evaluate their MOA prediction performance according to a statistically rigorous framework. Second, we extend this conventional pipeline to the simultaneous analysis of multiple cell lines, each with potentially different morphological baselines. For this, we propose multitask autoencoders, including a domain-adaptive model used to construct domain-invariant feature representations across cell lines. We apply these methods to a pilot screen of two triple negative breast cancer cell lines as models for two different molecular subtypes of the disease.</p>
Antimicrobial Action and Mechanism of Piscidin Against Helicobacter pylori
Open the record for dataset details and reuse information.
Energy Value of Macronutrients From Pistachio Nuts and Mechanisms of Nutrient Action
ClinicalTrials.gov study NCT00942695. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00974805. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mechanism of Action of Transcranial Direct Current Stimulation in Neurofibromatosis Type 1
ClinicalTrials.gov study NCT04991428. IPD Sharing: YES. Countries: 1. Publications: 0.
Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases
ClinicalTrials.gov study NCT03340155. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Acamprosate Treatment: Mechanisms of Action
ClinicalTrials.gov study NCT00004552. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mechanisms of Metabolic and Hormone Action on Plaque Formation in Brain and Carotid Vessels in Patients With Prostate Adenocarcinoma
ClinicalTrials.gov study NCT03718338. IPD Sharing: NO. Countries: 1. Publications: 0.
Identifying REsponders and Exploring Mechanisms of ACTION of the Endobronchial Coil Treatment for Emphysema
ClinicalTrials.gov study NCT02179125. IPD Sharing: Not stated. Countries: 2. Publications: 0.
The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
ClinicalTrials.gov study NCT05926336. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.