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306 results for “mitral valve”
Data from: Severity of mitral valve degeneration is associated with chromosome 15 loci in Whippet dogs
Mitral valve degeneration (MVD) is the most common form of heart disease in dogs, frequently leading to left-sided congestive heart failure and cardiac mortality. Although breed-specific disease characteristics and overrepresentation point towards a genetic origin for MVD, a causative mutation and complete molecular pathogenesis are unknown. Whippet dogs are overrepresented in incidence of MVD, suggesting an inherited component in this breed. Expressivity of this condition is variable with some dogs showing evidence of more severe disease at earlier ages than other dogs. This phenomenon makes a traditional case versus control genetic study prone to phenotyping error. This study sought to avoid these common pitfalls by identifying genetic loci associated with severity of MVD in Whippets through a genome-wide association study (GWAS). 138 Whippet dogs were characterized for MVD by echocardiographic examination and a novel disease severity score was developed and adjusted for age in each subject. Single nucleotide polymorphism (SNP) genotype data (170k Illumina CanineHD SnpChip) was obtained for DNA isolated from blood of each study subject. Continuous variable genome wide association was performed after correction for population stratification by efficient mixed model association expedited (EMMAX) in 130 dogs. A genome wide significant association was identified on chromosome 15 (peak locus 57,770,326; Padj = 0.049) and secondary loci of suggestive association were identified on chromosome 2 (peak locus 37,628,875; Padj = 0.079). Positional candidate genes were identified within the primary and secondary loci including follistatin-related protein 5 precursor (FSTL5) and Rho GTPase-activating protein 26 (ARHGAP26). These results support the hypothesis that severity of MVD in whippets has a genetic basis and warrants further study by either candidate gene sequencing or next-generation techniques.
Mitralign Percutaneous Annuloplasty System for Chronic Functional Mitral Valve Regurgitation
ClinicalTrials.gov study NCT01740583. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
ClinicalTrials.gov study NCT06341166. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
ClinicalTrials.gov study NCT06738537. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair
ClinicalTrials.gov study NCT00483236. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation
ClinicalTrials.gov study NCT06414265. IPD Sharing: NO. Countries: 3. Publications: 0.
Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve
ClinicalTrials.gov study NCT07097740. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery
ClinicalTrials.gov study NCT01646541. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity
ClinicalTrials.gov study NCT02003885. IPD Sharing: Not stated. Countries: 1. Publications: 0.
AMENDTM Mitral Valve Repair System, Annuloplasty Ring Applied in a Transcatheter Method
ClinicalTrials.gov study NCT02602613. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
ClinicalTrials.gov study NCT06378996. IPD Sharing: NO. Countries: 1. Publications: 0.
Abbott Cephea Mitral Valve Disease Registry
ClinicalTrials.gov study NCT07069673. IPD Sharing: NO. Countries: 1. Publications: 0.
The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases
ClinicalTrials.gov study NCT06025149. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry (AP ViV Registry)
ClinicalTrials.gov study NCT07058935. IPD Sharing: NO. Countries: 6. Publications: 0.
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
ClinicalTrials.gov study NCT04245956. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mi-STITCH™ and Mi-KNOT™ Device Technologies - Improvement of Mitral Valve Repair
ClinicalTrials.gov study NCT05034471. IPD Sharing: NO. Countries: 1. Publications: 0.
GISE Registry of Transcatheter Treatment of Mitral Valve Regurgitation With the MitraClip G4
ClinicalTrials.gov study NCT05455489. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ESPB Versus PVPB Regarding Their Effect on Peri-operative Opioid Consumption in Patients Undergoing Minimally Invasive Mitral Valve Replacement
ClinicalTrials.gov study NCT05884164. IPD Sharing: NO. Countries: 1. Publications: 0.
Mitral Valve Area Using 3-dimensional Transesophageal Echocardiography
ClinicalTrials.gov study NCT01694251. IPD Sharing: Not stated. Countries: 1. Publications: 0.
HighFLO Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve
ClinicalTrials.gov study NCT04888247. IPD Sharing: Not stated. Countries: 6. Publications: 0.
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OpenNeuro
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