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456 results for “motifs”
Assessment of the Humoral Immune Response to the SARS-CoV-2 Spike Protein Receptor Binding Motif
<p><strong>Figure S1.</strong> Purification of human antibodies against the RBM region of the SARS-CoV-2 spike protein using a recombinant RBM Sepharose 4B affinity column (3 x 1 cm, inner diameter) (A) and SDS-PAGE (10%) analysis of the eluate (1) alongside a standard low molecular weight marker (Sigma Chemical Co, Saint Louis, Mo, U.S.A.) stained with Coomassie Blue. <strong>Table S1</strong>: Microscale thermophoresis (MST) traces of anti-RBM antibodies binding to different concentrations of S1WT (red) and S2WT (green) peptides by MST. Relative fluorescence (RF) between the bound and unbound state was determined over a time of 21s with 20s MST-on time for evaluation. The blue bar indicates the ΔRF before the temperature gradient was applied, whereas the red bar shows the ΔRF during the thermophoresis. For interaction experi ments, the amount of NT.647-labeled antibodies was kept constant, while the concentration of unlabeled peptides varied from 0.5 µg/mL–0.12 ng/mL. The assay was performed in PBS containing 0.05% Tween 20 and after a short incubation period, the samples were analyzed in standard glass MST NT.115 capillaries. <strong>Table S2:</strong> One-dose regime AstraZeneca-Oxford vaccinated serum information. <strong>Table S3</strong>: Heterologous booster dose vaccinated serum information.</p>
Vitamin D Effect on A Disintegrin-like And Metalloprotease Thrombospondin1 Motif 13& Interleukin 6 in Leukemia
ClinicalTrials.gov study NCT05149339. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Study With Modafinil in Patients Treated With Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer (MOTIF)
ClinicalTrials.gov study NCT00917748. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target
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Data from: DNA motifs are not general predictors of recombination in two Drosophila sister species.
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Interaction motifs variability in a Mediterranean palm under environmental disturbances: the mutualism‐antagonism continuum
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Identification and characterization of epicuticular proteins of nematodes sharing motifs with cuticular proteins of arthropods
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Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs
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Hybrid networks reveal contrasting effects of agricultural intensification on antagonistic and mutualistic motifs
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Data from: Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes
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FIG. 10. — A-D in Contribution des motifs colorés résiduels dans la discrimination d'espèces nouvelles de Cryptochorda Mörch 1858 Mollusca: Gastropoda: Harpidae de l'Éocène du bassin de Paris et du Cotentin
FIG. 10. — A-D, Cryptochorda (s.str.) pyrenaicensis Cossmann, 1923. Cuisien (Yprésien) dela Tuilerie, Gan (Pyrénées-Atlantiques). A, MNHN.F.J10882 (coll. O'Gorman), H.: 24,9 mm; B, MNHN.F.A71481 (coll. O'Gorman), H.: 25,7 mm; C, MNHN.F.A57359 (coll. Pacaud), H.: 34,2 mm – Protoconque; D, MNHN.F.J14638 (coll. Cossmann), H.: 37,2 mm. E-G, Cryptochorda (s.str.) teae n. sp. Cuisien (Yprésien) de Cava Rossi, Monte di Malo (Vicenza, Italie). E, Holotype MGP-PD 31931 (coll. Quaggiotto), H.: 40,2 mm; F, Paratypes MCZ 5761 (coll. Checchi), H.: 37,6 mm; G, MCZ 5762 (coll. Checchi), H.: 38,4 mm. Échelle: C3, 2 mm.
Data from: Meta-analysis of Arabidopsis thaliana phospho-proteomics data reveals compartmentalization of phosphorylation motifs
Protein (de)phosphorylation plays an important role in plants. To provide a robust foundation for subcellular phosphorylation signaling network analysis and kinase-substrate relationships, we performed a meta-analysis of 27 published and unpublished in-house mass spectrometry–based phospho-proteome data sets for Arabidopsis thaliana covering a range of processes, (non)photosynthetic tissue types, and cell cultures. This resulted in an assembly of 60,366 phospho-peptides matching to 8141 nonredundant proteins. Filtering the data for quality and consistency generated a set of medium and a set of high confidence phospho-proteins and their assigned phospho-sites. The relation between single and multiphosphorylated peptides is discussed. The distribution of p-proteins across cellular functions and subcellular compartments was determined and showed overrepresentation of protein kinases. Extensive differences in frequency of pY were found between individual studies due to proteomics and mass spectrometry workflows. Interestingly, pY was underrepresented in peroxisomes but overrepresented in mitochondria. Using motif-finding algorithms motif-x and MMFPh at high stringency, we identified compartmentalization of phosphorylation motifs likely reflecting localized kinase activity. The filtering of the data assembly improved signal/noise ratio for such motifs. Identified motifs were linked to kinases through (bioinformatic) enrichment analysis. This study also provides insight into the challenges/pitfalls of using large-scale phospho-proteomic data sets to nonexperts.
Data from: Genetic regulatory network motifs constrain adaptation through curvature in the landscape of mutational (co)variance
Systems biology is accumulating a wealth of understanding about the structure of genetic regulatory networks, leading to a more complete picture of the complex genotype-phenotype relationship. However, models of multivariate phenotypic evolution based on quantitative genetics have largely not incorporated a network-based view of genetic variation. Here we model a set of two-node, two-phenotype genetic network motifs, covering a full range of regulatory interactions. We find that network interactions result in different patterns of mutational (co)variance at the phenotypic level (the M-matrix), not only across network motifs but also across phenotypic space within single motifs. This effect is due almost entirely to mutational input of additive genetic (co)variance. Variation in M has the effect of stretching and bending phenotypic space with respect to evolvability, analogous to the curvature of space-time under general relativity, and similar mathematical tools may apply in each case. We explored the consequences of curvature in mutational variation by simulating adaptation under divergent selection with gene flow. Both standing genetic variation (the G-matrix) and rate of adaptation are constrained by M, so that G and adaptive trajectories are curved across phenotypic space. Under weak selection the phenotypic mean at migration-selection balance also depends on M.
PhD Thesis - Emergence of cortical network motifs
<p>Annotated representative video of mice performing sensorimotor task.</p>
DISTINCTIVE FEATURES OF THE WEDDING MOTIF IN ABDULLA QAHHOR'S NOVEL "SAROB"
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Nanomotif: Identification and Exploitation of DNA Methylation Motifs in Metagenomes using Oxford Nanopore Sequencing
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Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT
<p>Underlying data of the<em> in silico</em> work performed in this study. </p> <p>1. i-Tasser predictions for HTTExon1Q<sub>48 </sub></p> <p>2. HDOCK results of DNAJB1-HTTExon1Q<sub>48 </sub>docking</p> <p>3. TIGER2h structures and trajectories. The original data and filtered trajectories for the individual clusters</p> <p>4. MD Simulation structures and trajectories for DNAJB1 protein variants alone and as complexes with HTTExon1Q<sub>48.</sub></p>
Supplementary material 5 from: Suntronpong A, Thapana W, Twilprawat P, Prakhongcheep O, Somyong S, Muangmai N, Peyachoknagul S, Srikulnath K (2017) Karyological characterization and identification of four repetitive element groups (the 18S – 28S rRNA gene, telomeric sequences, microsatellite repeat motifs, Rex retroelements) of the Asian swamp eel (Monopterus albus). Comparative Cytogenetics 11(3): 435-462. https://doi.org/10.3897/compcytogen.v11i3.11739
Supplementary Table 5 : Data type: Table
Supplementary material 4 from: Suntronpong A, Thapana W, Twilprawat P, Prakhongcheep O, Somyong S, Muangmai N, Peyachoknagul S, Srikulnath K (2017) Karyological characterization and identification of four repetitive element groups (the 18S – 28S rRNA gene, telomeric sequences, microsatellite repeat motifs, Rex retroelements) of the Asian swamp eel (Monopterus albus). Comparative Cytogenetics 11(3): 435-462. https://doi.org/10.3897/compcytogen.v11i3.11739
Supplementary Table 4 : Data type: Table
Supplementary material 1 from: Suntronpong A, Thapana W, Twilprawat P, Prakhongcheep O, Somyong S, Muangmai N, Peyachoknagul S, Srikulnath K (2017) Karyological characterization and identification of four repetitive element groups (the 18S – 28S rRNA gene, telomeric sequences, microsatellite repeat motifs, Rex retroelements) of the Asian swamp eel (Monopterus albus). Comparative Cytogenetics 11(3): 435-462. https://doi.org/10.3897/compcytogen.v11i3.11739
Supplementary Table 1 : Data type: Table
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.