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206
datasets available to search
ShareScore release 0.9.0
Dataset results
206 results for “rationality”
A rationally designed dual PI3-kinase (PI3K) and BET-inhibitory chimeric small molecule demonstrates potent anti-neoplastic activity versus MYC-driven haematological cancers in vivo [RNA-seq]
GEO Series GSE188437. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic targeting of GCB- and ABC-DLBCL by rationally designed BCL6 inhibitor
GEO Series GSE80351. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Rational redesign of antigen binding domain improves in vivo efficacy of the CD22-CAR
GEO Series GSE313971. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma [SNP]
GEO Series GSE72732. Homo sapiens. 7 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
DNA methylation as a therapeutic target in RB1 deficient and neuroendocrine prostate cancer and rational co-targeting with B7-H3 [22Rv1sgRB1]
GEO Series GSE216713. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
GEO Series GSE145630. Escherichia coli. 18 samples. Type: Other.
Rational design of cyanobacteria aptamer sensitizes prostate cancer to hormone therapy
GEO Series GSE232596. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Rational and scalable strategies to identify small “molecular glue” degraders
GEO Series GSE142405. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [scRNA-seq]
GEO Series GSE255516. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma [expression]
GEO Series GSE72927. Homo sapiens. 24 samples. Type: Expression profiling by array.
Identification of targets for rational pharmacological therapy in childhood craniopharyngioma
GEO Series GSE68015. Homo sapiens. 112 samples. Type: Expression profiling by array; Third-party reanalysis.
Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML
GEO Series GSE89521. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
BiTE-secreting T cells rationally combine with PD-1 blockade and promote remodeling of the local immune landscape to enhance response durability in ovarian cancer
GEO Series GSE280954. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Targeting of REST with rationally-designed small-molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells
GEO Series GSE234912. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Rational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer
GEO Series GSE228587. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Rational cell fate engineering through chromatin dynamics [CUT&TAG]
GEO Series GSE243514. Mus musculus. 8 samples. Type: Other.
Rational cell fate engineering through chromatin dynamics [CUT&TAG II]
GEO Series GSE263597. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
GEO Series GSE218774. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens [scRNA-seq]
GEO Series GSE237569. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Figure 3 from: Nastyukha Y, Kostyana K, Maksymovych M, Boretska O (2020) The role of the State Drug Formulary of Ukraine in providing rational pharmacotherapy for elderly patients. Pharmacia 67(4): 261-268. https://doi.org/10.3897/pharmacia.67.e57794
Figure 3 The distribution of drugs, which require monitoring, according to the ATC classification.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.