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2,914 results for “replacement”
Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology
<p>This compressed ZIP file includes three components</p> <p>The Full Guideline Document (FINAL COPY) for the <strong>2022 Saudi Guideline for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children</strong></p> <p>In addition to two guideline reporting checklists to ensure the quality of this adoloped guideline:-</p> <p><strong>1- AGREE Reporting Checklist</strong></p> <p><strong>2- RIGHT-Ad@pt Checklist</strong></p> <p>As a supplementary to the submitted article entitled:_</p> <p><strong>Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology</strong></p>
The efficacy and safety of meal replacement in patients with type 2 diabetes: a systematic review and meta-analysis
<p>There are supplemental materials for a systematic review and meta-analysis, which studied the efficacy and safety of meal replacement in patients with type 2 diabetes, with a focus on subgroup analysis of variable participant characteristics and MR prescription.</p>
Gut content metabarcoding of specialized feeders is not a replacement for environmental DNA assays of their reef environment
<p>In tropical marine ecosystems, the coral-based diet of benthic-feeding reef fishes provides a window into the composition and health of coral reefs. In this study, for the first time, we compare multi-assay metabarcoding sequences of environmental DNA (eDNA) isolated from seawater and partially digested gut items from an obligate corallivore butterflyfish (<em>Chaetodon</em> <em>lunulatus</em>) resident at coral reef sites in the South China Sea. We specifically tested the proportional and statistical overlap of the different approaches (seawater versus gut content metabarcoding) in characterizing eukaryotic community composition on coral reefs. Based on 18S rRNA and ITS2 rRNA sequence data, which differed in their taxonomic sensitivity, we found that gut content detections were only partially representative of the eukaryotic communities detected in the seawater. Overall, our results indicate that dietary metabarcoding of specialized feeders can be complimentary to, but is no replacement for, more comprehensive environmental DNA assays of reef environments that can include the processing of different substrates (seawater, sediment, plankton) or traditional observational surveys. These molecular assays, in tandem, might be best suited to highly productive but cryptic oceanic environments (coral reefs, kelp forests, seagrass meadows) that contain an abundance of organisms that are often small, epiphytic, symbiotic, or cryptic.</p>
Lineage replacement and evolution captured by three years of the United Kingdom Covid Infection Survey
<p>The Office for National Statistics COVID-19 Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community and collected data on the United Kingdom (UK) epidemic from April 2020 until March 2023 before being paused. Here, we report on the epidemiological and evolutionary dynamics of SARS-CoV-2 determined by analysing the sequenced samples collected by the ONS-CIS during this period. We observed a series of sweeps or partial sweeps, with each sweeping lineage having a distinct growth advantage compared to its predecessors. The sweeps also generated an alternating pattern in which most samples had either S-gene target failure (SGTF) or non-SGTF over time. Evolution was characterised by steadily increasing divergence and diversity within lineages but with step increases in divergence associated with each sweeping major lineage. This led to a faster overall rate of evolution when measured at the between-lineage level compared to within-lineages, and fluctuating levels of diversity. These observations highlight the value of viral sequencing integrated into community surveillance studies to monitor the viral epidemiology and evolution of SARS-CoV-2, and potentially other pathogens, particularly in the current phase of the pandemic with routine RT-PCR testing now ended in the community.</p>
Data from: Barotropic instability during eyewall replacement
<div> <div>Prior to landfall in Puerto Rico, Hurricane Maria (2017) underwent an eyewall replacement cycle. The National Oceanic and Atmospheric Administration (NOAA) San Juan (TJUA) radar captured a robust outer convective ring with an inner ring first distorted into an ellipse and then disintegrated. To understand the dynamical processes during eyewall replacement, this work interprets the eyewall replacement event using the non-divergent barotopic model with a linear stability analysis and non-linear numerical simulations. For the linear stability analysis, the model's axisymmetric basic state vorticity distribution is piece-wise uniform in five regions: eye, inner eyewall, moat, outer eyewall, and far field. The stability of such structures is investigated by solving a simple eigenvalue/eigenvector problem. For the non-linear model, the evolution into a more stable structure is simulated using the non-linear barotropic model. Three types of instability and vorticity rearrangement are identified: (1) instability across the outer ring of enhanced vorticity, (2) instability across the low vorticity moat, and (3) instability across the inner ring of enhanced vorticity. This dataset includes (1) a loop of the NOAA TJUA radar during the landfall of Hurricane Maria (2017) in GIF format to show the convective evolution, (2) the output from the five-region linear stability analysis in NetCDF format, and (3) the output from the non-divergent barotropic model in NetCDF format and GIF format to show the vortex evolution. These data are provided without restrictions for further exploration into understanding barotropic instability during eyewall replacement.</div> </div>
Early Neuromuscular Electrical Stimulation For Quadriceps Muscle Activation Deficits Following Total Knee Replacement
ClinicalTrials.gov study NCT00800254. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement
ClinicalTrials.gov study NCT00152971. IPD Sharing: Not stated. Countries: 4. Publications: 1.
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
ClinicalTrials.gov study NCT02491281. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.
ClinicalTrials.gov study NCT03365999. IPD Sharing: NO. Countries: 1. Publications: 8.
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
ClinicalTrials.gov study NCT02132312. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy
ClinicalTrials.gov study NCT02891850. IPD Sharing: Not stated. Countries: 21. Publications: 1.
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease Who Have Reached Therapeutic Goals With Enzyme Replacement Therapy (ENCORE)
ClinicalTrials.gov study NCT00943111. IPD Sharing: Not stated. Countries: 12. Publications: 7.
Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery
ClinicalTrials.gov study NCT00846807. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Sugar-replacement Sweeteners, and Blood Sugar Control
ClinicalTrials.gov study NCT01128829. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
ClinicalTrials.gov study NCT03506347. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
ClinicalTrials.gov study NCT01505465. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Nicotine Replacement Therapy in the Intensive Care Unit
ClinicalTrials.gov study NCT01362959. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
ClinicalTrials.gov study NCT03326999. IPD Sharing: NO. Countries: 1. Publications: 1.
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery
ClinicalTrials.gov study NCT00874822. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study
ClinicalTrials.gov study NCT00600106. IPD Sharing: NO. Countries: 1. Publications: 42.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.