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1,530 results for “treatment response”
Electrochemotherapy as Palliative Treatment in Patients with Recurrent and/or Metastatic Head and Neck Tumours: Features Analysis for an Early Determination of the Partial Responsive Patients
<p>We uploaded the data of enrolled patients in the manuscript "Electrochemotherapy as Palliative Treatment in Patients with Recurrent and/or Metastatic Head and Neck Tumours: Features Analysis for an Early Determination of the Partial Responsive Patients" </p>
Sup_Tables 1-4_A serum proteome signature stratifies treatment response to csDMRD in pediatric noninfectious uveitis
<p>Supplementary tables 1 to 4. A serum proteome signature stratifies treatment response to csDMRD in pediatric noninfectious uveitis</p>
Meta-analysis of phenotypic plasticity in response to thermal treatments in invertebrates
<p>Populations must adapt to environmental changes to remain viable. Both evolution and phenotypic plasticity contribute to adaptation, with plasticity possibly being more important for coping with rapid change. Adaptation is complex in species with separate sexes, as the sexes can differ in the strength or direction of natural selection, the genetic basis of trait variation, and phenotypic plasticity. Many species show sex differences in plasticity, yet how these differences influence extinction susceptibility remains unclear. We first extend theoretical models of population persistence in changing environments and show that persistence is affected by sexual dimorphism for phenotypic plasticity, trait genetic architecture, and sex-specific selection. Our models predict that female-biased adaptive plasticity—particularly in traits with modest-to-low cross-sex genetic correlations— typically promotes persistence, though we also identify conditions where sexually monomorphic or male-biased plasticity promotes persistence. We then perform a meta-analysis of sex-specific plasticity under manipulated thermal conditions. Although examples of sexually dimorphic plasticity are widely observed, systematic sex differences are rare. An exception—cold resistance—is systematically female-biased and represents a trait wherein sexually dimorphic plasticity might elevate population viability in changing environments. We discuss our results in light of debates about the roles of evolution and plasticity in extinction susceptibility.</p>
Mouse RNASeq data for "The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer", part 1
Open the record for dataset details and reuse information.
Mouse RNASeq data for "The tumor microbiome reacts to hypoxia and can influence response to radiation treatment in colorectal cancer", part 2
Open the record for dataset details and reuse information.
Radioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
<p><span><span><span>The dataset contains underlying data and code for reproduction of the main findings of this study.</span></span></span></p> <h2><span><span>Abstract</span></span></h2> <p><span><span>Antifibrotic therapy with </span><span>nintedanib</span><span> is the clinical </span><span>mainstay</span><span> in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, </span><span>provides</span><span> quantitative insights into organ-scale pathophysiology, generating digital disease fingerprints. Here, we used an integrative analysis of radiomic and proteomic profiles (</span><span>radioproteomics</span><span>) to assess whether changes in radiomic signatures can stratify the degree of antifibrotic response to </span><span>nintedanib</span><span> in (experimental) fibrosing ILD. Unsupervised clustering of delta radiomic profiles revealed two distinct imaging phenotypes in mice treated with </span><span>nintedanib</span><span>, contrary to conventional densitometry readouts</span><span>, which showed a more</span><span> uniform response. Integrative analysis of delta radiomics and proteomics </span><span>demonstrated</span><span> that these phenotypes reflected different treatment response states, as further </span><span>evidenced</span><span> on transcriptional and cellular levels</span><span>. Importantly, </span><span>radioproteomic</span><span>s</span><span> signatures paralleled disease- and drug related biological pathway activity with high specificity, including extracellular matrix (ECM) remodeling, cell cycle activity, wound healing, and metabolic activity. Evaluation of the preclinical molecular response-defining features, particularly those linked to ECM remodeling, in a cohort of </span><span>nintedanib</span><span>-treated fibrosing ILD patients, accurately stratified patients based on their extent of lung function decline. </span><span>In conclusion, delta radiomics has great potential to serve as a non-invasive and readily accessible surrogate of molecular response phenotypes in fibrosing ILD.</span><span> This could pave the way for personalized treatment strategies and improved patient outcomes.</span></span><span><span><span> </span></span></span></p> <p><span> </span></p> <p> </p>
Clinical Dataset for the Paper 'Machine Learning Prediction of Treatment Response to Biological Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis'
<p>This dataset accompanies the manuscript titled "Machine Learning Prediction of Treatment Response to Biological Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis." It includes clinical data used for training and evaluating the machine learning models described in the paper. The dataset contains baseline clinical data of 154 RA patients who were treated with bDMARDs. The labels for remission, and effectiveness (remission and low disease activity) were applied after a 6-month follow-up based on EULAR criteria on DAS28ESR. The sustained effectiveness label indicates maintaining effectiveness within 6 months after initially achieving effectiveness.</p> <p><strong>Crossponder Authors:</strong></p> <ul> <li>Fatemeh Salehi (email: <a rel="noreferrer">fatemeh.salehihafshejni@fau.de</a>)</li> </ul>
Exploration of Biomarkers for the Susceptibility, Early Detection and Treatment Response of Brain Tumours using Epidemiological Techniques
<p>The following resource is from Lily Andrews thesis entitled: Exploration of Biomarkers for the Susceptibility, Early Detection and Treatment Response of Brain Tumours using Epidemiological Techniques. This presents tables that were too large to place in the appendix of the thesis.</p>
Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme
<p>Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line.</p>
[dataset] Behavioral expression of father-daughter bonds affects sociality and responsiveness to oxytocin and vasopressin treatments in captive juvenile female titi monkeys (Plecturocebus cupreus)
<p>[dataset] Social bonds influence physiology and behavior, which can shape how individuals respond to physical and affective challenges. Coppery titi monkey (<em>Plecturocebus cupreus</em>) offspring form selective bonds with their fathers, making them ideal for investigating how father-daughter bonds influence juveniles’ responses to oxytocin (OT) and vasopressin (AVP) manipulations. We quantified expression of father-daughter bond-related behaviors in females (n = 10) and gave acute intranasal treatments of saline, low/medium/high OT, low/high AVP, or OT receptor antagonist (OTA) to subjects prior to a parent preference test. While females spent more time in proximity to their parents than strangers, we found a large degree of individual variation. Females with greater expression of bonding behaviors responded to OT treatments in a dose-dependent manner. Subjects also spent less time in proximity to strangers when treated with High OT (p = 0.003) and Low OT (p = 0.007), but more time when treated with High AVP (p = 0.007), Low AVP (p = 0.009), and OTA (p = 0.001). Findings from the present study suggest variation in expression of bond-related behaviors may alter responsiveness to OT and AVP, increasing engagement with unfamiliar social others. This enhanced sociality with strangers may promote formation of pair bonds with partners.</p>
Fig. 6 in Identification of methoxylchalcones produced in response to CuCl treatment and pathogen infection in barley
Fig. 6. Accumulation of PMC and TMC in JA-treated leaves of various barley cultivars. Leaf segments were treated with 0.5 M JA solution for 72 h by floating method. Distilled water containing 0.25% Tween20 was used as a control. Data represent mean and standard deviation values obtained from three independent samples (3 plant/sample). Asterisks indicate a statistically significant difference from the value of the control (*p <0.05; **p <0.01; Student's t-test).
Fig. 3 in Identification of methoxylchalcones produced in response to CuCl treatment and pathogen infection in barley
Fig. 3. The kinetics of the accumulation of 2ʹ,3,4,4ʹ,6ʹ-pentamethoxychalcone (PMC, A), 2ʹ-hydroxy-3,4,4ʹ,6ʹ-tetramethoxychalcone (TMC, B), 12-oxo-phytodienoic acid (OPDA, C), jasmonic acid (JA, D), JA-Ile (E), 9-oxooctadeca-10,12-dienoic acid (9-KODE, F), and 13-oxooctadeca-9,11-dienoic acid (13-KODE, G) in B. sorokiniana-infected leaves. The metabolites in the leaves were extracted at 0, 6, 12, 24, 48, and 72 h after inoculation. Data represent mean and standard deviation values obtained from three independent samples (3 plant/sample). Asterisks indicate a statistically significant difference from the values of the intact leaves (*p <0.05; **p <0.01; Dunnett's test).
Fig. 2. 1H–1H in Identification of methoxylchalcones produced in response to CuCl treatment and pathogen infection in barley
Fig. 2. 1H–1H COSY correlations (indicated by blue bold line) of 1 (A) and chemical structures of compounds 1–3 (B). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 1 in Identification of methoxylchalcones produced in response to CuCl treatment and pathogen infection in barley
Fig. 1. Comparison of total ion and selected ion chromatograms of extracts from CuCl2-treated and control barley leaves. The barley leaves were treated with 0.5 mM CuCl2 solution by the floating method. Metabolites in the leaves were extracted 72 h after treatment and analyzed by LC-MS. Three independent samples (3 plant/sample) from either CuCl2 treated or control leaves were analyzed, and increased accumulation of 1–3 in the CuCl2 treated leaves was detected in all analyses.
Fig. 4 in Identification of methoxylchalcones produced in response to CuCl treatment and pathogen infection in barley
Fig. 4. Accumulation of TMC, PMC, and OPDA in barley leaves treated with 0.5 mM CuCl2 (A) and oxylipins (B) For the treatment of CuCl2, the third leaves of barley seedlings were floated in a 0.5 mM CuCl2 solution containing 0.25% Tween20, and in distilled water containing 0.25% Tween20 as a control for 72 h. For treatments with oxylipins, droplets of 1 mM solutions of JA, OPDA, and 9-KODE containing 0.25% Tween20 were placed on leaves and incubated for 72 h. Droplets of distilled water containing 0.25% Tween20 were placed on leaves as a control. Data represent mean and standard deviation values obtained from three independent samples (3 plant/sample). Asterisks indicate a statistically significant difference from the value of the control (*p <0.05; **p <0.01; Student's t-test).
Treatment of Post-concussion Syndrome With TMS: Using FNIRS as a Biomarker of Response
ClinicalTrials.gov study NCT04568369. IPD Sharing: NO. Countries: 1. Publications: 21.
A Comparative Study of MRI, US and CE for Assessing Treatment Response in Known Crohn's Disease
ClinicalTrials.gov study NCT03435016. IPD Sharing: YES. Countries: 1. Publications: 0.
Periodontal Treatment Response in Type II Diabetic Patients
ClinicalTrials.gov study NCT01881074. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia
ClinicalTrials.gov study NCT05020600. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Chronic Inflammatory Disease, Lifestyle and Treatment Response
ClinicalTrials.gov study NCT03173144. IPD Sharing: YES. Countries: 1. Publications: 4.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.