Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
3,223
datasets available to search
ShareScore release 0.9.0
Dataset results
3,223 results for “Human Study”
Study of White Adipose Tissue Remodeling by Cryolipolysis in Humans
ClinicalTrials.gov study NCT04819321. IPD Sharing: NO. Countries: 1. Publications: 18.
68Ga-NI-FAPI PET/CT: First-in-human Study
ClinicalTrials.gov study NCT06688305. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Toward a mechanistic understanding of human-induced rapid environmental change: a case study linking energy development, nest predation, and predators
Open the record for dataset details and reuse information.
Data from: Shifting niches of marine predators due to human exploitation: the diet of the South American sea lion (Otaria flavescens) since the late Holocene as a case study
Open the record for dataset details and reuse information.
Data from: Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population
Open the record for dataset details and reuse information.
Data from: A prospective cohort study examining cervical cancer screening methods in HIV-positive and HIV-negative Cambodian women: a comparison of human papilloma virus testing, visualization with acetic acid, and digital colposcopy
Open the record for dataset details and reuse information.
Data from: Fencing solves human‐wildlife conflict locally but shifts problems elsewhere: a case study using functional connectivity modelling of the African elephant
Open the record for dataset details and reuse information.
Data from: Leopard in a tea-cup: a study of leopard habitat-use and human-leopard interactions in north-eastern India
Open the record for dataset details and reuse information.
Data from: Combining human acceptance and habitat suitability in a unified socio-ecological suitability model: a case study of the wolf in Switzerland
Open the record for dataset details and reuse information.
Maximizing human effort for analyzing scientific images: a case study using digitized herbarium sheets
<p>This directory contains "gold standard" set of phenological annotations of herbarium specimen photographs, in Acer_Prunus_gold_standard_phenological_data.csv. The methods used to generate these data are described in Brenskelle, L., R. P. Guralnick, M. Denslow, and B. J. Stucky. 2020. Maximizing human effort for analyzing scientific images: A case study using digitized herbarium sheets. Applications in Plant Sciences 8(6): e11370.</p>
Data used for "Studying human-nature relationships through a network lens: A systematic review"
<p>This is the data set used in the systematic literature review presented in Kluger et al. (<em>accepted for publicatio</em>n) Studying human-nature relationships through a network lens: A systematic review. <em>People and Nature</em>.</p> <p>The sheet "Full_analysis" includes all papers (n=138) identified - and classified relevant - through the literature search in the webofknowledge data base. For being classified as relevant, the study had to apply a network analytical approach and deal with human-nature relationships.</p> <p>For further details on the review process and decision criteria, please see the method section of the main manuscript.</p>
A geometric morphometric approach to the study of sexual dimorphism in the modern human frontal bone
<p>Code and data to replicate the results reported in the paper "A geometric morphometric approach to the study of sexual dimorphism in the modern human frontal bone"</p>
A Taxonomy of Contemporary Arctic Studies under Social Sciences and Humanities Domain
<p>This database serves a list of the scientific studies related to the developments in the Arctic Region from the perspective of Social Sciences and Humanities. It analyzes the Arctic studies considering their structural features, related key words, relevance to PESTEL-DEL analysis (extension of the well-known PESTEL methodology by including the dimensions of Defense-Security, Energy and Logistics), geographical coverage and methodological framework. The database covers 169 most recent scientific studies published between 2007 and 2019. It addresses topics including political issues and disputes in the Arctic Region, potential economic activities as well as economic opportunities and challenges, social and ecological structure of the region, technological developments based on the changing conditions, environmental concerns as a result of climate change and new industrial activities, legal disputes regarding continental shelf and EEZ, national defense and security efforts of the actors in the Arctic, and potential energy reserves and new logistics routes that have become accessible due to melting glaciers. </p>
Perceptual correlates of homosynaptic long term potentiation in human nociceptive pathways: a replication study
<p>Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibers induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can be observed in humans. In 20 healthy volunteers we applied HFS to the left or right volar forearm. Before and after applying HFS we delivered single electrical test stimuli through the HFS electrode while a second electrode at the contralateral arm served as control condition. Moreover, to test the efficacy of the HFS protocol we quantified changes in mechanical pinprick sensitivity before and after HFS of the skin surrounding both electrodes. The perceived intensity was collected for both electrical and mechanical stimuli. After HFS, the perceived pain intensity elicited by the mechanical pinprick stimuli applied on the skin surrounding the HFS-treated site was significantly higher compared to control site (heterotopic effect). Furthermore, we found a higher perceived pain intensity for single electrical stimuli delivered to the HFS-treated site compared to the control site (homotopic effect). Whether the homotopic effect reflects a perceptual correlate of homosynaptic LTP remains to be elucidated.</p>
Data from: How scientists perceive the evolutionary origin of human traits: results of a survey study
Various hypotheses have been proposed for why the traits distinguishing humans from other primates originally evolved, and any given trait may have been explained both as an adaptation to different environments and as a result of demands from social organization or sexual selection. To find out how popular the different explanations are among scientists, we carried out an online survey among authors of recent scientific papers in journals covering relevant fields of science (palaeoanthropology, palaeontology, ecology, evolution, human biology). Some of the hypotheses were clearly more popular among the 1266 respondents than others, but none was universally accepted or rejected. Even the most popular of the hypotheses were assessed "very likely" by <50 % of the respondents, but many traits had 1–3 hypotheses that were found at least moderately likely by >70 % of the respondents. An ordination of the hypotheses identified two strong gradients. Along one gradient, the hypotheses were sorted by their popularity, measured by the average credibility score given by the respondents. The second gradient separated all hypotheses postulating adaptation to swimming or diving into their own group. The average credibility scores given for different subgroups of the hypotheses were not related to respondent's age or number of publications authored. However, (palaeo)anthropologists were more critical of all hypotheses, and much more critical of the water-related ones, than were respondents representing other fields of expertise. Although most respondents did not find the water-related hypotheses likely, only a small minority found them unscientific. The most popular hypotheses were based on inherent drivers, i.e. they assumed the evolution of a trait to have been triggered by the prior emergence of another human-specific behavioural or morphological trait, but opinions differed as to which of the traits came first.
Data from: Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome
During chemical transmission, the function of synaptic proteins must be coordinated to efficiently release neurotransmitter. Synaptotagmin 2, the Ca2+ sensor for fast, synchronized neurotransmitter release at the human neuromuscular junction, has recently been implicated in a dominantly inherited congenital myasthenic syndrome associated with a non-progressive motor neuropathy. In one family, a proline residue within the C2B Ca2+-binding pocket of synaptotagmin is replaced by a leucine. The functional significance of this residue has not been investigated previously. Here we show that in silico modeling predicts disruption of the C2B Ca2+-binding pocket, and we examine the in vivo effects of the homologous mutation in Drosophila. When expressed in the absence of native synaptotagmin, this mutation is lethal, demonstrating for the first time that this residue plays a critical role in synaptotagmin function. To achieve expression similar to human patients, the mutation is expressed in flies carrying one copy of the wild type synaptotagmin gene. We now show that Drosophila carrying this mutation developed neurological and behavioral manifestations similar to those of human patients and provide insight into the mechanisms underlying these deficits. Our Drosophila studies support a role for this synaptotagmin point mutation in disease etiology.
Data from: A multimodal image guiding system for Navigated Ultrasound Bronchoscopy (EBUS): a human feasibility study
Background: Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is the endoscopic method of choice for confirming lung cancer metastasis to mediastinal lymph nodes. Precision is crucial for correct staging and clinical decision-making. Navigation and multimodal imaging can potentially improve EBUS-TBNA efficiency. Aims: To demonstrate the feasibility of a multimodal image guiding system using electromagnetic navigation for ultrasound bronchoschopy in humans. Methods: Four patients referred for lung cancer diagnosis and staging with EBUS-TBNA were enrolled in the study. Target lymph nodes were predefined from the preoperative computed tomography (CT) images. A prototype convex probe ultrasound bronchoscope with an attached sensor for position tracking was used for EBUS-TBNA. Electromagnetic tracking of the ultrasound bronchoscope and ultrasound images allowed fusion of preoperative CT and intraoperative ultrasound in the navigation software. Navigated EBUS-TBNA was used to guide target lymph node localization and sampling. Navigation system accuracy was calculated, measured by the deviation between lymph node position in ultrasound and CT in three planes. Procedure time, diagnostic yield and adverse events were recorded. Results: Preoperative CT and real-time ultrasound images were successfully fused and displayed in the navigation software during the procedures. Overall navigation accuracy (11 measurements) was 10.0 ± 3.8 mm, maximum 17.6 mm, minimum 4.5 mm. An adequate sample was obtained in 6/6 (100%) of targeted lymph nodes. No adverse events were registered. Conclusions: Electromagnetic navigated EBUS-TBNA was feasible, safe and easy in this human pilot study. The clinical usefulness was clearly demonstrated. Fusion of real-time ultrasound, preoperative CT and electromagnetic navigational bronchoscopy provided a controlled guiding to level of target, intraoperative overview and procedure documentation.
Data from: Understanding human queuing behaviour at exits: an empirical study
The choice of the exit to egress from a facility plays a fundamental role in pedestrian modelling and simulation. Yet, empirical evidence for backing up simulation is scarce. In this contribution, we present three new groups of experiments that we conducted in different geometries. We varied parameters such as the width of the doors, the initial location and number of pedestrians which in turn affected their perception of the environment. We extracted and analysed relevant indicators such as distance to the exits and density levels. The results put in evidence the fact that pedestrians use time-dependent information to optimize their exit choice, and that, in congested states, a load balancing over the exits occurs. We propose a minimal modelling approach that covers those situations, especially the cases where the geometry does not show a symmetrical configuration. Most of the models try to achieve the load balancing by simulating the system and solving optimization problems. We show statistically and by simulation that a linear model based on the distance to the exits and the density levels around the exit can be an efficient dynamical alternative.
Data from: Vomiting as a symptom and transmission risk in norovirus illness: evidence from human challenge studies
Background: In the US, noroviruses are estimated to cause 21 million cases annually with economic losses reaching $2 billion. Outbreak investigations frequently implicate vomiting as a major transmission risk. However, little is known about the characteristics of vomiting as a symptom or the amount of virus present in emesis. Methodology and Principal Findings: Emesis samples and symptomology data were obtained from previous norovirus human challenge studies with GI.1 Norwalk virus, GII.2 Snow Mountain virus, and a pilot study with GII.1 Hawaii virus. Viral titers in emesis were determined using strain-specific quantitative RT-PCR. In all four studies, vomiting was common with 40–100% of infected subjects vomiting at least once. However, only 45% of subjects with vomiting also had diarrhea. Most of the emesis samples had detectable virus and the mean viral titers were 8.0 x 105 and 3.9 x 104 genomic equivalent copies (GEC)/ml for GI and GII viruses, respectively (p = 0.02). Sample pH was correlated with GII.2 Snow Mountain virus detection. Conclusions and Significance: Half of all subjects with symptomatic infection experienced vomiting and the average subject shed 1.7 x 108 GEC in emesis. Unlike shedding through stool, vomiting is more likely to result in significant environmental contamination, leading to transmission through fomites and airborne droplets. This quantitative data will be critical for risk assessment studies to further understand norovirus transmission and develop effective control measures. The correlation between sample pH and virus detection is consistent with a single site of virus replication in the small intestine and stomach contents becoming contaminated by intestinal reflux. Additionally, the frequency of vomiting without concurrent diarrhea suggests that epidemiology studies that enroll subjects based on the presence of diarrhea may be significantly underestimating the true burden of norovirus disease.
Data from: Numerical simulations of targeted delivery of magnetic drug aerosols in the human upper and central respiratory system: a validation study
In the present study, we investigate the concept of the targeted delivery of pharmaceutical drug aerosols in an anatomically realistic geometry of the human upper and central respiratory system. The geometry considered extends from the mouth inlet to the 8th generation of the bronchial bifurcations and is identical to the phantom model used in the experimental studies of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12]. In our computer simulations, we combine the transitional Reynolds-Averaged Navier-Stokes (RANS) and the wall-resolved Large Eddy Simulation (LES) methods for the air phase with the Lagrangian approach for the particulate (aerosol) phase. We validated simulations against recently obtained magnetic resonance velocimetry (MRV) measurements of [Banko {em et al.} (2015), Exp. Fluids, {bf 56} (117):1-12] that provide full a 3D mean velocity field for steady inspiratory conditions. Both approaches produced good agreement with experiments, and the transitional RANS approach is selected for the multi-phase simulations of aerosols transport, because of significantly lower computational costs. The local and total deposition efficiency are calculated for different classes of pharmaceutical particles (in the $0.1mu$m$le d_{rm p} le 10mu$m range) without and with a paramagnetic core (the shell-core particles). For the latter, an external magnetic field is imposed. The source of the imposed magnetic field was placed in the proximity of the first bronchial bifurcation. We demonstrated that both total- and local-depositions of aerosols at targeted locations can be significantly increased by an applied magnetization force. This finding confirms the possible potential for further advancement of the magnetic drug targeting (MDT) technique for more efficient treatments for respiratory diseases.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.