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12,346 results for “derivatives”
Global oceanic seamless POC concentration products derived from MODIS-Aqua and Terra
<p>The dataset integrates seamless POC concentration daily products for the global ocean, derived from MODIS-Aqua and Terra XGBoost satellite retrieval products. It covers the time span from 2017 to 2020. The POC concentration in the product used int32 to integer data, specifically, the raw POC concentration (mg m-3) is first multiplied by 10000 and then rounded using int32.</p>
Global oceanic seamless POC concentration products derived from MODIS-Terra
<p>The dataset integrates seamless POC concentration daily products for the global ocean from 2009 to 2016, derived from MODIS-Terra‘s XGBoost satellite retrieval products. The POC concentration in the product used int32 to integer data, specifically, the raw POC concentration (mg m-3) is first multiplied by 10000 and then rounded using int32.</p>
Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury by inhibiting ferroptosis
<div>Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in the clinic unsatisfactory. Metformin has been demonstrated to be beneficial in alleviating HIRI in recent studies, however, the underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota in mice, which was confirmed by the results of fecal microbiota transplantation treatment but showed the elimination of the beneficial effects when gut bacteria were depleted using antibiotics. Detailedly, through 16S rRNA and metagenomic sequencing, we identified that the metformin-reshaped microbiota was characterized by the increase of gamma-aminobutyric acid (GABA) producing bacteria. This increase was further confirmed by the elevation of GABA synthesis key enzymes, glutamic acid decarboxylase, and putrescine aminotransferase, in gut microbes of metformin-treated mice and healthy volunteers. Furthermore, the benefit of GABA against HIRI-induced ferroptosis was demonstrated in GABA-treated mice. Collectively, our data indicate that metformin can mitigate HIRI-induced ferroptosis by reshaping gut microbiota, with GABA identified as a key metabolite.</div>
Global oceanic seamless POC concentration products derived from MODIS-Aqua and Terra
<p>The dataset integrates seamless POC concentration daily products for the global ocean from 2021 to 2022 with a 9-km resolution, derived from MODIS-Aqua and Terra XGBoost satellite retrieval products. The POC concentration in the product used int32 to integer data, specifically, the raw POC concentration (mg m-3) is first *10000 and then rounded using int32.</p>
Global oceanic seamless POC concentration monthly products derived from MODIS-Aqua and Terra
<p>The dataset integrates seamless POC concentration daily products with a 9-km resolution for the global ocean from 2003 to 2022, derived from MODIS-Aqua and Terra XGBoost satellite retrieval products. The POC concentration in the product used int32 to integer data, specifically, the raw POC concentration (mg m-3) is first *10000 and then rounded using int32.</p>
Human-derived fecal microbiota transplantation alleviates mitochondrial dysfunction and social deficits in the BTBR mouse model for autism
<p><span><span>Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by social communication deficiencies and stereotypic behaviors influenced by hereditary and/or environmental risk factors. There are currently no approved medications for treating the core symptoms of ASD. Human fecal microbiota transplantation (FMT) has emerged as a potential intervention to improve autistic symptoms, but the underlying mechanisms are not fully understood. </span></span><span><span><span><span>In this study, we evaluated the effects of human-derived FMT on behavioral and multi-omics profiles of the BTBR mice, an established model for ASD. FMT effectively alleviated the social deficits in the BTBR mice and normalized their distinct plasma metabolic profile, notably reducing the elevated long-chain acylcarnitines. Integrative analysis linked these phenotypic changes to specific <em>Bacteroides</em> species and vitamin B<sub>6</sub> metabolism. Indeed, vitamin B<sub>6</sub> supplementation improved the social behaviors in BTBR mice. Collectively, these findings shed new light on the interplay between FMT and vitamin B<sub>6</sub> metabolism and revealed a potential mechanism underlying the therapeutic role of FMT in ASD.</span></span></span></span></p>
Transcriptome analysis of immune-inflammatory regulation in Tremella Fuciformis-derived Polysaccharide reeducated B16 cells subcutaneous model
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Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate the motor disorder and brain pathological injury in mice with cerebral palsy
<p>Supplementary Table 1.The statistics of the pole-climbing experiments and the horizontal network test</p> <p>Supplementary Table 2.Results of Kruskal–Wallis test as presented in pole-climbing experiments and the horizontal network test.</p> <p>Supplementary Figure 1. Identification of human umbilical cord mesenchymal stem cell exosomes (hUC-MSCs-exos)</p> <p>Supplementary Figure 2. Results of horizontal network test and pole-climbing experiments.</p> <p> </p>
Data for Deriving WMO cloud classes from ground-based RGB pictures with a residual neural network ensemble
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Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance.
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Supplementary Data Sets for Machine Learning Tracks the Role of Slab-Derived Fluids in Large Igneous Province/CUGBZL
<p>Supplementary Dataset S1: All data collcted from both the GEOROC database and recent literature published in Chinese and English journals and books.<span></span></p> <p>Supplementary Dataset S2: Data after cleaning.</p> <p>Supplementary Dataset S3: Prediction results.</p>
Data and scripts supporting "Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors"
<p>This submission contains the processed sequencing data and analysis scripts, as well as the raw and processed LC-MS metabolomics files accompanying our manuscript "Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors" (Cell Reports Medicine, 2024)</p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate themotor disorder and brain pathological injury inmice with cerebral palsy
<p>This research design.</p>
Semiconductor Porous Hydrogen-Bonded Organic Frameworks Based on Tetrathiafulvalene Derivatives
<p>Relevant data for publication with DOI:</p> <table> <tbody> <tr> <td><a href="https://doi.org/10.1021/jacs.1c07802"><span>https://doi.org/10.1021/jacs.1c07802</span></a></td> </tr> </tbody> </table>
Dataset: Green synthesis of 1,3,5-triazine derivatives using a sonochemical protocol
<p>Dataset for publication Green synthesis of 1,3,5-triazine derivatives using a sonochemical protocol</p> <p>converted bio-chromoatographic experiments</p> <p> </p> <p>1) experiment desription</p> <p>2) chromatographic data</p>
Dataset: Low-Basicity 5-HT6 Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation
<p>Biochromatographic data for publication: Low-Basicity 5-HT6 Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation</p> <p> </p>
Designing Quinazoline Derivatives to Prevent Alzheimer's disease in silico and in vitro studies
<p>Input files, parameter files, topology files for molecular docking, MD, and perturbation simulations</p>
Association of Peripheral Monocytic-Myeloid-Derived Suppressor Cells with Molecular Subtypes in Single Center Endometrial Cancer Patients Receiving Carboplatin + Paclitaxel/Avelumab (MITO END-3 Trial)
<p><span>The MITO-END3 trial compared carboplatin and paclitaxel (</span><span>CP</span><span>) with avelumab plus carboplatin and paclitaxel (</span><span>CPA)</span><span> as first-line treatment in endometrial cancer (EC) patients and </span><span>demonstrated a significant interaction between avelumab response and mismatch repair status. To investigate prognostic/predictive biomarker, </span><span>twenty-nine MITO-END3-EC patients were evaluated at pre-treatment (B1) and at the end of CP/CPA treatment (B2) for </span><span>peripheral Myeloid derived suppressor cells (MDSC) and Tregs. </span><span>At B2, <span>effector</span> Tregs frequency was significantly higher in patients treated with CPA as compared to CP (p=0.038). Both treatments (CP/CPA) induced significant decrease in peripheral M-MDSC (-5.41%) in TCGA 2-MSI-High as compared to TCGA-category 4 tumors (p=0.004). In accordance, both treatments induced M-MDSCs (+5.34%) in MSS patients as compared to MSI-High patients (p=0.001). Moreover, in a subgroup of patients, </span><span>primary tumors were highly infiltrated by M-MDSCs in MSS as compared to MSI-high ECs. </span><span>A post hoc analysis displayed higher frequeny of M-MDSCs (p=0.020) and lower frequency of CD4+ (p<0.005) at pretreatment in EC patients as compared to healthy donors. </span><span>In conclusion, </span><span>the</span><span> peripheral evaluation of MDSCs and Tregs correlated with molecular features in EC treated with CP/CPA and may add insights in identifying EC patients responder to first line chemo/chemo-immunotherapy. </span></p>
Processed data for the "Deriving Semantics-Aware Fuzzers from Web API Schemas" paper
<p>Processed data for the "Deriving Semantics-Aware Fuzzers from Web API Schemas" paper. Each directory in the archive consists of:</p> <p>- metadata.json. Metadata about a test run - tested fuzzer name, run duration, etc</p> <p>- fuzzer.json - Structured fuzzer output</p> <p>- deduplicated_cases.json - Deduplicated reported failures, when fuzzers provide it</p> <p>- sentry.json - Cleaned Sentry events for this run</p> <p>- target.json - Parsed stdout for Gitlab & Disease.sh targets that were tested without Sentry integration</p>
CrIS-derived NH3 emissions over the US
<p>CrIS-derived monthly NH3 emissions over the US for the year 2014 </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.