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3,223 results for “Human Study”
Data from: Metabolomic perfusate analysis during kidney machine perfusion: the pig provides an appropriate model for human studies
Introduction: Hypothermic machine perfusion offers great promise in kidney transplantation and experimental studies are needed to establish the optimal conditions for this to occur. Pig kidneys are considered to be a good model for this purpose and share many properties with human organs. However it is not established whether the metabolism of pig kidneys in such hypothermic hypoxic conditions is comparable to human organs. Methods: Standard criteria human (n = 12) and porcine (n = 10) kidneys underwent HMP using the LifePort Kidney Transporter 1.0 (Organ Recovery Systems) using KPS-1 solution. Perfusate was sampled at 45 minutes and 4 hours of perfusion and metabolomic analysis performed using 1-D 1H-NMR spectroscopy. Results: There was no inter-species difference in the number of metabolites identified. Of the 30 metabolites analysed, 16 (53.3%) were present in comparable concentrations in the pig and human kidney perfusates. The rate of change of concentration for 3-Hydroxybutyrate was greater for human kidneys (p<0.001). For the other 29 metabolites (96.7%), there was no difference in the rate of change of concentration between pig and human samples. Conclusions: Whilst there are some differences between pig and human kidneys during HMP they appear to be metabolically similar and the pig seems to be a valid model for human studies.
Supplemental package of a study on the implications of AI-based tools for the human aspects of software engineering
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Single-cell RNA-seq dataset and code for human colorectal cancer liver metastasis study
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Causality of 486 human blood metabolites on gastric cancer: a two-sample Mendelian randomization study
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Dataset: Modification of Gradient HPLC Method for Determination of Small Molecules' Affinity to Human Serum Albumin under Column Safety Conditions: Robustness and Chemometrics Study
<p>Dataset for publication.</p> <p> </p>
Multimodal Analysis for Human ex vivo Studies Shows Extensive Molecular Changes from Delays in Blood Processing
<p>This is an assembled raw data in Seurat object. Expression profiling data can be accessed from <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156989">https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156989</a>.</p>
Ethnobotanical study of medicinal plants used by Ensaro people to treat human diseases
<p class="CxSpFirst"><strong>Abstract </strong></p> <p class="CxSpMiddle"><strong>Introduction</strong>: - People all over the world have been using medicinal plants to treat various ailments and diseases throughout history. It is still common in developing countries. Because is easily accessible, affordable, and trusted by the communities. Although there are several ethnobotanical studies on medicinal plants in Ethiopia, the number of medicinal plant species and indigenous knowledge documented is still low compared to the high diversity of culture and habitats.</p> <p class="CxSpMiddle"><strong>Methods: -</strong> Ethnobotanical data were collected during the 13th of February 2019 and the 26th of October 2020 through Semi-structured interviews, field observation, a guided field walk, and focus group discussions</p> <p><strong>Result: - </strong>the study documented 142 medicinal plant species distributed in<strong> </strong>125 genera and 56 families which used to treat 52 ailments. Most of these species were collected from wild habitats. The most used plant families were Fabaceae (14) followed by lamiaceae (9) and Solanaceae (9). Most of these medicinal plants were herbs followed by shrubs.</p> <p class="CxSpMiddle"><strong>Conclusion</strong></p> <p class="CxSpMiddle">The study revealed a relatively high diversity of medicinal plants that indicated the existence of indigenous knowledge of using medicinal plants to treat ailments and diseases. The findings of this study supported up the idea that indigenous knowledge of using medicinal plants is still alive in highly degraded areas. To make sustainable use of these medicinal plants in the study area, local people must collaborate with natural resource administrators to manage them before they become seriously threatened. Both ex-situ and In-situ conservation strategies should be combined and employed urgently for optimal conservation results</p>
Fig. 8 in Anatomical Study of the Right Forearm and Hand of One Western Gorilla (Gorilla gorilla) for Comparison with Humans with Respect to Motions of the Thumb and Fingers
Fig. 8. Extensor tendons of the fingers and thumb. A. EDCV tendon comes off EDCIV tendon. The proper tendon sheath of EDM is seen. EIP tendon is not seen. Connexus intertendineus is not seen between EDCII and III, III and IV tendons; B. A thin and short fibrous band (a white arrow) is seen between the distal portion of EDCV and EDCIV tendons at MP joint level; C. APL tendon attaches to the radial part of the 1st metacarpal base. A thin tendinous slip of its ulnar margin extends more distally and attaches to the proximal phalanx (a thick white arrow).
Fig. 6 in Anatomical Study of the Right Forearm and Hand of One Western Gorilla (Gorilla gorilla) for Comparison with Humans with Respect to Motions of the Thumb and Fingers
Fig. 6. The ulnar antebrachial branch of the median nerve (UABM). proximal: The median nerve trifurcates at the level of the distal border of the pronator teres. The most ulnar one is the branch UABM; distal: It runs ulno-distally in the distal forearm and comes close to but does not unite with the ulnar nerve on the ulnar side of the wrist. It bifurcates there to the radial and ulnar bundles.
Fig. 1 in Anatomical Study of the Right Forearm and Hand of One Western Gorilla (Gorilla gorilla) for Comparison with Humans with Respect to Motions of the Thumb and Fingers
Fig. 1. The short and thin thumb, and two skin creases not seen in the human hand. It is different from the human hand to see the hypothenar and the transeminential creases.
NanoString dataset for study: Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study
<p>Raw NanoString data for study DOI:10.1002/path.5367</p>
Data from: Incidence and risk factors of first-line antiretroviral treatment failure among human immunodeficiency virus-infected children in Amhara regional state, Ethiopia: a retrospective follow-up study
Objective: This study aimed to assess the incidence and risk factors of treatment failure among Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome infected (AIDS) children who were on Antiretroviral Therapy (ART) in Amhara National Regional State, Ethiopia. Methods: A retrospective follow-up study was conducted from January 2010 to March 2016. A total of 824 children under the age of 15 years who had started ART were included in the study. Data were collected from children's medical chart and ART registration logbook using a standard checklist. A Weibull regression model was used to identify the risk factors for treatment failure. Adjusted Hazard Ratios with 95% confidence intervals were used to declare statistical significance. Results: The mean (±SD) age of the children was 6.4 ± 3.6 years with a median (IQR) follow up of 30.5 (IQR: 14.6, 51.4) months. Sixty-three children (7.7%, 95%CI:5.8, 9.5) developed treatment failure. Seventeen (27.0%) of whom were immunological and 46 (73.0 %) clinical failures. The incidence rate of treatment failure was 22.1/10000 person-months. The cumulative probability of failure was 0.4 with 28562.5 person-month observations. Lack of disclosure [AHR=4. 4, 95%CI (1.8, 11.3)], opportunistic infections during initiation of ART [AHR= 2.3, 95% CI (1.3, 4.1)] and prolonged follow up [AHR = 0.06, 95% CI (0.02, 0.18)] were the main predictors of treatment failure. Conclusion: This study revealed that the incidence of treatment failure remains a significant public health concern in Ethiopia. Undisclosed HIV status to children, the presence of opportunistic infections during initiation of ART and prolonged follow up was found to be the main predictors of treatment failure. Hence, early detection of the treatment failures and further studies on viral monitor need to consider.
Figure 5 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 5 Compound 5 induces the ER-mediated apoptosis. A) Representative Western blot showing the enhanced release of Smac/DIABLO but not cytochrome c from the mitochondria (MF) into the cytosol (CF) of compound 5-treated A549 lung cancer cells (GI50). Equal protein loading was controlled by staining membranes with Ponceau S (a representative section of the stained membrane is shown). The experiment was repeated three times and the corresponding quantification is shown in (B), B) Quantification of smac/DIABLO and cytochrome C levels in vehicle-treated control A549 cells and cells treated with GI50 amount of compound 5 or 5% DMSO as a negative control. M: mitochondria fraction; C: cytosol fraction. Scale bars: mean ± SEM of three independent experiments. ** p < 0.01 compared to vehicle-treated control cells, C) Representative Western blot showing the induction of phosphorylation of eukaryotic initiation factor-2 (eIF-2) in A549 cells treated with GI50 amounts of compound 5. For comparison purposes, thapsigargin (TG), an ER stress-causing drug was used (3 μM, 2 h) as a positive control. The experiment was repeated three times.
Figure 4 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 4 Compound 5 causes caspase activation. A) qRT-PCR analysis of caspase 3, 4, 8 and 9 mRNA in compound 5-treated cells (GI50) as compared to vehicle-treated control cells [set as 1 arbitrary unit (a.u.)]. Values were normalized to β-actin. Scale bars: mean ± SEM of three independent experiments performed in triplicates. *p < 0.05, **p < 0.01 compared to vehicle-treated control cells, B) Representative Western blots showing cleavage "activation' of procaspase 3 to the active form p17, procaspase 4 to the active form p20, and procaspase 9 to the active forms p35/p37. C: vehicle-treated control cells; 0.5%: 0.5% DMSO-treated cells; 1%: 1% DMSO-treated cells; 5%: 5% DMSO-treated cells; C.5: Compound 5-treated cells. The experiment was repeated three times.
Figure 2 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 2 The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) assay results for compound 5 against MCF10A cells, and white blood cells (WBC) after 24, 48 and 72 h of treatment.
Figure 3 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 3 Compound 5 induces apoptosis in A549 lung cancer cells. A) Fluorescence images of A549 lung cancer cells showing fragmented nuclei after DAPI staining. Scale bar: 10 µm, B) Detection of DNA fragmentation by agarose gel electrophoresis. Cells were treated and genomic DNA was extracted and electrophoresed on 1.5% agarose gels. M: DNA molecular weight marker; C: vehicle-treated control cells; 1%: 1% DMSO-treated cells; 5%: 5% DMSO-treated cells; C.5: Compound 5-treated cells. Arrows indicate DNA fragments. Three experiments were performed with similar results.
Figure 6 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 6 3D View of the target compounds (5, 7A, 6B and 6C) docked against ATP binding site of EGFR kinase.
Caco-2 in vitro model of human gastrointestinal tract for studying the absorption of titanium dioxide and silver nanoparticles from seafood
<p><a href="https://www.sciencedirect.com/topics/chemistry/titanium-dioxide-nanoparticle">Titanium dioxide nanoparticles</a> (TiO<sub>2</sub> NPs) are widely used in industry as a white pigment (paints, paper industry and toothpastes), photocatalysts (environmental decontamination and photovoltaic cells), inorganic UV filter (sunscreens and personal care products) and as a <a href="https://www.sciencedirect.com/topics/chemistry/food-additive">food additive</a> (E171) and antimicrobial food packaging material. <a href="https://www.sciencedirect.com/topics/chemistry/silver-nanoparticle">Silver nanoparticles</a> (Ag NPs) are used in photonics, microelectronics, catalysis and medicine due to their catalytic activity, magnetic and optical polarizability, electrical and <a href="https://www.sciencedirect.com/topics/chemistry/thermal-conductivity">thermal conductivities</a> and enhanced Raman scattering. They also have antibacterial, antifungal and <a href="https://www.sciencedirect.com/topics/chemistry/antiviral-activity">antiviral activities</a>, as well as anti-inflammatory potential. The huge increase in the use of nano-based products, mainly metallic <a href="https://www.sciencedirect.com/topics/chemistry/nanoparticle">NPs</a>, implies the presence of <a href="https://www.sciencedirect.com/topics/chemistry/nanomaterial">nanomaterials</a> in the environment, and hence, the unintentional human ingestion through water or foods (gastrointestinal tract is the main pathway of NPs intake in humans).</p> <p>The presence of TiO<sub>2</sub> NPs and Ag NPs in seafood samples was firstly established using an ultrasound assisted <a href="https://www.sciencedirect.com/topics/chemistry/enzymatic-hydrolysis">enzymatic hydrolysis</a> procedure and sp-ICP-MS analysis. Several clams, cockles, mussels, razor clams, oysters and variegated scallops, which contain TiO<sub>2</sub> NPs and Ag NPs, were subjected to an <em>in vitro</em> digestion process simulating human gastrointestinal digestion in the stomach and in the small and large intestine to determine the bioaccessibility of these NPs. Caco-2 cells were selected as model of human intestinal epithelium for transport studies because of the development of membrane transporters that are responsible for the uptake of chemicals. Parameters as transepithelial electrical resistance (TEER) and permeability of Lucifer Yellow were studied for establishing cell monolayer integrity. TiO<sub>2</sub> NPs and Ag NPs transport as well as total Ti and Ag concentrations passing through the gastrointestinal epithelial barrier model (0–2 h) were assessed by sp-ICP-MS and ICP-MS in several molluscs.</p>
Human Study of Demystifying Dependency Bugs in Deep Learning Stack
<p>A docker of human study which is the reproduce of id 396(d.tar) in our dataset.</p>
Fig. 1. Important 1H–13C in Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
Fig. 1. Important 1H–13C-HMBC correlations of metabolites 5 and 6.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.