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3,430 results for “PD”
Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans (Visium).
GEO Series GSE273489. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
TET2 inhibits PD-L1 gene expression in breast cancer cells through histone deacetylation
GEO Series GSE164032. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the anti-tumor response under PD-1 blockade [scRNA-seq]
GEO Series GSE136125. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Enhanced efficacy of simultaneous PD-1 and PD-L1 immune checkpoint blockade in high grade serous ovarian cancer
GEO Series GSE160755. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment
GEO Series GSE134388. Homo sapiens; Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Expression data in PD-L1 positive and PD-L1 negative human melanoma samples
GEO Series GSE65041. Homo sapiens. 11 samples. Type: Expression profiling by array.
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion [ATAC-seq]
GEO Series GSE245447. Homo sapiens; Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity
GEO Series GSE165952. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Other.
KIR Polymorphism is Associated with Primary Resistance to PD-1 Blockade in Lung Cancer
GEO Series GSE111414. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking
GEO Series GSE109485. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade
GEO Series GSE292146. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Parkinson's Anxiety Network (anxiety-network-pd)
<p>An <em>a priori</em> anxiety network, based on previously reported results in structural and microstructural Parkinson’s disease anxiety literature.</p> <p>This network will be used in a region of interest analysis in a neuroimaging study characterising the microstructural basis of anxiety in early Parkinson's disease. It will be used alongside a High Density Anxiety Network <strong>(10.5281/zenodo.17158446).</strong></p> <p>This network was updated in September 2025 and replaced a previous version originally published in November 2024. Following advice from an advisory thesis committee, a systematic review of PD anxiety neuroannatomical literature was conducted to inform the network, replacing a previous narrative review. This resulted in small changes to the annatomical nodes of the network. The update includes the addition of the left inferior frontal gyrus (opercular and triangular part), bilateral medial orbital gyrus, left anteroventral nucleus of the thalamus, bilateral substantia nigra pars compacta and reticulata and ventral tegmental area. The left inferior frontal gyrus pars orbitalis was removed. All other regions remain the same. </p>
Figure 6 from: Scheffrahn RH, Bourguignon T, Akama PD, Sillam-Dussès D, Šobotník J (2018) Roisinitermes ebogoensis gen. & sp. n., an outstanding drywood termite with snapping soldiers from Cameroon (Isoptera, Kalotermitidae). ZooKeys 787: 91-105. https://doi.org/10.3897/zookeys.787.28195
Figure 6 Live habitus of soldier and brachypterous nymphs of Roisinitermesebogoensis gen.et sp. n.
Figure 1 from: Nobis M, Gudkova PD, Pendry CA (2019) Synopsis of the tribe Stipeae (Poaceae) in Nepal. PhytoKeys 128: 97-119. https://doi.org/10.3897/phytokeys.128.34637
Figure 1 Districts of Nepal.
Figure 8 from: Bannikova AA, Jenkins PD, Solovyeva EN, Pavlova SV, Demidova TB, Simanovsky SA, Sheftel BI, Lebedev VS, Fang Y, Dalen L, Abramov AV (2019) Who are you, Griselda? A replacement name for a new genus of the Asiatic short-tailed shrews (Mammalia, Eulipotyphla, Soricidae): molecular and morphological analyses with the discussion of tribal affinities. ZooKeys 888: 133-158. https://doi.org/10.3897/zookeys.888.37982
Figure 8 The male karyotype of Parablarinella griselda (ZMMU S-195179) with 2n = 49; NFa = 50.
Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD- 1 agents
<p><strong>ABSTRACT</strong></p> <p><strong>Background</strong></p> <p>CD73 is an ectonucleotidase producing the immunosuppressor mediator adenosine. Elevated levels of circulating CD73 in patients with cancer have been associated with disease progression and poor response to immunotherapy. Immunosuppressive pathways associated with exosomes can affect T-cell function and the therapeutic efficacy of anti-programmed cell-death<br> protein 1 (anti-PD-1) therapy. Here, we conducted a retrospective pilot study to evaluate levels of exosomal CD73 before and<br> early during treatment with anti-PD-1 agents in patients with melanoma and its potential contribution to affect T-cell functions and to influence the clinical outcomes of anti-PD-1 monotherapy.</p> <p><strong>Methods</strong></p> <p>Exosomes were isolated by mini size exclusion chromatography from serum of patients with melanoma (n=41) receiving nivolumab or pembrolizumab monotherapy. Expression of CD73 and programmed death-ligand 1 (PD-L1) were evaluated on exosomes enriched<br> for CD63 by on-bead flow cytometry. The CD73 AMPase activity was evaluated by mass spectrometry, also in the presence of selective inhibitors of CD73. Interferon (IFN)-γ production and granzyme B expression were measured in CD3/28 activated T cells incubated with exosomes in presence of the CD73 substrate AMP. Levels of CD73 and PD-L1 on exosomes were correlated with therapy response. Exosomes isolated from healthy subjects were used as control.</p> <p><strong>Results</strong></p> <p>Isolated exosomes carried CD73 on their surface, which is enzymatically active in producing adenosine. Incubation of exosomes with CD3/28 activated T cells in the presence of AMP resulted in a significant reduction of IFN-γ release, which was reversed by the<br> CD73 inhibitor APCP or by the selective A2A adenosine receptor antagonist ZM241385. Expression levels of exosomal CD73 from serum of patients with melanoma were not significantly different from those in healthy subjects. Early on-treatment, expression levels of both CD73 and PD-L1 on exosomes isolated from patients receiving pembrolizumab or nivolumab monotherapy were<br> significantly increased compared with baseline. Early during therapy exosomal PD-L1 increased in responders, while exosomal CD73 resulted significantly increased in non-responders.</p> <p><strong>Conclusions </strong></p> <p>CD73 expressed on exosomes from serum of patients with melanoma produces adenosine and contributes to suppress T-cell functions. Early on-treatment, elevated expression levels of exosomal CD73 might affect the response to anti-PD-1 agents in patients with melanoma who failed to respond to therapy.</p> <p> </p> <p><strong>Funding </strong></p> <p>This work was supported by FARB 2020 University of Salerno (SM), P.O.R. Campania FESR 2007–2013 - O.O. 2.1 - OCKEY (SM), POR Campania, FESR 2014/2020 (Asse 1—Obiettivo specifico 1.2—Azione 1.2) Project: Campania OncoTerapie CUP: B61G18000470007 and Italian Ministry of Health (IT-MOH) through 'Ricerca Corrente' M2/M (PAA).</p>
Association of PD-L1 immunoexpression with the clinicopathological characteristics and its prognostic significance in OPMD and OSCC – Cross sectional study
<p>Histopathological images for study titled Association of PD-L1 immunoexpression with the clinicopathological characteristics and its prognostic significance in OPMD and OSCC – Cross sectional study </p> <p> </p>
Multimodal imaging data in PD
<p>In this work we explored structural and metabolic alterations within the nigrostriatal system in a population of <em>de novo</em> PD patients. We assessed the degree and spatial pattern of dopaminergic denervation (FDOPA), microstructural integrity (FW), and iron accumulation (R2*) within several regions of the nigrostriatal system, including spatial divisions of the SNc and striatum.</p>
Chidamide Decitabine Plus Anti-PD-1 Antibody for Patients With R/R cHL Who Are Transplant-ineligible or Refused Transplant.
ClinicalTrials.gov study NCT06393361. IPD Sharing: NO. Countries: 1. Publications: 0.
Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy
ClinicalTrials.gov study NCT07306286. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.