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29,897 results for “activism”
Shared and differential default-mode related patterns of activity in an autobiographical, a self-referential and an attentional task
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Layer-dependent activity in human prefrontal cortex during working memory
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Tandem Tag Assay Optimized for Semi-automated in vivo Autophagic Activity Measurement in Arabidopsis thaliana roots
<p>This is demo data set for AuTToFlux, the semi-automated assay for <em>in vivo</em> autophagic activity measurement in <em>Arabidopsis thaliana</em> roots.</p> <p>The protocol and software required for the assay are available here: <a href="https://github.com/jonasoh/AuTToFlux">https://github.com/jonasoh/AuTToFlux</a></p>
Raw data for Maier et al. "Seasonal controls on the diet, metabolic activity, tissue reserves and growth of the cold-water coral Lophelia pertusa"
<p>All raw data presented in the article:</p> <p>Maier SR, Bannister RJ, van Oevelen D and Kutti T: Seasonal controls on the diet, metabolic activity, tissue reserves and growth of the cold-water coral <em>Lophelia pertusa</em>. Coral Reefs, <em>in press.</em></p>
Dataset for: Synchrony and symmetry-breaking in active flagellar coordination
<p><strong>We upload video files accompanying the article <em>Synchrony and symmetry-breaking in active flagellar coordination</em> – all scalebars are 10 µm. Files are in uncompressed .avi format. </strong></p> <ol> <li>V1 – A quadriflagellate gait transition from a spinning gait to a trotting gait. </li> <li>V2 – A quadriflagellate symmetry breaking gait.</li> <li>V3 – Another quadriflagellate symmetry breaking gait. </li> <li>V4 – A quadriflagellate resetting its forward-swimming gait after a shock response.</li> <li>V5 – A quadriflagellate gait with two of four flagella active. </li> <li>V6 – A quadriflagellate being caught by micropipette aspiration.</li> <li>V7 – Demonstrating gait-mechanosensitivity in a micropipette-fixed quadriflagellate.</li> <li>V8 – The axial rotation of an octoflagellate during swimming.</li> <li>V9 – The rotary breaststroke of an octoflagellate during swimming.</li> <li>V10 – The octoflagellate search gait in which one flagellum is extended. </li> <li>SV1 – A quadriflagellate gait with 1 out of 4 flagella active.</li> <li>SV2 – A quadriflagellate gait with 2 out of 4 flagella active.</li> <li>SV3 – A quadriflagellate gait with 3 out of 4 flagella active.</li> <li>SV4 – A quadriflagellate gait with 4 out of 4 flagella active.</li> <li>SV5 – A quadriflagellate being caught by micropipette aspiration (top view).</li> <li>SV6 – An octoflagellate "phase slip".</li> <li>SV7 – Another example of the octoflagellate search gait (one flagellum is extended). </li> </ol>
BIDS Data for "Effects of Acute and Chronic Reuptake Inhibitionon on Optogenetically Induced Serotonergic Activity"
<p>Base data package for the “Effects of Acute and Chronic Reuptake Inhibitionon Optogenetically Induced Serotonergic Activity” article, formatted corresponding to the Brain Imaging Data Structure.</p>
Venus coronae activity classification
<p>This is a KML file based on the coronae classification that accompanies the manuscript "Corona structures driven by plume-lithosphere interactions and evidence for ongoing plume activity on Venus" by Gülcher et al. (2020) <em>(Nature Geoscience, </em><strong>13</strong>, 547-554, <a href="https://doi.org/10.1038/s41561-020-0606-1">https://doi.org/10.1038/s41561-020-0606-1</a><em>)</em>. The final version relates to the published manuscript, and includes more data points and an improved analysis compared to the first version (review round) than the first version. This KML file includes all of the coronae that were analysed in this study (from Table 3) and can be used in Google Earth or Google Venus. Markers are color-coded depending on the inferred corona activity (Table 2).</p>
Effect of metabolosome encapsulation peptides on enzyme activity, co-aggregation, incorporation and bacterial microcompartment formation
<p><strong>Supplementary Video 1</strong>. This approach revealed the structures formed by fvMT and BMC shell proteins are remarkably varied in size, shape and volume.</p> <p><strong>Supplementary Video 2. </strong>Recombinant BMCs containing L20-fvMT and -</p> <p><strong>Supplementary Video 3. </strong> Allowing us to quantitate the volume (empty: 54900±11013 nm<sup>3</sup> (n=29); L20-fvMT: 336411±177722 nm<sup>3 </sup>(n=60)) and the largest diameter (empty: 61.77±15.38 nm (n=29); L20-fvMT: 127.51±60.97 nm (n=60)) of these structures</p>
Effects of anthropogenic activity on global terrestrial gross primary production (LAI and FAPAR)
<p>This data set contains the 100-member ensembles of monthly leaf area index (LAI) and fraction of absorbed photosynthetically active radiation (FAPAR) estimated using GIMMS3g LAI and FAPAR and d4PDF air temperature by the method described in Sasai et al. (2016) for historical and non-warming climates in 1951-2010/2011. Data is 0.5625-degree (640×320) 4-byte binary (.raw). Undefined value is -9999.</p> <p>For more details, please check the ReadmeVeg.pdf</p> <p>If you questions, please contact Irina Melnikova (irina.melnikova.russia@gmail.com)</p>
Data Set to 'Sodium-induced population shift drives activation of thrombin'
<p>The data set 10.5281/zenodo.3688506 contains the raw data used for the preparation of the manuscript 'Sodium-induced population shift drives activation of thrombin' (doi:10.1038/s41598-020-57822-0). To limit the required storage space, the trajectories are deposited only as coordinates of the analysed loop. The data set is separated into following parts:</p> <ul> <li>X-ray: Data used in the analysis of the PDB structures of thrombin, including a list of the PDB IDs, results of the PCA and values of the introduced features in the structures.</li> <li>cMD: Input parameters, topologies and starting coordinates of classical MD simulation based on different PDB structures (3bei, 3lu9 – with Na<sup>+</sup> ions and without Na<sup>+</sup> ions), resulting trajectories, projection on X-ray PCA and values of the introduced features during the simulations.</li> <li>TMD: Input parameters, topologies and starting coordinates of the targeted MD simulations, resulting trajectories, projection on X-ray PCA and RMSD values.</li> <li>Seeded-Simulations: Input parameters, topologies and starting coordinates of classical MD simulations that are started from cluster representatives of the TMD simulations and resulting trajectories (3*100 simulations, each lasting 200 ns), separated into simulations with Na+ and without Na+, additionally values of the introduced features during the simulations.</li> <li>MSM: For both systems (with and without Na<sup>+</sup>), files are provided that can be loaded with pyemma (TICA objects, kmeans clusterings, calculated implied timescales and MSMs); additionally TICs of the seeded simulations, psi-dihedrals of the seeded simulations, RMSD values of the E and E<sup>*</sup> states and representative structures of the E and E<sup>*</sup> states</li> </ul> <p>A more detailed description of the included files can be found in the README files in each folder.</p>
DATA SET FOR: Active faulting, submarine surface rupture and seismic migration along the Liquiñe-Ofqui fault system, Patagonian Andes
<p>Data description: These data corresponde to high-resolution bathymetry and seismic reflection profiles obtained in the inner fjord west of Puerto Aysén (between 73.13°- 72.68°W and 45.32°-45.47°S; Figs. 1 and 2). The data set was obtained during a geophysical study as part of the DETSUFA project (Deslizamientos Tsunamigénicos en el Fiordo de Aysén; Lastras et al., 2013), which took place between March 4th and 17th, 2013, aboard the R/V BIO Hésperides.<br> <br> KONGSBERG SIMRAD multibeam EM-1002S was used to obtain bathymetric data, and it works with 111 beams at a 96 kHz sonar frequency and with a maximum ping rate of >10 Hz. Equidistant mode was used for swath bathymetry acquisition. This array maximized the number of beams facilitating data acquisition and obtaining a homogenized final grid with improved resolution, with tracks separated every 150 m. The swath thickness was the same regardless of width, generating a 50% overlap between each track, with the exception of areas located near the coast. Expendable Bathythermograph (XBT) probes were used at specific sites to measure changes in water sound velocity due to eventual changes in fresh water circulation, tides, and sediment.<br> <br> Seismic reflection data were acquired using an array of two BOLT air guns (165 and 175 inches3), which were towed behind the vessel stern. The configuration used in the seismic sources was 2,000 psi, a depth of 3 m for the gun, with a firing rate of 15 m over the seafloor. A 100 m long mini-streamer with a 25 m active section, corresponding to one single channel, recovered the shots. The seismic data were recorded by using the DELPH SEISMICPLUS system with a recording length of 4.0 s and a preamplifier gain of 8 Hz. The raw seismic data were processed aboard the SMT Kingdom Suite, including the navigation and standard processes of electrical noise removing (50 Hz filter), gain amplifier and bandpass filtering, to improve data visualization. Postprocessing included the migration of the sea bottom diffractions and the muting of the water column performed in Seismic-Unix.</p> <p>Files:</p> <p>Raw Seismic reflection data for lines 05, 06 and 07 (SU & SEG files)</p> <p>Masked Seismic profiles for lines 05, 06 and 07 (SU, PDF & PS files)</p> <p>Bathymetry of inner and outer Aysén Fjord (ASCII file)</p>
Raw data related to: "Resiquimod-Mediated Activation of Plasmacytoid Dendritic Cells Is Amplified in Multiple Sclerosis"
<p><strong>Introduction</strong></p> <p>Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. The cause of multiple sclerosis is unknown but there are several evidences that associate the genetic basis of the disease with environmental causes. An important association between viral infection and development of MS is clearly demonstrated. Viruses have a strong impact on innate immune cells. In particular, myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs), are able to respond to viruses and to activate the adaptive immune response.</p> <p><strong>Methods</strong></p> <p> In this study we mimic viral infection using synthetic single-strand RNA, Resiquimod, and we compared the response of both DC subsets derived from healthy donors and MS patients by characterizing the expression of costimulatory molecules on the DC surface.</p> <p><strong>Results</strong></p> <p>We found that pDCs from MS patients express higher levels of OX40-L. Moreover, we found that blood cells from MS patients and healthy donors upon Resiquimod-stimulation are enriched in a subpopulation of pDCs, characterized by a high amount of costimulatory molecules.</p> <p><strong>Conclusion</strong></p> <p>Overall, these results indicate that activation of pDCs is enhanced in MS, likely due to a latent viral infection, and that costimulatory molecules expressed on pDCs could mediate a protective response against the viral trigger of autoimmunity.</p>
Fine-Grained Activities of Daily Living Data with Structural Vibration and Electrical Load Sensing
<p>Fine-grained non-intrusive monitoring of activities of daily living (ADL) enables various smart building applications, including ADL pattern assessments for older adults at risk for loss of safety or independence. We utilize structural vibration sensing and electrical load sensing to acquire multiple fine-grained kitchen activities under a lab structure setting.</p> <p>Each file contains the following values:<br> -RawData: time series of data for each channel (vibration on the table, vibration on the floor, load)<br> -Label: manually fine-grained labels of events<br> -Table: detected events start/stop index for vibration sensor on the table<br> -Floor: detected events start/stop index for vibration sensor on the floor<br> -Load: detected events start/stop index for load sensor<br> <br> Label notation:<br> 1 -- operating the kettle<br> 2 -- kettle on<br> 3 -- operating the microwave<br> 4 -- microwave on<br> 5 -- put things on the stove<br> 6 -- operating with stove<br> 7 -- stove on<br> 8 -- operating vacuum<br> 9 -- sweep floor<br> 10 -- walking/step<br> 11 -- miscellaneous<br> 12 -- synchronization signal (knock on the floor)<br> 13 -- vacant<br> 14 -- microwave door open</p>
Dataset of "Gravity Wave Activity in the Atmosphere of Mars During the 2018 Global Dust Storm: Simulations With a High-Resolution Model" (2/2)
<p>This dataset contains the GrADS data of high-resolution Mars GCM results used for figures in the paper "Gravity Wave Activity in the Atmosphere of Mars During the 2018 Global Dust Storm: Simulations With a High-Resolution Model" by T. Kuroda, A.S. Medvedev and E. Yiğit.</p> <p>Each file contains two-dimensional (X: longitude, Y: latitude) data of surface pressure (Ps) and dust opacity in infrared wavelength (tau), and three-dimensional (X: longitude, Y: latitude, Z:sigma-level) data of temperature (T), zonal wind velocity (u), meridional wind velocity (v) and vertical wind velocity (w). Each tar.xz file contains snapshots of those data in every 1/6 Sol for Ls of 30 degrees. The dust scenario implemented for producing this dataset is taken from Montabone et al. (2020).</p> <p>data270rdc-my34.tar.xz: for Ls=270-300 (48 Sols)</p> <p>data300rdc-my34.tar.xz: for Ls=300-330 (51 Sols)</p> <p>data330rdc-my34.tar.xz: for Ls=330-360 (56 Sols)</p>
Temperature Activates Contact Aging in Silica Nanocontacts
<p>Data presented in the CECAM workshop: Emergence of surface and interface structure from friction, fracture and deformation ( link: cecam.org/index.php/workshop-details/215). </p> <p>Here we unravel the temperature dependence of both static friction and contact stiffness on a silica contact. Further in-depth details are provided in the associated peer-reviewed freely available publication (https://doi.org/10.1103/PhysRevX.9.041045).</p> <p> </p>
Recombinant Costimulatory Fusion Proteins as Functional Immunomodulators Enhance Antitumor Activity in Murine B16F10 Melanoma
<p>Cancer immunotherapy has emerged as an important therapeutic modality in preclinical and clinical oncology. Blocking inhibitory signaling and engaging stimulatory signaling enable some patients to produce an efficient antitumor response. In this work, we demonstrate unique and unexpected immunomodulatory features of different costimulatory ligand proteins with no combination of tumor-associated products, which bridge innate and adaptive immune responses against cancer in preventive as well as therapeutic efficacy.</p>
Supplementary Material for the paper: Automatic Document Screening of Medical Literature Using Word and Text Embeddings in an Active Learning Setting
<p>This is the dataset used in the paper: Automatic Document Screening of Medical Literature Using Word and Text Embeddings in an Active Learning Setting. </p> <p>It is composed of: </p> <p>- Pre-trained models using active learning for document screening on HealthCLEF and Epistemonikos datasets. </p> <p>- Epistemonikos and HealthCLEF datasets containing medical questions and relevant/non relevant articles. </p> <p>- Embeddings and Document Representations used for experiments on both datasets. </p> <p>Scripts to run experiments can be found at: <a href="https://github.com/afcarvallo/active_learning_document_screening">https://github.com/afcarvallo/active_learning_document_screening</a></p> <p> </p> <p><strong>Paper abstract:</strong></p> <p>Document screening is a fundamental task within Evidence-based Medicine (EBM), a practice that provides scientific evidence to support medical decisions. Several approaches have tried to reduce physicians' workload of screening and labeling vast amounts of documents to answer clinical questions. Previous works tried to semi-automate document screening, reporting promising results, but their evaluation was conducted on small datasets, which hinders generalization. Moreover, recent works in natural language processing have introduced neural language models, but none have compared their performance in EBM. In this paper, we evaluate the impact of several document representations such as TF-IDF along with neural language models (BioBERT, BERT, Word2vec, and GloVe) on an active learning-based setting for document screening in EBM. Our goal is to reduce the number of documents that physicians need to label to answer clinical questions. We evaluate these methods using both a small challenging dataset (HealthCLEF 2017) as well as a larger one but easier to rank (Epistemonikos). Our results indicate that word as well as textual neural embeddings always outperform the traditional TF-IDF representation. When comparing among neural and textual embeddings, in the HealthCLEF dataset the models BERT and BioBERT yielded the best results. On the larger dataset, Epistemonikos, Word2Vec and BERT were the most competitive, showing that BERT was the most consistent model across different corpuses. In term of active learning, an uncertainty sampling strategy combined with logistic regression achieved the best performance overall, above other methods under evaluation, and in fewer iterations.</p>
Data for article "Triazene-Activated Donor–Acceptor Cyclopropanes: Ring-Opening and (3 + 2) Annulation Reactions"
<p>This upload contains raw data (NMR, X-Ray) files for the article: </p> <p>A. A. Suleymanov, E. Le Du, Z. Dong, B. Muriel, R. Scopelliti, F. Fadaei-Tirani, J. Waser, K. Severin, </p> <p>"Triazene-Activated Donor-Acceptor Cyclopropanes: Ring-Opening and (3 + 2) Annulation Reactions"</p> <p><em>Org. Lett. </em><strong>2020</strong>, DOI: 10.1021/acs.orglett.0c01527<em>.</em></p>
Data from: Responses of activity rhythms to temperature cues evolve in Drosophila populations selected for divergent timing of eclosion
Even though the rhythm in adult emergence and rhythm in locomotor activity are two different rhythmic phenomena that occur at distinct life-stages of the fly life cycle, previous studies have hinted at similarities in certain aspects of the organisation of the circadian clock driving these two rhythms. For instance, the period gene plays an important regulatory role in both rhythms. In an earlier study, we have shown that selection on timing of adult emergence behaviour in populations of Drosophila melanogaster leads to the co-evolution of temperature sensitivity of circadian clocks driving eclosion. In this study, we were interested in asking if temperature sensitivity of the locomotor activity rhythm has evolved in our populations with divergent timing of adult emergence rhythm, with the goal of understanding the extent of similarity (or lack of it) in circadian organisation between the two rhythms. We found that in response to simulated jetlag with temperature cycles, late chronotypes (populations selected for predominant emergence during dusk) indeed re-entrain faster than early chronotypes (populations selected for predominant emergence during dawn) to 6-h phase-delays, thereby indicating enhanced sensitivity of the activity/rest clock to temperature cues in these stocks (entrainment is the synchronisation of internal rhythms to cyclic environmental time-cues). Additionally, we found that late chronotypes show higher plasticity of phases across regimes, day-to-day stability in phases and amplitude of entrainment, all indicative of enhanced temperature sensitive activity/rest rhythms. Our results highlight remarkably similar organisation principles between emergence and activity/rest rhythms.
Science Communication Webinars Series: Developing Public Outreach Activities
<p>Blue-Action coordinated a series of webinars on climate science communication in 2020. These were aimed at early-career researchers, but anyone who wishes to engage people with their research at any stage will find them valuable.</p> <p>This webinar was delivered on 22nd May 2020 by <a href="https://www.sciencefestival.co.uk/staff/creative">Laura Curtis-Moss</a>, part of the Blue-Action <a href="http://www.blue-action.eu/index.php?id=3503&L=788">Societal Engagement Group</a>. Laura works as a freelance education and science engagement specialist <a href="http://www.linkedin.com/in/lauramosseducation">www.linkedin.com/in/lauramosseducation</a>. </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.