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2,642 results for “blindness”
Finerenone added to RAS/SGLT2 blockade for non-diabetic chronic kidney disease. Results of a preclinical double-blinded randomized controlled trial.
GEO Series GSE226353. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat [seq]
GEO Series GSE181413. Nannospalax ehrenbergi; Mus musculus. 90 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson’s disease: A randomized double-blind prospective study [RNA-Seq]
GEO Series GSE296011. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Results from blind survey of LEO using MWA
<p>The attached data contains the measurements of the transient RFI events detected using the RFISeeker software in the 20 hours of blind survey conducted using the MWA in the FM band. The data contains the time, frequency, and position (ra-dec, alt-az, x,y) of the events (x,y pixel location when images using WSClean with -size 1400 1400 -scale 5amin -weight natural). The metadata contains the information to recreate the WCS object of each of these observations.</p>
Data from: Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial
Objectives: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. Design: Prospective double-blinded placebo-controlled trial testing for difference in infection rates. Setting: Primary care in regional North Queensland, Australia. Participants: 52 patients undergoing lower limb skin lesion excision. Interventions: 2 g dose of cephalexin 30–60 min before excision. Main outcome measures: Incidence of SSI. Results: Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI −0.39% to 46.82%), relative reduction of 65.00% (95% CI −12.70% to 89.13%) and number-needed-to-treat of 4.3. Conclusions: Administration of a single 2 g dose of cephalexin 30–60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this. Trial registration number: ACTRN12611000595910.
Figure 2 from: Aalbu RL, Kanda K, Smith AD (2017) Reinstatement of Eschatoporiini Blaisdell, 1906, a unique tribe of blind cavernicolous Tenebrionidae from California, with a new species from Napa County (Coleoptera, Tenebrionidae, Lagriinae). ZooKeys 688: 135-149. https://doi.org/10.3897/zookeys.688.13575
Figure 2 - Habitus of Eschatoporis styx sp. n.: A Dorsal B Lateral.
Figure 5 from: Aalbu RL, Kanda K, Smith AD (2017) Reinstatement of Eschatoporiini Blaisdell, 1906, a unique tribe of blind cavernicolous Tenebrionidae from California, with a new species from Napa County (Coleoptera, Tenebrionidae, Lagriinae). ZooKeys 688: 135-149. https://doi.org/10.3897/zookeys.688.13575
Figure 5 - Dorsal habitus of Eschatoporis nunenmacheri Blaisdell.
Figure 5 from: Deng H, Wen H, Xiao N, Zhou J (2016) A new blind species of the cave genus Oreonectes from Guizhou, China (Nemacheilinae). ZooKeys 637: 47-59. https://doi.org/10.3897/zookeys.637.10202
Figure 5 - Maximum likelihood phylogenetic trees of Nemacheilinae.
Figure 3 from: Deng H, Wen H, Xiao N, Zhou J (2016) A new blind species of the cave genus Oreonectes from Guizhou, China (Nemacheilinae). ZooKeys 637: 47-59. https://doi.org/10.3897/zookeys.637.10202
Figure 3 - Genetic distance between Oreonectes daqikongensis sp. n. and species of Nemacheilinae.
Figure 2 from: Deng H, Wen H, Xiao N, Zhou J (2016) A new blind species of the cave genus Oreonectes from Guizhou, China (Nemacheilinae). ZooKeys 637: 47-59. https://doi.org/10.3897/zookeys.637.10202
Figure 2 - Collection localities of Oreonectes daqikongensis sp. n.
Dataset for the EEG study of colocation in sighted and blind infants
<p> </p> <p><strong>Behavioural data</strong></p> <p>data_gori_colocationEEG_behav_unisensory.txt.</p> <p>Orienting responses and reaction times (RT) are reported, based on the scoring of two independent naive raters, for each trial of each subject(participant_id), group (SVI/S), posture (Uncrossed/Crossed), and sensory condition (Tactile only, Auditory only).</p> <p>Trial is the trial number, condition is the sensory condition, audio and tactile respectively refer to the side of the stimulated hand, response_status reports if the response is defined or undefined, trigger is the trigger denoting the stimulation in the EEG recording, response modality reports if the modality used by subjects to respond/not to respond to stimuli (hand, eye, both hands, no motion), group is if the subject was a sighted (S) or a severely visually impaired (SVI) infant, age is the age expressed in months, RT_rater1, RT_rater 2 and RT are respectively the RT assigned by the two raters and the merge of the two estimations (for RTs, the mean), the same organization for response_side, and for response_modality (for those variables, when the estimation of the two raters did not agree, the merged classification was set to unknown, that is uncertain/undefined).</p> <p> </p> <p><strong>EEG data</strong> </p> <p>eeglab_bids.zip</p> <p>EEG data of the study in BIDS format.</p> <p>conditions are coded as follows: posture (u=uncrossed, c= crossed), hand stimulated with audio (l=left, r=right, n=none), hand stimulated with touch (l=left, r=right, n=none), onset/offset of the stimuls, respectively 1/2; e.g. onset auditory stimulus not presented and tactile stimulus presented to left hand in uncorssed posture: u-an-tl-1.</p>
Figure 3 from: Wu T-J, Wei M-L, Lan J-H, Du L-N (2018) Triplophysa anshuiensis, a new species of blind loach from the Xijiang River, China (Teleostei, Nemacheilidae). ZooKeys 744: 67-77. https://doi.org/10.3897/zookeys.744.21742
Figure 3 Posterior chamber of air bladder of Triplophysa anshuiensis sp. n.
Figure 2 from: Wu T-J, Wei M-L, Lan J-H, Du L-N (2018) Triplophysa anshuiensis, a new species of blind loach from the Xijiang River, China (Teleostei, Nemacheilidae). ZooKeys 744: 67-77. https://doi.org/10.3897/zookeys.744.21742
Figure 2 Type locality of Triplophysa anshuiensis sp. n., a cave in Anshui Village, Guangxi, China.
Expression of Extraocular opsin Genes and Light-Dependent Basal Activity of Blind Cavefish
<p><strong>Background. </strong>Animals living in well-lit environments utilize optical stimuli for detecting visual information, regulating the homeostatic pacemaker, and controlling patterns of body pigmentation. In contrast, many subterranean animal species without optical stimuli have evolved regressed binocular eyes and body pigmentation. Interestingly, some fossorial and cave-dwelling animals with regressed eyes still respond to light. These light-dependent responses may be simply evolutionary residuals or they may be adaptive, where negative phototaxis provides avoidance of predator-rich surface environments. However, the relationship between these non-ocular light responses and the underlying light-sensing Opsin proteins has not been fully elucidated.</p> <p><strong>Methods. </strong>To highlight the potential functions of opsins in a blind subterranean animal, we used the Mexican cave tetra to investigate opsin gene expression in the eyes and several brain regions of both surface and cave-dwelling adults.<strong> </strong>We performed database surveys, expression analyses by quantitative reverse transcription PCR (RT-qPCR), and light-dependent locomotor activity analysis using pinealectomized fish, one of the high-opsin expressing organs of cavefish.</p> <p><strong>Results. </strong>Based on conservative criteria, we identified 33 opsin genes in the cavefish genome. Surveys of available RNAseq data found 26 of these expressed in the surface fish eye as compared to 24 expressed in cavefish extraocular tissues, 20 of which were expressed in the brain. RT-qPCR of 26 opsins in surface and cavefish eye and brain tissues showed the highest opsin-expressing tissue in cavefish was the pineal organ, which expressed exo-rhodopsin at 72.7 % of the expression levels in surface fish pineal. However, a pinealectomy resulted in no change to the light-dependent locomotor activity in juvenile cavefish and surface fish. Therefore, we conclude that, after 20,000 or more years of evolution in darkness, cavefish light-dependent basal activity is regulated by a non-pineal extraocular organ.</p>
Figure 9 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 9 - Iandumoema smeagol sp. n. Male (holotype): right leg IV, ventral view.
Figure 8 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 8 - Iandumoema smeagol sp. n. Male (holotype): right leg IV, dorsal view.
Figure 7 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 7 - Iandumoema smeagol sp. n. Male (holotype): right trochanter IV, dorsal view.
Figure 5 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 5 - Iandumoema smeagol sp. n. Male (holotype): habitus, ventral view.
Figure 3 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 3 - Photography of Iandumoema smeagol sp. n. Male (holotype): habitus, dorsal view.
Figure 4 from: Pinto-da-Rocha R, Fonseca-Ferreira R, Bichuette ME (2015) A new highly specialized cave harvestman from Brazil and the first blind species of the genus: Iandumoema smeagol sp. n. (Arachnida, Opiliones, Gonyleptidae). ZooKeys 537: 79-95. https://doi.org/10.3897/zookeys.537.6073
Figure 4 - Iandumoema smeagol sp. n. Male (holotype): habitus, right lateral view.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.