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2,800 results for “CD8+ T cells”
Potent anti-tumor immunity and reversal of CD8 T cell exhaustion by spatially and functionally targeting Treg cells in the tumor microenvironment
<p>1×10<sup>6</sup> of splenic GFP<sup>+</sup> Tregs were purified from WT (n=4) and KO mice (n=4) via FACS isolation. RNA was extracted using RNeasy Micro Kit (Qiagen) following its standard protocol and RNA degradation and contamination was monitored on 1% agarose gels. For RNA sequencing, libraries were prepared using NEBNext® Ultra TM RNA Library Prep Kit for Illumina® (NEB, USA) following manufacturer’s recommendations and index codes were added to attribute sequences to each sample. The clustering of the index-coded samples was performed on a cBot Cluster Generation System using PE Cluster Kit cBot-HS (Illumina) according to the manufacturer’s instructions. After cluster generation, the library preparations were sequenced on an Illumina platform and paired-end reads were generated. All samples were prepared at the same time and sequenced on the same lane. Original image data file from high-throughput sequencing platforms (like Illumina) is transformed to sequenced reads (called Raw Data or Raw Reads) by CASAVA base recognition (Base Calling). Raw data in FASTQ format were processed through fastp. In this step, clean data (clean reads) were obtained by removing reads containing adapter and poly-N sequences and reads with low quality from raw data. All the downstream analyses were based on the clean data with high quality. Reference mouse genome and gene model annotation files were downloaded from genome website browser (NCBI/UCSC/Ensembl). Paired-end clean reads were mapped against the reference genome using the Spliced Transcripts Alignment to a Reference (STAR) software. FeatureCounts was used to count the read numbers mapped of each gene. And then RPKM (Reads Per Kilobase of exon model per Million mapped reads) of each gene was calculated based on the length of the gene and reads count mapped to this gene. The FPKM gene expression matrix, R code, DEG list, and targeted gene list are uploaded in this project.</p>
Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study
ClinicalTrials.gov study NCT05875740. IPD Sharing: NO. Countries: 1. Publications: 0.
Immunotherapy of CD8+NKG2D+ AKT Cell With Chemotherapy to Pancreatic Cancer
ClinicalTrials.gov study NCT02929797. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Preliminary Study for Selective Detection of the CD8+ Myelin Specific T Cell in the Blood of Multiple Sclerosis Patients
ClinicalTrials.gov study NCT02142764. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors
ClinicalTrials.gov study NCT05902520. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous Cytomegalovirus (CMV) Specific CD8+ T Cells as Treatment for CMV Reactivation
ClinicalTrials.gov study NCT01326273. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adoptive Transfer of Specific HCC Antigens CD8+ T Cells for Treating Patients With Relapsed/Advanced HCC
ClinicalTrials.gov study NCT03175705. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
CD8 DLI for Patients With Relapse or Residual Disease Following Allogeneic Stem Cell Transplantation
ClinicalTrials.gov study NCT00038818. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
ClinicalTrials.gov study NCT06658379. IPD Sharing: NO. Countries: 1. Publications: 0.
Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS
ClinicalTrials.gov study NCT06043713. IPD Sharing: NO. Countries: 1. Publications: 0.
Nonmyeloablative Stem Cell Transplantation With CD8-depleted or Unmanipulated Peripheral Blood Stem Cells (PBSC)
ClinicalTrials.gov study NCT00693927. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express t
ClinicalTrials.gov study NCT01082926. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Functional Plasticity of Human IL-17-producing CD8+ T Cells
ClinicalTrials.gov study NCT03291639. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluate the Clinical Feasibility of a Novel Neoantigen-Reactive CD8+ T Cell (NART) Detection Technology for Postoperative MRD Surveillance of Pancreatic Cancer
ClinicalTrials.gov study NCT06941987. IPD Sharing: NO. Countries: 1. Publications: 0.
The Changes of CD8+T Cells Frequency and Function During Antiviral Therapy
ClinicalTrials.gov study NCT03209037. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor
ClinicalTrials.gov study NCT06105021. IPD Sharing: NO. Countries: 1. Publications: 0.
CD8+ T-cell PET/CT Imaging in COVID-19 Patients
ClinicalTrials.gov study NCT04874818. IPD Sharing: NO. Countries: 1. Publications: 0.
Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer
ClinicalTrials.gov study NCT06437574. IPD Sharing: NO. Countries: 1. Publications: 0.
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study
ClinicalTrials.gov study NCT02424916. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans
ClinicalTrials.gov study NCT04852289. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.