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1,472
datasets available to search
ShareScore release 0.9.0
Dataset results
1,472 results for “EGFR”
Myeloid EGFR deficiency accelerates recovery from Aki via macrophage efferocytosis and neutrophil apoptosis
GEO Series GSE261530. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Survival outcome of tyrosine kinase inhibitors beyond progression in association to radiotherapy in oligoprogressive EGFR-mutant non-small-cell lung cancer."
<p><strong>Aim:</strong> The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy in <em>EGFR</em>-mutated non-small-cell lung cancer patients experiencing disease progression under TKIs could be a valid an option. <strong>Patients & methods:</strong> We included 131 patients experiencing disease progression during first-line TKI. In group A, patients received TKI beyond progression and site(s) of progression were irradiated; in group B, patients remained on TKI alone beyond progression; and group C stopped TKI at first disease progression. <strong>Results:</strong> Median overall survival resulted longer in group A versus B and C (p < 0.0001). Group A had a trend toward a longer second progression-free survival (measured from the time of first progression until second progression) versus group B (p = 0.06). <strong>Conclusion:</strong> TKI beyond progression in association with local ablative treatment is a valid treatment option in oligoprogressive patients.</p> <p> </p> <p> </p>
Dataset related to article "Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC "
<p>This record contains raw data related to article “Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC"</p> <p>Molecular characterization of non-small-cell lung cancer (NSCLC) is essential to define the correct therapeutic algorithm in metastatic disease. Approximately 90% of epidermal growth factor receptor (EGFR) mutations are usually associated with sensitivity to EGFR tyrosine kinase inhibitors (TKIs). The remaining 10% defines a small, extremely heterogeneous subgroup of mutations, with a varied profile of sensitivity and response to target therapies.This retrospective observational study includes 47 patients affected by metastatic NSCLC harboring uncommon EGFR mutations (single or compound mutation). Patients were treated with EGFR-targeting TKIs or platinum-based chemotherapy as first-line treatment.Median OS resulted longer in the compound mutation group when compared to single rare mutations (33.6 vs 12 months; P = 0.473); a similar result was observed for PFS (16 vs 7.6 months; P = 0.281), although statistical significance was not reached. ORR, PFS and OS resulted similar for patients treated with first-line EGFR TKIs or chemotherapy. No difference in terms of PFS and OS was found according to the TKI administered.Compound mutations seem to be a good prognostic indicator for OS; they are also predictive of response to 1st and 2nd generation EGFR TKIs, as well as exon 19 insertions and mutations in codon 719 of exon 18. For mutations in exon 18 (not in codon 719) and exon 20 insertions, chemotherapy seems the most effective available option. The addition of immunotherapy to chemotherapy could change this approach in the next future.</p>
An Expanded Access Protocol for Mobocertinib in Refractory Non-small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Exon20 Insertion Mutations
ClinicalTrials.gov study NCT04535557. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer [mRNA]
GEO Series GSE125330. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
CD8+ T cell-1 dependent antitumor response boosted by dual blockade of PD-1 and VGFR2 following EGFR-tyrosine kinase inhibitors against lung cancer with Egfr mutation
GEO Series GSE197260. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Small cell neuroendocrine transdifferentiation in EGFR-mutant lung cancer evolving from mesenchymal drug-tolerant state
GEO Series GSE155157. Homo sapiens. 4 samples. Type: Expression profiling by array.
Epidermal Growth Factor Rejuvenates Aged Hematopoietic Stem Cells [EGFR Dominant Negative]
GEO Series GSE266959. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq shows the effect of EGFR-TKIs Dacomitinib on HaCaT cells
GEO Series GSE278965. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome reveals drug-resistance signature and immunosuppressive microenvironment in lung adenocarcinoma harboring EGFR mutation
GEO Series GSE253718. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Mapping EGFR-mediated local invasion and response to Cetuximab in head and neck cancer
GEO Series GSE273463. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
RNA-binding protein TRA2A promotes glioblastoma by mediating m6A RNA modification of IFITs to recycle p-EGFR
GEO Series GSE252489. Homo sapiens. 6 samples. Type: Other.
NCOA6 is a potent prostate cancer suppressor essential for NFY-mediated restriction of EGFR overexpression
GEO Series GSE155757. Mus musculus; Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
Scrambled Control and EGFR Knockdown Cells Cultured under Normoxia and Hypoxia
GEO Series GSE44804. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Transcriptional profiling of EGFR variants in mouse Glioblastoma model
GEO Series GSE183910. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
HER2 and EGFR dependent activation of RalA in breast cancer
GEO Series GSE19295. Homo sapiens. 8 samples. Type: Expression profiling by array.
Genetic, clinical, and biomarker correlates of EGFR inhibitor-related rash
GEO Series GSE115468. Homo sapiens. 50 samples. Type: Expression profiling by array.
C-ATF6 improves EGFR tyrosine kinase inhibitor sensitivity in non-small cell lung cancer via modulation of the calcium homeostasis network.
GEO Series GSE285632. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of gefitinib short-term resistance gene expression in EGFR mutant NSCLC cell lines
GEO Series GSE75309. Homo sapiens. 24 samples. Type: Expression profiling by array.
Mevastatin Promotes Healing by Targeting Caveolin-1 to Restore EGFR Signaling
GEO Series GSE137441. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.