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4,008 results for “Heart failure”
Study of Dapansutrile Capsules in Heart Failure
ClinicalTrials.gov study NCT03534297. IPD Sharing: NO. Countries: 1. Publications: 2.
B-lines-guided Heart Failure Management in Heart Failure Patients
ClinicalTrials.gov study NCT05035459. IPD Sharing: NO. Countries: 1. Publications: 2.
Cardiac Rehab for Advanced Heart Failure-LVAD Candidates
ClinicalTrials.gov study NCT03132441. IPD Sharing: NO. Countries: 1. Publications: 6.
Renal Hemodynamic Effects of RLX030A in Subjects With Chronic Heart Failure (CHF)
ClinicalTrials.gov study NCT01546532. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Hybrid Ablation of Atrial Fibrillation in Heart Failure
ClinicalTrials.gov study NCT05411614. IPD Sharing: NO. Countries: 1. Publications: 0.
Oxygen Pulse and Its Curve Patterns in Male Patients With Heart Failure and Chronic Obstructive Pulmonary Disease With and in Healthy Men
ClinicalTrials.gov study NCT05189301. IPD Sharing: NO. Countries: 1. Publications: 1.
Telemedical Interventional Monitoring in Heart Failure
ClinicalTrials.gov study NCT00543881. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Optimized Medico-pharmaceutical Collaboration in the Drug Management of Patients With Heart Failure
ClinicalTrials.gov study NCT03902028. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Prediction model of in-hospital mortality in intensive care unit patients with heart failure: machine learning-based, retrospective analysis of the MIMIC-III database
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Data from: Development and validation of warning system of ventricular tachyarrhythmia in patients with heart failure with heart rate variability data
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Data for: A numerical study of a left ventricular expander for heart failure with preserved ejection fraction
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Data from: Why do so few patients with heart failure participate in cardiac rehabilitation? A cross-sectional survey from England, Wales and Northern Ireland
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Adiponectin stimulates exosome release to enhance mesenchymal stem cell driven therapy of heart failure in mice
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Data from: Early prediction of in-hospital mortality in patients with congestive heart failure in intensive care unit: a retrospective observational cohort study
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HDL particle size and cholesterol content in Heart Failure. Supplementary Material
<p>Supplementary material corresponding to the article entitled Particle Size and Cholesterol Content of circulating HDL correlate with Cardiovascular Death in Chronic Heart Failure.</p>
The Ubiquitin Ligase WWP1 Contributes to Shifts in Matrix Proteolytic Profiles and a Myocardial Aging Phenotype with Diastolic Heart Failure
<p><strong><em>Aims</em></strong>. Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes consistent with the aging HFpEF phenotype.</p> <p><strong><em>Methods and Results.</em></strong> Global WWP1 O/E was achieved in mice (n=11) and echocardiography (40 MHz) performed to measure LV mass, EF, Doppler velocities (early-E, late/atrial-A), myocardial relaxation (E’), and isovolumetric relaxation time (IVRT) at 4, 6, and 8 weeks. Age matched wild type animals (n=15) were included as referent controls. LV EF was identical (60+1% vs 60+1%, p>0.90) with no difference in LV mass (67+3 vs 75+5, p>0.25) at 4 weeks. However, at 8 weeks of age, LV mass increased by over two-fold, E/A fell (impaired passive filling), and E/E’ was lower and IVRT prolonged (impaired LV relaxation) - all p<0.05. Collagen percent area increased by over two-fold and fibrillar collagen expression (rtPCR) by over 1.5 fold (p<0.05) with WWP1 O/E. WWP1 with an anti-WWP1 antibody could be identified in isolated cardiac fibroblasts with WWP1 increased by over two-fold in O/E fibroblasts (p<0.05).</p> <p><strong><em>Conclusion.</em></strong> Inducing WWP1 expression caused LVH, preserved systolic function, but impaired diastolic dysfunction, consistent with the HFpEF phenotype. Targeting the WWP1 pathway may be a novel therapeutic target for this intractable form of HF associated with aging.</p>
Raw data for the article: MicroRNA-30d and -483-3p for bi-ventricular remodelling and miR-126-3p for pulmonary hypertension in advanced heart failure
<p><strong>Aims: </strong>MicroRNAs play a role in pathogenic mechanisms leading to heart failure. We measured a panel of 754 miRNAs in the myocardial tissue and in the serum of patients with heart failure with reduced ejection fraction due to dilatative idiopathic cardiomyopathy (DCM, N = 10) or ischaemic cardiomyopathy (N = 3), referred to left ventricular assist device implant. We aim to identify circulating miRNAs with high tissue co-expression, significantly associated to echocardiographic and haemodynamic measures.</p> <p><strong>Methods and results: </strong>We have measured a panel of 754 miRNAs in the myocardial tissue [left ventricular (LV) apex] and in the serum obtained at the same time in a well selected study population of end-stage heart failure with reduced ejection fraction due to either DCM or ischaemic cardiomyopathy, referred to continuous flow left ventricular assist device implant. We observed moderate agreement for miR-30d, miR-126-3p, and miR-483-3p. MiR-30d was correlated to LV systolic as well as diastolic volumes (r = 0.78, P = 0.001 and r = 0.80, P = 0.005, respectively), while miR-126-3p was associated to mPAP and PCWP (r = -0.79, P = 0.007 and r = -0.80, P = 0.005, respectively). Finally, serum miR-483-3p had an association with right ventricular end diastolic diameter (r = -0.73, P = 0.02) and central venous pressure (CVP) (r - 0.68 p 0.03).</p> <p><strong>Conclusions: </strong>In patients with DCM, few miRNAs are co-expressed in serum and tissue: They are related to LV remodelling (miR-30d), post-capillary pulmonary artery pressure (miR-126-3p), and right ventricular remodelling/filling pressures (miR-483-3p). Further studies are needed to confirm their role in diagnosis, prognosis or as therapeutic targets in heart failure with reduced ejection fraction.</p>
Figure 1 from: Bak PG, Belenichev IF, Kucherenko LI, Abramov AV, Khromylоva OV (2021) Morpho-functional indicators changes of rats' myocardium in experimental doxorubicin-induced chronic heart failure and its pharmacological modulation with new 4-amino-1,2,4-triazole derivative. Pharmacia 68(4): 919-925. https://doi.org/10.3897/pharmacia.68.e75298
Figure 1 Hypothetical mechanism of the compound "Hypertril" positive effect on the morpho-functional parameters of rat cardiomyocytes in experimental doxorubicin-induced CHF.
DRUGS USED IN HEART FAILURE
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A COMPARISON OF HOSPITAL-BASED EXERCISE AND HOME-BASED TELE-EXERCISE TRAINING ON CAPILLARY BLOOD LACTATE PARAMETERS AND MAXIMUM OXYGEN VOLUME IN HEART FAILURE REDUCED EJECTION FRACTION PATIENTS
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.