Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
29,897
datasets available to search
ShareScore release 0.9.0
Dataset results
29,897 results for “activism”
Data from: Response to persistent er stress in plants: a multiphasic process that transitions cells from prosurvival activities to cell death
The unfolded protein response (UPR) is a highly conserved response that protects plants from adverse environmental conditions. The UPR is elicited by endoplasmic reticulum (ER) stress, in which unfolded and misfolded proteins accumulate within the ER. Here, we induced the UPR in maize (Zea mays) seedlings to characterize the molecular events that occur over time during persistent ER stress. We found that a multiphasic program of gene expression was interwoven among other cellular events, including the induction of autophagy. One of the earliest phases involved the degradation by regulated IRE1-dependent RNA degradation (RIDD) of RNA transcripts derived from a family of peroxidase genes. RIDD resulted from the activation of ZmIRE1 for promiscuous ribonuclease activity that attacks the mRNAs of secreted proteins. This was followed by an upsurge in expression of the canonical UPR genes indirectly driven by ZmIRE1 due to its splicing of Zmbzip60 to make an active transcription factor that directly upregulates many of the UPR genes. At the peak of UPR gene expression, a global wave of alternative RNA processing led to the production of many aberrant UPR gene transcripts, likely tempering the ER stress response. During later stages of ER stress, ZmIRE1's activity declined as did the expression of survival modulating genes, Bax inhibitor1 and Bcl-2-associated athanogene7, amidst a rising tide of cell death. Thus, in response to persistent ER stress, maize seedlings embark on a course of gene expression and cellular events progressing from adaptive responses to cell death.
Training of 7-month-old infants' manual object exploration skills: Effects of active and observational experience
<p>Dataset representing the data of the paper "Training of 7-month-old infants' manual object exploration skills: Effects of active and observational experience."</p>
Movement patterns and activity levels are shaped by the neonatal environment in Antarctic fur seal pups
<p>All data for the article "Movement patterns and activity levels are shaped by the neonatal environment in Antarctic fur seal pups", published in Scientific Reports.</p> <p>Both the raw data (csv files labelled with individual ID) and the collated data (allData.csv, data5min.csv, furSeals_finalData.csv) are provided. Please see the “README.txt” file for more information on what each raw data file contains. The RMarkddown.pdf includes all code used in the manuscript. If you have any further questions, please don’t hesitate to contact me (Rebecca Nagel) at renagel2@gmail.com.</p>
Data from: Stability of spontaneous, correlated activity in mouse auditory cortex
<p>Neural systems can be modeled as complex networks in which neural elements are represented as nodes linked to one another through structural or functional connections. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system's topological organization and to better understand its function. Here, we used two-photon calcium imaging to record spontaneous activity from the same set of cells in mouse auditory cortex over the course of several weeks. We reconstruct functional networks in which cells are linked to one another by edges weighted according to the correlation of their fluorescence traces. We show that the networks exhibit modular structure across multiple topological scales and that these multi-scale modules unfold as part of a hierarchy. We also show that, on average, network architecture becomes increasingly dissimilar over time, with similarity decaying monotonically with the distance (in time) between sessions. Finally, we show that a small fraction of cells maintain strongly-correlated activity over multiple days, forming a stable temporal core surrounded by a fluctuating and variable periphery. Our work indicates a framework for studying spontaneous activity measured by two-photon calcium imaging using computational methods and graphical models from network science. The methods are flexible and easily extended to additional datasets, opening the possibility of studying cellular level network organization of neural systems and how that organization is modulated by stimuli or altered in models of disease.</p>
Data from: Spatiotemporally precise optogenetic activation of sensory neurons in freely walking Drosophila
<p>Previous work has characterized how walking <i>Drosophila</i> coordinate the movements of individual limbs (DeAngelis, Zavatone-Veth, and Clark, 2019). To understand the circuit basis of this coordination, one must characterize how sensory feedback from each limb affects walking behavior. However, it has remained difficult to manipulate neural activity in individual limbs of freely moving animals. Here, we demonstrate a simple method for optogenetic stimulation with body side-, body segment-, and limb-specificity that does not require real-time tracking. Instead, we activate at random, precise locations in time and space and use post hoc analysis to determine behavioral responses to specific activations. Using this method, we have characterized limb coordination and walking behavior in response to transient activation of mechanosensitive bristle neurons and sweet-sensing chemoreceptor neurons. Our findings reveal that activating these neurons has opposite effects on turning, and that activations in different limbs and body regions produce distinct behaviors.</p>
Habitat complexity dampens selection on prey activity level
<p>Conspecific prey individuals often exhibit persistent differences in behavior (i.e., animal personality) and consequently vary in their susceptibility to predation. How this form of selection varies across environmental contexts is essential to predicting ecological and evolutionary dynamics, yet remains currently unresolved. Here, we use three separate predator–prey systems (sea star–snail, wolf spider–cricket, and jumping spider–cricket) to independently examine how habitat structural complexity influences the selection that predators impose on prey behavioral types. Prior to conducting staged predator–prey interaction encounters, we ran prey individuals through multiple behavioral assays to determine their average activity level. We then allowed individual predators to interact with groups of prey in either open or structurally complex habitats and recorded the number and individual identity of prey that were eaten. Habitat complexity had no effect on overall predation rates in any of the three predator–prey systems. Despite this, we detected a pervasive interaction between habitat structure and individual prey activity level in determining individual prey survival. In open habitats, all predators imposed strong selection on prey behavioral types: sea stars preferentially consumed sedentary snails, while spiders preferentially consumed active crickets. Habitat complexity dampened selection within all three systems, equalizing the predation risk that active and sedentary prey faced. These findings suggest a general effect of habitat complexity that reduces the importance of prey activity level in determining individual predation risk. We reason this occurs because activity level (i.e., movement) is paramount in determining risk within open environments, whereas in complex habitats, other behavioral traits (e.g., escape ability to a refuge) may take precedence.</p>
Insecticidal activity of Lantana camara extract oil on controlling maize grain weevils
<p>Currently farmers are faced by serious post-harvest problems from weevils especially in storage of grains. When grains exposed to insects they become less marketable and loss quality of grain. In this study the insecticidal property of methanol, ethanol and ethyl acetate extracted oil from Lantana Camara leaf for controlling of maize weevils, Sitophilus Zeamais were studied. Gas Chromatography-Mass spectrometry (GC-MS) and Fourier transform infrared spectroscopy (FT-IR) was used to identify the chemical composition and Functional group of solvent extracted oil respectively. Adult weevil's repellency and mortality were studied by the effect of extract oil concentration at 0% (w/w), 2% (w/w), 3% (w/w), 5% (w/w), 7% (w/w), and 10% (w/w) to weight of grain maize and exposed days. Repellency effect was also conducted at 6, 12 and 24 h at different concentration oil. The number of weevil's death increases significantly as exposed time increases. The extracted oil by the three-solvent fraction had direct repellent and toxic effect to the weevil. From all treatment applied, extracted by methanol fraction had showed highest percentage mortality (74%). The lowest mortality rate was observed in ethyl acetate fraction oil (26%), at 2% (w/w) concentration. The effect of lantana Camara leaf powder and extracted oil on repellency and mortality was showed directly proportional to concentration dosage.</p>
Detailed data sets of MMP-cliffs, SAR transfer series, RECAP-MMPs and compound activities
<p>An up-to-date version of three MMP-based data sets derived from compounds included in the latest release of ChEMBL is presented. These data sets include activity cliffs, structure-activity relationship (SAR) transfer series, and second generation MMPs based upon retrosynthetic rules. The structural data and information are provided in eight different files comprising the data sets of MMP-cliffs, SAR transfer series, and RECAP-MMPs. Compound activities are incorporated in files of RECAP-MMPs. For transfer series, substituted fragments are also provided. All MMP-cliffs, SAR transfer series with approximate or regular potency progression, and RECAP-MMPs are provided in canonical SMILES representation on a per-target basis separately for the Ki and IC50 subsets. The corresponding files are clearly designated.</p>
Supporting data for: A linear response, DFT+U study of trends in the oxygen evolution activity of transition metal rutile dioxides
<p>This directory contains all of the finished calculations required for fully analysis of the paper "A linear response, DFT+U study of trends in the oxygen evolution activity of transition metal rutile dioxides" by Zhongnan Xu, Jan Rossmeisl, and John R Kitchin. To use this repository, download the supporting information file and run the scripts present in either 'supporting-information.pdf' or 'supporting-information.org'.</p> <p>The is the release of the supporting data before the first submission to the first journal.</p>
Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity
<p>Details of the conditional probability calculations on exemplary the matrix provided in Figure 3 of the publication (see Gupta-Ostermann, Hirose, Odagami & Bajorath, Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity, F1000Research 2015, 4:75 , DOI: 10.12688/f1000research.6271.1 ) is provided in an excel sheet. </p> <p>Informative SARMs from the PRISM library are included. Due to proprietary issues the structural information of compounds is not included. Key and value fragments of SARMs are provided with an identifier.</p>
Currently available 3D activity cliffs and 2D-analogs of 3D-cliff compounds
<p>Three dimensional activity cliffs (3D-cliffs) were systematically determined based on currently available X-ray structures in PDB. The list of all 236, 292, 595 3D-cliffs that were identified from the K<sub>i</sub>, IC<sub>50</sub>, and K<sub>i</sub>/IC<sub>50</sub> sets, respectively, is provided. In addition, on the basis of matched molecular pairs, the 2D structural analogs of 3D-cliff compounds identified from ChEMBL database (release 19) are given.</p>
Sets of ChEMBL compounds with high or low confidence activity data
<p>Two sets of compounds assembled from ChEMBL release 20 that were annotated with high or low confidence activity data were provided in separate files. For each compound in a file, the unique compound identifier (i.e., molregno), the number of targets in individual years (from 1976 to 2014) and the list of target annotations (if any) was given.</p>
Compounds with multi-target activities forming target cliffs and selectivity cliffs
<p>On the basis of high-confidence activity data assembled from ChEMBL release 20, compounds active against one or more pairs of targets are provided (in the file 'Compounds_In_Target_Pairs.xlsx') for the K<sub>i</sub> and IC<sub>50</sub> value-based data sets, respectively. Target cliffs formed by selective compounds are listed in the file 'Target_Cliffs.xlsx'. In addition, selectivity cliffs formed by structurally analogous compounds with significantly different selectivity are given in the file 'Selectivity_Cliffs.xlsx'. The content of individual files is detailed in the README file.</p>
Multielectrode array recordings of spontaneous activity in developing neuronal cultures
<p>These data are to accompany the following paper:</p> <p>Charlesworth P, Morton A, Eglen SJ, Komiyama NH, Grant SGN (2015) Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns. Neuropharmacology</p> <p>Available at: http://dx.doi.org/10.1016/j.neuropharm.2015.07.027.</p> <p> </p> <p>For further details about the data, please see h<span>ttp://damtp.cam.ac.uk/user/sje30/papers/charlesworth2015_data.pdf</span></p>
Angiotensin II status and sympathetic activation among hypertensive patients in Uganda: a cross-sectional study
<p>A cross sectional study conducted at Mulago, the national referral hospital. Blood samples were taken to measure angiotensin II, metanephrines, normetanephrines and urine samples for creatinine and sodium. The angiotensin II categories were defined using the Mosby's Diagnostic and Laboratory Test References. 9th ed while the metanephrines and normetanephrine cartegories were defined using the Makerere University Biosafety II Immunology Laboratory reference values.</p>
Dataset for: Spinal motion and muscle activity during active trunk movements - comparing sheep and humans adopting upright and quadrupedal postures
<p>Datasets used for the manuscript "Spinal motion and muscle activity during active trunk movements - comparing sheep and humans adopting upright and quadrupedal postures", accepted in PLOS ONE</p>
Activity classes from different categories
<p>A total of 102 activity classes (ACs) were assembled from ChEMBL version 20 and were classified as “easy” (i.e. yielded generally high compound recall using different fingerprints in benchmarking calculations), “preferred/intermediate” (moderate compound recall), and “difficult” (low compound recall). In addition, 10000 randomly selected ZINC compounds were provided. For each compound, both MACCS and ECFP4 fingerprints were given. Furthermore, the general information for these ACs was provided in the excel file.</p> <p> </p> <p> </p>
Compound activity records associated with original publications in ChEMBL 21
<p>Provided are two sets of compound activity records (set 1 and set 2) that were traced back to original publications and assembled from ChEMBL release 21. For each compound-target combination, the corresponding potency measurements and publications are provided. In addition, the list of unique publications is given for both sets 1 and 2.</p>
East-African Social Sciences and Humanities Journals active in 2008-2009
<p>Research Data of „East-African Social Sciences and Humanities Publishing: A Handmade Bibliometrics Approach“, Proceedings of the 21st International Conference on Science and Technology Indicators, València (Spain), September 14-16, 2016.</p> <p>Abstract of the paper: For Eastern Africa, very little information about the SSH knowledge production can be found from a European perspective. Adequate indicators like information-rich bibliographic databases that cover East-Africa-based journals and book publishers are lacking. This research in progress explores their indexing situation in detail, their development, which is closely connected to political history, their (non-)usage, and affiliations as well as career-stages of their authors. Furthermore, it also pays attention to East-Africa-based SSH researchers who use other publication venues. Any bibliometric analysis in this field needs to rely on manual data collection, otherwise it would be heavily biased. This study lays out the foundation for citation analyses, qualitative research on the publications' content and the self-description of East-African scholars against the background of an academic environment that is often described as “international”.</p>
East-African Social Sciences and Humanities Journals active in 2008-2009
<p>Research Data of „East-African Social Sciences and Humanities Publishing: A Handmade Bibliometrics Approach“, Proceedings of the 21st International Conference on Science and Technology Indicators, València (Spain), September 14-16, 2016.</p> <p>Abstract of the paper: For Eastern Africa, very little information about the SSH knowledge production can be found from a European perspective. Adequate indicators like information-rich bibliographic databases that cover East-Africa-based journals and book publishers are lacking. This research in progress explores their indexing situation in detail, their development, which is closely connected to political history, their (non-)usage, and affiliations as well as career-stages of their authors. Furthermore, it also pays attention to East-Africa-based SSH researchers who use other publication venues. Any bibliometric analysis in this field needs to rely on manual data collection, otherwise it would be heavily biased. This study lays out the foundation for citation analyses, qualitative research on the publications' content and the self-description of East-African scholars against the background of an academic environment that is often described as “international”.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.