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2,721 results for “CONNECTIVITY”

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zenodo28/100

STRIDE Project C - Performance Measurement and Management Using Connected and Automated Vehicle Data

<p>The main objective of this study is to develop a methodological framework to estimate system performance measurements using CV data. The study also provides a validation of the framework as a proof of concept by determining performance measurements from traditional and CV data. In doing so, the microscopic simulation software VISSIM with trajectory conversion algorithm (TCA) is used to generate CV data, particularly basic safety message (BSM) for a study corridor located in Birmingham, AL. The estimated performance measures can be used by a system operator, planner, or an automated system to support decisions associated with these processes. The measurements can be also used to derive information for dissemination to travelers, third-party data aggregators, traveler information service providers, and other agencies.&nbsp; The collected and archived data includes real-world data collected from different sources in addition to simulation model results.</p>

opencc-by-4.0Apr 2020View details →
zenodo28/100

Side views of nose-leaves, showing the principal forms of the connecting process in the _R7z. simpleX group (a) and the Rh. lepidus group (6, c, d). a. Rh. borneensis typicus\ b. Rh. cornutus pumilus; c. Rh. monoceros; d. Rh. empusa. in On some Bats of the Genus Rhinolophus, with Remarks on their Mutual Affinities, and Descriptions of Twenty-six new Forms.

Side views of nose-leaves, showing the principal forms of the connecting process in the _R7z. simpleX group (a) and the Rh. lepidus group (6, c, d). a. Rh. borneensis typicus\ b. Rh. cornutus pumilus; c. Rh. monoceros; d. Rh. empusa.

opencc-by-4.0Dec 1905View details →
zenodo28/100

A dataset of long-term consistency values of resting-state fMRI connectivity maps in a single individual derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol

<p>This dataset contains preprocessed resting state fMRI data (.nii.gz) with accompanying confound files (.tsv) from the Single Individual volunteer for Multiple Observations across Networks (SIMON; http://fcon_1000.projects.nitrc.org/indi/retro/SIMON.html) dataset that has been minimally preprocessed using the NeuroImaging Analysis Kit (NIAK; http://niak.simexp-lab.org/build/html/PREPROCESSING.html). Preprocessing steps included:&nbsp; (1) Slice timing correction; (2) Estimation of rigid-body motion in fMRI runs, both within- and between sessions; (3) Linear or non-linear coregistration of the structural scan in stereotaxic space; (4) Individual coregistration between structural and functional scans; (5) Resampling of functional scans in stereotaxic space. Confound files (.tsv) have been included for purposes of scrubbing and regression of confounds using NIAK or other analysis software, allowing for further processing without conflicts.</p>

opencc-by-4.0Apr 2020View details →
zenodo28/100

Fig. 1 in Connecting systematic and ecological studies using DNA barcoding in a population survey of Drosophilidae (Diptera) from Mt Oku (Cameroon)

Fig. 1. Percent success and failure in obtaining a COI sequence from specimens. A. Total number of flies in the sample. B. Date of field collection (month indicated in lowercase Roman numerals). n = number of specimens used.

opencc-by-3.0Feb 2017View details →
zenodo28/100

How Do Data Archives Stay Connected to User Needs?

<p>This video has been realized in occasion of the CESSDA Training Days 2019. The CESSDA Training Days were a two-day training event showcasing diverse training resources on both CESSDA tools and services. They took place on November 27 and 28, 2019, and were hosted by the GESIS &ndash; Leibniz-Institute for the Social Sciences in Cologne, Germany.</p> <p>In this video, Jonas Recker discusses the concept of the &ldquo;Designated Community&rdquo; from the OAIS Reference Model.</p> <p>The video is also available for <a href="https://youtu.be/mTnz47X02U4">viewing on Youtube</a>.</p>

opencc-by-4.0Jun 2020View details →
zenodo28/100

Effect of Unloading and Reloading on Bearing Strength of Unconfined Cold-formed Steel Bolted Connections

<p>This database&nbsp;presents the experimental investigation of cold-formed steel unconfined double-shear bolted connections where the applied load was stopped at different stages of loading (25% or 65% of the ultimate failure load under monotonic loading) followed by unloading, and finally reloading until failure. A total of 78 bolted connections of cold-formed steel subjected to loading-unloading and reloading condition with sheet thicknesses ranging from 0.55 to 3.0 mm, bolted with 10, 12 or 16 mm bolts were investigated.</p>

opencc-by-4.0Jul 2020View details →
dryad28/100

Data from: Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.

Objective: The purpose of this cross-sectional study was to investigate the contributions of altered cerebellar resting-state functional connectivity (FC) to cognitive impairment in Parkinson disease (PD). Methods: We conducted morphometric and resting-state functional connectivity MRI (FC-MRI) analyses contrasting 81 PD and 43 age-matched healthy controls using rigorous quality assurance measures. To investigate the relationship of cerebellar FC to cognitive status, we compared PD participants without cognitive impairment (Clinical Dementia Rating scale, CDR=0; n=47) to PD participants with impaired cognition (CDR≥0.5; n=34). Comprehensive measures of cognition across the five cognitive domains were assessed for behavioral correlations. Results: The PD participants had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. In contrast, weaker FC between vermis and dorsolateral prefrontal cortex was found in the cognitively impaired PD group compared to PD participants without cognitive impairment. This effect correlated with deficits in attention, executive functions and global cognition. No group differences in cerebellar lobular volumes or regional cortical thickness of the significant cortical clusters were observed. Conclusion: These results demonstrate a correlation between cerebellar vermal FC and cognitive impairment in PD. The absence of significant atrophy in cerebellum or relevant cortical areas suggests this could be related to local pathophysiology such as neurotransmitter dysfunction.

opencc-zeroJul 2020View details →
dryad28/100

Evolution of the speech‐ready brain: The voice/jaw connection in the human motor cortex

<p>A prominent model of the origins of speech, known as the "frame/content" theory, posits that oscillatory lowering and raising of the jaw provided an evolutionary scaffold for the development of syllable structure in speech. Because such oscillations are non‐vocal in most non‐human primates, the evolution of speech required the addition of vocalization onto this scaffold in order to turn such jaw oscillations into vocalized syllables. In the present functional MRI study, we demonstrate overlapping somatotopic representations between the larynx and the jaw muscles in the human primary motor cortex. This proximity between the larynx and jaw in the brain might support the coupling between vocalization and jaw oscillations to generate syllable structure. This model suggests that humans inherited voluntary control of jaw oscillations from ancestral species, but added voluntary control of vocalization onto this via the evolution of a new brain area that came to be situated near the jaw region in the human motor cortex.</p>

opencc-zeroAug 2020View details →
dryad28/100

Data from: Habitat suitability and connectivity modeling reveal priority areas for Indiana bat (Myotis sodalis) conservation in a complex habitat mosaic

Context <p>Conservation for the Indiana bat (<i>Myotis sodalis), </i>a federally endangered species in the United States of America, is typically focused on local maternity sites; however, the species is a regional migrant, interacting with the environment at multiple spatial scales. Hierarchical levels of management may be necessary, but we have limited knowledge of landscape-level ecology, distribution, and connectivity of suitable areas in complex landscapes.</p> Objectives <p>We sought to 1) identify factors influencing <i>M. sodalis </i>maternity colony distribution in a mosaic landscape, 2) map suitable maternity habitat, and 3) quantify connectivity importance of patches.</p> Methods <p>Using 3 decades of occurrence data, we tested <i>a priori</i>,<i> </i>hypothesis-driven<i> </i>habitat suitability models. We mapped suitable areas and quantified connectivity importance of habitat patches with probabilistic habitat availability metrics.</p> Results <p>Factors improving landscape-scale suitability included limited agriculture, more forest cover, forest edge, proximity to medium-sized water bodies, lower elevations, and limited urban development. Areas closer to hibernacula and rivers were suitable. Binary maps showed that thirty percent of the study area was suitable for <i>M. sodalis</i> and 29% was important for connectivity. Most suitable patches were important for intra-patch connectivity and far fewer contributed to inter-patch connectivity.</p> Conclusions <p>While simple models may be effective for small, homogenous landscapes, complex models are needed to explain habitat suitability in large, mixed landscapes. Suitability modeling identified factors that made sites attractive as maternity areas. Connectivity analysis improved our understanding of important areas for bats, identified suitable patches that may be isolated from the habitat network, and prioritized areas to target restoration.</p>

opencc-zeroSep 2020View details →
dryad28/100

Data from: Genetic connectivity of Lionfish (Pterois volitans) in marine protected areas of the Gulf of Mexico and Caribbean Sea

<p><span><span><span><span><span><span><span><span><span><span><span>Lionfish (<i>Pterois volitans</i>) have rapidly invaded the tropical Atlantic and spread across the wider Caribbean in a relatively short period of time. Because of its high invasion capacity, we used it as a model to identify the connectivity among nine marine protected areas (MPAs) situated in four countries in the Gulf of Mexico and the Caribbean Sea.<span class="MsoBookTitle"><span><span><span><span><span><span><span><span><span><span><span><span>This study provides evidence of local genetic differentiation of <i>P. volitans</i>in the Gulf of Mexico and the Caribbean Sea.</span></span></span></span></span></span></span></span></span></span></span></span></span>A total of 475 lionfi</span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>s</span></span></span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span><span><span>h samples were characterized with 12 microsatellites, with 6 to 20 alleles per locus. Departures from Hardy-Weinberg equilibrium (HWE) were found in 10 of the 12 loci, all caused by heterozygous excess. Moderate genetic differentiation was observed between Chiriviche, Venezuela and Xcalak , México localities (F<sub>ST</sub>= 0.012), and between the Los Roques and Veracruz (F<sub>ST</sub>= 0.074) sites. STRUCTURE analysis found that four genetic entities best fit our data. A unique genetic group in the Gulf of Mexico may imply that the lionfish invasion unfolded both in a counter-clockwise manner in the Gulf of Mexico<span><span>.</span></span>In spite of thenotable dispersion of <i>P. volitans</i>, our results show some genetic structure, as do other noninvasive Caribbean fish species, suggesting that the connectivity in some MPAs analyzed in the Caribbean is limited and caused by only a few source individuals with subsequent genetic drift leading to local genetic differentiation. This indicates that <i>P. volitans</i>dispersion could be caused by mesoscale phenomena, which produce stochastic connectivity pulses. Due to the isolation of some MPAs from others, these findings may hold a promise for local short-term control of by means of intensive fishing, even in MPAs, and may have regional long-term effects.</span></span></span></span></span></span></span></span></span></span></span></p>

opencc-zeroOct 2020View details →
dryad28/100

Using stable isotopes to estimate migratory connectivity for a patchily distributed, wetland-associated Neotropical migrant

<p>Estimates of migratory connectivity are needed for full annual cycle population models of migratory bird species experiencing rapid declines in abundance. One technique to determine migratory connectivity is through stable isotope analysis. This low-resolution method may be influenced by how data are calibrated between isotopes measured in precipitation and those measured in feathers, and can be informed by incorporating relative abundance into the assignment model. eBird abundance maps are a new tool combining citizen science data into a predictive species distribution model. In the Prothonotary Warbler (Protonotaria citrea), a wetland-associated songbird with a patchy breeding distribution, we sought to use stable-hydrogen isotope analysis informed by a species-specific calibration equation and eBird abundance data to determine the strength of migratory connectivity. We developed a species-specific calibration equation using known-origin samples from the breeding grounds and found that stable-hydrogen isotope values measured in precipitation explained 50% of the variation in stable-hydrogen isotope values among feathers. We found that the assignment model incorporating eBird abundance data correctly identified the true origins of 66% of individuals, and that the average assignment area (as a measure of precision) was 64% of the breeding distribution. These results represented a 7% increase in precision and a 3% decrease in accuracy when compared to a model that was not informed by abundance. Based on these models, wintering populations from 6 countries represented a mix of likely breeding origins, suggesting low migratory connectivity for Prothonotary Warblers. We found evidence that wintering latitude was related to likely breeding origin, with individuals at western wintering locations more likely to have southern breeding origins, but this relationship was weak. These results corroborate studies using archival light-level geolocators and high-resolution genetic markers, which also demonstrated weak migratory connectivity in this species. For patchily distributed species, eBird abundance data may not provide a useful increase in precision and accuracy for isotope assignments.</p>

opencc-zeroNov 2020View details →
dryad28/100

Urban specialization reduces habitat connectivity by a highly mobile wading bird

<p>Background</p> <p>Mobile animals transport nutrients and propagules across habitats, and are crucial for the functioning of food webs and for ecosystem services. Human activities such as urbanization can alter animal movement behavior, including site fidelity and resource use. Because many urban areas are adjacent to natural sites, mobile animals might connect natural and urban habitats. More generally, understanding animal movement patterns in urban areas can help predict how urban expansion will affect the roles of highly mobile animals in ecological processes.</p> <p>Methods</p> <p>Here, we examined movements by a seasonally nomadic wading bird, the American white ibis (Eudocimus albus), in South Florida, USA. White ibis are colonial wading birds that forage on aquatic prey; in recent years, some ibis have shifted their behavior to forage in urban parks, where they are fed by people. We used a spatial network approach to investigate how individual movement patterns influence connectivity between urban and non-urban sites. We built a network of habitat connectivity using GPS tracking data from ibis during their non-breeding season and compared this network to simulated networks that assumed individuals moved indiscriminately with respect to habitat type.</p> <p>Results</p> <p>We found that the observed network was less connected than the simulated networks, that urban-urban and natural-natural connections were strong, and that individuals using urban sites had the least-variable habitat use. Importantly, the few ibis that used both urban and natural habitats contributed the most to connectivity.</p> <p>Conclusions</p> <p>Habitat specialization in urban-acclimated wildlife could reduce the exchange of propagules and nutrients between urban and natural areas, which has consequences both for beneficial effects of connectivity such as gene flow and for detrimental effects such as the spread of contaminants or pathogens.</p>

opencc-zeroDec 2019View details →
dryad28/100

Urban versus rural? The effects of residential status on species identification skills and connection to nature

<p>1. Urbanization and urban lifestyles increasingly disconnect people from nature in a process that was termed the 'extinction of experience'. This loss of human-nature interactions can undermine both cognitive (ecological knowledge) and affective (emotional connection to nature) relations to nature, further impacting capabilities to experience, care for, benefit from and act to protect nature. Yet, the extent to which the urban life influences both cognitive and affective relations to nature, remains poorly understood and research is confined to a few countries and cultures.</p> <p>2. We explored how cognitive and affective relations to nature can be related to people's childhood and current place of residency. We expected that urban dwellers, who have less opportunities to experience nature than their rural counterparts, will be less connected to nature and demonstrate lower ecological knowledge than their rural counterparts.</p> <p>3. We conducted four surveys in Israel, in urban and rural settings between 2015 and 2018 (N= 1706) to measure and compare (urban vs. rural) the following variables: (1) species identification skills (correctly identified); (2) familiarity (recognized), as two measures of cognitive relation with nature and (3) nature relatedness, as a measure of emotional connection to nature.</p> <p>4. The ability to identify common plant, bird and butterfly species was poor in general (Av.=3.83 out of 12), and lower for urban dwellers (Av.=2.48) compared to their rural counterparts (Av.=6.56). Differences in correct species identifications between urban and rural dwellers varied with taxa and peaked for butterflies (only 26 respondents managed to identify one species or more). We also identified an important gap between familiarity and species identification skills, especially for urban residents. Finally, people who currently live or used to live in rural areas during their childhood had higher scores of nature relatedness than their urban counterparts.</p> <p>5. Our results highlight that decreased opportunity to interact with nature reduces cognitive and affective relations to nature. Such reductions can affect the overall preferences for human-nature relationships and exacerbate a pervasive negative cycle that modifies relational values such as, care for nature, sense of belonging, place and identity that influence both humans well-being and environmental stewardship.     </p>

opencc-zeroDec 2020View details →
dryad28/100

Evolutionary stability, landscape heterogeneity, and human land-usage shape population genetic connectivity in the Cape Floristic Region biodiversity hotspot

<p>As human-induced change eliminates natural habitats, it impacts genetic diversity and population connectivity for local biodiversity. The South African Cape Floristic Region (CFR) is the most diverse extratropical area for plant biodiversity, and much of its habitat is protected as a UNESCO World Heritage site. There has long been great interest in explaining the underlying factors driving this unique diversity, especially as much of the CFR is endangered by urbanization and other anthropogenic activity. Here, we use a population and landscape genetic analysis of SNP data from the CFR endemic plant <i>Leucadendron salignum</i> or "common sunshine conebush" as a model to address the evolutionary and environmental factors shaping the vast CFR diversity. We found that high population structure, along with relatively deeper and older genealogies, are characteristic of the southwestern CFR, whereas, low population structure and more recent lineage coalescence depicts the eastern CFR. Population network analyses show genetic connectivity is facilitated in areas of lower elevation and higher seasonal precipitation. These population genetic signatures corroborate CFR species-level patterns consistent with high Pleistocene biome stability and landscape heterogeneity in the southwest, but with coincident instability in the east. Finally, we also find evidence of human land-usage as a significant gene flow barrier, especially in severely-threatened lowlands where genetic connectivity has been historically the highest. These results help identify areas where conservation plans can prioritize protecting high genetic diversity threatened by contemporary human activities within this unique cultural UNESCO site.</p>

opencc-zeroDec 2020View details →
dryad28/100

By animal, water, or wind: can dispersal mode predict genetic connectivity in riverine plant species?

<div class="page"> <div class="section"> <div class="layoutArea"> <div class="column"> <p>Seed dispersal is crucial to gene flow among plant populations. Although the effects of geographic distance and barriers to gene flow are well studied in many systems, it is unclear how seed dispersal mediates gene flow in conjunction with interacting effects of geographic distance and barriers. To test whether distinct seed dispersal modes (i.e. hydrochory, anemochory, and zoochory) have a consistent effect on the level of genetic connectivity (i.e., gene flow) among populations of riverine plant species, we used unlinked single-nucleotide polymorphisms (SNPs) for eight co-distributed plant species sampled across the Rio Branco, a putative biogeographic barrier in the Amazon Basin. We found that animal-dispersed plant species exhibited higher levels of genetic diversity and lack of inbreeding as a result of the stronger genetic connectivity than plant species whose seeds are dispersed by water or wind. Interestingly, our results also indicated that the Rio Branco facilitates gene dispersal for all plant species analyzed, irrespective of their mode of dispersal. Our findings indicate that seed dispersal mode and riverscape features can greatly impact genetic structure, representing reliable predictors of genetic connectivity in riverine plant species. These results may help improve conservation and management policies in Amazonian riparian forests, where degradation and deforestation rates are high.</p> </div> </div> </div> </div>

opencc-zeroJan 2021View details →
dryad28/100

Data from: Interactions between demography, genetics, and landscape connectivity increase extinction probability for a small population of large carnivores in a major metropolitan area

The extinction vortex is a theoretical model describing the process by which extinction risk is elevated in small, isolated populations owing to interactions between environmental, demographic, and genetic factors. However, empirical demonstrations of these interactions have been elusive. We modelled the dynamics of a small mountain lion population isolated by anthropogenic barriers in greater Los Angeles, California, to evaluate the influence of demographic, genetic, and landscape factors on extinction probability. The population exhibited strong survival and reproduction, and the model predicted stable median population growth and a 15% probability of extinction over 50 years in the absence of inbreeding depression. However, our model also predicted the population will lose 40–57% of its heterozygosity in 50 years. When we reduced demographic parameters proportional to reductions documented in another wild population of mountain lions that experienced inbreeding depression, extinction probability rose to 99.7%. Simulating greater landscape connectivity by increasing immigration to greater than or equal to one migrant per generation appears sufficient to largely maintain genetic diversity and reduce extinction probability. We provide empirical support for the central tenet of the extinction vortex as interactions between genetics and demography greatly increased extinction probability relative to the risk from demographic and environmental stochasticity alone. Our modelling approach realistically integrates demographic and genetic data to provide a comprehensive assessment of factors threatening small populations.

opencc-zeroDec 2015View details →
dryad28/100

Data from: Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity

Objective: The purpose of this study was to characterize the functional brain changes involved in THC modulation of chronic neuropathic pain. Methods: Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed at baseline and after sublingual THC administration. We examined functional connectivity of the anterior cingulate cortex (ACC) and pain related network dynamics using graph theory measures. Results: THC significantly reduced patients' pain compared to placebo. THC-induced analgesia was correlated with a reduction in functional connectivity between the anterior cingulate cortex (ACC) and the sensorimotor cortex. Moreover, the degree of reduction was predictive of the response to THC. Graph theory analyses of local measures demonstrated reduction in network connectivity in areas involved in pain processing, and specifically in the dorsolateral prefrontal cortex (DLPFC), which were correlated with individual pain reduction. Conclusions: These results suggest that the ACC and DLPFC, two major cognitive-emotional modulation areas, and their connections to somatosensory areas, are functionally involved in the analgesic effect of THC in chronic pain. This effect may therefore be mediated through induction of functional disconnection between regulatory high-order affective regions and the sensorimotor cortex. Moreover, baseline functional connectivity between these brain areas may serve as a predictor for the extent of pain relief induced by THC.

opencc-zeroDec 2017View details →
dryad28/100

Data from: Alpha and beta diversity of connected benthic–subsurface invertebrate communities respond to drying in dynamic river ecosystems

Drying disturbances are the primary determinant of aquatic community biodiversity in dynamic river ecosystems. Research exploring how communities respond to disturbance has focused on benthic invertebrates in surface sediments, inadequately representing a connected community that extends into the subsurface. We compared subsurface and benthic invertebrate responses to drying, to identify common and context-dependent spatial patterns. We characterized community composition, alpha diversity and beta diversity across a gradient of drying duration. Subsurface communities responded to drying, but these responses were typically less pronounced than those of benthic communities. Despite compositional changes and in contrast to reductions in benthic alpha diversity, the alpha diversity of subsurface communities remained stable except at long drying durations. Some primarily benthic taxa were among those whose subsurface frequency and abundance responded positively to drying. Collectively, changing composition, stable richness and taxon-specific increases in occurrence provide evidence that subsurface sediments can support persistence of invertebrate communities during drying disturbances. Beta-diversity patterns varied and no consistent patterns distinguished the total diversity, turnover or nestedness of subsurface compared to benthic communities. In response to increasing drying duration, beta diversity increased or remained stable for benthic communities, but remained stable or decreased for subsurface communities, likely reflecting contrasts in the influence of mass effects, priority effects and environmental filtering. Dissimilarity between subsurface and benthic communities remained stable or increased with drying duration, suggesting that subsurface communities maintain distinct biodiversity value while also supporting temporary influxes of benthic taxa during drying events. As temporary rivers increase in extent due to global change, we highlight that recognizing the connected communities that extend into the subsurface sediments can enable holistic understanding of ecological responses to drying, the key determinant of biodiversity in these dynamic ecosystems.

opencc-zeroAug 2019View details →
dryad28/100

Data from: Delay of gratification is associated with white matter connectivity in the dorsal prefrontal cortex: a diffusion tensor imaging study in chimpanzees (Pan troglodytes)

Individual variability in delay of gratification (DG) is associated with a number of important outcomes in both non-human and human primates. Using diffusion tensor imaging (DTI), this study describes the relationship between probabilistic estimates of white matter tracts projecting from the caudate to the prefrontal cortex (PFC) and DG abilities in a sample of 49 captive chimpanzees (Pan troglodytes). After accounting for time between collection of DTI scans and DG measurement, age and sex, higher white matter connectivity between the caudate and right dorsal PFC was found to be significantly associated with the acquisition (i.e. training phase) but not the maintenance of DG abilities. No other associations were found to be significant. The integrity of white matter connectivity between regions of the striatum and the PFC appear to be associated with inhibitory control in chimpanzees, with perturbations on this circuit potentially leading to a variety of maladaptive outcomes. Additionally, results have potential translational implications for understanding the pathophysiology of a number of psychiatric and clinical outcomes in humans.

opencc-zeroDec 2014View details →
dryad28/100

Data from: Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

Developing neuronal systems intrinsically generate coordinated spontaneous activity that propagates by involving a large number of synchronously firing neurons. In vivo, waves of spikes transiently characterize the activity of developing brain circuits and are fundamental for activity-dependent circuit formation. In vitro, coordinated spontaneous spiking activity, or network bursts (NBs), interleaved within periods of asynchronous spikes emerge during the development of 2D and 3D neuronal cultures. Several studies have investigated this type of activity and its dynamics, but how a neuronal system generates these coordinated events remains unclear. Here, we investigate at a cellular level the generation of network bursts in spontaneously active neuronal cultures by exploiting high-resolution multielectrode array recordings and computational network modelling. Our analysis reveals that NBs are generated in specialized regions of the network (functional neuronal communities) that feature neuronal links with high cross-correlation peak values, sub-millisecond lags and that share very similar structural connectivity motifs providing recurrent interactions. We show that the particular properties of these local structures enable locally amplifying spontaneous asynchronous spikes and that this mechanism can lead to the initiation of NBs. Through the analysis of simulated and experimental data, we also show that AMPA currents drive the coordinated activity, while NMDA and GABA currents are only involved in shaping the dynamics of NBs. Overall, our results suggest that the presence of functional neuronal communities with recurrent local connections allows a neuronal system to generate spontaneous coordinated spiking activity events. As suggested by the rules used for implementing our computational model, such functional communities might naturally emerge during network development by following simple constraints on distance-based connectivity.

opencc-zeroDec 2016View details →

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Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.
Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record

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