Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,544
datasets available to search
ShareScore release 0.9.0
Dataset results
1,544 results for “microenvironment”
Sexually dimorphic gene expression responses of bovine embryos to the maternal microenvironment
GEO Series GSE276275. Bos taurus. 20 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Single-cell transcriptomic reveals functional heterogeneity of myeloid cells in glioma microenvironment"
<p>This record contains raw data related to article “single-cell transcriptomic reveals functional heterogeneity of myeloid cells in glioma microenvironment."</p> <p>High grade gliomas (HGG) are highly aggressive tumors with a particularly severe prognosis and an unmet medical need. HGG are characterized by a high degree of heterogeneity due to genetic and metabolic driving forces, either within and between individual patients. Temporal and spatial HGG heterogeneity contributes to response variability to conventional and adjuvant therapies among patients. HGG are also highly infiltrated by immune cells, tumor-associated macrophages (TAM) in particular, which are key drivers of the local immunosuppression supporting HGG progression and its resistance to immunomodulating therapeutic strategies. As the impact of HGG heterogeneity on macrophage biology remain poorly understood, we perform single-cell RNA sequencing, that reveals a large and dynamic myeloid landscape in patients with primary or secondary gliomas. To define the role in local immunosuppression and tumor progression, resident microglia and monocyte-derived macrophages are characterized, exhibiting additional heterogeneity across glioma subtypes. Understanding the immunosuppressive mechanisms operating in HGG is key to guide patients’ selection and optimize success rate of immunomodulating therapies.</p>
The processed data of a landscape of immune microenvironment for Solid Tumors
<h3>This study provides a comprehensive and detailed atlas of the immune microenvironment for solid tumors. The dataset includes processed single-cell sequencing data from 25 types of solid tumors and 3 normal tissues.</h3>
Effects of Ilex paraguariensis extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)
GEO Series GSE301490. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.