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1,601 results for “Prognosis;”
Dataset related to article "Radiomics-based prognosis classification for high-risk prostate cancer treated with radiotherapy "
<p>This record contains raw data related to article “Radiomics-based prognosis classification for high-risk prostate cancer treated with radiotherapy"</p> <p>Abstract:</p> <p><strong>Objective: </strong> The present study aimed to investigate if CT-based radiomics features could correlate to the risk of metastatic progression in high-risk prostate cancer patients treated with radical RT and long-term androgen deprivation therapy (ADT).</p> <p><strong>Materials and methods: </strong> A total of 157 patients were investigated and radiomics features extracted from the contrast-free treatment planning CT series. Three volumes were segmented: the prostate gland only (CTV_p), the prostate gland with seminal vesicles (CTV_psv), and the seminal vesicles only (CTV_sv). The patients were split into two subgroups of 100 and 57 patients for training and validation. Five clinical and 62 radiomics features were included in the analysis. Considering metastases-free survival (MFS) as an endpoint, the predictive model was used to identify the subgroups with favorable or unfavorable prognoses (separated by a threshold selected according to the Youden method). Pure clinical, pure radiomic, and combined predictive models were investigated.</p> <p><strong>Results: </strong> With a median follow-up of 30.7 months, the MFS at 1 and 3 years was 97.2% ± 1.5 and 92.1% ± 2.0, respectively. Univariate analysis identified seven potential predictors for MFS in the CTV_p group, 11 in the CTV_psv group, and 9 in the CTV_sv group. After elastic net reduction, these were 4 predictors for MFS in the CTV_p group (positive lymph nodes, Gleason score, H_Skewness, and NGLDM_Contrast), 5 in the CTV_psv group (positive lymph nodes, Gleason score, H_Skewnesss, Shape_Surface, and NGLDM_Contrast), and 6 in the CTV_sv group (positive lymph nodes, Gleason score, H_Kurtosis, GLCM_Correlation, GLRLM_LRHGE, and GLZLM_SZLGE). The patients' group of the training and validation cohorts were stratified into favorable and unfavorable prognosis subgroups. For the combined model, for CTV_p, the mean MFS was 134 ± 14.5 vs. 96.9 ± 22.2 months for the favorable and unfavorable subgroups, respectively, and 136.5 ± 14.6 vs. 70.5 ± 4.3 months for CTV_psv and 150.0 ± 4.2 vs. 91.1 ± 8.6 months for CTV_sv, respectively.</p> <p><strong>Conclusion: </strong> Radiomic features were able to predict the risk of metastatic progression in high-risk prostate cancer. Combining the radiomic features and clinical characteristics can classify high-risk patients into favorable and unfavorable prognostic groups.</p>
Dataset related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"
<p>This record contains raw data related to article "Phase II study of hypofractionated radiation therapy in elderly patients with newly diagnosed glioblastoma with poor prognosis"</p> <p>OBJECTIVE::</p> <p>To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity.</p> <p>METHODS::</p> <p>Patients with newly diagnosed glioblastoma, age ⩾70 years, Karnofsky performance scale (KPS) score ⩽60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70.88 Gy.</p> <p>RESULTS::</p> <p>Thirty patients were treated, with a median age of 75 years. Concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT) was administered in 7 (23.3%) and 11 (40.7%) patients received only adjuvant TMZ-CHT. The median, 6-month PFS, and 12-month PFS were 5.0 months, 43.3%, and 20%, respectively. The median, 6-month OS, and 12-month OS were 8 months, 90%, and 30%, respectively. At the last observation time, 26 patients (86.7%) were dead and 4 (13.3%) were alive. No increase in steroid drugs was required during radiotherapy treatment and a reduction was possible in 12 (40%). Patients with KPS=60, RPA V, MGMT methylated status, neurological status stable or improved after surgery and who underwent HFRT with concurrent and adjuvant CHT, had the better outcome.</p> <p>CONCLUSION::</p> <p>HFRT has proven to be feasible and effective, with limited morbidity, for selected elderly and frail patients with newly diagnosed glioblastoma. The primary objective of this study was not reached in the whole cohort but only in selected patients, who need more aggressive treatment.</p>
A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis
GEO Series GSE46177. Homo sapiens. 96 samples. Type: Methylation profiling by array.
S100A9 Overexpression Drives Chemoresistance and Poor Prognosis in AML with Adavivint as a Targeted Therapeutic
GEO Series GSE283851. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Dynamic Transcriptome Analysis Reveal New Prognosis Biomarker in Colorectal Cancer (gene expression)
GEO Series GSE41011. Homo sapiens. 31 samples. Type: Expression profiling by array.
Immune gene signatures in oropharyngeal cancers are associated with inverse prognosis by HPV-status
GEO Series GSE162738. Homo sapiens. 51 samples. Type: Expression profiling by high throughput sequencing.
An alpha-enolase (ENO1) related gene signature predicts prognosis risk and therapeutic response in diffuse large B-cell lymphoma
GEO Series GSE292371. Homo sapiens. 4 samples. Type: Other.
NR3C1, LAX1 and RCAN3 as circulating epigenetic biomarkers for prognosis and chemotherapy response prediction in metastatic pancreatic cancer
GEO Series GSE316251. Homo sapiens. 8 samples. Type: Methylation profiling by genome tiling array.
RNA Binding Patterns of Ischemic Heart Failure Prognosis Indicator Eukaryotic Translation Initiation Factor 3m Reveal its Unique Role in Regulation of Nitrative Damage after Myocardial Ischemia-Reperf
GEO Series GSE217286. Rattus norvegicus; Homo sapiens. 4 samples. Type: Other.
RNA Binding Patterns of Ischemic Heart Failure Prognosis Indicator Eukaryotic Translation Initiation Factor 3m Reveal its Unique Role in Regulation of Nitrative Damage after Myocardial Ischemia-Reperf
GEO Series GSE217285. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Monocyte phenotype indicates a poor prognosis in paracetamol (acetaminophen) induced acute liver failure but not in non-ae hepatitis: a prospective observational cohort study
GEO Series GSE80751. Homo sapiens. 22 samples. Type: Expression profiling by array.
Gene expression signature involved in estrogen receptor status and prognosis of breast cancers.
GEO Series GSE12080. Homo sapiens. 16 samples. Type: Expression profiling by array.
Differentially expressed noncoding RNAs as potential biomarkers for DIPG diagnosis and prognosis
GEO Series GSE138402. Homo sapiens. 12 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Recombinant GM-CSF enhances the bactericidal ability of PMNs by increasing intracellular IL-1β and improves the prognosis of secondary Pseudomonas aeruginosa pneumonia in sepsis
GEO Series GSE227162. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA Signatures Correlate with Diagnosis, Distant Metastasis and Prognosis in nasopharyngeal carcinoma
GEO Series GSE36682. Homo sapiens. 68 samples. Type: Non-coding RNA profiling by array.
Clinical value of nine circulating miRNAs in prognosis and diagnosis of PDAC
GEO Series GSE163031. Homo sapiens; synthetic construct. 15 samples. Type: Non-coding RNA profiling by array.
Gene expression changes associated with prognosis of Merkel cell carcinoma
GEO Series GSE36150. Homo sapiens. 15 samples. Type: Expression profiling by array.
miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma
GEO Series GSE71923. Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Mus musculus x Mus spretus. 14 samples. Type: Non-coding RNA profiling by array.
Breast tumor subtypes correlate with prognosis
GEO Series GSE18908. Homo sapiens. 111 samples. Type: Expression profiling by array.
Prediction of breast cancer prognosis by gene expression profile of TP53 status.
GEO Series GSE5546. Homo sapiens. 40 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.