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273 results for “Human immunodeficiency virus”
Data from: Incidence and risk factors of first-line antiretroviral treatment failure among human immunodeficiency virus-infected children in Amhara regional state, Ethiopia: a retrospective follow-up study
Objective: This study aimed to assess the incidence and risk factors of treatment failure among Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome infected (AIDS) children who were on Antiretroviral Therapy (ART) in Amhara National Regional State, Ethiopia. Methods: A retrospective follow-up study was conducted from January 2010 to March 2016. A total of 824 children under the age of 15 years who had started ART were included in the study. Data were collected from children's medical chart and ART registration logbook using a standard checklist. A Weibull regression model was used to identify the risk factors for treatment failure. Adjusted Hazard Ratios with 95% confidence intervals were used to declare statistical significance. Results: The mean (±SD) age of the children was 6.4 ± 3.6 years with a median (IQR) follow up of 30.5 (IQR: 14.6, 51.4) months. Sixty-three children (7.7%, 95%CI:5.8, 9.5) developed treatment failure. Seventeen (27.0%) of whom were immunological and 46 (73.0 %) clinical failures. The incidence rate of treatment failure was 22.1/10000 person-months. The cumulative probability of failure was 0.4 with 28562.5 person-month observations. Lack of disclosure [AHR=4. 4, 95%CI (1.8, 11.3)], opportunistic infections during initiation of ART [AHR= 2.3, 95% CI (1.3, 4.1)] and prolonged follow up [AHR = 0.06, 95% CI (0.02, 0.18)] were the main predictors of treatment failure. Conclusion: This study revealed that the incidence of treatment failure remains a significant public health concern in Ethiopia. Undisclosed HIV status to children, the presence of opportunistic infections during initiation of ART and prolonged follow up was found to be the main predictors of treatment failure. Hence, early detection of the treatment failures and further studies on viral monitor need to consider.
Single-Dose Study of MK-4250 Monotherapy in Anti-Retroviral Therapy-Naive, Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-4250-002)
ClinicalTrials.gov study NCT03351699. IPD Sharing: YES. Countries: 1. Publications: 0.
Addressing Drug Use Stigma in Human Immunodeficiency Virus (HIV) Care and Treatment Clinics in Tanzania
ClinicalTrials.gov study NCT04863898. IPD Sharing: YES. Countries: 1. Publications: 0.
Dose Ranging, Switch Study of Islatravir (MK-8591) and Ulonivirine (MK-8507) Once-Weekly in Virologically-Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) [MK-8591-013]
ClinicalTrials.gov study NCT04564547. IPD Sharing: YES. Countries: 3. Publications: 0.
Evaluation of a Human Immunodeficiency Virus (HIV) Blood Screening Assay
ClinicalTrials.gov study NCT00686205. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant
ClinicalTrials.gov study NCT02797470. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)
ClinicalTrials.gov study NCT00552240. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MK-8583 Single Dose Study in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8583-002)
ClinicalTrials.gov study NCT03552536. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety and Efficacy Trial of Serostim® in the Treatment of Subjects With Human Immunodeficiency Virus-associated Adipose Redistribution Syndrome (HARS)
ClinicalTrials.gov study NCT00294164. IPD Sharing: Not stated. Countries: 0. Publications: 1.
NATURAL HISTORY-Hepatitis C Virus/ Human Immunodeficiency Virus Coinfection
ClinicalTrials.gov study NCT00315432. IPD Sharing: Not stated. Countries: 0. Publications: 1.
The Antiviral Efficacy of Concurrent Zidovudine and 2',3'-Dideoxyinosine or 2',3'-Dideoxycytidine in Patients With Human Immunodeficiency Virus Disease
ClinicalTrials.gov study NCT00002001. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Study of Enfuvirtide (Fuzeon) in Participants With Advanced Human Immunodeficiency Virus (HIV) Infection
ClinicalTrials.gov study NCT02582983. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus
ClinicalTrials.gov study NCT01822522. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Status of Chronic Liver Disease in Hepatitis C Virus (HCV) Patients Coinfected With Human Immunodeficiency Virus (HIV) in Andalusia
ClinicalTrials.gov study NCT02511496. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Switching Nevirapine Immediate Release( IR) Based Regimen to Nevirapine Extended Release (XR) Based Regimen in Human Immunodeficiency Virus One (HIV-1) Infected Patients
ClinicalTrials.gov study NCT00819052. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy
ClinicalTrials.gov study NCT00264875. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic
ClinicalTrials.gov study NCT05911360. IPD Sharing: YES. Countries: 12. Publications: 0.
Long Term Follow-Up Study of Human Immunodeficiency Virus Type 1 (HIV-1) Positive Patients Who Have Received OZ1 Gene Therapy as Part of a Clinical Trial
ClinicalTrials.gov study NCT01177059. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study to Evaluate the Efficacy of GS-9131 Functional Monotherapy in Human Immunodeficiency Virus (HIV)-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen With
ClinicalTrials.gov study NCT03472326. IPD Sharing: NO. Countries: 2. Publications: 0.
Treatment of Abnormal Adipose Tissue Accumulation in Human Immunodeficiency Virus (HIV) Patients
ClinicalTrials.gov study NCT00082628. IPD Sharing: Not stated. Countries: 2. Publications: 0.
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