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547 results for “Infection Control”
A Controlled Study of the Safety and Efficacy of Lessertia Frutescens in HIV-infected South African Adults
ClinicalTrials.gov study NCT00549523. IPD Sharing: NO. Countries: 1. Publications: 2.
A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand
ClinicalTrials.gov study NCT00362596. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Infection Control in ERCP Using a Duodenoscope With a Disposable Cap
ClinicalTrials.gov study NCT04040504. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Impact of the Ebola outbreak on Trypanosoma brucei gambiense infection medical activities in coastal Guinea, 2014-2015: a retrospective analysis from the Guinean national Human African Trypanosomiasis control program
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Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis Infection
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Data from: Evidence that hepatitis C virus genome partly controls infection outcome
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Schizophrenia and Bartonella spp. infection: A pilot case–control study
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Data from: Inter- and intra-specific variation of spider mite susceptibility to fungal infections: implications for the long-term success of biological control
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Data from: Syphilis infection among homosexual men reporting contact with syphilis: a case control study
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Bulk RNA seq of macrophages isolated from Kmo morphant or control morphant zebrafish larvae infected with <em>Salmonella Typhimurium</em>
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Figure 1 from: Senapati S, Dash J, Sethi M, Chakraborty S (2020) Bioengineered probiotics to control SARS-CoV-2 infection. Research Ideas and Outcomes 6: e54802. https://doi.org/10.3897/rio.6.e54802
<p>Figure 1 Bioengineered probiotics to control SARS-CoV-2 infection. (a) Pathogenesis of SARS-CoV-2 depends on interaction between S protein of virus and angiotensin-converting enzyme 2 (ACE2) expressed on the surface of host cells. (b (1)) Engineered probiotics with expression of cell bound ACE2, sequesters the virus by making it bind to the ACE2 receptor on its surface thus inhibiting the viral entry into gut epithelial cells. (b (2)) The secreted form of ACE2 (sACE2) produced by probiotics confiscates the virus by binding to S proteins and masking their binding sites for gut epithelial ACE2. (c) The sACE2 could also have systemic effects due to its absorption into circulation and inhibiting the virus binding at distant organs like lungs.</p>
Genotype count for all coding variants in type I IFN genes investigated in 659 life-threatening COVID-19 patients and 534 asymptomatic/mild infected controls
<p>Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.</p>
Efficacy of Mass Drug Administration approved and candidate anthelmintics on L1 C. elegans is similar to L4 on mebendazole, and similar or lower to previously published efficacy with other anthelmintics on L4, suggesting a novel, pre-infective control
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Supplementary figure 1. Histopathological analysis of the pseudobranch tissues in Atlantic salmon following SAV3 challenge (by cohabitation) at 16 dpc showing no histological difference between (A) Control fish (non infected) and (B) SAV3-infected fish from HD group at 16 dpc.
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RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
<p><span>Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity <em>in vitro</em>, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were highly susceptible to IAV and Sendai virus infection compared to control mice. FGF9-OE mice displayed elevated and persistent viral loads, increased expression of cytokines and chemokines, and increased numbers of infiltrating immune cells as early as 1 day post-infection (dpi). Gene expression analysis showed an elevated type I interferon (IFN) signature in the conducting airway epithelium and analysis of IAV tropism uncovered a dramatic shift in infection from the conducting airway epithelium to the alveolar epithelium in FGF9-OE lungs. These results demonstrate that FGF9 signaling primes the conducting airway epithelium to rapidly induce a localized, protective IFN and proinflammatory cytokine response during viral infection. Although this response protects the airway epithelial cells from IAV infection, it allows for early and enhanced infection of the alveolar epithelium, ultimately leading to increased morbidity and mortality. Our study illuminates a novel role for FGF9 in regulating respiratory virus infection and pathogenesis.</span></p>
Figure 1 in Placebo-Controlled Phase 3 Trial of a Recombinant Glycoprotein 120 Vaccine to Prevent HIV-1 Infection
Figure 1. Flow of study participants in the present trial (VAX004). rgp, recombinant glycoprotein.
Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism
<p>Human plasma metabolomics dataset generated from controlled human hookworm infection study. <br><br><span>Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal disease. However, full-scale clinical trials examining hookworm therapy are limited by the inability to scale-up the production of hookworm larvae to infect sufficient numbers of patients. With the aim of overcoming this challenge, this study infected four healthy individuals with hookworm larvae that had been reanimated from cryopreserved eggs, to examine their viability and immunogenicity. We</span><span> demonstrate that reanimated cryopreserved hookworm larvae establish a viable hookworm infection and elicit a similar immune response to larvae cultured from fresh stool. Furthermore, </span><span>a refined understanding of the therapeutic mechanisms of hookworm is imperative to determine which diseases to target with hookworm therapy. To investigate potential therapeutic mechanisms, this study infected 13 healthy individuals with hookworm and assessed changes in the immune cells, microbiome, and metabolome.</span><span> <span>We identified potential immunoregulatory mechanisms by which hookworm may provide a beneficial </span></span><span>effect on its host, including increased expression of CTLA-4 on regulatory T cells (Tregs) and upregulation of tryptophan metabolism. In summary, our findings demonstrate the feasibility of full-scale clinical trials examining hookworm therapy by minimising the reliance on human donors and optimising the culturing process, thereby enabling viable hookworm larvae to be mass-produced and enabling on-demand inoculation of patients. Furthermore, this study provides insights into the complex interactions between helminths and their host, which could inform the development of novel therapeutic strategies.</span></p>
Fig. 7 in Patterns of Fasciola hepatica infection in Danish dairy cattle: implications for on-farm control of the parasite based on different diagnostic methods
Fig. 7 Results of generalised additive mixed models (GAMM) showing the relative effects of animal age, season of sampling, and date of the sampling (for longer-term temporal trends) within the studied farms. Each combination of farm and diagnostic test was modelled independently. The estimates are shown using solid lines and shaded areas indicate 95% confidence intervals. The y-axis is on the natural logarithm scale
Antiviral Tfh response by "immunotolerant" virus carriers drives antibody-mediated control of congenital infection
<p>Analysed and annotated SingleCellExperiment object </p>
Knowledge and attitude of infection prevention and control practices among health care workers caring for patients with suspected or confirmed COVID-19
<p><b>Background: </b>COVID-19 pandemic is growing rapidly, accounting for an increasing proportion of cases worldwide. Infection in healthcare facilities enhances very likely the local outbreaks, impacting mainly the elderly and vulnerable populations. All activities used to minimize the risk of infection spread are referred to as infection control measures.<b> </b>Therefore, this study aimed to; determine the proportion of SARS-COV2 infection among heath care workers (HCWs) caring for patients with suspected or confirmed COVID-19, assess their knowledge and attitude to infection control practices and recommend strategies to decrease the risk of SARS-COV2 infection among them.<b> </b></p> <p><b>Methods: </b>This is an electronic-based cross-sectional analytical study conducted in Egypt to assess the knowledge, attitude of HCWs to infection control practices for patients with suspected or confirmed COVID-19 infection. A purposive sample of 520 participants was targeted through electronic data collection, and they were asked to fill a structured questionnaire form and submit it.</p> <p><b>Results: </b>The study revealed that 11% of the HCWs were infected with SARS-Cov2.<b> </b>Their mean knowledge percent score regarding infection control prevention practices was 36.19 ± 11.26. The higher rate of infection was among Internal Medicine specialists (75%) with little experience (76.7%), affiliated with the Ministry of Health (46.7%). About (89%) mentioned that the leading cause of infection was the shortage in Personal Protective Equipment PPE.</p> <p><b>Conclusion: </b>There was a high proportion of SARS-COV2 infection among HCWs in EGYPT, especially among those working in Cairo governorate in Internal Medicine Departments, with fewer years of experience, due to lack of knowledge about infection prevention and control measures and shortage of Personal Protective Equipment in their working facilities.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.