Find research datasets worth reusing

openGEO-OpenSep 2009View details →

Identification of genes related to local aggressiveness and metastatical potential in mesenchymal tumors

GEO Series GSE14541. Homo sapiens. 204 samples. Type: Expression profiling by array.

openGEO-OpenMay 2011View details →

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging- Related Transcriptional Networks (ChIP-chip)

GEO Series GSE28638. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by genome tiling array.

openGEO-OpenMay 2011View details →

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging- Related Transcriptional Networks

GEO Series GSE28641. Mus musculus. 26 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array.

openGEO-OpenJan 2012View details →

Combined Use of Laser Capture Microdissection and Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions

GEO Series GSE26866. Homo sapiens. 37 samples. Type: Expression profiling by array.

openGEO-OpenMay 2014View details →

Related insects show differing amounts of population differentiation and localization of transcribed genes in response to climate (Erynnis propertius)

GEO Series GSE56404. Gesta propertius. 12 samples. Type: Expression profiling by array.

opennotspecifiedNov 2017View details →

Distribution. NC DRCongo, a few localities in the Congo Basin on left bank of the Congo River; its exact distribution is unknown but is probably related to the forest block extension and limited by rivers. in Muridae

Distribution. NC DRCongo, a few localities in the Congo Basin on left bank of the Congo River; its exact distribution is unknown but is probably related to the forest block extension and limited by rivers.

opennotspecifiedApr 2019View details →

FIGURE 10. Collecting method for M in The return of the Duke - locality data for Megadytes ducalis Sharp, 1882, the world's largest diving beetle, with notes on related species (Coleoptera: Dytiscidae)

FIGURE 10. Collecting method for M. lherminieri in Guadeloupe: (A) Close up view at Etang Fromager, Le Moule, Grande- Terre, Guadeloupe, 18 V 2012, N16°19'18"/W61°24'04"; (B) Example of a trap with Megadytes and other diving beetles inside (trapping session in the pond shown in Fig. 9A); (C) Female of M. lherminieri from Guadeloupe (Photos: M. Manuel).

opennotspecifiedApr 2019View details →

FIGURE 4 in The return of the Duke - locality data for Megadytes ducalis Sharp, 1882, the world's largest diving beetle, with notes on related species (Coleoptera: Dytiscidae)

FIGURE 4. Megadytes ducalis, male specimen from collection Guignot: A) median lobe with parameres in ventral view, B) tip of median lobe in lateral view, C) anterior half median lobe in ventro-apical view; Megadytes ducalis, holotype: D) median lobe in ventral view (Foto: R. Angus). Scale bars = 1.5 mm.

opennotspecifiedDec 2019View details →

Abbreviations: ILK: indigenous and local knowledge; IPLCs: indigenous peoples and local communities; NBSAPs: national biodiversity strategies and action plans. a Strategic Plan for Biodiversity 2011–2020. Figure 6. Summary of progress towards the Aichi Targets. Scores are based on quantitative analysis of indicators, a systematic review of the literature, fifth National Reports to the CBD, and available information on countries' stated intentions to implement additional actions by 2020. Progress towards target elements is scored as "Good" (substantial positive trends at a global scale relating to in Summary for policymakers of the global assessment report on biodiversity and ecosystem services - unedited advance version

Abbreviations: ILK: indigenous and local knowledge; IPLCs: indigenous peoples and local communities; NBSAPs: national biodiversity strategies and action plans. a Strategic Plan for Biodiversity 2011–2020. Figure 6. Summary of progress towards the Aichi Targets. Scores are based on quantitative analysis of indicators, a systematic review of the literature, fifth National Reports to the CBD, and available information on countries' stated intentions to implement additional actions by 2020. Progress towards target elements is scored as "Good" (substantial positive trends at a global scale relating to

opennotspecifiedJun 2020View details →

Fig. 7 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 7. Levels of JAs (A) and some non-oxylipin metabolites (B) in leaves of WT (blue squares), lox10 (red circles) and opr7opr8 (green triangles) after wounding treatment. Values are mean ± standard error (n ≥ 4). Statistical differences are presented in Supplemental Fig. S2.

opennotspecifiedJun 2020View details →

Fig. 3 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 3. Basal levels of oxylipins in roots of WT, lox10 and opr7opr8. (A) 9-LOX-derived products; (B), (C) and (D) 13-LOX-derived products; (E) α-DOX-derived 2-HOD and 10-HOD generated by reactive oxygen species (ROS). Values are mean ± standard error (n = 5). Different letters show significant differences (one-way ANOVA, S–N–K, P <0.05).

opennotspecifiedJun 2020View details →

Fig. 4. 9 in Relative contribution of LOX10, green leaf volatiles and JA to woundinduced local and systemic oxylipin and hormone signature in Zea mays (maize)

Fig. 4. 9-LOX-derived oxylipin accumulation in leaves of WT (blue squares), lox10 (red circles) and opr7opr8 (green triangles) after wounding treatment. Values are mean ± standard error (n ≥ 4). Statistical differences are presented in Supplemental Fig. S2.

ClinicalTrials.gov20/100

Study on the Efficacy of Autologous Fat Grafting in Improving Hair Transplantation Outcomes for Patients With Localized Scleroderma-Related Alopecia

ClinicalTrials.gov study NCT06646146. IPD Sharing: NO. Countries: 0. Publications: 0.

closedIPD-NOFeb 2026View details →

Dataset related to article "Predicting survival and local control after radiochemotherapy in locally advanced head and neck cancer by means of computed tomography based radiomics."

PURPOSE: To appraise the ability of a radiomics signature to predict clinical outcome after definitive radiochemotherapy (RCT) of stage III-IV head and neck cancer. METHODS: A cohort of 110 patients was included in a retrospective analysis. Radiomics texture features were extracted from the gross tumor volumes contoured on planning computed tomography (CT) images. The cohort of patients was randomly divided into a training (70 patients) and a validation (40 patients) cohorts. Textural features were correlated to survival and control data to build predictive models. All the significant predictors of the univariate analysis were included in a multivariate model. The quality of the models was appraised by means of the concordance index (CI). RESULTS: A signature with 3 features was identified as predictive of overall survival (OS) with CI = 0.88 and 0.90 for the training and validation cohorts, respectively. A signature with 2 features was identified for progression-free survival (PFS; CI = 0.72 and 0.80); 2 features also characterized the signature for local control (LC; CI = 0.72 and 0.82). In all cases, the stratification in high- and low-risk groups for the training and validation cohorts led to significant differences in the actuarial curves. In the validation cohort the mean OS times (in months) were 78.9 ± 2.1 vs 67.4 ± 6.0 in the low- and high-risk groups, respectively, the PFS was 73.1 ± 3.7 and 50.7 ± 7.2, while the LC was 78.7 ± 2.1 and 63.9 ± 6.5. CONCLUSION: CT-based radiomic signatures that correlate with survival and control after RCT were identified and allow low- and high-risk groups of patients to be identified.

Dataset related to article "Impact of hypofractionated schemes in radiotherapy for locally advanced head and neck cancer patients."

OBJECTIVE: To analyze two cohorts of locally advanced head and neck cancer (LAHNC) patients treated with two schedules of hypofractionated radiotherapy and 5 versus 3 mm clinical target volume-planning target volume (CTV-PTV) margins. METHODS: 145 patients were included. The patient cohort was divided into two groups. Group A included 97 patients treated with 69.96/54.45 grays (Gy) to the high-risk and low-risk volumes, respectively, in 33 fractions, with 5 mm margins. Group B included 48 patients treated with 66/54 Gy in 30 fractions using 3 mm margins. Toxicity was recorded according to the Common Toxicity Criteria version 3. Patient outcomes for locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) were determined. RESULTS: Median follow-up was 26 months. In terms of toxicity, acute dysphagia worsened significantly (P = 0.003) in group B, whereas acute salivary toxicity tended to significance (P = 0.071). No significant late toxicity differences were recorded. Rates of LRC at 1 and 2 years were 90.1% ± 2.6% and 84.2% ± 3.4%, respectively, with superiority for group A (P = 0.045). The statistical significance remained for the low-dose level (P = 0.007) but not for high dose (P = 0.110). Rates of DFS at 1 and 2 years were 84.9% ± 3.1% and 76.5% ± 3.9%, respectively, whereas rates of OS were 95.9% ± 1.8% and 91.6% ± 2.7%, respectively. No differences were observed between the two groups in terms of DFS (P = 0.270) and OS (P = 0.152). CONCLUSION: The use of reduced CTV to PTV margins and dose reduction with hypofractionation schedule can improve the pattern of toxicity in LAHNC patients. This approach resulted in an increased rate of locoregional progression, particularly in low-risk regions. LEVEL OF EVIDENCE: 4 Laryngoscope, 2019.

restrictedOct 2022View details →

Dataset related to article "Locally Advanced Non-Small Cell Lung Cancer: Clinical Outcome, Toxicity and Predictive Factors in Patients Treated with Hypofractionated Sequential or Exclusive Radiotherapy "

This record contains raw data related to article “Locally Advanced Non-Small Cell Lung Cancer: Clinical Outcome, Toxicity and Predictive Factors in Patients Treated with Hypofractionated Sequential or Exclusive Radiotherapy" Abstract: Background: This study evaluated the outcome, toxicity and predictive factors in patients unfit for concurrent chemo-radiotherapy (CT-RT) treated with hypofractionated sequential CT-RT or exclusive radiotherapy (RT) for locally advanced non-small cell lung cancer (LA-NSCLC). Methods: We included patients affected by LA-NSCLC (stage IIA-IVA) treated with a total dose of 50-60 Gy in 20 fractions. The primary outcomes were local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS) and overall survival (OS). Univariate analysis was used to correlate outcomes with prognostic factors. Results: Between 2011 and 2019, 210 patients were treated, 113 (53.8%) with sequential CT-RT and 97 (46.2%) with exclusive RT. After a median follow-up of 15.3 months, 74 patients (35.2%) had a local progression and 133 (63.3%) had a distant progression. The one-, two- and five-year LC were 73.6%, 55.3% and 47.9%, respectively. At the time of analysis, 167 patients (79.5%) died. The one-, two- and five-year OS were 64.7%, 36% and 20%, respectively. PTV volume correlated with PFS (p = 0.001) and LC (p = 0.005). Acute and late toxicity occurred in 82% and 26% of patients. Conclusions: Albeit with the known limitations of a retrospective and heterogeneous study, our work shows that hypofractionated sequential CT-RT or exclusive RT offer a good local control and toxicity profile and a promising survival rate in LA-NSCLC patients unfit for the concurrent CT-RT scheme.

opennotspecifiedApr 2019View details →

FIGURE 2 in The return of the Duke - locality data for Megadytes ducalis Sharp, 1882, the world's largest diving beetle, with notes on related species (Coleoptera: Dytiscidae)

FIGURE 2. Habitus in lateral view of: A) M. ducalis, B) M. lherminieri, C) M. magnus.

restrictedOct 2022View details →

Dataset related to article "Locally Advanced Non-Small Cell Lung Cancer: Clinical Outcome, Toxicity and Predictive Factors in Patients Treated with Hypofractionated Sequential or Exclusive Radiotherapy"

This record contains data related to article "Locally Advanced Non-Small Cell Lung Cancer: Clinical Outcome, Toxicity and Predictive Factors in Patients Treated with Hypofractionated Sequential or Exclusive Radiotherapy" Background: This study evaluated the outcome, toxicity and predictive factors in patients unfit for concurrent chemo-radiotherapy (CT-RT) treated with hypofractionated sequential CT-RT or exclusive radiotherapy (RT) for locally advanced non-small cell lung cancer (LA-NSCLC). Methods: We included patients affected by LA-NSCLC (stage IIA-IVA) treated with a total dose of 50–60 Gy in 20 fractions. The primary outcomes were local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS) and overall survival (OS). Univariate analysis was used to correlate outcomes with prognostic factors. Results: Between 2011 and 2019, 210 patients were treated,113 (53.8%) with sequential CT-RT and 97 (46.2%) with exclusive RT. After a median follow-up of 15.3 months, 74 patients (35.2%) had a local progression and 133 (63.3%) had a distant progression. The one-, two- and five-year LC were 73.6%, 55.3% and 47.9%, respectively. At the time of analysis, 167 patients (79.5%) died. The one-, two- and five-year OS were 64.7%, 36% and 20%, respectively. PTV volume correlated with PFS (p = 0.001) and LC (p = 0.005). Acute and late toxicity occurred in 82% and 26% of patients. Conclusions: Albeit with the known limitations of a retrospective and heterogeneous study, our work shows that hypofractionated sequential CT-RT or exclusive RT offer a good local control and toxicity profile and a promising survival rate in LA-NSCLC patients unfit for the concurrent CT-RT scheme.

zenodo12/100

Dataset related to article "Computed tomography based radiomic signature as predictive of survival and local control after stereotactic body radiation therapy in pancreatic carcinoma"

PURPOSE: To appraise the ability of a radiomics signature to predict clinical outcome after stereotactic body radiation therapy (SBRT) for pancreas carcinoma. METHODS: A cohort of 100 patients was included in this retrospective, single institution analysis. Radiomics texture features were extracted from computed tomography (CT) images obtained for the clinical target volume. The cohort of patients was randomly divided into two separate groups for the training (60 patients) and validation (40 patients). Cox regression models were built to predict overall survival and local control. The significant predictors at univariate analysis were included in a multivariate model. The quality of the models was appraised by means of area under the curve and concordance index. RESULTS: A clinical-radiomic signature associated with Overall Survival (OS) was found significant in both training and validation sets (p = 0.01 and 0.05 and concordance index 0.73 and 0.75 respectively). Similarly, a signature was found for Local Control (LC) with p = 0.007 and 0.004 and concordance index 0.69 and 0.75. In the low risk group, the median OS and LC in the validation group were 14.4 and 28.6 months while in the high-risk group were 9.0 and 17.5 months respectively. CONCLUSION: A CT based radiomic signature was identified which correlate with OS and LC after SBRT and allowed to identify low and high-risk groups of patients.

zenodo12/100

Dataset related to article "Reirradiation of Locally Recurrent Prostate Cancer With Volumetric Modulated Arc Therapy."

PURPOSE: This study explores the efficacy and safety of reirradiation with modern radiation therapy techniques in patients previously irradiated for prostate cancer and affected by local relapse of disease. METHODS AND MATERIALS: Patients affected by previously irradiated prostate cancer were enrolled in this reirradiation study if they had a biochemical relapse and a 11C-choline positron emission tomography scan revealing the presence of a local recurrence of disease. Reirradiation consisted of a stereotactic treatment delivered by image guided radiation therapy-volumetric modulated arc therapy with flattening filter-free technology in 5 daily fractions. RESULTS: Twenty-three patients underwent reirradiation to the prostate, prostatic bed, or prostate and local recurrence. Re-treatment consisted of a median total dose of 25 Gy in 5 fractions. A biochemical response was observed in all cases. Acute toxicity was mainly genitourinary (GU) grade 1 to 2 (n = 13; 56.5%). One patient (4.3%) had grade 3 hematuria. A grade 1 GU late toxicity was registered in 4 patients (17.4%) and grade 3 in 1 patient (4.3%, urethral obstruction). Gastrointestinal toxicity was negligible. Regression analysis showed that only a short elapsed time in months from primary radiation therapy was significantly correlated with acute GU toxicity. After a median follow-up of 33 months (range, 5-58 months), the median biochemical recurrence-free survival was 19 months, and the 2-year biochemical recurrence-free survival (BRFS) was 41.7%. Median local control was 30 months; the 2-year local control rate was 58.1%. CONCLUSIONS: Reirradiation of patients with prostate cancer who underwent previous radiation therapy is a valuable option that can be safely considered to delay the beginning of hormonal treatment.